骨肿瘤
基因
试剂
文献样例
产品评述样例
EWS
Ewing sarcoma breakpoint region 1
总数:4
The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. 2009 至该文献
为了说明EWS-FLI1蛋白通过与微卫星序列结合来实现其转录激活作用,使用了Santa Cruz公司的抗FLI-1 C19抗体进行免疫沉淀实验。 更多
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
总数:3
Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. 2004 至该文献
PTHLH
parathyroid hormone-like hormone
总数:3
Intracrine PTHrP protects against serum starvation-induced apoptosis and regulates the cell cycle in MCF-7 breast cancer cells. 2002 至该文献
为研究甲状旁腺相关肽(PTHrP)的增生效应机制,采用Oncogene生产的鼠源性PTHrP 单克隆抗体用于免疫细胞化学和流式细胞术实验。 更多
NOV
nephroblastoma overexpressed gene
总数:1
Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. 2006 至该文献
runt相关转录因子2 (RUNX2)
runt-related transcription factor 2
总数:16
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation. 2009 至该文献
为了测定在幼年皮肌炎病理性钙化中SIBLING蛋白和骨组分的存在,使用了R&D Systems公司的抗Cbfa1抗体来进行免疫组化实验。 更多
Fli-1
Friend leukemia virus integration 1
总数:8
EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. 2009 至该文献
为研究EWS/ETS对尤文氏肿瘤细胞中dickkopf蛋白家族表达的调控作用,使用了Santa cruz公司的抗FLI1抗体来进行ChIP分析。 更多
DKK1
dickkopf 1 homolog (Xenopus laevis)
总数:5
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. 2008 至该文献
为了考察Dickkopfs (Dkks)和Kremen2 (Krm2)在胃肠道癌症中表达的变化,使用了Abcam公司的抗DKK-1的山羊抗人抗体进行了免疫组化实验。 更多
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
总数:2
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. 2009 至该文献
为了说明Lyn能抑制破骨细胞的形成,使用了Abcam公司的RANK单克隆抗体进行免疫印迹实验。 更多
MMP13
matrix metallopeptidase 13 (collagenase 3)
总数:7
Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas. 2008 至该文献
为了研究鼻窦和口腔恶性黑色素瘤病人中基质金属蛋白酶的表达以及其预兆作用,采用了Oncogene的鼠单克隆抗MMP13抗体进行免疫组织化学试验。 更多
ACP5
acid phosphatase 5, tartrate resistant
总数:1
Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study. 2006 至该文献
RANKL
tumor necrosis factor (ligand) superfamily, member 11
总数:7
Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils. 2007 至该文献
为了研究患类风湿性关节炎病人的RANK、RANK-L、和骨保护素不同表达,使用了R&D Systems公司的单克隆抗人体OPG抗体,进行了酶联免疫吸附测定实验。 更多
IGFBP5
insulin-like growth factor binding protein 5
总数:1
Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3. 2005 至该文献
ezrin
总数:26
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 至该文献
为了研究铜绿假单胞菌外膜囊泡对细菌致病基因的远程运输,使用了BD Biosciences公司的ezrin鼠抗来进行免疫印记实验。 更多
CTSK
cathepsin K
总数:2
Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II. 2004 至该文献
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
总数:8
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. 2009 至该文献
为了研究ROCK1和ROCK2在调节角化细胞黏附和终末分化中的不同作用,采用了Santa Cruz的抗ROCK1抗体进行免疫印迹实验 更多
趋化因子受体4 (CXCR4)
chemokine (C-X-C motif) receptor 4
总数:39
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析,采用Biolegend的抗CXCR4抗体以3ug/ml浓度进行细胞多因子分选实验。 更多
Sox9
SRY (sex determining region Y)-box 9
总数:7
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. 2010 至该文献
为了研究beta-catenin在调控Kras依赖的acini进入胰腺导管腺癌前癌祖细胞的重排过程中的作用,采用了Santa Cruz Biotechnology公司的兔抗Sox9 抗体产品(1:1000),进行了免疫荧光实验 更多
WWOX
WW domain containing oxidoreductase
总数:1
JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. 2003 至该文献
