DNA修复
基因
试剂
文献样例
产品评述样例
53BP1
tumor protein p53 binding protein 1
总数:18
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. 2011 至该文献
为了研究染色体结构异常可由染色体分离错误引起，采用了Santa Cruz的抗53BP1抗体进行免疫细胞化学实验。 更多
ALKBH2
alkB, alkylation repair homolog 2 (E. coli)
ALKBH3
alkB, alkylation repair homolog 3 (E. coli)
APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
总数:7
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. 2008 至该文献
为了研究APE1的转录调节功能以及它与肿瘤细胞的药物抗性的关联，使用了Novus Biologicals公司的鼠抗APE1单克隆抗体来进行染色质免疫沉淀实验。 更多
毛细血管扩张性共济失调症突变蛋白 (ATM)
ataxia telangiectasia mutated
总数:49
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. 2011 至该文献
为了研究染色体结构异常可由染色体分离错误引起，采用了Cell Signaling的抗1981位丝氨酸磷酸化ATM抗体进行免疫细胞化学实验。 更多
ATR
ataxia telangiectasia and Rad3 related
总数:23
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 至该文献
为了研究DNA损伤应答过程中RHINO对ATR活化的重要作用，采用Santa Cruz的抗ATR抗体进行蛋白印迹实验。 更多
乳腺癌1号基因 (BRCA1)
breast cancer 1, early onset
总数:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 至该文献
Calbiochem的 抗BRCA1抗体以免疫共沉淀的方法来研究其在乳腺癌中apicobasal 极性和对肿瘤干细胞的作用 更多
BRCA2
breast cancer 2, early onset
总数:10
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 至该文献
为了研究FAN1在通过单泛素化FANCI-FANCD2复合物促进DNA链间交联修复，使用了EMD公司的抗BRCA2抗体来进行免疫荧光实验。 更多
C17orf70
chromosome 17 open reading frame 70
C19orf40
chromosome 19 open reading frame 40
CCNH
cyclin H
总数:3
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. 2005 至该文献
为研究人牙本质基质蛋白1(Dmp1)在Ras-Raf-Arf信号通路传导中的作用，采用Santa Cruz生产的cyclin H抗体用于免疫印迹实验。 更多
CCNO
cyclin O
cdk7
cyclin-dependent kinase 7
总数:8
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 至该文献
为了研究即刻早期反应基因表达调控因MED23突变而被破坏并导致智力障碍，采用Santa Cruz的多抗CDK7抗体进行ChIP和蛋白印迹实验。 更多
DDB1
damage-specific DNA binding protein 1, 127kDa
总数:5
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. 2007 至该文献
为了研究泛素/蛋白酶体系统在HIV-1病毒的Vpr蛋白诱导细胞周期G2阻滞中的作用，采用了Abcam公司的DDB1抗体，进行了蛋白质印迹实验。 更多
DDB2
damage-specific DNA binding protein 2, 48kDa
总数:1
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应，采用了Abcam DDB2抗体进行了蛋白质印迹实验。
DNA ligase I
ligase I, DNA, ATP-dependent
总数:4
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. 2006 至该文献
DNA ligase IV
ligase IV, DNA, ATP-dependent
总数:4
The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo. 2009 至该文献
为了研究cernunnos/XLF的C末端区域在调控体内DNA修复中的作用，采用了Abcam公司的DNA ligase IV 抗体产品，进行了免疫印迹实验。 更多
DNA聚合酶β (DNA polymerase beta)
polymerase (DNA directed), beta
总数:1
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. 2003 至该文献
DNA-PKcs
protein kinase, DNA-activated, catalytic polypeptide
总数:11
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. 2009 至该文献
为了研究腺相关病毒和腺病毒共感染对诱导细胞DNA损伤应答的影响，使用了NeoMarkers公司的抗DNA-PKcs抗体来进行免疫印迹分析和免疫荧光实验。 更多
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
总数:2
Biochemical analysis of the damage recognition process in nucleotide excision repair. 2003 至该文献
ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
总数:4
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应，采用了Santa Cruz XPB抗体进行了蛋白质印迹实验。 更多
ERCC6
excision repair cross-complementing rodent repair deficiency, complementation group 6
总数:2
The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. 2006 至该文献
ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8
FANCA
Fanconi anemia, complementation group A
