阿片类物质信号
基因
试剂
文献样例
产品评述样例
ACTH
proopiomelanocortin
总数:14
SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation. 2009 至该文献
使用Calbiochem人促肾上腺皮质激素孵育细胞,来证明SUMO化在减少CDK7引起的SF-1磷酸化中发挥作用。 更多
ADCY1
adenylate cyclase 1 (brain)
总数:2
Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase. 2005 至该文献
ADCY10
adenylate cyclase 10 (soluble)
总数:1
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. 2006 至该文献
为了研究可溶性腺苷酸环化酶在神经生长因子1信号中的作用,采用了Santa Cruz公司的sAC抗体进行免疫组织化学和免疫细胞化学分析。
ADCY2
adenylate cyclase 2 (brain)
总数:3
Stable expression of adenylyl cyclase 2 leads to the functional rescue of human 5-HT6 receptor in a CHODUKX cell line. 2007 至该文献
为了研究腺苷酸环化酶2的稳定表达能导致CHODUKX细胞系中人5-HT6受体功能修复,采用了Santa Cruz Biotechnology公司的AC2抗体进行蛋白质印迹分析 更多
ADCY3
adenylate cyclase 3
总数:3
Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons. 2009 至该文献
为了研究内皮亚型的一氧化氮合成酶在成年小鼠的嗅感觉神经元中的功能,使用了Santa Cruz Biotechnologies公司的抗ACIII抗体来进行免疫荧光试验。 更多
ADCY5
adenylate cyclase 5
总数:5
Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism. 2009 至该文献
为研究磷酸二酯酶的细胞内定位以及其在葡萄糖和脂类代谢中所起的调控作用,使用了Santa Cruz公司的抗腺苷酸环化酶V抗体来进行免疫组化分析。 更多
ADCY6
adenylate cyclase 6
总数:2
Chronic antidepressant treatment prevents accumulation of gsalpha in cholesterol-rich, cytoskeletal-associated, plasma membrane domains (lipid rafts). 2005 至该文献
ADCY8
adenylate cyclase 8 (brain)
总数:1
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. 2001 至该文献
钙调蛋白 (calmodulin)
calmodulin 1 (phosphorylase kinase, delta)
总数:18
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. 2008 至该文献
Cdk5
cyclin-dependent kinase 5
总数:12
p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease. 2006 至该文献
CREB
cAMP responsive element binding protein 1
总数:64
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells. 2009 至该文献
为了说明在人NT2细胞中血管活性肠肽可以促进HCMV MIE的表达,使用了Epitomics公司的兔单克隆抗CREB抗体来进行蛋白印迹实验。 更多
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
总数:7
A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization. 2009 至该文献
为证实钙调蛋白激活的腺苷酸环化酶对可卡因敏感性形成的重要作用,使用了Cell Signaling公司的兔源抗DARPP32抗体来进行免疫组化分析。 更多
Gbeta
guanine nucleotide binding protein (G protein), beta polypeptide 1
总数:7
Clathrin-mediated endocytosis of m3 muscarinic receptors. Roles for Gbetagamma and tubulin. 2004 至该文献
为了从人体SK-N-SH成神经瘤细胞中检测和分离出mGbeta,使用了Santa Cruz Biotechnology公司的兔多克隆抗Gbeta抗体,进行了免疫印迹实验,并且为了确定Gbeta仅限于人体SK-N-SH成神经瘤细胞中,使用此抗体,进行了免疫细胞化学实验。 更多
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
总数:2
Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells. 2004 至该文献
GNA14
guanine nucleotide binding protein (G protein), alpha 14
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
总数:8
Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor. 2008 至该文献
为了研究羧基末端双亮氨酸在C5a受体的磷酸化和内化过程中的作用,采用了Sigma-Aldrich的百日咳毒素(Gi抑制剂)处理细胞 更多
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
总数:4
Stimulation by n6-cyclopentyladenosine of A1 adenosine receptors, coupled to galphai2 protein subunit, has a capacitative effect on human spermatozoa. 2001 至该文献
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
总数:5
Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3). 2002 至该文献
在免疫印迹实验中使用了Santa Cruz Biotechnology公司的Galphai3抗体(1:1000稀释)用于描述一个假定的细胞膜DHEA受体特征并详细说明其相关G蛋白。 更多
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
总数:2
Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. 2009 至该文献
为了阐明纳洛酮五肽在细丝蛋白A上的结合位点会阻断Mu受体,采用了Santa Cruz Biotechnology的Gαs/olf 抗体进行免疫沉淀试验。 更多
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
