黑色素瘤
基因
试剂
文献样例
产品评述样例
B-Raf
B-Raf proto-oncogene, serine/threonine kinase
总数:8
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 至该文献
为了研究Raf-1对神经胶质瘤形成的作用,采用了Santa Cruz Biotechnology的抗Braf抗体进行免疫印迹实验。 更多
MC1R
melanocortin 1 receptor
总数:1
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. 2005 至该文献
NRAS
NRAS proto-oncogene, GTPase
总数:4
Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3. 2007 至该文献
Santa Cruz Biotechnology的兔抗Ras多克隆抗体被用于蛋白质印迹实验,来研究单纯疱疹病毒(mtHSV)能用于治疗肿瘤而非其他器官的机制。 更多
MLANA
melan-A
总数:6
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 至该文献
为了进一步研究Wnt5A和ROR2的关系,采用Lab Vision公司的MART1抗体,进行了蛋白印记实验。 更多
tyrosinase
总数:10
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 至该文献
为了研究固定液在磷酸化蛋白免疫组化测定中的作用使用了R&D公司的鼠抗pTyr抗体来进行免疫组化实验。 更多
GNAQ
G protein subunit alpha q
总数:11
Caveolin-1 alters Ca(2+) signal duration through specific interaction with the G alpha q family of G proteins. 2008 至该文献
使用Santa Cruz 生物公司的抗Gαq抗体进行免疫组化实验来研究caveolin-1 和G蛋白家族Gαq 在钙信号持续过程中的相互作用效果。 更多
p16
cyclin dependent kinase inhibitor 2A
总数:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 至该文献
为了研究Raf-1对神经胶质瘤形成的作用,采用了Santa Cruz Biotechnology的抗p19抗体进行免疫组化实验。 更多
PMEL
premelanosome protein
总数:3
A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. 2008 至该文献
为了研究开关I区在募集Rab效应蛋白中的作用,采用了Lab Vision公司的小鼠单克隆HMB45抗体(1:100),进行了免疫细胞化学实验。 更多
ABCB5
ATP binding cassette subfamily B member 5
总数:1
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点,使用了ProSci公司的ABCB5抗体(1:2000)来进行免疫印记实验。
C-kit (C-kit)
KIT proto-oncogene, receptor tyrosine kinase
总数:42
Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. 2012 至该文献
为了分析成人功能性血管的细胞起源,采用了NeoMarkers的小鼠抗人CD17单克隆抗体,进行免疫组织化学实验。 更多
SOX10
SRY-box transcription factor 10
总数:1
Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. 2008 至该文献
使用Santa Cruz生物公司的羊Sox10(1:50) 抗体进行免疫组织化学实验以证明神经嵴分化的去甲肾上腺素能的交感神经节中,Hand2是多功能DNA结合蛋白,影响分化和细胞特异性基因表达。
TYRP1
tyrosinase related protein 1
总数:2
Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL. 2005 至该文献
MIA
MIA SH3 domain containing
总数:3
Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells. 2005 至该文献
SNRPE
small nuclear ribonucleoprotein polypeptide E
总数:3
Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. 2008 至该文献
为了检测蛋白酶体抑制剂和组蛋白酰基转移酶抑制剂在GBM细胞株中产生的效应,采用了Santa Cruz Biotechnology的鼠抗B-Raf单抗,进行蛋白质印迹实验 更多
PAX3
paired box 3
总数:1
Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy. 2008 至该文献
NY ESO 1 (NY ESO 1)
cancer/testis antigen 1B
总数:2
Selective cancer-germline gene expression in pediatric brain tumors. 2008 至该文献
OCA2
OCA2 melanosomal transmembrane protein
S100B
S100 calcium binding protein B
总数:23
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. 2010 至该文献
为了研究Nkx2.2和Nkx6.2在调节髓鞘形成中的作用,采用了BD公司的抗鼠S100B抗体产品(1:1000),进行了免疫荧光实验。 更多
NG2
chondroitin sulfate proteoglycan 4
总数:12
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. 2010 至该文献
为了研究Nkx2.2和Nkx6.2在调节髓鞘形成中的作用,采用了Chemicon公司的抗NG2抗体产品(1:1500),进行了免疫荧光实验。 更多
Cdk4
cyclin dependent kinase 4
总数:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 至该文献
为了研究脆性X智力低下蛋白在的功能对成人神经干细胞/神经祖细胞的增殖和分化所起的调控作用,使用了Millipore公司的抗CDK4抗体来进行蛋白印迹分析。 更多
WNT5A
Wnt family member 5A
总数:4
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 至该文献
为了研究Wnt5A对ROR2的影响,采用BD公司的Wnt5A抗体,进行了蛋白印记实验。 更多
KDM5B
lysine demethylase 5B
总数:2
The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. 2010 至该文献
为了探索髓部结合因子在调控骨骼肌终末分化过程中发挥的作用,采用Abcam抗trimethyl H3K4抗体进行免疫共沉淀试验。 更多
ATF2
activating transcription factor 2
总数:20
