头颈部肿瘤
基因
试剂
文献样例
产品评述样例
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
CCR7
chemokine (C-C motif) receptor 7
总数:9
Role of Twist in head and neck carcinoma with lymph node metastasis. 2008 至该文献
为了研究Twist在头颈癌转移中的作用,采用了R&D Systems的抗CCR7抗体进行免疫组化实验。 更多
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
p63
tumor protein p63
总数:25
Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. 2010 至该文献
为了研究PAD2在犬乳腺组织上皮细胞中的作用,采用了NeoMarkers的抗p63的抗体进行了免疫荧光实验。 更多
Cyp2e1
cytochrome P450, family 2, subfamily E, polypeptide 1
总数:7
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 至该文献
使用牛津大学生物医学研究的抗CYP2E1(1:1000) 抗体进行免疫印迹实验来研究心肌CPR和CPR依赖酶在阿霉素介导的急性心脏毒性中的作用。 更多
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Cyp1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
总数:15
Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. 2009 至该文献
为确定芳香烃受体在胃癌发生过程中的功能性意义,并探讨其在胃癌治疗中可能发挥的作用,将Chemicon International提供的抗CYP 1A1抗体(AB1258)用于蛋白免疫印迹实验中。 更多
表皮生长因子受体 (EGFR)
epidermal growth factor receptor
总数:147
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 至该文献
为了研究MMP-10和CTSF在糖尿病患者角膜伤口治愈不良中的作用,采用了Epitomics的抗磷酸化-EGFR(Tyr845)抗体进行免疫组化试验。 更多
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
GSTM1
glutathione S-transferase mu 1
总数:2
14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation. 2008 至该文献
为了研究因组蛋白H3乙酰化而激活的基因,采用Millipore的抗GST的抗体进行免疫印迹实验。 更多
p53
tumor protein p53
总数:239
The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma. 至该文献
为了研究可能的抑癌基因ECRG4对食管癌细胞迁移和浸润的影响,采用了Santa Cruz公司的抗p53的抗体进行免疫印迹实验。 更多
GSTP1
glutathione S-transferase pi 1
总数:9
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 至该文献
为了说明在医学上难以治愈的癫痫病人的大脑中谷胱甘肽s转移酶-π具有较高的表达量,采用了Lab Vision Corporation公司的抗GSTP抗体进行免疫细胞化学实验。 更多
cortactin
总数:17
Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp. 至该文献
为了研究在人肿瘤细胞的中CIP4对细胞的运动能力和侵袭能力的影响,采用了Upstate的抗cortactin抗体进行了免疫组化检测。 更多
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
总数:2
How do human cells react to the absence of mitochondrial DNA?. 2009 至该文献
运用Invitrogen公司的抗SDH抗体,进行免疫印迹实验以研究缺乏线粒体DNA时人细胞的反应性。 更多
p73
tumor protein p73
总数:21
Regulation of p73 by Hck through kinase-dependent and independent mechanisms.. 2007 至该文献
为了研究Hck调控p73功能的机制,采用Santa Cruz的兔多抗p73抗体进行蛋白印迹和免疫沉淀实验。 更多
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
DR5
tumor necrosis factor receptor superfamily, member 10b
总数:15
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 至该文献
为了研究Fas配体和TRAIL在调控鼠胸腺移植物抗宿主病中的作用,采用了eBioscience公司的抗DR5抗体产品,进行了流式细胞分析实验。 更多
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
总数:1
A pilot study on subacute ethanol treatment of ALDH2 KO mice. 2007 至该文献
Ku70
X-ray repair complementing defective repair in Chinese hamster cells 6
总数:17
Ku70 corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway.. 2010 至该文献
为了研究Ku70和FANCC的关联以及它们在DNA修复应答中的功能,使用了Neomarkers公司的抗Ku70抗体来进行免疫印迹分析。 更多
Ku80
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
总数:21
Ku70 corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway.. 2010 至该文献
为了研究Ku70和FANCC的关联以及它们在DNA修复应答中的功能,使用了Neomarkers公司的小鼠抗Ku80抗体来进行免疫印迹分析。 更多
XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
总数:3
Domain mapping of the Rad51 paralog protein complexes. 2004 至该文献
ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
