Factors involved in megakaryocyte development and platelet production
基因
试剂
文献样例
产品评述样例
abl
ABL proto-oncogene 1, non-receptor tyrosine kinase
总数:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 至该文献
为了研究c-Abl酪氨酸激酶在调控心脏的生长和发育中的作用,采用了Calbiochem公司的c-Abl 抗体产品( 1:1,000 ),进行了免疫印迹实验 更多
CAPZA1
capping actin protein of muscle Z-line subunit alpha 1
CAPZA2
capping actin protein of muscle Z-line subunit alpha 2
CAPZB
capping actin protein of muscle Z-line subunit beta
CBX5
chromobox 5
总数:7
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 至该文献
为了研究UV引起的DNA损伤及应激反应,采用了Santa Cruz HP1抗体进行了蛋白质印迹实验。 更多
cdc42
cell division cycle 42
总数:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 至该文献
为了研究肺部发炎部位slit2对嗜酸性粒细胞和嗜中性粒细胞的影响,采用了Santa Cruz Biotechnology公司的抗Cdc42抗体进行蛋白免疫印迹试验。 更多
CDK2
cyclin dependent kinase 2
总数:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 至该文献
为了研究cdc6在cdk1和分离酶介导的染色体分离中的作用,采用了Santa Cruz的抗人Cdk2抗体进行免疫印迹实验。 更多
Cdk5
cyclin dependent kinase 5
总数:8
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 至该文献
为了揭示在CXCL12诱发的T淋巴细胞迁移过程中CRMP2功能的分子机制,采用了Santa Cruz Biotechnology公司的抗Cdk5(SC-173)抗体,抗Cdk5第15位Tyr磷酸化抗体(SC-12928),抗Cdk5第159位Ser磷酸化抗体(SC-12919)进行免疫印迹实验。 更多
CENPE
centromere protein E
总数:3
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 至该文献
为了研究Pcid2通过调控MAD2表达在B细胞生存中发挥的决定性作用,采用了艾碧康生物公司的抗CENP-E单克隆抗体进行免疫印迹试验。 更多
EHD1
EH domain containing 1
总数:1
A role for EHD4 in the regulation of early endosomal transport. 2008 至该文献
为了研究EHD4在早期内体的转运调控中的功能,使用了AnaSpec公司的兔抗EHD1多克隆抗体来进行免疫印记分析和免疫沉淀实验。
EHD2
EH domain containing 2
总数:2
Molecular composition and ultrastructure of the caveolar coat complex. 2013 至该文献
为了研究胞膜窖衣被复合物的结构组成,Abcam的羊抗EHD2抗体被用于进行蛋白质免疫印迹实验。 更多
GATA-1 (GATA-1)
GATA binding protein 1
总数:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 至该文献
GATA-4 (GATA-4)
GATA binding protein 4
总数:7
Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). 2008 至该文献
为了说明cyt b5基因在性腺切除诱导的肾上腺皮质瘤表达上调和cyt b5基因是这一肿瘤潜在雄性激素合成的标记物,采用Santa Cruz生物技术公司的羊抗鼠GATA4抗体以1:200稀释,进行免疫组织化学实验。 更多
GATA3
GATA binding protein 3
总数:4
Lhx2 maintains stem cell character in hair follicles. 2006 至该文献
GATA6
GATA binding protein 6
总数:3
Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. 2008 至该文献
H3
H3 clustered histone 14
总数:32
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 至该文献
为了分析在人类特异的脑前额神经中转录起始位点的组蛋白甲基化修饰,采用了Upstate的抗组蛋白H3K4抗体,进行RNA免疫沉淀实验。 更多
H3-3B
H3.3 histone B
总数:5
Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. 2005 至该文献
HBG1
hemoglobin subunit gamma 1
总数:1
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. 2011 至该文献
为了研究镰刀细胞贫血能够通过对BCL11A的失活以保持人胎儿血红蛋白的表达而治疗,采用Invitrogen的FITC标记的单抗HbF抗体进行流式细胞分选实验。
HDAC1
histone deacetylase 1
总数:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 至该文献
为了说明IRF5同HATs和HDACs一起调控促炎细胞因子的转录水平表达,使用了Upstate Biotechnology公司的抗HDAC1抗体进行蛋白印迹实验。 更多
HDAC2
histone deacetylase 2
总数:24
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo. 2009 至该文献
为了研究胰脏癌中HDAC的活性与RelA/p65的活化之间的联系,使用了Abcam公司的抗HDAC2抗体来进行免疫组化分析。 更多
H3C6
H3 clustered histone 6