总数:2
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. 2009 至该文献
为了阐明DNA损伤特异的FANCA1449位丝氨酸的磷酸化是ATR的下游反应并且在FA通路中发挥重要作用，采用了Cascade Bioscience公司的抗FANCA抗体，进行了蛋白质印迹实验。 更多
FANCB
Fanconi anemia, complementation group B
FANCC
Fanconi anemia, complementation group C
总数:2
Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution. 2003 至该文献
FANCD2
Fanconi anemia, complementation group D2
总数:9
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 至该文献
为了研究FAN1在通过单泛素化FANCI-FANCD2复合物促进DNA链间交联修复，使用了Novus Biological公司的抗FANCD2多克隆抗体来进行免疫荧光实验。 更多
FANCE
Fanconi anemia, complementation group E
总数:1
The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments. 2004 至该文献
FANCF
Fanconi anemia, complementation group F
总数:1
The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments. 2004 至该文献
FANCG
Fanconi anemia, complementation group G
FANCI
Fanconi anemia, complementation group I
总数:1
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 至该文献
为了研究FAN1在通过单泛素化FANCI-FANCD2复合物促进DNA链间交联修复，使用了Abcam公司的抗FANCI抗体来进行免疫荧光实验。
FANCL
Fanconi anemia, complementation group L
Fanconi anemia complementation group M
Fanconi anemia, complementation group M
FEN1
flap structure-specific endonuclease 1
总数:2
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score. 2006 至该文献
为了研究人初级前列腺癌中结构特异的核酸内切酶(FEN-1)得表达和潜在的临床意义，采用了Novocastra公司的多克隆抗FEN-1抗体进行免疫组织化学分析 更多
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
总数:3
Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro. 2003 至该文献
在免疫印迹实验中使用了Santa Cruz Biotechnology公司的抗TFIIH p62抗体用于研究CDK11p110信号和蛋白复合物的特性以及其在转录和RNA表达中的作用。 更多
GTF2H2
general transcription factor IIH, polypeptide 2, 44kDa
GTF2H3
general transcription factor IIH, polypeptide 3, 34kDa
总数:1
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. 2009 至该文献
为了研究在脂肪基质细胞(ASCs)中对芳香化酶转录和雌性激素生物合成的调控机制，采用了Santa Cruz Biotechnology公司的TFIIH抗体，进行了蛋白质印迹实验。
GTF2H4
general transcription factor IIH, polypeptide 4, 52kDa
总数:1
Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. 2004 至该文献
H2A组蛋白家族成员X (H2AX)
H2A histone family, member X
总数:57
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. 2011 至该文献
为了研究染色体结构异常可由染色体分离错误引起，采用了Upstate的抗gammaH2AX抗体进行免疫细胞化学实验。 更多
Ku70
X-ray repair complementing defective repair in Chinese hamster cells 6
总数:17
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. 2010 至该文献
为了研究Ku70和FANCC的关联以及它们在DNA修复应答中的功能，使用了Neomarkers公司的抗Ku70抗体来进行免疫印迹分析。 更多
Ku80
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
总数:21
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. 2010 至该文献
为了研究Ku70和FANCC的关联以及它们在DNA修复应答中的功能，使用了Neomarkers公司的小鼠抗Ku80抗体来进行免疫印迹分析。 更多
LIG3
ligase III, DNA, ATP-dependent
总数:3
Enhancement of DNA ligase I level by gemcitabine in human cancer cells. 2002 至该文献
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
总数:2
Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. 2001 至该文献
MBD4
methyl-CpG binding domain protein 4
MDC1
mediator of DNA-damage checkpoint 1
总数:7
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. 2011 至该文献
为了研究染色体结构异常可由染色体分离错误引起，采用了Abcam的抗MDC1抗体进行免疫细胞化学实验。 更多
MGMT
O-6-methylguanine-DNA methyltransferase
MNAT1
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
总数:2
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". 2006 至该文献
MPG