总数:5
Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. 2009 至该文献
为了阐明纳洛酮五肽在细丝蛋白A上的结合位点会阻断Mu受体,采用了Santa Cruz Biotechnology的Gαo 抗体进行免疫沉淀试验。 更多
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
总数:14
Anaphylactic shock depends on endothelial Gq/G11. 2009 至该文献
为了研究内皮Gq/G11介导的信号通路对调节过敏反应的功能,使用了Santa Cruz Biotechnology公司的抗Gnaq抗体来进行免疫印迹实验。 更多
GNAT1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
总数:3
A critical role of CaBP4 in the cone synapse. 2005 至该文献
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
总数:1
Cone cell survival and downregulation of GCAP1 protein in the retinas of GC1 knockout mice. 2004 至该文献
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
GNB5
guanine nucleotide binding protein (G protein), beta 5
总数:1
Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. 2007 至该文献
GNG10
guanine nucleotide binding protein (G protein), gamma 10
GNG11
guanine nucleotide binding protein (G protein), gamma 11
GNG12
guanine nucleotide binding protein (G protein), gamma 12
GNG13
guanine nucleotide binding protein (G protein), gamma 13
GNG3
guanine nucleotide binding protein (G protein), gamma 3
GNG4
guanine nucleotide binding protein (G protein), gamma 4
GNG5
guanine nucleotide binding protein (G protein), gamma 5
GNG7
guanine nucleotide binding protein (G protein), gamma 7
GNG8
guanine nucleotide binding protein (G protein), gamma 8
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GRK2
adrenergic, beta, receptor kinase 1
总数:8
Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2. 2008 至该文献
为了研究在冠状动脉旁路移植中,GRK2对心肌肾上腺素受体信号解偶联的作用,采用了Santa Cruz Biotechnolog的GRK2多抗,进行心肌衰弱水平的免疫检测 更多
GNAT3
guanine nucleotide binding protein, alpha transducing 3
总数:1
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. 2006 至该文献
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
总数:7
Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. 2007 至该文献
为了研究在Purkinje神经元细胞膜钙ATP酶2缺失的小脑的分子变化,采用了Calbiochem公司的IP3R1抗体进行蛋白质印迹杂家和免疫组织化学分析。 更多
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
总数:2
Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression. 2005 至该文献
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
总数:11
Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. 2008 至该文献
为了研究在氟伏沙明和sigma-1受体激动剂的作用下,神经生长因子诱导的突触生长的细胞信号通路,采用了Calbiochem-Novabiochem的xesto海绵硬蛋白C处理细胞 更多
mu opioid receptor
opioid receptor, mu 1
总数:10
Endomorphin-2 is released from newborn rat primary sensory neurons in a frequency- and calcium-dependent manner. 2008 至该文献
为了检测鼠原代感觉神经元细胞表达的功能依赖性释放因子END-2,采用Novus Biologicals公司的兔抗MOR抗体,进行免疫细胞化学实验。 更多
PDE1A
phosphodiesterase 1A, calmodulin-dependent
PDE1B
phosphodiesterase 1B, calmodulin-dependent
总数:2
Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase.. 2006 至该文献
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE4A
phosphodiesterase 4A, cAMP-specific
总数:4
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. 2008 至该文献
为了研究β1肾上腺素受体刺激肌细胞收缩时,蛋白磷酸酶2A在限制蛋白激酶A对受磷蛋白和肌钙蛋白磷酸化中的作用,采用了Calbiochem的磷酸二酯酶4抑制剂咯利普兰处理细胞 更多
PDE4B
phosphodiesterase 4B, cAMP-specific
总数:3
Characterization of cAMP degradation by phosphodiesterases in the accessory olfactory system. 2002 至该文献
PDE4C
phosphodiesterase 4C, cAMP-specific
总数:1
Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca(2+) responses in endothelial cells. 2008 至该文献
PDE4D
phosphodiesterase 4D, cAMP-specific
总数:4
Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells. 2008 至该文献
phospholipase C beta 4
phospholipase C, beta 4
