白血病
基因
试剂
文献样例
产品评述样例
MLL
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
总数:2
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 至该文献
为了阐明c-Myb在MLL相关白血病中的作用，实验使用了Upstate Biotechnology公司的抗MLL抗体进行免疫共沉淀。 更多
AFF1
AF4/FMR2 family, member 1
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
总数:1
The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. 2002 至该文献
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
总数:2
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 至该文献
为了研究在人HEK293T细胞中DOT1L的重组和H3K79的单、双或者三甲基化的动态状态， 采用了Bethyl公司的抗DOT1L 抗体(A300-954A or 953A)进行ChIP分析 更多
ENL
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MECOM
MDS1 and EVI1 complex locus
UGCG
UDP-glucose ceramide glucosyltransferase
PU 1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
总数:10
Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. 2006 至该文献
GFI1
growth factor independent 1 transcription repressor
总数:3
Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. 2009 至该文献
使用Santa Cruz公司的Gfi-1 (N-20) 抗体进行免疫共沉淀以研究Gfi-1与Miz-1相互作用从而抑制CDKN2B，转录 p15INK4B的机制。 更多
AML1
runt-related transcription factor 1
总数:3
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. 2008 至该文献
Sigma公司生产的抗RUNX1多克隆抗体（兔）可用于免疫细胞化学实验，来研究E4orf6、E1B-55K及 RUNX1间的相互作用，以及RUNX1与病毒DNA?RNA核心的联系。 更多
cdk9
cyclin-dependent kinase 9
总数:11
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression.. 2011 至该文献
为了研究即刻早期反应基因表达调控因MED23突变而被破坏并导致智力障碍，采用Santa Cruz的多抗CDK9抗体进行ChIP和蛋白印迹实验。 更多
FLT3
fms-related tyrosine kinase 3
总数:6
Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. 2006 至该文献
为了研究三氧化二砷降低急性髓性白血病(AML)细胞增殖的机制，采用了Santa Cruz Biotechnology的抗FLT3(S18)抗体进行免疫印迹试验。 更多
CCNT1
cyclin T1
总数:5
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 至该文献
为了研究与目标基因启动子结合的NF-kappa B分子活性受ING4调控的情况，使用了Santa Cruz公司的的抗cyclin T1抗体来进行蛋白印迹分析。 更多
ETO
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
总数:3
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation.. 2011 至该文献
为了研究p300调控的AML1-ETO融合蛋白乙酰化对白血病发生至关重要，采用Santa Cruz的抗ETO抗体进行蛋白印迹,免疫沉淀和ChIP实验。 更多
Bcl 2
B-cell CLL/lymphoma 2
总数:128
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. 2008 至该文献
为了研究SGC7901/VCR细胞中miR-15b和miR-16对BCL2蛋白表达的影响，采用了Santa Cruz Biotechnology公司的BCL2抗体进行免疫印迹实验。 更多
GATA-2
GATA binding protein 2
总数:4
Cross talk between retinoic acid signaling and transcription factor GATA-2. 2004 至该文献
GATA-1
GATA binding protein 1 (globin transcription factor 1)
总数:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 至该文献
ZO 1
tight junction protein 1 (zona occludens 1)
总数:53
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 至该文献
为了研究MMP-10和CTSF在糖尿病患者角膜伤口治愈不良中的作用，采用了Invitrogen的抗ZO-1抗体进行免疫组化试验。 更多
MYB
v-myb myeloblastosis viral oncogene homolog (avian)
总数:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 至该文献
为了阐明c-Myb在MLL相关白血病中的作用，实验使用了Upstate Biotechnology公司的抗c-Myb抗体进行免疫共沉淀。 更多
人类白细胞抗原b (HLA B)
major histocompatibility complex, class I, B
总数:1
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 至该文献
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
总数:11
Cytoplasmic p53 and Activated Bax Regulate p53-dependent, Transcription-independent Neural Precursor Cell Apoptosis. 2010 至该文献
为了研究活化的Bax在调控依赖p53而非其转录活性依赖的神经祖细胞凋亡中的作用，采用了Zymed公司的抗NPM抗体产品，进行了免疫印迹实验。 更多
肿瘤坏死因子受体超家族成员6 (Fas)
Fas (TNF receptor superfamily, member 6)
总数:52
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点，使用了Santa Cruz Biotechnology公司的FAS抗体(1:500)来进行免疫印记实验。 更多
KIR2DS1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
HSPA4
heat shock 70kDa protein 4
总数:35
PUMA- and Bax-induced autophagy contributes to apoptosis. 2009 至该文献
为了研究PUMA或Bax诱导的线粒体自噬对细胞凋亡的促进作用，使用了Transduction Labs公司的抗HSP 70抗体进行免疫印迹实验。 更多
KIR2DS5
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR2DS4
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
HLA-C
major histocompatibility complex, class I, C
总数:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 至该文献