总数:5
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 至该文献
为了研究AMP激活的蛋白激酶调节细胞对代谢压力的反应的机制,使用了Abcam公司的抗组蛋白H3,抗组蛋白H3 K9Me以及抗组蛋白H3 S10ph抗体来进行免疫印迹分析。 更多
IFNA1
interferon alpha 1
总数:11
The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.. 2010 至该文献
为了研究伊波拉病毒VP35蛋白在调节病毒和脂多糖诱导的树突细胞成熟中的作用,采用了PBL Laboratories公司的抗IFNalpha抗体产品,进行了流式细胞分析实验。 更多
IFNB1
interferon beta 1
总数:9
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 至该文献
IRF-1 (IRF-1)
interferon regulatory factor 1
总数:14
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 至该文献
为研究干扰素调控因子4(IRF-4)在EBV病毒感染人类B淋巴细胞中的作用,采用了Santa Cruz Biotechnology公司的抗IRF-1抗体进行蛋白质印迹试验。 更多
IRF-2 (IRF-2)
interferon regulatory factor 2
总数:7
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 至该文献
为研究干扰素调控因子4(IRF-4)在EBV病毒感染人类B淋巴细胞中的作用,采用了Santa Cruz Biotechnology公司的抗IRF-2抗体进行蛋白质印迹试验。 更多
Janus激酶2 (Jak2)
Janus kinase 2
总数:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 至该文献
为了确定在受体信号激活过程中促红细胞生成素受体的受体因素,使用了Upstate公司的抗JAK2抗体来进行免疫沉淀实验和免疫印记分析。 更多
KDM1A
lysine demethylase 1A
总数:4
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 至该文献
为了研究长间隔非编码RNA作为支架调节组蛋白修饰复合物和基因表达的功能,使用了Abcam公司的兔抗LSD1抗体来进行免疫沉淀实验和染色质免疫沉淀实验。 更多
KIF23
kinesin family member 23
总数:6
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 至该文献
为了研究有丝分裂过程中非催化亚基Mob1是怎样与染色体复合物的相互作用机制,采用了Abcam公司有丝分裂驱动蛋白样蛋白抗体,进行细胞免疫荧光实验。 更多
KIF2C
kinesin family member 2C
总数:1
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 至该文献
为了研究Haspin介导的组蛋白H3 Thr-3磷酸化调节染色体乘客复合体在中心体的富集的机制,使用了Abnova公司的小鼠抗MCAK单克隆抗体来进行免疫印迹实验。
KIF3A
kinesin family member 3A
总数:3
Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. 2009 至该文献
为了说明KSHV被膜蛋白在病毒质粒的细胞转运过程中的重要作用,采用了西格玛的兔抗KIF3A 抗体进行免疫荧光试验。 更多
KIF3C
kinesin family member 3C
总数:1
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 至该文献
KIF5A
kinesin family member 5A
总数:1
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. 2005 至该文献
KIF5B
kinesin family member 5B
总数:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 至该文献
为研究驱动蛋白5B在癌细胞中的作用,将Abcam提供的抗KIF5B抗体ab5629用于蛋白免疫印迹实验中。 更多
KIF5B
kinesin family member 5B
总数:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 至该文献
为研究驱动蛋白5B在癌细胞中的作用,将Abcam提供的抗KIF5B抗体ab5629用于蛋白免疫印迹实验中。 更多
KIF5C
kinesin family member 5C
总数:4
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. 2008 至该文献
为了研究依赖活性的分泌的,POMC/ACTH囊泡到质膜之间的后高尔基转运机制,采用了Santa Cruz的KHC抗体,进行蛋白质印迹和免疫细胞化学实验 更多
KIFAP3
kinesin associated protein 3
总数:3
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 至该文献
KLC1
kinesin light chain 1
总数:2
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. 2009 至该文献
为证实突变的SOD1可以通过隔离KAP3来降低轴突的胆碱乙酰转移酶运输量和乙酰胆碱的释放量,使用了Chemicon公司的抗KLC抗体来进行蛋白印迹分析。 更多
CARMIL1
capping protein regulator and myosin 1 linker 1
MAFK
MAF bZIP transcription factor K
总数:3
Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. 2007 至该文献
为了研究调停Cr的细胞反应的分子事件,使用了Santa Cruz Biotechnology 公司的MafG/k抗体,进行了免疫印迹实验。 更多
mSin3A
SIN3 transcription regulator family member A
总数:15
Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. 2010 至该文献