Cdk4
cyclin-dependent kinase 4
总数:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 至该文献
为了研究脆性X智力低下蛋白在的功能对成人神经干细胞/神经祖细胞的增殖和分化所起的调控作用,使用了Millipore公司的抗CDK4抗体来进行蛋白印迹分析。 更多
PDGFR alpha
platelet-derived growth factor receptor, alpha polypeptide
总数:14
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. 2008 至该文献
为了证明人结肠直肠癌的扩散与PDGFRalpha/beta的表达有直接关系,采用了Santa Cruz Biotechnology的抗PDGFRA抗体进行了免疫印迹和免疫组化实验。 更多
MICA
MHC class I polypeptide-related sequence A
总数:3
Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. 2008 至该文献
为了研究IFN-alpha和IFN-gamma在肿瘤细胞中的不同作用,采用了R&D Systems的MICA抗体进行了流式细胞实验。 更多
MCP-1
chemokine (C-C motif) ligand 2
总数:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响,采用了Santa Cruz公司的抗MCP-1抗体进行了免疫组织化学实验。 更多
osteoprotegerin
tumor necrosis factor receptor superfamily, member 11b
总数:2
Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin. 2007 至该文献
在夹心酶联免疫分析实验中使用了R&D Systems公司的小鼠抗人OPG和生物素标记的山羊抗人OPG用于检测人血管平滑肌细胞条件培养基中OPG的浓度。 更多
MMP-1
matrix metallopeptidase 1 (interstitial collagenase)
总数:12
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 至该文献
为研究CD147促使成肌纤维细胞分化在组织变构中的作用,采用了Calbiochem公司的抗MMP-1单克隆抗体进行蛋白质印迹试验。 更多
BMI1
BMI1 polycomb ring finger oncogene
总数:8
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 至该文献
为了研究LMP2A在鼻咽癌进展中的作用,采用了Upstate Biotechnology的抗Bmi-1抗体进行了免疫印迹实验。 更多
整合素αⅤ (integrin alpha v)
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
总数:22
Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. 2009 至该文献
为了研究β3 integrin介导的vimentin中间纤维细胞表面募集的功能,使用了Chemicon公司的抗integrin alpha-V抗体来进行免疫荧光实验。 更多
p63
tumor protein p63
总数:25
Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. 2010 至该文献
为了研究PAD2在犬乳腺组织上皮细胞中的作用,采用了NeoMarkers的抗p63的抗体进行了免疫荧光实验。 更多
mTOR
mechanistic target of rapamycin (serine/threonine kinase)
总数:32
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H?-ATPase.. 2011 至该文献
为了研究泡状H+-ATPase参与到mTOR通路中mTORC1的转位和激活,采用Cell Signaling的抗mTOR抗体进行蛋白印迹和免疫细胞化学实验。 更多
c-Jun
jun proto-oncogene
总数:102
Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. 2010 至该文献
为了说明在人角质形成细胞HaCaT中,维甲酸能够通过多条信号通路包括RXR和JNK通路来抑制CYP4F11的表达,使用了Cell Signaling Technology公司的c-Jun单抗来进行免疫印记实验。 更多
HER2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
总数:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 至该文献
为了研究双调蛋白(amphiregulin)的表达与结直肠癌的肝转移之间的关系,采用了Zymed Laboratories公司的抗c-erbB-2的抗体进行免疫组化实验。 更多
CXCL12
chemokine (C-X-C motif) ligand 12
总数:8
PTCH1 dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts. 2009 至该文献
为了研究痣样基底细胞癌综合征成纤维细胞中PTCH1+/−基因表型与基底细胞癌发生的相关性,采用了Abcam公司生产的兔抗人SDF1-alpha(又叫CXCL12)多克隆抗体用于免疫印迹实验。 更多
鼠双微基因2 (MDM2)
Mdm2 p53 binding protein homolog (mouse)
总数:38
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 至该文献
为了研究如何通过基于基因标签的方法检测mTOR是p73的一个调控因子,采用了Santa Cruz的单抗mdm2(SMP14)抗体进行免疫印迹实验。 更多
β1整合素 (beta1 integrin)
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
总数:84
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 至该文献
为了研究乳癌细胞中由uPAR介导的细胞信号转导激发的特性,采用了Biolegend的抗CD29-FITC抗体进行流式细胞实验。 更多
caveolin-1