总数:2
Biochemical analysis of the damage recognition process in nucleotide excision repair. 2003 至该文献
XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
总数:4
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. 2007 至该文献
CD44
CD44 molecule (Indian blood group)
总数:45
Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. 2009 至该文献
为了研究人乳腺癌细胞中与转移相关的质膜蛋白表达量的改变,采用了Abcam公司的抗CD44(ab6124)抗体进行免疫印迹、流式细胞术、免疫组化以及免疫细胞化学实验。 更多
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
总数:143
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制,使用了Santa Cruz Biotechnology公司的anti-p65抗体来进行染色质免疫共沉淀实验。 更多
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
总数:7
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 至该文献
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
SLUG
snail homolog 2 (Drosophila)
总数:2
Btbd7 regulates epithelial cell dynamics and branching morphogenesis.. 2010 至该文献
为了研究Btbd7在促进上皮组织重构和分支形态发生中的作用,使用了Santa Cruz Biotechnology公司的抗Snail2抗体来进行免疫荧光实验。 更多
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
RAD51
RAD51 homolog (S. cerevisiae)
总数:20
SIRT6 promotes DNA repair under stress by activating PARP1.. 2011 至该文献
为了研究氧化应激条件下DNA修复能被SIRT6通过PARP1活化加强,采用Calbiochem的抗Rad51抗体进行免疫细胞化学实验。 更多
p16
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
总数:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 至该文献
为了研究Raf-1对神经胶质瘤形成的作用,采用了Santa Cruz Biotechnology的抗p19抗体进行免疫组化实验。 更多
caspase-8
caspase 8, apoptosis-related cysteine peptidase
总数:73
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. 2009 至该文献
为了研究SARS冠状病毒激活PKR和PERK并且克服eIF2α对病毒mRNA翻译的抑制作用的机制,使用了Cell Signaling公司的小鼠抗casp8单克隆抗体来进行免疫印迹分析。 更多
c-Met
met proto-oncogene (hepatocyte growth factor receptor)
总数:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 至该文献
为了研究固定液在磷酸化蛋白免疫组化测定中的作用使用了R&D公司的兔抗pMET抗体来进行免疫组化实验。 更多
Src
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
总数:116
miR-126 regulates angiogenic signaling and vascular integrity. 2008 至该文献
为了研究miR-126对血管完整性和血管生成的调控作用,采用了Cell Signaling的抗SRC和抗磷酸化SRC (Tyr416)抗体进行免疫印迹实验。 更多
Bip
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
总数:46
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. 2009 至该文献
为了研究知母皂甙AIII对肿瘤细胞造成细胞毒性的机制,使用了Santa Cruz公司的抗GRP78抗体来进行蛋白印迹分析。 更多
HIF-1 alpha
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
总数:62
Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha. 2010 至该文献
为了研究PTPRZ1启动子上HIF结合及Ets结合的基序并且说明了HIF-2可以激活PTPRZ1,使用了Novus Biologicals公司的HIF1alpha抗体进行染色质免疫沉淀实验。 更多
TWIST1
twist homolog 1 (Drosophila)
总数:3
Role of Twist in head and neck carcinoma with lymph node metastasis. 2008 至该文献
为了研究Twist在头颈癌转移中的作用,采用了Santa Cruz Biotechnology的抗Twist抗体进行免疫组化实验。 更多
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
总数:80
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制,使用了Santa Cruz Biotechnology公司的anti-p50抗体来进行染色质免疫共沉淀实验。 更多
VHL
von Hippel-Lindau tumor suppressor
总数:12
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. 2008 至该文献
为了研究VHL肿瘤抑制基因通过成纤维细胞生长因子受体信号通路对内皮功能的影响,采用了Cell Signaling的鼠单抗VHL抗体进行免疫印迹和免疫组化实验。 更多
snail 1锌指蛋白 (SNAI1)
snail homolog 1 (Drosophila)
总数:4
Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. 2008 至该文献
为了研究四旋蛋白TM4SF5在接触抑制和肿瘤发生中的作用,采用Santa Cruz Biotechnology公司的抗Snail1抗体进行免疫印迹实验。 更多
Notch1
notch 1