为了研究组蛋白去乙酰酶抑制剂对Sin3复合物的亚基ING2作用,采用Abcam抗Sin3a的抗体进行免疫印迹实验。 更多
MYB
MYB proto-oncogene, transcription factor
总数:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 至该文献
为了阐明c-Myb在MLL相关白血病中的作用,实验使用了Upstate Biotechnology公司的抗c-Myb抗体进行免疫共沉淀。 更多
NF E2 (NF E2)
nuclear factor, erythroid 2
总数:5
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. 2010 至该文献
为了研究NF-E2在调控ROS累积和巨核细胞成熟中的作用,采用了Santa Cruz Biotechnology公司的抗p45抗体产品,进行了免疫沉淀实验。 更多
p53
tumor protein p53
总数:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 至该文献
为了研究JMJD6通过负调控p53促进结直肠的癌变,采用了Abcam抗p53 的抗体进行了蛋白印迹实验。 更多
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
总数:20
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells. 2009 至该文献
为了说明在人NT2细胞中血管活性肠肽可以促进HCMV MIE的表达,使用了Santa Cruz Biotechnology公司的兔多克隆抗PKA催化亚基抗体来进行蛋白印迹实验。 更多
PRKACG
protein kinase cAMP-activated catalytic subunit gamma
总数:4
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. 2006 至该文献
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
总数:9
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 至该文献
在免疫组化实验中使用了EMD Biosciences公司的针对RIalpha的单克隆抗体用于检测人肾上腺样本中PKA的亚基Calpha。 更多
PRKAR2A
protein kinase cAMP-dependent type II regulatory subunit alpha
总数:9
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. 2008 至该文献
为了研究在β1AR刺激的肌细胞收缩过程中,PP2A限制PKA对受磷蛋白和Tnl磷酸化的作用,采用了Santa Cruz Biotechnology的抗PKA RII抗体,进行蛋白质印迹实验 更多
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
总数:3
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 至该文献
在免疫组化实验中使用了EMD Biosciences公司的针对RIIbeta的单克隆抗体用于检测人肾上腺样本中PKA的亚基Calpha。 更多
Rab5
RAB5A, member RAS oncogene family
总数:19
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. 2009 至该文献
为了研究腺病毒膜蛋白RID-alpha诱导的胆固醇的转运途径,探究了RID-alpha激活胆固醇自我调节的机理,采用了BD公司RAS家族抗体,进行细胞免疫荧光实验。 更多
Ras相关C3肉毒杆菌毒素底物1 (Rac1)
Rac family small GTPase 1
总数:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 至该文献
为研究RhoGDI2通过Rho GTPases抑制代谢的作用,采用了Millipore公司的抗Rac1单克隆抗体(1:1,000)进行免疫印迹试验。 更多
RACGAP1
Rac GTPase activating protein 1
总数:3
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 至该文献
为了研究有丝分裂过程中非催化亚基Mob1是怎样与染色体复合物的相互作用机制,采用了Abcam公司Rac的GTP酶激活蛋白1抗体,进行细胞免疫荧光实验。 更多
RAD51C
RAD51 paralog C
总数:3
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. 2007 至该文献
RCOR1
REST corepressor 1
总数:3
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 至该文献
为了研究长间隔非编码RNA作为支架调节组蛋白修饰复合物和基因表达的功能,使用了Upstate公司的兔抗CoREST抗体来进行免疫印迹分析。 更多
SH2B1
SH2B adaptor protein 1
总数:1
SLAM-associated protein as a potential negative regulator in Trk signaling. 2005 至该文献
SH2B3
SH2B adaptor protein 3
总数:1
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. 2010 至该文献
为了说明Lnk可以通过调节小鼠血小板中由外向内的整合蛋白αIIbβ3信号通路对体内血栓形成起到稳定作用,采用了Abcam公司的抗人Lnk抗体,进行免疫印迹试验。
WEE1
WEE1 G2 checkpoint kinase
总数:2
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. 2009 至该文献
为了研究FANCM在有丝分裂过程中的降解机制,使用了Santa Cruz Biotechnology公司的兔抗WEE1抗体来进行免疫印迹分析。 更多
ZFPM1
zinc finger protein, FOG family member 1
总数:1
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. 2006 至该文献
ZFPM2
zinc finger protein, FOG family member 2