为了研究主要组织相容性复合体作为一种附属因子在促进 HCoV-HKU1 感染过程中的作用，采用英杰的纯化的羊免疫球蛋白作为同型标准品。 更多
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
总数:2
Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. 2003 至该文献
c-Myc
v-myc myelocytomatosis viral oncogene homolog (avian)
总数:143
Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis.. 2011 至该文献
为了研究去氢表雄酮和神经生长因子受体之间的相互作用，采用了Santa Cruz公司的抗c-myc (9E10, sc-40)抗体进行了免疫印记和免疫共沉淀实验。 更多
HLA-A
major histocompatibility complex, class I, A
总数:8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 至该文献
为了研究研究肿瘤和肿瘤基质细胞间的相互作用，采用了Santa Cruz Biotechnology HLA-A（A-18)抗体进行了免疫组化实验。 更多
CD34
CD34 molecule
总数:76
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用，采用了Hycult Biotech的抗CD34抗体进行免疫组化实验。 更多
p38
mitogen-activated protein kinase 14
总数:185
IL-33 mediates inflammatory responses in human lung tissue cells. 至该文献
为了研究IL-33在人肺组织细胞的免疫反应中的作用，采用了Cell Signaling Technology公司的抗磷酸化的p38 MAPK抗体进行免疫印迹实验。 更多
Akt
v-akt murine thymoma viral oncogene homolog 1
总数:418
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H?-ATPase.. 2011 至该文献
为了研究泡状H+-ATPase参与到mTOR通路中mTORC1的转位和激活，采用Cell Signaling的抗Akt和抗S473磷酸化Akt抗体进行蛋白印迹实验。 更多
Janus激酶2 (Jak2)
Janus kinase 2
总数:34
Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor.. 2010 至该文献
为了确定在受体信号激活过程中促红细胞生成素受体的受体因素，使用了Upstate公司的抗JAK2抗体来进行免疫沉淀实验和免疫印记分析。 更多
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
总数:80
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制，使用了Santa Cruz Biotechnology公司的anti-p50抗体来进行染色质免疫共沉淀实验。 更多
caspase-8
caspase 8, apoptosis-related cysteine peptidase
总数:73
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. 2009 至该文献
为了研究SARS冠状病毒激活PKR和PERK并且克服eIF2α对病毒mRNA翻译的抑制作用的机制，使用了Cell Signaling公司的小鼠抗casp8单克隆抗体来进行免疫印迹分析。 更多
毛细血管扩张性共济失调症突变蛋白 (ATM)
ataxia telangiectasia mutated
总数:49
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations.. 2011 至该文献
为了研究染色体结构异常可由染色体分离错误引起，采用了Cell Signaling的抗1981位丝氨酸磷酸化ATM抗体进行免疫细胞化学实验。 更多
caspase-3
caspase 3, apoptosis-related cysteine peptidase
总数:209
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis.. 2011 至该文献
为了研究myc依赖的癌症需要SUMO化修饰来促进肿瘤发生，采用Cell Signaling的抗Cleaved caspase-3抗体进行蛋白印迹实验。 更多
Wilms瘤抑癌基因 (WT1)
Wilms tumor 1
总数:17
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi. 2010 至该文献
为了研究HtrA2对凋亡和WT1的原癌活性的调节作用，使用了NeoMarkers公司的抗WT1抗体来进行免疫印迹分析。 更多
磷酸酶张力蛋白同源基因 (PTEN)
phosphatase and tensin homolog
总数:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 至该文献
为了说明Skp2参与非p19Arf-p53途径的细胞衰老，使用了Neomarkers公司的PTEN抗体来进行免疫组化实验。 更多
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
总数:6
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析，采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。 更多
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
总数:114
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 至该文献
为了研究多发性骨髓瘤中细胞周期蛋白K和细胞周期蛋白D1b的作用，采用了Cell Signaling的抗Stat3和抗磷酸化Stat3 (Ser727)抗体进行免疫印迹实验。 更多
ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP-binding cassette, sub-family B (MDR/TAP), member 1
总数:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点，使用了Santa Cruz Biotechnology公司的MDR1抗体(1:500)来进行免疫印记实验。 更多
端粒末端转移酶逆转录酶 (TERT)
telomerase reverse transcriptase
总数:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 至该文献
为了研究磷酸化的Akt对后囊的作用采用了Calbiochem公司的抗TERT抗体（1:350稀释）来进行免疫组化实验。 更多
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
总数:15
Vitamin d induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达，采用了Affinity BioReagents公司的抗VDR（MA1-710，1：400）单克隆抗体进行免疫细胞化学实验。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
p16
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
总数:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 至该文献
为了研究Raf-1对神经胶质瘤形成的作用，采用了Santa Cruz Biotechnology的抗p19抗体进行免疫组化实验。 更多
p53
tumor protein p53
总数:239
The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma. 至该文献
为了研究可能的抑癌基因ECRG4对食管癌细胞迁移和浸润的影响，采用了Santa Cruz公司的抗p53的抗体进行免疫印迹实验。 更多