克罗恩病
基因
试剂
文献样例
产品评述样例
NOD2
nucleotide-binding oligomerization domain containing 2
总数:2
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. 2006 至该文献
ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
interleukin 23 receptor
总数:2
Cutting edge: A critical functional role for IL-23 in psoriasis. 至该文献
为了研究IL－23在银屑病中扮演的角色并寻找慢性上皮炎症性疾病的新的治疗策略，采用了R&D Systems的抗IL-23R抗体进行流式细胞和免疫组化实验。 更多
IRGM
immunity-related GTPase family, M
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
OCTN2
solute carrier family 22 (organic cation/carnitine transporter), member 5
DLG5
discs, large homolog 5 (Drosophila)
总数:1
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. 2009 至该文献
为了研究Sds22在调控表皮细胞的极性和形态中的作用，采用了Developmental Studies Hybridoma Bank公司的鼠抗Dlg抗体产品(1:100)，进行了免疫荧光实验。
NKX2-3
NK2 homeobox 3
CCNY
cyclin Y
BSN
bassoon (presynaptic cytomatrix protein)
总数:1
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. 2008 至该文献
PTPN2
protein tyrosine phosphatase, non-receptor type 2
总数:2
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 至该文献
为了研究MDA5 和PTPN2在调节胰岛beta细胞对病毒双链RNA副产物的反应中的作用，采用了R&D Systems公司的抗PTPN2抗体产品，进行了免疫印迹实验。 更多
LYRM4
LYR motif containing 4
SLC22A23
solute carrier family 22, member 23
HERC2
hect domain and RLD 2
TUCAN
caspase recruitment domain family, member 8
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
总数:2
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. 2010 至该文献
为了研究吐根信号对哺乳动物器官大小的调控作用，使用了Cell Signaling公司的Mst1抗体，进行了免疫印迹实验。 更多
MYO9B
myosin IXB
总数:1
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. 2005 至该文献
DEFA5
defensin, alpha 5, Paneth cell-specific
IL 23
interleukin 23, alpha subunit p19
NCF4
neutrophil cytosolic factor 4, 40kDa
总数:2
Synaptic localization of a functional NADPH oxidase in the mouse hippocampus. 2005 至该文献
Upstate Biotechnology的p40phox抗体被用于蛋白质印迹实验，来研究在小鼠海马体中一个功能性的NADPH氧化酶的突触定位。 更多
NLRP3
NLR family, pyrin domain containing 3
总数:1
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. 2006 至该文献
Toll样受体4 (TLR4)
toll-like receptor 4
总数:36
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. 2008 至该文献
为了研究回肠粘膜中TLR2、TLR4和及其转膜辅助受体CD14的表达情况，采用Santa Cruz Biotechnology公司的羊抗TLR4多克隆抗体（1：10）进行免疫组织化学实验。 更多
hBD-2
defensin, beta 4A
总数:11
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. 2010 至该文献
为了研究来自骨关节炎和风湿性关节炎病人的混合滑膜组织培养中TNF和去甲肾上腺素对人嗜中性粒细胞多肽1-3分泌水平的抑制作用，采用了Biologo的兔多抗人HBD-2抗体以1：100稀释进行免疫组化和1:1000稀释进行ELISA实验。 更多
PHOX2B
paired-like homeobox 2b
总数:1
Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. 2008 至该文献
IL27
interleukin 27
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
总数:2
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.. 2005 至该文献
TPMT
thiopurine S-methyltransferase
总数:1
Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. 2008 至该文献
为了研究自噬是硫嘌呤甲基转移酶的同种异型酶 TPMT*3A降解的机制之一，采用了Abgent的抗TPMT抗体进行免疫印迹实验。
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
总数:114
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用，采用了Cell Signaling的抗Stat3和抗磷酸化Stat3 (Ser727)抗体进行免疫印迹实验。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
NR1I2
nuclear receptor subfamily 1, group I, member 2
总数:8
SIRT6 promotes DNA repair under stress by activating PARP1.. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强，采用Calbiochem的兔多抗PAR抗体进行免疫沉淀实验。 更多
EP4
prostaglandin E receptor 4 (subtype EP4)
总数:10
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. 2008 至该文献
为了研究CD30信号在霍奇金细胞系和间变性大细胞淋巴瘤(ALCL)细胞系中的重要作用，采用了Abcam的鼠单克隆抗PTGER4抗体进行流式细胞分析。 更多
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
总数:2
Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter. 2007 至该文献
为研究P3HR1 细胞和 EBV转染的293细胞中诱骗受体3（DcR3）的表达上调是否出现在EBV复活之前，采用BioLegend 公司生产的DcR3抗体用于免疫印迹实验。 更多
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
总数:1
Disruption of the Nramp1 (also known as Slc11a1) gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver. 2002 至该文献
DEFB1
defensin, beta 1
总数:2
Nuclear hBD-1 accumulation in malignant salivary gland tumours. 2008 至该文献
白细胞介素1beta (IL-1beta)
interleukin 1, beta
总数:28
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. 2009 至该文献
为了研究牙龈卟啉单胞菌所致牙周炎中基质金属蛋白酶8的作用，在免疫染色试验中将R&D Systems的interleukin-1β作用于石蜡包被的组织样品上。 更多
