克罗恩病
基因
试剂
文献样例
产品评述样例
NOD2
nucleotide binding oligomerization domain containing 2
总数:2
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. 2006 至该文献
白细胞介素23受体 (interleukin 23 receptor)
总数:3
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了R&D Systems公司PE标记的抗IL-23R抗体进行流式细胞计数。 更多
PTPN2
protein tyrosine phosphatase non-receptor type 2
总数:2
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 至该文献
为了研究MDA5 和PTPN2在调节胰岛beta细胞对病毒双链RNA副产物的反应中的作用,采用了R&D Systems公司的抗PTPN2抗体产品,进行了免疫印迹实验。 更多
DLG5
discs large MAGUK scaffold protein 5
总数:1
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. 2009 至该文献
为了研究Sds22在调控表皮细胞的极性和形态中的作用,采用了Developmental Studies Hybridoma Bank公司的鼠抗Dlg抗体产品(1:100),进行了免疫荧光实验。
BSN
bassoon presynaptic cytomatrix protein
总数:1
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. 2008 至该文献
CIBAR2
CBY1 interacting BAR domain containing 2
SLC22A23
solute carrier family 22 member 23
MEKK4
mitogen-activated protein kinase kinase kinase 4
总数:3
MEKK4 is an effector of the embryonic TRAF4 for JNK activation. 2005 至该文献
NCF4
neutrophil cytosolic factor 4
总数:2
A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis. 2006 至该文献
FOP
centrosomal protein 43
总数:1
Daughter centriole elongation is controlled by proteolysis. 2010 至该文献
为了研究蛋白质水解在子中心粒延长中的作用,采用了Proteintech Group的兔抗人FGFR1OP抗体进行免疫细胞化学实验。
MST1
macrophage stimulating 1
总数:2
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. 2010 至该文献
为了研究吐根信号对哺乳动物器官大小的调控作用,使用了Cell Signaling公司的Mst1抗体,进行了免疫印迹实验。 更多
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
TRAF4
TNF receptor associated factor 4
总数:4
Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. 2006 至该文献
为研究肿瘤坏死因子受体相关因子4(Traf4)的作用蛋白,采用Santa Cruz公司生产的Traf4抗体用于免疫印迹实验。 更多
TPMT
thiopurine S-methyltransferase
总数:1
Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. 2008 至该文献
为了研究自噬是硫嘌呤甲基转移酶的同种异型酶 TPMT*3A降解的机制之一,采用了Abgent的抗TPMT抗体进行免疫印迹实验。
MYO9B
myosin IXB
总数:1
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. 2005 至该文献
EP4
prostaglandin E receptor 4
总数:9
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. 2008 至该文献
为了研究CD30信号在霍奇金细胞系和间变性大细胞淋巴瘤(ALCL)细胞系中的重要作用,采用了Abcam的鼠单克隆抗PTGER4抗体进行流式细胞分析。 更多
DEFA5
defensin alpha 5
总数:1
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 至该文献
为了研究TLR4和HD5在子宫颈内上皮细胞中的免疫防御功能,采用ADL公司兔抗HD5抗体进行了免疫印迹实验。
Toll样受体4 (TLR4)
toll like receptor 4
总数:37
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 至该文献
为了研究TLR4和HD5在子宫颈内上皮细胞中的免疫防御功能,采用R&D公司单克隆小鼠抗TLR4抗体进行了免疫印迹实验。 更多
CARD9
caspase recruitment domain family member 9
IL12B
interleukin 12B
总数:2
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. 2005 至该文献
NLRP3
NLR family pyrin domain containing 3
总数:1
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. 2006 至该文献
肿瘤坏死因子甲 (TNF-alpha)
tumor necrosis factor
总数:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 至该文献
为了研究UNC93B1介导的内涵体TLRs不同的运输机制,采用eBiosciences公司的抗TNFα-PE或-APC抗体进行流式细胞术试验。 更多
STAT3
signal transducer and activator of transcription 3
总数:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 至该文献
为了研究酪氨酸激酶Tec在Th17细胞亚群CD44(high)CD62L(-)产生中的作用,采用了Santa Cruz Biotechnology公司的抗STAT3抗体进行了免疫印迹试验。 更多
CCR6
C-C motif chemokine receptor 6
总数:5
CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. 2007 至该文献
R&D Systems的大鼠抗小鼠CCR6抗体被用于流式细胞术,来研究CCR6在孤立淋巴滤泡(ILFs)中的作用。 更多
ITPA
inosine triphosphatase
总数:1
Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase. 2010 至该文献
为了研究人的P32T ITPase的功能,采用Proteintech Group的兔抗ITPA多克隆抗体进行免疫印迹实验。
