癫痫

基因

试剂

文献样例

产品评述样例

SCN1A
sodium voltage-gated channel alpha subunit 1

总数:4

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. 2006 至该文献

为了研究在SMEI Scn1a+/-杂合体中GABAergic抑制神经元里减少钠电流的作用，采用了Chemicon公司的抗NaV1.1抗体进行蛋白质印迹和免疫组织化学分析。更多

PCDH19
protocadherin 19

CDKL5
cyclin dependent kinase like 5

SCN2A
sodium voltage-gated channel alpha subunit 2

总数:3

A role for myosin VI in the localization of axonal proteins. 2011 至该文献

为了研究肌球蛋白VI对轴突蛋白定位作用，采用了Neuromab公司的鼠源抗Nav1.2抗体，进行免疫细胞试验更多

SCN3A
sodium voltage-gated channel alpha subunit 3

总数:1

Voltage-gated sodium channels in taste bud cells. 2009 至该文献

为了研究SCN2A, SCN3A 和SCN9A在调控味细胞动作电位中的作用，使用了Chemicon公司的兔多克隆抗SCN3A抗体，进行了免疫组织化学实验。

ARX
aristaless related homeobox

antiquitin
aldehyde dehydrogenase 7 family member A1

SYNGAP1
synaptic Ras GTPase activating protein 1

总数:3

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. 2006 至该文献

为了说明EphB2能控制特定种类的成熟谷氨酸突触的组成，采用了Affinity BioReagents公司的SynGAP抗体进行免疫组织化学分析。更多

KCNQ2
potassium voltage-gated channel subfamily Q member 2

总数:2

Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. 2006 至该文献

Chemicon的KCNQ2抗体被用于蛋白质印迹实验，来研究Kv7/KCNQ/M通道在控制细胞兴奋性中的作用。更多

ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP binding cassette subfamily B member 1

总数:15

p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献

为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点，使用了Santa Cruz Biotechnology公司的MDR1抗体(1:500)来进行免疫印记实验。更多

ROGDI
rogdi atypical leucine zipper

KCNQ3
potassium voltage-gated channel subfamily Q member 3

总数:1

Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. 2006 至该文献

Chemicon的KCNQ3抗体被用于蛋白质印迹实验，来研究Kv7/KCNQ/M通道在控制细胞兴奋性中的作用。

SCN1B
sodium voltage-gated channel beta subunit 1

GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2

总数:2

Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina. 2005 至该文献

Kir4.1 (Kir4.1)
potassium inwardly rectifying channel subfamily J member 10

总数:5

MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet. 2007 至该文献

GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1

总数:3

Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X. 2009 至该文献

为了研究GABAA受体α1突变致NMD和ERAD活性增强而导致的遗传性癫痫，采用了Chemicon公司生产的抗人GABAA受体α1单克隆抗体用于免疫印迹实验。更多

CYP2C9
cytochrome P450 family 2 subfamily C member 9

总数:4

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 至该文献

MEF2C
myocyte enhancer factor 2C

总数:3

c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. 2010 至该文献

为了研究诱导多能干细胞的心脏潜能与核重新编程的关系，使用了proteintech公司的Mef2c兔抗(10056-1-AP; 1:50稀释)来进行免疫细胞化学实验。更多

LGI1
leucine rich glioma inactivated 1

MRP2
ATP binding cassette subfamily C member 2

总数:7

ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. 2006 至该文献

POLG
DNA polymerase gamma, catalytic subunit

UGT2B7
UDP glucuronosyltransferase family 2 member B7

ATP1A2
ATPase Na+/K+ transporting subunit alpha 2

总数:4

Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells. 2005 至该文献

TSC1
TSC complex subunit 1

总数:9

Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. 2010 至该文献

为了研究PC-1蛋白的羧基端如何增强TSC2和TSC1的相互作用从而抑制mTOR信号通路的机制，作者使用Zymed Laboratories公司的抗TSC1抗体进行免疫印迹和免疫沉淀实验。更多

TSC2
TSC complex subunit 2

总数:26

Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. 2010 至该文献

为了研究PC-1蛋白的羧基端如何将TSC锚定在膜上从而抑制mTOR信号通路的机制，作者使用Epitomics公司的抗TSC2抗体进行免疫印迹和免疫沉淀实验。更多

CACNA1A
calcium voltage-gated channel subunit alpha1 A

总数:1

Voltage-dependent calcium channels of dog basilar artery. 2007 至该文献

Alomone Laboratories的兔源Cav2.1多克隆抗体被用于蛋白质印迹实验，来研究依赖电压的钙离子通道的电生理学特性和分子特征。

GLUT1
solute carrier family 2 member 1

总数:23

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. 2009 至该文献

为了研究葡萄糖的缺少对KRAS信号途径发生突变所起的作用，使用了Abcam公司的兔源多克隆抗GLUT1抗体进行蛋白印迹试验。更多

CYP2C19
cytochrome P450 family 2 subfamily C member 19

人类白细胞抗原b (HLA B)
major histocompatibility complex, class I, B

总数:1

Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 至该文献

HERG
potassium voltage-gated channel subfamily H member 2

总数:6

Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo. 2008 至该文献

为了研究herg对于调节SH-SY5Y细胞生长和增殖的重要作用，采用了Santa Cruz公司的抗HERG(sc-15968,1:1000)抗体进行了免疫印记实验。更多

EPHX1
epoxide hydrolase 1

BDNF
brain derived neurotrophic factor

总数:11

Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 至该文献

在免疫组化实验中使用Chemicon International抗BDNF抗体，来证明新生C57BL/6小鼠脑皮层神经营养因子的表达差异。更多

哺乳动物雷帕霉素靶蛋白 (mTOR)
mechanistic target of rapamycin kinase

总数:33

A gene signature-based approach identifies mTOR as a regulator of p73. 2008 至该文献

为了研究如何通过基于基因标签的方法检测mTOR是p73的一个调控因子，采用了Santa Cruz的多抗mTOR(N-19 (alpha-FRAP))抗体进行免疫印迹实验。更多

IL-6 (IL-6)
interleukin 6

总数:43

IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献

为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生，采用了R&D Systems公司的抗IL-6抗体进行细胞刺激。更多

MTHFR
methylenetetrahydrofolate reductase

基质金属蛋白酶-9 (MMP-9)
matrix metallopeptidase 9

总数:45

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 至该文献

为了研究蛋白激酶D1抑制乳腺肿瘤细胞侵袭的机制，采用了Epitomics公司的抗MMP-9抗体，进行了免疫组织化学实验。更多

ApoE基因 (ApoE)
apolipoprotein E

总数:19

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 至该文献

为了研究高效肝炎C病毒颗粒的形成条件，采用了Calbiochem公司的抗ApoE抗体进行蛋白免疫印迹实验。更多