N-methylpurine-DNA glycosylase
Mre11
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
总数:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. 2009 至该文献
为了研究E1B-55K/E4orf6复合物同eIF2α的关系，采用了Calbiochem公司的兔单克隆Mre11抗体，进行了蛋白印记实验。 更多
MYH
mutY homolog (E. coli)
总数:2
Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase. 2004 至该文献
为了对四种主要的损伤特异的DNA糖基化酶修复基因的防护效应进行比较，采用了Oncogene Research Products公司的hMYH抗体(1:1000)，进行了蛋白质印迹实验。 更多
Nbs1
nibrin
总数:27
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强，采用Cell Signaling的抗NBS1抗体进行蛋白印迹实验。 更多
NTHL1
nth endonuclease III-like 1 (E. coli)
总数:1
Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase. 2004 至该文献
为了对四种主要的损伤特异的DNA糖基化酶修复基因的防护效应进行比较，采用了Proteintech Group公司的hNTH抗体(1:2500)，进行了蛋白质印迹实验。
OGG1
8-oxoguanine DNA glycosylase
总数:8
Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. 2006 至该文献
为了研究氧化应激条件下哺乳动物线粒体中hogg1蛋白突变导致细胞死亡，采用Novus Biologicals的多抗hOGG1抗体进行蛋白印迹实验。 更多
PALB2
partner and localizer of BRCA2
增殖细胞核抗原 (PCNA)
proliferating cell nuclear antigen
总数:84
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 至该文献
为了研究DNA损伤应答过程中RHINO对ATR活化的重要作用，采用Santa Cruz的抗PCNA抗体进行蛋白印迹实验。 更多
POLD1
polymerase (DNA directed), delta 1, catalytic subunit 125kDa
POLD2
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
POLD4
polymerase (DNA-directed), delta 4
POLE
polymerase (DNA directed), epsilon
POLE2
polymerase (DNA directed), epsilon 2 (p59 subunit)
POLH
polymerase (DNA directed), eta
总数:1
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. 2009 至该文献
为了研究人体癌症细胞TLSDNA多聚酶eta和kappa在调控自然发生DNA结构中的作用，使用了Abcam公司的POLH多克隆抗体，进行了免疫印迹实验。
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
总数:1
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. 2009 至该文献
为研究STAGA亚单位ADA2b在调节人GCN5催化作用中所扮演的角色，将Santa Cruz提供的抗RNA聚合酶II大亚单位抗体(N20)用于蛋白免疫印迹实验中。
POLR2C
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D
polymerase (RNA) II (DNA directed) polypeptide D
POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F
polymerase (RNA) II (DNA directed) polypeptide F
总数:3
Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. 2004 至该文献
POLR2G
polymerase (RNA) II (DNA directed) polypeptide G
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RAD23B
RAD23 homolog B (S. cerevisiae)
总数:2
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应，采用了Abcam RAD23B抗体进行了蛋白质印迹实验。 更多
Rad50
RAD50 homolog (S. cerevisiae)
总数:13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. 2008 至该文献
为了说明在连环体的形成以及Ad DNA复制的抑制时，对于Nbs1的利用是不同的，使用了GeneTex公司的抗Rad50抗体来进行蛋白印迹实验。 更多
RAD51
RAD51 homolog (S. cerevisiae)
总数:20
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强，采用Calbiochem的抗Rad51抗体进行免疫细胞化学实验。 更多
RAD52
RAD52 homolog (S. cerevisiae)
总数:1
WRN interacts physically and functionally with the recombination mediator protein RAD52. 2003 至该文献
REV1
REV1 homolog (S. cerevisiae)
REV3L
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
RFC1
replication factor C (activator 1) 1, 145kDa
RFC2
replication factor C (activator 1) 2, 40kDa
RFC3
replication factor C (activator 1) 3, 38kDa
RFC4
replication factor C (activator 1) 4, 37kDa
总数:1
Raf-1 activation disrupts its binding to keratins during cell stress. 2004 至该文献
RFC5
replication factor C (activator 1) 5, 36.5kDa
RNA聚合酶II (RNA polymerase II)