NR1I2
nuclear receptor subfamily 1 group I member 2
总数:8
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强,采用Calbiochem的兔多抗PAR抗体进行免疫沉淀实验。 更多
NOD1
nucleotide binding oligomerization domain containing 1
hBD-2 (hBD-2)
defensin beta 4A
总数:11
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. 2010 至该文献
为了研究来自骨关节炎和风湿性关节炎病人的混合滑膜组织培养中TNF和去甲肾上腺素对人嗜中性粒细胞多肽1-3分泌水平的抑制作用,采用了Biologo的兔多抗人HBD-2抗体以1:100稀释进行免疫组化和1:1000稀释进行ELISA实验。 更多
PHOX2B
paired like homeobox 2B
总数:1
Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. 2008 至该文献
Tyk2
tyrosine kinase 2
总数:13
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. 2008 至该文献
为研究新型酪氨酸激酶JAK-2抑制剂Z3可以抑制JAK-2介导的病理性细胞生长,采用了Santa Cruz 生物技术公司的抗Tyk2和抗磷酸化TyK2多克隆抗体分别进行免疫共沉淀实验和western免疫印迹实验。 。 更多
CDKAL1
CDK5 regulatory subunit associated protein 1 like 1
PTPN22
protein tyrosine phosphatase non-receptor type 22
CD14
CD14 molecule
总数:80
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 至该文献
为了研究EPEC蛋白NleE在人类树突细胞中抑制NF-kappa B信号通路的作用,采用了AbDSerotec公司PE-Cy5交联的抗CD14抗体进行了流式细胞实验。 更多
TRAF6
TNF receptor associated factor 6
总数:17
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 至该文献
为了研究在B细胞中TNIK在经典的NF-kB和JNK通路中扮演何种角色及如何发挥这种作用,采用了Santa Cruz Biotechnology的TRAF6 (H-274)抗体进行免疫印迹实验。 更多
IL-10 (IL-10)
interleukin 10
总数:23
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 至该文献
为了研究肠道正常菌群如何调节免疫系统,采用了R&D Systems 抗IL-10 抗体进行了ELISA检测。 更多
TNFRSF6B
TNF receptor superfamily member 6b
总数:2
Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter.. 2007 至该文献
为研究P3HR1 细胞和 EBV转染的293细胞中诱骗受体3(DcR3)的表达上调是否出现在EBV复活之前,采用BioLegend 公司生产的DcR3抗体用于免疫印迹实验。 更多
DEFB1
defensin beta 1
总数:2
Nuclear hBD-1 accumulation in malignant salivary gland tumours. 2008 至该文献
Toll样受体5 (TLR5)
toll like receptor 5
总数:4
Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.. 2008 至该文献
为了研究toll样受体在莱姆疏螺旋体病发病机制中的作用,采用Santa Cruz公司的兔多克隆抗TLR5抗体(2 μg/ml),进行蛋白质印迹实验。 更多
糖皮质激素受体 (glucocorticoid receptor)
nuclear receptor subfamily 3 group C member 1
总数:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 至该文献
为了研究移动的cDCs在调控CD11c, MHC II, 和CD86中的作用,使用了BD公司的鼠单克隆抗鼠Gr-l抗体,进行了免疫流式细胞计量分析。 更多
IL-1beta (IL-1beta)
interleukin 1 beta
总数:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了R&D Systems公司的抗IL-1-beta抗体进行细胞刺激。 更多
CXCR3
C-X-C motif chemokine receptor 3
总数:11
A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. 2008 至该文献
为了研究基于计算机的多肽组学能够系统性的发现抑制内皮细胞增殖和迁移的多肽,采用了R&D Systems的单抗CXCR3抗体进行抑制或激活实验。 更多
ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP binding cassette subfamily B member 1
总数:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点,使用了Santa Cruz Biotechnology公司的MDR1抗体(1:500)来进行免疫印记实验。 更多
PPARgamma
peroxisome proliferator activated receptor gamma
总数:28
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点,使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析和染色质免疫沉淀实验。 更多
Janus激酶2 (Jak2)
Janus kinase 2
总数:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 至该文献
为了确定在受体信号激活过程中促红细胞生成素受体的受体因素,使用了Upstate公司的抗JAK2抗体来进行免疫沉淀实验和免疫印记分析。 更多
IL-17 (IL-17)
interleukin 17A
总数:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了eBioscience公司的抗IL-17A抗体进行流式细胞计数和细胞刺激。 更多
IL33
interleukin 33
总数:1
IL-33 exacerbates antigen-induced arthritis by activating mast cells. 2008 至该文献
TNFR1
TNF receptor superfamily member 1A
总数:23
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. 2009 至该文献
为了研究TRAF2对应激诱导的细胞死亡的抑制机制,采用了Santa Cruz的抗TNFR1抗体进行免疫印迹实验 更多
TNFR2
TNF receptor superfamily member 1B
总数:14
