高血压
基因
试剂
文献样例
产品评述样例
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
总数:16
Independent {beta}-Arrestin2 and Gq/Protein Kinase C{zeta} Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor. 2009 至该文献
为了研究在血管平滑肌细胞中G蛋白依赖性的通路和β-arrestin依赖性的通路激活ERK依赖性的EGFR活化的机制,使用了Sigma公司的Angiotensin II蛋白来刺激活化β-arrestin信号转导通路。 更多
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
血管紧张素转化酶 (ACE)
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
总数:10
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. 2009 至该文献
为了研究neprilysin在调控慢性低氧作用下肺动脉血管重塑过程中的作用,采用了Santa Cruz公司的抗ACE抗体产品,进行了免疫组化实验。 更多
AGTR1
angiotensin II receptor, type 1
总数:12
Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. 2008 至该文献
Santa Cruz公司生产的兔源性血管紧张素Ⅱ1型受体基因(AT1R)多克隆抗体可用于免疫细胞化学实验,来研究血管紧张素原AGT基因的表达及其与其它RAS成员表达的关系。 更多
eNOS
nitric oxide synthase 3 (endothelial cell)
总数:46
Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons. 2009 至该文献
为了研究内皮亚型的一氧化氮合成酶在成年小鼠的嗅感觉神经元中的功能,使用了Biomol公司的兔抗eNOS多克隆抗体来进行免疫荧光试验。 更多
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
总数:3
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 至该文献
肾素 (renin)
总数:4
Expression of components of the renin-angiotensin system in autosomal recessive polycystic kidney disease. 2005 至该文献
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
WNK4
WNK lysine deficient protein kinase 4
总数:2
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. 2004 至该文献
RGS2
regulator of G-protein signaling 2, 24kDa
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
SCNN1B
sodium channel, nonvoltage-gated 1, beta
总数:2
Vascular ENaC proteins are required for renal myogenic constriction. 2005 至该文献
GLUT5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
总数:2
Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1. 2007 至该文献
ADRA2B
adrenergic, alpha-2B-, receptor
总数:1
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities. 2002 至该文献
为了检测在人Mz-ChA-1和TFK-1细胞中alpha2B-AR的表达,采用了Santa Cruz Biotechnology公司的羊的多克隆抗alpha2B-AR (clone C-19)抗体和抗alpha2B肾上腺素受体的兔的多克隆抗体(clone H-96)进行蛋白质印迹分析和免疫组织化学分析。
AGTR2
angiotensin II receptor, type 2
总数:6
Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane. 2007 至该文献
Santa Cruz Biotechnology的山羊抗AT2多克隆抗体(1 : 300)被用于蛋白质印迹实验,来研究AII在依赖SGLT1的葡萄糖转移穿过刷状缘膜(BBM)过程中的作用。 更多
SA
acyl-CoA synthetase medium-chain family member 3
内皮素1 (endothelin 1)
总数:11
Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. 2008 至该文献
为了检测eNOS和ET-1的分布与在切断四肢的CRPS病人的皮肤组织中通过由内皮标记CD31免疫反应代表的血管浓度有关,采用R&D systems鼠的抗人ET-1抗体(3G10),进行免疫组织化学实验。 更多
ADRB2
adrenergic, beta-2-, receptor, surface
总数:7
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. 2009 至该文献
为研究NHERF1, NHERF2,和PDZK1各自在CFTR介导的肠阴离子分泌过程中起的作用,使用了Santa Cruz公司的兔源抗Adrb2抗体来进行蛋白印迹分析。 更多
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
NPPA
natriuretic peptide A
总数:2
1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte.. 2007 至该文献
SPAK
serine threonine kinase 39
总数:1
Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. 2003 至该文献
为研究神经系统中应激激活蛋白激酶(SPAK)与Na+-K+-2Cl协同转运蛋白的相互作用情况,采用Calbiochem 公司的SPAK多克隆抗体用于免疫印迹实验。
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
ADRB1
adrenergic, beta-1-, receptor
总数:2
Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. 2005 至该文献
Affinity Bioreagents的β1 肾上腺素受体抗体被用于蛋白质印迹实验,来研究在心脏中瘦蛋白活化的机制。 更多
SLC12A3
solute carrier family 12 (sodium/chloride transporters), member 3
总数:1
Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. 2003 至该文献
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
总数:2
Sodium depletion activates the aldosterone-sensitive neurons in the NTS independently of thirst. 2007 至该文献
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
总数:30
Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. 2009 至该文献
