脂肪组织
基因
试剂
文献样例
产品评述样例
FTO
fat mass and obesity associated
脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing
总数:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献
为了研究DLK在调控3T3-L1脂肪细胞分化中的作用，使用了Calbiochem公司的兔多克隆抗adiponectin抗体，进行了免疫印迹和沉淀实验。 更多
肥胖荷尔蒙 (leptin)
总数:6
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗Ob抗体来进行免疫印迹分析。 更多
RBP4
retinol binding protein 4, plasma
PNPLA2
patatin-like phospholipase domain containing 2
总数:1
Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific. 2008 至该文献
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
resistin
总数:2
Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. 2004 至该文献
PNPLA3
patatin-like phospholipase domain containing 3
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
激素敏感脂酶 (hormone sensitive lipase)
lipase, hormone-sensitive
脂肪酸合成酶 (fatty acid synthase)
总数:6
EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy. 2009 至该文献
为了研究表皮生长因子突变常常与肿瘤发生有关，研究了Akt介导的在表皮生长因子诱导下固醇调节结合蛋白1的切割以及移位机理，并发现了一种新的治疗由于表皮生长因子激活的胶质母细胞瘤，采用了Cell Signaling公司脂肪酸合成酶抗体，进行免疫化学荧光实验。 更多
脂蛋白脂肪酶 (lipoprotein lipase)
总数:2
Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. 2002 至该文献
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:28
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析。 更多
uncoupling protein 2
uncoupling protein 2 (mitochondrial, proton carrier)
总数:3
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 2005 至该文献
Santa Cruz Biotechnology的Ucp2抗体被用于蛋白质印迹实验，来研究通过破坏解偶联蛋白-2基因来增强对感染性微生物的抗性的分子机制。 更多
ADIPOR1
adiponectin receptor 1
GDF15
growth differentiation factor 15
总数:5
Activation of p53 by MEG3 non-coding RNA. 2007 至该文献
ADRB3
adrenergic, beta-3-, receptor
总数:1
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. 2003 至该文献
Santa Cruz Biotechnology的β3-肾上腺素受体抗体被用于蛋白质印迹实验，来证明在一个给定的外围组织中瘦蛋白直接作用的生理意义。
melanocortin 4 receptor
芳香酶 (aromatase)
cytochrome P450, family 19, subfamily A, polypeptide 1
总数:6
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. 2009 至该文献
为了研究在脂肪基质细胞(ASCs)中对芳香化酶转录和雌性激素生物合成的调控机制，采用了Serotec公司的α-芳香化酶抗体，进行了蛋白质印迹实验。 更多
硬脂酰CoA去饱和酶 (stearoyl CoA desaturase)
stearoyl-CoA desaturase (delta-9-desaturase)
总数:1
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. 2002 至该文献
AZGP1
alpha-2-glycoprotein 1, zinc-binding
总数:2
Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-{alpha} in adipocytes. 2010 至该文献
为了研究TNFalpha在调控锌α2糖蛋白在肥胖小鼠脂肪和肝脏组织表达中的作用，采用了 Santa Cruz Biotechnology公司的抗多克隆羊抗ZAG抗体产品(1:500)，进行了免疫印迹实验。 更多
visfatin
nicotinamide phosphoribosyltransferase
总数:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 至该文献
为了研究DBC1在调控SIRT1的活性和高脂饮食诱发的小鼠脂肪肝中的作用，采用了Bethyl Laboratories公司的NAMPT抗体产品，进行了免疫印迹实验
催乳激素 (prolactin)
总数:3
Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors. 2001 至该文献
FGF21
fibroblast growth factor 21
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
总数:1
Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. 2006 至该文献
ghrelin
ghrelin/obestatin prepropeptide
总数:6
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究格瑞林酰基转移酶抑制剂在小鼠中的作用，采用了Abcam抗ghrelin抗体进行了免疫印迹实验。 更多
CETP
cholesteryl ester transfer protein, plasma
IRS-1
insulin receptor substrate 1
总数:36
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. 2011 至该文献
为了通过磷酸化蛋白组学研究Grb10是胰岛素信号通路的负调控因子，采用Invitrogen的抗磷酸化IRS (Y612)进行蛋白印迹实验。 更多