总数:2
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. 2005 至该文献
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
总数:10
Expression and mechanism of spleen tyrosine kinase activation by angiotensin II and its implication in protein synthesis in rat vascular smooth muscle cells. 2007 至该文献
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
总数:5
Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin. 2005 至该文献
PLCB2
phospholipase C, beta 2
总数:3
Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. 2005 至该文献
PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
总数:3
Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells. 2004 至该文献
PP1
protein phosphatase 1, catalytic subunit, alpha isozyme
总数:20
Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. 2008 至该文献
PP2AC
protein phosphatase 2, catalytic subunit, alpha isozyme
总数:27
Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging. 2009 至该文献
为了阐明活化AKT在海马受损中的作用,实验使用了Cell Signaling公司的抗PP2A-A抗体进行免疫印迹。 更多
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
总数:15
Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells. 2006 至该文献
Upstate Biotechnology的抗PP2A-A亚基抗体被用于蛋白质印迹实验,来研究在对人卵巢癌细胞进行顺氯氨铂治疗后,蛋白磷酸酶2A和Chk2的相互作用在调节Thr-68的磷酸化作用方面的功能。 更多
PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
总数:2
Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. 2004 至该文献
信号调节激酶1能激活雷帕霉素使其抑制活化的细胞凋亡,Upstate Biotechnology的PP2A-B抗体被用于蛋白质印迹实验,来研究蛋白磷酸酶5在该过程中的作用。 更多
PPP2R5D
protein phosphatase 2, regulatory subunit B', delta
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
总数:5
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. 2009 至该文献
为了研究TAK1-TAB1-TAB2通路通过磷酸化RCAN1对钙调磷酸酶-NFAT信号通路的调控,使用了Santa Cruz Biotechnology公司的抗磷酸化CnA抗体来进行免疫印迹分析。 更多
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
总数:2
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. 2005 至该文献
Chemicon的兔抗磷酸酶抗体被用于免疫组化实验,来研究触发星形胶质细胞活性的机制。 更多
PPP3CC
protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
总数:5
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. 2006 至该文献
为了研究ASK1和控制心肌病死亡和生长的钙调磷蛋白磷酸酶-NFAT之间的直接相互作用和可逆调节,采用了Sigma公司的CnB1抗体进行了蛋白质印迹分析 更多
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
总数:29
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. 2008 至该文献
为了研究蛋白激酶信号在丙型肝炎病毒感染的作用,采用了西格玛公司的forskolin(FK)作为PKA的激动剂来作用于细胞。 更多
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
总数:7
Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation. 2008 至该文献
为了研究在人绒毛膜癌中内皮素受体介导的激活有丝分裂激活蛋白激酶(MAPK)途径的机理,采用了BIOMOL公司的Rp-cAMPS(特异性的蛋白酶K抑制剂)加入到细胞培养中 更多
PRKACG
protein kinase, cAMP-dependent, catalytic, gamma
总数:5
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. 2006 至该文献
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
总数:10
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 至该文献
在免疫组化实验中使用了EMD Biosciences公司的针对RIalpha的单克隆抗体用于检测人肾上腺样本中PKA的亚基Calpha。 更多
PRKAR2A
protein kinase, cAMP-dependent, regulatory, type II, alpha
总数:10
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. 2008 至该文献
为了研究在β1AR刺激的肌细胞收缩过程中,PP2A限制PKA对受磷蛋白和Tnl磷酸化的作用,采用了Santa Cruz Biotechnology的抗PKA RII抗体,进行蛋白质印迹实验 更多
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
总数:3
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 至该文献
在免疫组化实验中使用了EMD Biosciences公司的针对RIIbeta的单克隆抗体用于检测人肾上腺样本中PKA的亚基Calpha。 更多
prodynorphin
总数:4
PROPELLER MRI visualizes detailed pathology of hippocampal sclerosis. 2008 至该文献
使用Serotec的多克隆抗强啡肽抗体进行免疫组织化学实验来比较海马的PROPELLER图像处理与人海马样本切片的常规序列之间的区别。 更多