为了说明在RINm5F胰腺β细胞质膜中表达的RyR2可以调控Ca2+进入,使用了Santa Cruz Biotechnology公司的兔多克隆钙联蛋白抗体进行蛋白印迹实验。 更多
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
总数:2
Vascular ENaC proteins are required for renal myogenic constriction. 2005 至该文献
ZNF260
zinc finger protein 260
G protein coupled receptor kinase 4
G protein-coupled receptor kinase 4
总数:2
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements. 2005 至该文献
EDNRA
endothelin receptor type A
总数:8
Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation. 2008 至该文献
为了研究在人绒毛膜癌中内皮素受体介导的激活有丝分裂激活蛋白激酶(MAPK)途径的机理,采用了西格玛奥德里奇公司的内皮素受体拮抗剂BQ788应用到细胞培养中。 更多
ADRA1A
adrenergic, alpha-1A-, receptor
总数:2
D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin. 2007 至该文献
CYBA
cytochrome b-245, alpha polypeptide
总数:4
Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. 2008 至该文献
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
总数:2
Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1. 2009 至该文献
为了研究转录因子Ets-1在调控Natriuretic Peptide Receptor-A基因表达中的作用,采用了Santa Cruz公司的NPRA抗体产品,来进行免疫印迹实验。 更多
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
总数:1
Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. 2007 至该文献
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
总数:2
Characterization of the thymic IL-7 niche in vivo. 2009 至该文献
为了研究体内不同生理环境对胸腺IL-7水平的调控,使用了Becton Dickinson公司的抗Ly51抗体来进行流式细胞分析。 更多
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
ADRB3
adrenergic, beta-3-, receptor
总数:1
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. 2003 至该文献
Santa Cruz Biotechnology的β3-肾上腺素受体抗体被用于蛋白质印迹实验,来证明在一个给定的外围组织中瘦蛋白直接作用的生理意义。
CRP
C-reactive protein, pentraxin-related
总数:15
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用,将Sigma提供的抗CRP抗体应用于蛋白免疫印迹实验中。 更多
EPHX2
epoxide hydrolase 2, cytoplasmic
总数:1
Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. 2004 至该文献
nNOS
nitric oxide synthase 1 (neuronal)
总数:16
Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP. 2008 至该文献
为了研究细胞核因子kappa-B对烟胺比林一氧化氮合酶在星形胶质细胞中用MPTP低水平炎症刺激的选择性诱导的作用,采用Sigma-Aldrich公司的化学Co. NOS1抑制剂7-NI,进行细胞处理实验。 更多
EDNRB
endothelin receptor type B
总数:9
Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. 2008 至该文献
圣克鲁斯生物技术公司多克隆羊抗人类内皮素B受体(C-20,sc-21196)抗体用于免疫印迹来研究蛋白激酶C和丝裂原活化蛋白激酶信号途径在体外培养的人乳内动脉系统对B型内皮素受体调控的作用 更多
chromogranin A
chromogranin A (parathyroid secretory protein 1)
总数:24
The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. 2008 至该文献
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
总数:1
Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. 2004 至该文献
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
总数:4
Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells. 2005 至该文献
SGK1
serum/glucocorticoid regulated kinase 1
总数:5
Trafficking of ENaC subunits in response to acute insulin in mouse kidney. 2007 至该文献
Santa Cruz Biotechnology的p-SGK-1特异性抗体被用于蛋白质印迹实验来,来研究体内胰岛素处理的原生肾组织中的ENaC上游调节机制。 更多
CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
总数:8
Voltage-dependent calcium channels of dog basilar artery. 2007 至该文献
Alomone Laboratories的兔源Cav1.2多克隆抗体被用于蛋白质印迹实验,来研究依赖电压的钙离子通道的电生理学特性和分子特征。 更多
KLC1
kinesin light chain 1
总数:2
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. 2009 至该文献
为证实突变的SOD1可以通过隔离KAP3来降低轴突的胆碱乙酰转移酶运输量和乙酰胆碱的释放量,使用了Chemicon公司的抗KLC抗体来进行蛋白印迹分析。 更多
ADRA1B
adrenergic, alpha-1B-, receptor
总数:1
Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. 2001 至该文献
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:41
Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer. 2008 至该文献
为了研究对自诱导铜绿假单胞菌表达为炎症反应的细胞中的氧化物酶体增殖物激活受体的作用,在免疫印迹试验中使用了Cell Signaling的抗PPARγ抗体。 更多
CD13
alanyl (membrane) aminopeptidase
总数:16
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. 2009 至该文献