UCP1
uncoupling protein 1 (mitochondrial, proton carrier)
总数:1
Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells. 2001 至该文献
lamin A/C
总数:54
The honey bee epigenomes: differential methylation of brain DNA in queens and workers.. 2010 至该文献
为了说明WRAP53是形成卡恰尔身体的必要因素并且能够将SMN复合体定位到卡恰尔身体，使用了Santa Cruz Biotechnology公司的alpha-Lamin A/C兔抗(sc-20681)来进行免疫印记，免疫沉淀和免疫细胞组化实验。 更多
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
总数:1
UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. 2008 至该文献
血清淀粉样蛋白A蛋白 (SAA1)
serum amyloid A1
总数:2
Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins. 2003 至该文献
leptin receptor
总数:9
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 2007 至该文献
CNR1
cannabinoid receptor 1 (brain)
总数:3
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. 2008 至该文献
为了确认内源性大麻素信号途径的关键元件是否在骨关节炎和类风湿性关节炎患者的关节骨液中表达，采用了Calbiochem公司的抗大麻素受体1抗体进行了蛋白印迹实验。 更多
ADRB2
adrenergic, beta-2-, receptor, surface
总数:7
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 至该文献
为了研究β2-肾上腺素受体激动剂fenoterol的立体化学在决定受体G蛋白选择性和下游信号通路中的功能，使用了Santa Cruz Biotechnology公司的抗ADRB2 C末端抗体来进行免疫印迹分析。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
PAI-1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
总数:15
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 至该文献
为了研究人纤溶酶原和钩端螺旋体内皮抑制素样蛋白A之间的相互作用，采用Novus Biologicals公司的山羊抗人纤溶酶原抗体进行酶联免疫吸附实验。 更多
ADIPOR2
adiponectin receptor 2
apelin
C3
complement component 3
总数:12
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield.. 2011 至该文献
为了研究HIV的糖基化外膜能够被PGT抗体识别从而中和HIV病毒，采用AbD serotec的山羊抗人C3抗体进行ELISA实验。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用，采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多
骨形态发生蛋白2 (BMP2)
bone morphogenetic protein 2
总数:8
A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. 2008 至该文献
为了识别人子宫内膜中的TGF-beta家族的成员并判断它们是否参与了蜕膜化，使用了Santa Cruz公司的抗BMP2抗体来进行免疫组化分析。 更多
趋化因子 (RANTES)
chemokine (C-C motif) ligand 5
总数:14
Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice. 2009 至该文献
使用Chemicon抗α5抗体4°C 孵育人CD34+细胞30分钟，来研究α4、α5整合素和CXCR4等细胞因子在脐带血CD34+细胞治疗中的作用。 更多
沉默信息调节因子1 (SIRT1)
sirtuin 1
总数:13
SIRT6 promotes DNA repair under stress by activating PARP1.. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强，采用Abcam的抗SIRT1抗体进行蛋白印迹实验。 更多
糖皮质激素受体 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
总数:20
Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. 2009 至该文献
为了说明HSP90伴侣蛋白Cdc37能维持致癌蛋白激酶客户蛋白，使用了Santa Cruz Biotechnology公司的GR抗体进行蛋白印迹实验。 更多
血管紧张素转化酶 (ACE)
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
总数:8
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 至该文献
为了研究通过定量蛋白质组学发现新的BACE1底物，采用Santa Cruz的ACE抗体以1:1,000稀释进行蛋白印迹实验。 更多
ApoE基因 (ApoE)
apolipoprotein E
总数:17
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 至该文献
为了研究高效肝炎C病毒颗粒的形成条件，采用了Calbiochem公司的抗ApoE抗体进行蛋白免疫印迹实验。 更多
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
总数:1
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，在免疫印迹试验中使用了Sigma的抗PreMMP-2抗体作为第一抗体。
IL1A
interleukin 1, alpha
总数:5
Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. 2006 至该文献
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
总数:143
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制，使用了Santa Cruz Biotechnology公司的anti-p65抗体来进行染色质免疫共沉淀实验。 更多