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
总数:69
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. 2011 至该文献
为了研究组蛋白mRNA的3末端处理需要对RNA聚合酶II的4位苏氨酸进行磷酸化，采用Santa Cruz的抗Rpb1抗体进行蛋白印迹和ChIP实验。 更多
RPA1
replication protein A1, 70kDa
总数:12
Human SIRT6 promotes DNA end resection through CtIP deacetylation. 2010 至该文献
为了阐明SIRT6促进DNADNA末端切除的机制，使用了Calbiochem公司的小鼠抗RPA抗体来进行免疫印迹分析和免疫荧光实验。 更多
RPA2
replication protein A2, 32kDa
总数:11
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. 2009 至该文献
为了研究腺相关病毒和腺病毒共感染对诱导细胞DNA损伤应答的影响，使用了Abcam公司的抗S33和T21磷酸化RPA32抗体来进行免疫印迹分析。 更多
RPA3
replication protein A3, 14kDa
总数:1
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. 2003 至该文献
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
TCEA1
transcription elongation factor A (SII), 1
TDP1
tyrosyl-DNA phosphodiesterase 1
总数:1
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. 2002 至该文献
胸腺嘧啶DNA糖苷酶 (thymine DNA glycosylase)
thymine-DNA glycosylase
泛素蛋白A52残基核糖体蛋白融合产物1 (UBA52)
ubiquitin A-52 residue ribosomal protein fusion product 1
总数:22
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. 2004 至该文献
为了研究在干细胞因子复合体中Fbx7和Cdk1-细胞周期蛋白B-磷酸肝癌上调蛋白的相互作用，在免疫印迹试验中使用了Santa Cruz Biotechnology的抗泛素抗体。 更多
UBB
ubiquitin B
总数:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 至该文献
为了阐明BCL6和HB-EGF-CTF相互作用，并且这种相互作用可能会引起细胞周期蛋白D2在人胃癌细胞中表达，采用了Cell Signaling Technology公司的小鼠抗泛素单克隆抗体，进行了蛋白质印迹实验。 更多
UBC
ubiquitin C
总数:4
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family. 2007 至该文献
为了研究人切片中PGRN的遗传变异性是否与其他的神经变性疾病有关，比如阿尔茨海默病（AD）或者帕金森病(PD)，采用了Dako公司的抗泛素的抗体进行免疫组织化学分析。 更多
UBE2T
ubiquitin-conjugating enzyme E2T (putative)
总数:1
BCR/ABL-mediated increased expression of multiple known and novel genes that may contribute to the pathogenesis of chronic myelogenous leukemia. 2003 至该文献
泛肽 (ubiquitin)
ribosomal protein S27a
总数:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 至该文献
为了在内质网相关蛋白的降解途径（ERAD）中鉴定一种新的erasin-ubiquilin-p97/VCP复合体以及其功能，使用了Santa Cruz Biotechnology公司的抗体ubiquitin来进行免疫印迹分析。 更多
USP1
ubiquitin specific peptidase 1
XAB2
XPA binding protein 2
XPA
xeroderma pigmentosum, complementation group A
总数:4
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应，采用了Santa Cruz XPA抗体进行了蛋白质印迹实验。 更多
XPC
xeroderma pigmentosum, complementation group C
总数:2
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应，采用了Abcam XPC抗体进行了蛋白质印迹实验。 更多
XPF
excision repair cross-complementing rodent repair deficiency, complementation group 4
总数:1
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. 2003 至该文献
为研究非红细胞II血影蛋白在DNA内部链交联诱导范可尼贫血相关蛋白F（FANCA）和 核苷酸切除修复基因XPF募集到细胞核过程中的作用，采用M. Thelen 公司的XPF抗体用于免疫印迹和免疫沉淀实验。
XPG
excision repair cross-complementing rodent repair deficiency, complementation group 5
总数:2
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. 2007 至该文献
为了研究XPC蛋白在核苷酸切除修复中的作用，采用Lab Vision公司的抗XPG抗体进行免疫印迹实验。 更多
XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
总数:4
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. 2004 至该文献
XRCC4
X-ray repair complementing defective repair in Chinese hamster cells 4
总数:3
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. 2009 至该文献
为了研究腺相关病毒和腺病毒共感染对诱导细胞DNA损伤应答的影响，使用了Serotech公司的抗XRCC4抗体来进行免疫印迹分析。 更多
ZBTB32
zinc finger and BTB domain containing 32