为了研究neprilysin在调控慢性低氧作用下肺动脉血管重塑过程中的作用,采用了Santa Cruz公司的抗aminopeptidase N抗体产品,进行了免疫组化实验。 更多
DIO2
deiodinase, iodothyronine, type II
CALCRL
calcitonin receptor-like
总数:1
Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. 2002 至该文献
PDE4D
phosphodiesterase 4D, cAMP-specific
总数:4
Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells. 2008 至该文献
NOX1
NADPH oxidase 1
总数:1
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart. 2007 至该文献
Transduction Laboratory的抗Nox-1抗体被用于蛋白质印迹实验,来检测Nox-1在人心肌组织中的表达。
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
RAMP1
receptor (G protein-coupled) activity modifying protein 1
总数:1
Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. 2005 至该文献
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
总数:4
Orphan glutamate receptor delta1 subunit required for high-frequency hearing. 2007 至该文献
为研究孤儿谷氨酸受体δ亚单位的功能,采用Santa Cruz公司生产的钾钠氯化合物协同联合转运子-1( Nkcc1)抗体用于免疫组化实验。 更多
tyrosine hydroxylase
总数:38
Identification of novel Notch target genes in T cell leukaemia. 2009 至该文献
运用Sigma公司的抗TH抗体,进行免疫组织化学实验以研究RPE细胞移植在治疗帕金森病中的治疗效果。 更多
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
总数:1
Regulation of human methylenetetrahydrofolate reductase by phosphorylation. 2005 至该文献
TRPV4
transient receptor potential cation channel, subfamily V, member 4
总数:3
Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. 2009 至该文献
为了研究TRPV1和TRPV4离子通道共表达所起的调控作用,使用了Alomone公司的抗TRPV4抗体来进行免疫组化分析。 更多
GJA5
gap junction protein, alpha 5, 40kDa
总数:3
Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. 2008 至该文献
TRPC3
transient receptor potential cation channel, subfamily C, member 3
总数:8
Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. 2006 至该文献
载脂蛋白B (apoB)
apolipoprotein B (including Ag(x) antigen)
总数:14
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. 2008 至该文献
脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing
总数:11
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献
为了研究DLK在调控3T3-L1脂肪细胞分化中的作用,使用了Calbiochem公司的兔多克隆抗adiponectin抗体,进行了免疫印迹和沉淀实验。 更多
ApoE基因 (ApoE)
apolipoprotein E
总数:18
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. 2004 至该文献
为了证明正常中枢神经系统的载脂蛋白E表达和星形胶质细胞分泌的载脂蛋白E脂化需要ABCA1,在酶联免疫吸附试验中使用了Calbiochem的生物素化的山羊抗apoE抗体。 更多
PTGFR
prostaglandin F receptor (FP)
总数:1
Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. 2005 至该文献
calpastatin
总数:2
Effect of dietary protein on calpastatin in canine skeletal muscle. 2003 至该文献
Affinity Bioreagents的单克隆抗钙蛋白酶抑制蛋白抗体(1:10,000)被用于蛋白质印迹实验,来研究钙蛋白酶抑制蛋白灾骨骼肌蛋白降解过程中的作用。 更多
Na K 2Cl cotransporter
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
总数:5
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. 2003 至该文献
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 5
总数:1
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. 2005 至该文献
CALCB
calcitonin-related polypeptide beta
总数:10
Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivity. 2009 至该文献
为研究成纤维生长因子受体信号通路在Schwann细胞中所发挥的作用,及其对正常Schwann细胞轴突相互作用持续调控的影响,将Bachem提供的降钙素基因相关蛋白用于免疫组织化学实验中。 更多
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
总数:2
Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency. 2004 至该文献
为了阐明不对称二甲基精氨酸的水平,采用了Sigma公司的鼠抗LOX-1的多克隆抗体进行蛋白质印迹分析 更多
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
总数:5
RhoE Is required for keratinocyte differentiation and stratification. 2009 至该文献
为研究RhoE在角质化细胞的分化和层化过程中所发挥的角色,将Santa Cruz提供的兔多克隆抗ROCKII抗体(H-85)用于蛋白免疫印迹实验中。 更多
LIPG
lipase, endothelial
总数:2
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. 2009 至该文献
为了阐明LIPG失活突变是否和高密度脂蛋白胆固醇水平的提升有关,使用了Novus Biologicals公司的抗人EL多克隆抗体来进行免疫印迹分析。 更多
EP1
prostaglandin E receptor 1 (subtype EP1), 42kDa
总数:4
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2010 至该文献
为了研究mPGES-1在调控肿瘤生长、侵润和转移中的作用,采用了Cayman Chemicals公司的抗EP1抗体产品,进行了免疫印迹实验。 更多