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 至该文献
为了说明流感病毒感染期间IL-32表达水平的提高抑制病毒的复制,使用了Santa Cruz Biotechnology公司的anti-CREB2抗体来进行染色质免疫共沉淀实验。 更多
GRM1
glutamate metabotropic receptor 1
总数:7
Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. 2007 至该文献
YES1
YES proto-oncogene 1, Src family tyrosine kinase
总数:6
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 至该文献
为了揭示在CXCL12诱发的T淋巴细胞迁移过程中CRMP2功能的分子机制,采用了Upstate公司的兔抗Yes1(06.514)多克隆抗体进行免疫印迹和免疫细胞化学实验。 更多
Bim
BCL2 like 11
总数:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 至该文献
为了研究脱酰胺过程对Bcl-xL降解的调控作用,Calbiochem的抗Bim抗体被用于进行免疫沉淀实验。 更多
TRPM1
transient receptor potential cation channel subfamily M member 1
nestin
总数:24
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. 2012 至该文献
为了研究NKCC1对神经胶质瘤细胞的迁移作用的调控,采用了密理博公司的抗Nestin抗体进行了免疫组织化学实验。 更多
p75NTR
nerve growth factor receptor
总数:17
Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. 2008 至该文献
为了说明Barrett上皮细胞系在暴露于酸和胆汁盐后可以发生细胞表型的改变,使用了Novus Biologicals公司的抗p75NTR抗体来进行免疫细胞化学实验。 更多
WEE1
WEE1 G2 checkpoint kinase
总数:2
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. 2009 至该文献
为了研究FANCM在有丝分裂过程中的降解机制,使用了Santa Cruz Biotechnology公司的兔抗WEE1抗体来进行免疫印迹分析。 更多
RND3
Rho family GTPase 3
总数:3
RhoE Is required for keratinocyte differentiation and stratification. 2009 至该文献
为研究RhoE在角质化细胞的分化和层化过程中所发挥的角色,将密理博公司提供的小鼠单克隆抗RhoE抗体(4)用于蛋白免疫印迹实验中。 更多
FOXD3
forkhead box D3
总数:1
Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development. 2009 至该文献
使用M. Goulding兔抗FOXD3抗体培育胚胎切片来证明脊髓中存在依赖Atoh1的细胞类型。
NODAL
nodal growth differentiation factor
总数:1
A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. 2008 至该文献
Santa Cruz公司生产的Nodal抗体可用于免疫组化实验,来检测人子宫内膜组织中的TGF家族成员以及推测它们是否参与蜕膜化过程。
TTK
TTK protein kinase
总数:1
TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. 2005 至该文献
FLNA
filamin A
总数:9
Identification of a filamin docking site on PTP-PEST. 2006 至该文献
Chemicon International的抗细丝蛋白A的单克隆抗体被用于免疫细胞化学实验,来检测在HeLa细胞中PTP-PEST的表达。 更多
BRG1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
总数:13
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. 2011 至该文献
为了研究SWI/SNF在潜伏期HIV LTR转录激活前后的调节作用,采用了Abcam SMARCB4进行了蛋白质免疫印迹实验。 更多
IGF2BP1
insulin like growth factor 2 mRNA binding protein 1
MAGEA3
MAGE family member A3
总数:1
Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray. 2005 至该文献
血小板活化因子受体 (platelet activating factor receptor)
总数:1
Relative levels of semen platelet activating factor-receptor (PAFr) and ubiquitin in yearling bulls with high content of semen white blood cells: implications for breeding soundness evaluation. 2007 至该文献
为研究血小板活化因子(PAF)受体在生育中的作用,采用Cayman 公司生产的 PAF受体抗体用于免疫印迹和免疫细胞化学实验。
Raf-1
Raf-1 proto-oncogene, serine/threonine kinase
总数:46
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. 2010 至该文献
为了研究microRNA-7在舌鳞状细胞癌细胞中的作用, 采用了Santa Cruz Biotechnology的抗RAF1抗体进行了免疫印迹实验。 更多
β1整合素 (beta1 integrin)
integrin subunit beta 1
总数:85
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 至该文献
为了研究乳癌细胞中由uPAR介导的细胞信号转导激发的特性,采用了Biolegend的抗CD29-FITC抗体进行流式细胞实验。 更多
MDA-7 (MDA-7)
interleukin 24
总数:4
Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells. 2006 至该文献
为了说明Ad-mda7和赫赛汀结合使用可能是治疗乳腺癌的新方法,采用了S Chada(Introgen Therapeutics)公司的MDA-7抗体,进行蛋白质印迹杂家和免疫组织化学分析。 更多
IRF4
interferon regulatory factor 4
总数:6
Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma. 2009 至该文献
为从222例症状明显的伯基特淋巴瘤患者中分析其MUM1, bcl-6 和CD138的表达模式与EBV的相关性,将Dako提供的抗MUM-1/IRF4抗体(克隆:MUM1P)用于免疫组织化学实验中。 更多
Mcl-1
MCL1 apoptosis regulator, BCL2 family member
总数:34
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 至该文献