总数:17
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation.. 2010 至该文献
为研究eIF3f去泛素酶活性调节的Notch激活,采用了Cell Signaling公司的抗Notch V1744抗体进行蛋白质印迹试验。 更多
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
总数:114
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用,采用了Cell Signaling的抗Stat3和抗磷酸化Stat3 (Ser727)抗体进行免疫印迹实验。 更多
细胞周期蛋白D (cyclin D1)
总数:120
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 至该文献
为了研究在食道鳞状细胞癌中尿溶蛋白1A(UPK1A)的作用,采用了Cell Signaling Technology公司的抗cyclin-D1的抗体进行蛋白免疫印迹实验。 更多
NQO1
NAD(P)H dehydrogenase, quinone 1
总数:2
Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells. 2004 至该文献
RET
ret proto-oncogene
总数:8
siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. 2008 至该文献
为研究RET/PTC1癌基因特异性siRNA壳聚糖纳米颗粒在体内抑制甲状腺癌生长的效应,采用Abgent公司抗RET兔多克隆抗体(编号:AP7669b,0.25 mg/ml)进行了Western免疫印迹实验。 更多
iNOS
nitric oxide synthase 2, inducible
总数:38
MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells. 2008 至该文献
为了研究MEKK-1在细胞因子诱导的信号通路中的作用,采用Santa Cruz Biotechnologies抗NOS-2抗体进行免疫印迹实验。 更多
ERK1
mitogen-activated protein kinase 3
总数:249
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用,采用了Cell Signaling的抗p44/42 MAPK和抗磷酸化p44/42 MAPK (Thr202/Tyr204)抗体进行免疫印迹实验。 更多
mTOR
mechanistic target of rapamycin (serine/threonine kinase)
总数:32
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H?-ATPase.. 2011 至该文献
为了研究泡状H+-ATPase参与到mTOR通路中mTORC1的转位和激活,采用Cell Signaling的抗mTOR抗体进行蛋白印迹和免疫细胞化学实验。 更多
ERK2
mitogen-activated protein kinase 1
总数:484
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 至该文献
为了研究在气喘患者中由TGFbeta和IL-10抑制造成的对T细胞的抗性的信号传导机制,采用了Santa Cruze Biotechnology的抗ERK1/2抗体和抗磷酸化ERK1/2抗体进行了免疫印迹检测,免疫组化实验和流式细胞检测。 更多
TGF-beta1
transforming growth factor, beta 1
总数:33
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 至该文献
为研究CD147促使成肌纤维细胞分化在组织变构中的作用,采用了R&D Systems公司的抗pan-TGFβ抗体进行抑制试验。 更多
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
总数:55
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2010 至该文献
为了研究mPGES-1在调控肿瘤生长、侵润和转移中的作用,采用了Santa Cruz Biotechnology公司的抗COX-2抗体产品,进行了免疫印迹实验。 更多
c-Myc
v-myc myelocytomatosis viral oncogene homolog (avian)
总数:143
Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis.. 2011 至该文献
为了研究去氢表雄酮和神经生长因子受体之间的相互作用,采用了Santa Cruz公司的抗c-myc (9E10, sc-40)抗体进行了免疫印记和免疫共沉淀实验。 更多
血管内皮生长因子 (VEGF)
vascular endothelial growth factor A
总数:76
Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib. 2008 至该文献
为了研究不间断给药伊立替康(irinotecan)对结肠直肠癌细胞的影响,采用了Oncogene Research Products公司的VEGF-A抗体进行免疫组化实验。 更多
E钙粘蛋白 (E-cadherin)
cadherin 1, type 1, E-cadherin (epithelial)
总数:127
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 至该文献
为了研究在食道鳞状细胞癌中尿溶蛋白1A(UPK1A)的作用,采用了Santa Cruz Biotechnology公司的抗E-cadherin的抗体进行蛋白免疫印迹实验。 更多
ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP-binding cassette, sub-family B (MDR/TAP), member 1
总数:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点,使用了Santa Cruz Biotechnology公司的MDR1抗体(1:500)来进行免疫印记实验。 更多
存活素 (survivin)
baculoviral IAP repeat containing 5
总数:33
A survivin-ran complex regulates spindle formation in tumor cells. 2008 至该文献
为了研究survivin-Ran信号通路在肿瘤细胞纺锤体形成中的作用,采用了Novus Biologicals的抗人survivin抗体进行免疫印迹实验。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用,采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多