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
CD14
CD14 molecule
总数:77
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.. 2011 至该文献
为了研究能长期自我复制的人造血干细胞能够通过CD49f为标记物进行分离，采用Beckman Coulter的抗CD14PC7抗体进行流式细胞分选实验。 更多
白细胞介素10 (IL-10)
interleukin 10
总数:20
Identification of IL-17-producing FOXP3+ regulatory T cells in humans. 2009 至该文献
为了确定IL-17+，FOXP3+调节性T细胞产生于外周血中，使用了R&D Systems公司的白介素10酶联免疫吸附试剂盒进行酶联免疫吸附实验。 更多
糖皮质激素受体 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
总数:20
Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. 2009 至该文献
为了说明HSP90伴侣蛋白Cdc37能维持致癌蛋白激酶客户蛋白，使用了Santa Cruz Biotechnology公司的GR抗体进行蛋白印迹实验。 更多
IL 21
interleukin 21
总数:1
Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3. 2009 至该文献
为了证明在人的肝脏部位抗原3(LSA-3)上存在着多个不同的T细胞和B细胞表位，并研究其在诱导产生抗疟原虫的保护机制中的作用，采用了Unipath公司的小鼠抗IgG4抗体(1:3000)，进行了ELISA实验。
STAT4
signal transducer and activator of transcription 4
总数:10
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 至该文献
为了研究Stat4依赖的Th1相关基因的遗传程序，采用了Santa Cruz Biotechnology公司的抗Stat4抗体进行ChIP分析 更多
CTLA 4
cytotoxic T-lymphocyte-associated protein 4
总数:5
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell Extrinsic Function of CTLA-4.. 2011 至该文献
为了揭示CTLA-4为何能够抑制CD28的激活，采用Santa Cruz的抗CTLA-4抗体进行免疫细胞化学试验。 更多
Mediterranean fever
Toll样受体2 (TLR2)
toll-like receptor 2
总数:22
Inflammatory role of Toll-like receptors in human and murine adipose tissue. 2010 至该文献
为了研究人和鼠科脂肪组织中Toll样受体与网膜脂肪组织相关的炎症之间的关系，采用了Hycult Biotechnologies的单抗TLR2抗体进行ELISA实验。 更多
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:28
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析。 更多
Toll样受体9 (TLR9)
toll-like receptor 9
总数:6
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 至该文献
为了在人体皮肤的冷冻切片上研究Toll样受体在疣和传染性软疣的表现，使用了Santa Cruz Biotechnology公司的羊多克隆的抗人体TLR9产品，进行了免疫组织化学实验。 更多
LTA
lymphotoxin alpha (TNF superfamily, member 1)
白细胞介素2 (interleukin 2)
总数:15
Identification of IL-17-producing FOXP3+ regulatory T cells in humans. 2009 至该文献
为了确定IL-17+，FOXP3+调节性T细胞产生于外周血中，使用了R&D Systems公司的白介素2酶联免疫吸附试剂盒进行酶联免疫吸附实验。 更多
IFN-gamma
interferon, gamma
总数:59
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence.. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进，采用R&D Systems的抗IFN-gamma抗体以5ug/ml浓度进行细胞刺激实验。 更多
ghrelin
ghrelin/obestatin prepropeptide
总数:6
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究格瑞林酰基转移酶抑制剂在小鼠中的作用，采用了Abcam抗ghrelin抗体进行了免疫印迹实验。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用，采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多
ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP-binding cassette, sub-family B (MDR/TAP), member 1
总数:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点，使用了Santa Cruz Biotechnology公司的MDR1抗体(1:500)来进行免疫印记实验。 更多
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
总数:6
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析，采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。 更多
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
总数:80
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制，使用了Santa Cruz Biotechnology公司的anti-p50抗体来进行染色质免疫共沉淀实验。 更多
Janus激酶2 (Jak2)
Janus kinase 2
总数:34
Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor.. 2010 至该文献
为了确定在受体信号激活过程中促红细胞生成素受体的受体因素，使用了Upstate公司的抗JAK2抗体来进行免疫沉淀实验和免疫印记分析。 更多
MCP-1
chemokine (C-C motif) ligand 2
总数:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响，采用了Santa Cruz公司的抗MCP-1抗体进行了免疫组织化学实验。 更多
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
总数:15
Vitamin d induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达，采用了Affinity BioReagents公司的抗VDR（MA1-710，1：400）单克隆抗体进行免疫细胞化学实验。 更多
IL1RN
interleukin 1 receptor antagonist
总数:1
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. 2006 至该文献
p53
tumor protein p53
总数:239
The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma. 至该文献
为了研究可能的抑癌基因ECRG4对食管癌细胞迁移和浸润的影响，采用了Santa Cruz公司的抗p53的抗体进行免疫印迹实验。 更多
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
总数:55
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2010 至该文献
为了研究mPGES-1在调控肿瘤生长、侵润和转移中的作用，采用了Santa Cruz Biotechnology公司的抗COX-2抗体产品，进行了免疫印迹实验。 更多
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多