为了研究脱酰胺过程对Bcl-xL降解的调控作用,Santa Cruz Biotechnology的抗Mcl-1抗体被用于进行蛋白质免疫印迹实验。 更多
ADAM15
ADAM metallopeptidase domain 15
总数:4
Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. 2009 至该文献
MCAM
melanoma cell adhesion molecule
总数:4
Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. 2006 至该文献
基质金属蛋白酶-2 (MMP-2)
matrix metallopeptidase 2
总数:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 至该文献
为了研究MMP2表达在人胰腺细胞系BxPC-3的浸润及黏附中的作用,采用了Santa Cruz公司的MMP-2单克隆抗体用于免疫印迹实验。 更多
ING4
inhibitor of growth family member 4
总数:3
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 至该文献
为了研究与目标基因启动子结合的NF-kappa B分子活性受ING4调控的情况,使用了Abcam公司的的抗ING4抗体来进行蛋白印迹分析。 更多
EDNRB
endothelin receptor type B
总数:10
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 至该文献
为了研究缺血性心脏病病人体内ETB和AT1受体表达量上调,采用IBL的兔抗ETB抗体以1:400稀释进行免疫组织化学实验。 更多
PAR-1 (PAR-1)
coagulation factor II thrombin receptor
总数:7
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. 2007 至该文献
MEK1
mitogen-activated protein kinase kinase 1
总数:57
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 至该文献
为了研究在气喘患者中由TGFbeta和IL-10抑制造成的对T细胞的抗性的信号传导机制,采用了Cell Signaling Technology的抗MEK1抗体进行了流式细胞实验和免疫组化检测。 更多
p53
tumor protein p53
总数:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 至该文献
为了研究JMJD6通过负调控p53促进结直肠的癌变,采用了Abcam抗p53 的抗体进行了蛋白印迹实验。 更多
RAPGEF3
Rap guanine nucleotide exchange factor 3
总数:3
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. 2007 至该文献
MIR205
microRNA 205
SPARC
secreted protein acidic and cysteine rich
总数:11
Aberrant promoter methylation of SPARC in ovarian cancer. 2009 至该文献
为了研究SPARC在治疗卵巢癌中的作用,使用了Santa Cruz Biotechnology公司的抗人SPARC抗体来进行蛋白印迹实验和免疫组化实验。 更多
Skp2
S-phase kinase associated protein 2
总数:17
Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy. 2009 至该文献
为了在K562细胞中研究CSN对细胞自噬有重要作用,采用Zymed的抗Skp2抗体以1:1000稀释进行蛋白印迹实验。 更多
PDCD1
programmed cell death 1
总数:1
FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy. 2008 至该文献
CD133
prominin 1
总数:19
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. 2009 至该文献
为了说明在CD133(+) U87恶性胶质瘤细胞中MT1-MMP对于COX-2表达的调控作用,使用了Abcam公司的多克隆抗CD133抗体来进行蛋白印迹实验。 更多
Noxa
phorbol-12-myristate-13-acetate-induced protein 1
总数:4
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. 2007 至该文献
S100
S100 calcium binding protein A1
总数:20
Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. 2009 至该文献
为了说明放射性胶质中Tsc2基因功能的损失可以引起大脑结节状硬化综合症,使用了DakoCytomation公司的S100抗体进行免疫组化实验。 更多
GLI2
GLI family zinc finger 2
总数:1
Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. 2009 至该文献
为了研究Atoh1在小脑发育过程中音速小子蛋白信号途径中所起的作用,使用了Abcam公司的抗Gli2抗体来进行免疫组化分析。
VDR
vitamin D receptor
总数:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达,采用了Affinity BioReagents公司的抗VDR(MA1-710,1:400)单克隆抗体进行免疫细胞化学实验。 更多
整合素αⅤ (integrin alpha v)
integrin subunit alpha V
总数:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 至该文献
为了确定整合素αvβ3是否影响TGFBI介导的NSCLC细胞对化学疗法的敏感性,采用Chemicon Interational的抗整合素αvβ3单抗进行流式细胞术实验。 更多
MEK2
mitogen-activated protein kinase kinase 2
总数:16
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. 2010 至该文献
为研究如何通过两阶段MAPK反应区分上皮细胞盾壳菌的酵母和菌丝形态,采用了Cell Signaling Technologies公司的抗磷酸化MEK1/2抗体进行蛋白质印迹试验。 更多
小窝蛋白1 (caveolin-1)
caveolin 1
总数:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 至该文献
为了说明19号染色体的易位可能会引起Xp11.2易位相关的肾细胞癌,使用了Epitomics公司的抗calveolin-1抗体进行免疫组化实验。 更多
ERK1
mitogen-activated protein kinase 3
总数:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 至该文献
为研究BAD蛋白磷酸化在β-Arrestin-2介导的抗凋亡反应中的调控作用,采用了密理博公司的抗ERK1/2多克隆抗体进行免疫印迹和免疫沉淀试验。 更多