caveolin 1, caveolae protein, 22kDa
总数:59
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 至该文献
为了说明19号染色体的易位可能会引起Xp11.2易位相关的肾细胞癌,使用了Epitomics公司的抗calveolin-1抗体进行免疫组化实验。 更多
血管内皮生长因子 (VEGF)
vascular endothelial growth factor A
总数:76
Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib. 2008 至该文献
为了研究不间断给药伊立替康(irinotecan)对结肠直肠癌细胞的影响,采用了Oncogene Research Products公司的VEGF-A抗体进行免疫组化实验。 更多
p53
tumor protein p53
总数:239
The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma. 至该文献
为了研究可能的抑癌基因ECRG4对食管癌细胞迁移和浸润的影响,采用了Santa Cruz公司的抗p53的抗体进行免疫印迹实验。 更多
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
总数:114
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用,采用了Cell Signaling的抗Stat3和抗磷酸化Stat3 (Ser727)抗体进行免疫印迹实验。 更多
细胞周期蛋白D (cyclin D1)
总数:120
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 至该文献
为了研究在食道鳞状细胞癌中尿溶蛋白1A(UPK1A)的作用,采用了Cell Signaling Technology公司的抗cyclin-D1的抗体进行蛋白免疫印迹实验。 更多
p21
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
总数:173
The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma. 至该文献
为了研究可能的抑癌基因ECRG4对食管癌细胞迁移和浸润的影响,采用了Santa Cruz公司的抗p21的抗体进行免疫印迹实验。 更多
beta 连环蛋白 (beta-catenin)
catenin (cadherin-associated protein), beta 1, 88kDa
总数:151
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.. 2010 至该文献
为了研究在迁移的成纤维细胞中核移动调整至中心体的机制,使用了Zymed公司的小鼠抗CTNNB1抗体来进行免疫荧光实验。 更多
HIF-1 alpha
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
总数:62
Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha. 2010 至该文献
为了研究PTPRZ1启动子上HIF结合及Ets结合的基序并且说明了HIF-2可以激活PTPRZ1,使用了Novus Biologicals公司的HIF1alpha抗体进行染色质免疫沉淀实验。 更多
C-kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
总数:40
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析,采用Biolegend的抗CD117抗体以1ug/ml浓度进行细胞多因子分选实验。 更多
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
c-Met
met proto-oncogene (hepatocyte growth factor receptor)
总数:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 至该文献
为了研究固定液在磷酸化蛋白免疫组化测定中的作用使用了R&D公司的兔抗pMET抗体来进行免疫组化实验。 更多
E钙粘蛋白 (E-cadherin)
cadherin 1, type 1, E-cadherin (epithelial)
总数:127
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 至该文献
为了研究在食道鳞状细胞癌中尿溶蛋白1A(UPK1A)的作用,采用了Santa Cruz Biotechnology公司的抗E-cadherin的抗体进行蛋白免疫印迹实验。 更多
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
总数:80
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制,使用了Santa Cruz Biotechnology公司的anti-p50抗体来进行染色质免疫共沉淀实验。 更多
表皮生长因子受体 (EGFR)
epidermal growth factor receptor
总数:147
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 至该文献
为了研究MMP-10和CTSF在糖尿病患者角膜伤口治愈不良中的作用,采用了Epitomics的抗磷酸化-EGFR(Tyr845)抗体进行免疫组化试验。 更多
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
总数:55
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2010 至该文献
为了研究mPGES-1在调控肿瘤生长、侵润和转移中的作用,采用了Santa Cruz Biotechnology公司的抗COX-2抗体产品,进行了免疫印迹实验。 更多
TGF-beta1
transforming growth factor, beta 1
总数:33
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 至该文献
为研究CD147促使成肌纤维细胞分化在组织变构中的作用,采用了R&D Systems公司的抗pan-TGFβ抗体进行抑制试验。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用,采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多