Control of chemokine gradients by the retinal pigment epithelium. 2008 至该文献
HLA-C (HLA-C)
major histocompatibility complex, class I, C
总数:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 至该文献
为了研究主要组织相容性复合体作为一种附属因子在促进 HCoV-HKU1 感染过程中的作用,采用英杰的纯化的羊免疫球蛋白作为同型标准品。 更多
HLA-DRB1 (HLA-DRB1)
major histocompatibility complex, class II, DR beta 1
总数:7
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析,采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。 更多
CD32
Fc fragment of IgG receptor IIa
总数:9
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 至该文献
为了分析在人类特异的脑前额神经中转录起始位点的组蛋白甲基化修饰,采用了Upstate的抗IgG抗体,进行RNA免疫沉淀实验。 更多
CTLA 4 (CTLA 4)
cytotoxic T-lymphocyte associated protein 4
总数:6
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. 2011 至该文献
为了揭示CTLA-4为何能够抑制CD28的激活,采用Santa Cruz的抗CTLA-4抗体进行免疫细胞化学试验。 更多
STAT4
signal transducer and activator of transcription 4
总数:10
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 至该文献
为了研究Stat4依赖的Th1相关基因的遗传程序,采用了Santa Cruz Biotechnology公司的抗Stat4抗体进行ChIP分析 更多
白细胞介素2 (interleukin 2)
总数:17
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 至该文献
为了研究肠道正常菌群如何调节免疫系统,采用了BD Pharmingen™ 抗IL-2 抗体进行了流式分析检测。 更多
CD25
interleukin 2 receptor subunit alpha
总数:49
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 至该文献
为了研究树突细胞在调控自发性致死性自身免疫性疾病中的作用,采用了eBioscience公司的抗CD25抗体产品,进行了流失细胞分析实验。 更多
Toll样受体2 (TLR2)
toll like receptor 2
总数:22
Inflammatory role of Toll-like receptors in human and murine adipose tissue. 2010 至该文献
为了研究人和鼠科脂肪组织中Toll样受体与网膜脂肪组织相关的炎症之间的关系,采用了Hycult Biotechnologies的单抗TLR2抗体进行ELISA实验。 更多
p50
nuclear factor kappa B subunit 1
总数:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制,使用了Santa Cruz Biotechnology公司的anti-p50抗体来进行染色质免疫共沉淀实验。 更多
FasL (FasL)
Fas ligand
总数:12
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. 2006 至该文献
Toll样受体9 (TLR9)
toll like receptor 9
总数:6
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 至该文献
为了在人体皮肤的冷冻切片上研究Toll样受体在疣和传染性软疣的表现,使用了Santa Cruz Biotechnology公司的羊多克隆的抗人体TLR9产品,进行了免疫组织化学实验。 更多
MCP-1 (MCP-1)
C-C motif chemokine ligand 2
总数:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响,采用了Santa Cruz公司的抗MCP-1抗体进行了免疫组织化学实验。 更多
VDR
vitamin D receptor
总数:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达,采用了Affinity BioReagents公司的抗VDR(MA1-710,1:400)单克隆抗体进行免疫细胞化学实验。 更多
LCN2
lipocalin 2
总数:5
Lipocalin 2 promotes breast cancer progression. 2009 至该文献
为研究Lipocalin2蛋白对乳腺癌发展的影响,将R&D Systems提供的抗人Lcn2抗体用于免疫组织化学实验中。 更多
IFN丙 (IFN-gamma)
interferon gamma
总数:62
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进,采用R&D Systems的抗IFN-gamma抗体以5ug/ml浓度进行细胞刺激实验。 更多
MBL2
mannose binding lectin 2
总数:4
High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates. 2006 至该文献
UBC
ubiquitin C
总数:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 至该文献
为了研究突触的可塑性,采用了Enzo Life Sciences的抗Ubiquitin的抗体进行了免疫印迹实验。 更多
骨桥蛋白 (osteopontin)
secreted phosphoprotein 1
总数:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 至该文献
为了研究c-Src激酶是否会促使非典型小叶增生或小叶原位癌转变为浸润性小叶癌,使用了Calbiochem公司的抗osteopontin抗体(1:100)进行免疫荧光实验。 更多
IGF-1 (IGF-1)
insulin like growth factor 1
总数:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 至该文献
为研究胰岛素生长因子在骨髓瘤细胞生长过程中所发挥的作用,及其受体表达与骨髓瘤患者预后的相关性,将Abcam公司提供的兔抗胰岛素样生长因子1抗体用于蛋白免疫印迹实验中。 更多
IL-6 (IL-6)
interleukin 6
总数:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了R&D Systems公司的抗IL-6抗体进行细胞刺激。 更多
IL1RN
interleukin 1 receptor antagonist
总数:1
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. 2006 至该文献