胰岛素抵抗
基因
试剂
文献样例
产品评述样例
脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing
总数:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献
为了研究DLK在调控3T3-L1脂肪细胞分化中的作用，使用了Calbiochem公司的兔多克隆抗adiponectin抗体，进行了免疫印迹和沉淀实验。 更多
RBP4
retinol binding protein 4, plasma
胰岛素受体 (insulin receptor)
总数:22
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. 2009 至该文献
为验证以下假说，即：胰岛素信号提供了对抗Aβ衍生的可扩散性突触毒性的生理防御机制，将Santa Cruz提供的兔多克隆抗胰岛素受体alpha亚单位抗体用于蛋白免疫印迹和免疫细胞化学实验中。 更多
resistin
总数:2
Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. 2004 至该文献
IRS-1
insulin receptor substrate 1
总数:36
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. 2011 至该文献
为了通过磷酸化蛋白组学研究Grb10是胰岛素信号通路的负调控因子，采用Invitrogen的抗磷酸化IRS (Y612)进行蛋白印迹实验。 更多
visfatin
nicotinamide phosphoribosyltransferase
总数:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 至该文献
为了研究DBC1在调控SIRT1的活性和高脂饮食诱发的小鼠脂肪肝中的作用，采用了Bethyl Laboratories公司的NAMPT抗体产品，进行了免疫印迹实验
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
肥胖荷尔蒙 (leptin)
总数:6
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗Ob抗体来进行免疫印迹分析。 更多
胰岛素 (insulin)
总数:22
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究在已经设计好的grelin o-酰基转移酶抑制剂的小鼠体内体重和葡萄糖的控制，采用了Linco抗insulin抗体进行了免疫印迹实验。 更多
TRB3
tribbles homolog 3 (Drosophila)
总数:2
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. 2008 至该文献
为了研究蛋白合成受抑制后mTORC1信号途径的反应，使用了EMD Chemicals公司的抗TRB3抗体来进行蛋白印迹分析。 更多
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:28
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析。 更多
FGF21
fibroblast growth factor 21
FABP2
fatty acid binding protein 2, intestinal
ADIPOR2
adiponectin receptor 2
葡萄糖转运蛋白4 (GLUT4)
solute carrier family 2 (facilitated glucose transporter), member 4
总数:11
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. 2009 至该文献
为了研究ClipR-59介导的Akt细胞内区室化对脂肪细胞葡萄糖运输的调节作用，使用了Millipore公司的抗Glut4抗体来进行免疫印迹分析。 更多
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
总数:1
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，在免疫印迹试验中使用了Sigma的抗PreMMP-2抗体作为第一抗体。
ADIPOR1
adiponectin receptor 1
MTNR1B
melatonin receptor 1B
总数:1
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. 2006 至该文献
硬脂酰CoA去饱和酶 (stearoyl CoA desaturase)
stearoyl-CoA desaturase (delta-9-desaturase)
总数:1
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. 2002 至该文献
GIP
gastric inhibitory polypeptide
TIARP
STEAP family member 4
SREBP-1
sterol regulatory element binding transcription factor 1
总数:11
Activation of Wnt/beta-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells. 2009 至该文献
为了研究在骨骼肌细胞中β-连环蛋白信号的活化能够提高对胰岛素的敏感性的机制，采用了NeoMarkers公司的单克隆SREBP-1抗体，进行了蛋白质印记实验。 更多
性激素结合球蛋白 (sex hormone binding globulin)
sex hormone-binding globulin
总数:1
The inhibitory effect of androgen and sex-hormone-binding globulin on the intracellular cAMP level and tyrosinase activity of normal human melanocytes. 2003 至该文献
骨钙素 (osteocalcin)
bone gamma-carboxyglutamate (gla) protein
总数:2
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation. 2009 至该文献
为了测定在幼年皮肌炎病理性钙化中SIBLING蛋白和骨组分的存在，使用了R&D Systems公司的抗OC抗体来进行免疫组化实验。 更多
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
总数:6
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. 2009 至该文献
为了研究Myc在介导肥厚型心肌病和心衰中的功能，使用了Santa Cruz Biotechnology公司的兔抗PGC-1α多克隆抗体来进行免疫组化实验。 更多
PC 1
ectonucleotide pyrophosphatase/phosphodiesterase 1
总数:2
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. 2004 至该文献
ADRB3
adrenergic, beta-3-, receptor
总数:1
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. 2003 至该文献
Santa Cruz Biotechnology的β3-肾上腺素受体抗体被用于蛋白质印迹实验，来证明在一个给定的外围组织中瘦蛋白直接作用的生理意义。
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多
PNPLA2
patatin-like phospholipase domain containing 2
总数:1
Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific. 2008 至该文献
AHSG
alpha-2-HS-glycoprotein
总数:1
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 至该文献
为了研究非定向基于活性的蛋白解谱对识别活细胞中专一表达酶所起的作用，使用了R&D systems公司的抗fetuin A抗体来进行蛋白印迹分析。
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
FABP4
fatty acid binding protein 4, adipocyte
总数:2
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗A-FABP抗体来进行免疫印迹分析。 更多
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
apelin
ghrelin
ghrelin/obestatin prepropeptide
总数:6
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究格瑞林酰基转移酶抑制剂在小鼠中的作用，采用了Abcam抗ghrelin抗体进行了免疫印迹实验。 更多
leptin receptor
总数:9
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 2007 至该文献
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
总数:4
Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells. 2007 至该文献
为了阐明在人气道上皮细胞中Src介导的磷脂酰3激酶及其下游效应物Akt的激活是鼻病毒信号转导的关键，采用了Epitomics公司的兔抗p110β磷脂酰3激酶抗体，进行了蛋白质印迹实验。 更多
APOC3
apolipoprotein C-III
总数:3
Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. 2003 至该文献
胰高血糖素 (glucagon)
总数:12
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. 2009 至该文献
为了研究线粒体黄素蛋白细胞凋亡诱导因子的效应，使用了西格玛公司的抗胰高血糖素抗体来进行免疫组化分析。 更多
CD36
CD36 molecule (thrombospondin receptor)
总数:16
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 至该文献
为了说明在TRl信号通路的介导下间质干细胞能被极化成两种截然不同的表型，采用了eBiosciences公司的抗CD36抗体进行流式细胞术和免疫细胞化学实验。 更多
calpain 10
PCSK1
proprotein convertase subtilisin/kexin type 1
总数:1
RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor. 2006 至该文献
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
PTP1B
protein tyrosine phosphatase, non-receptor type 1
总数:9
Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance. 2008 至该文献
microsomal triglyceride transfer protein
FTO
fat mass and obesity associated
IRS-2
insulin receptor substrate 2
总数:12
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. 2011 至该文献
为了通过磷酸化蛋白组学研究Grb10是胰岛素信号通路的负调控因子，采用Cell Signaling的抗IRS2进行蛋白印迹和免疫沉淀实验。 更多
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
总数:1
Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. 2006 至该文献
酪酪肽 (peptide YY)
总数:1
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. 2006 至该文献
PNPLA3
patatin-like phospholipase domain containing 3