代谢综合征X
基因
试剂
文献样例
产品评述样例
脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing
总数:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献
为了研究DLK在调控3T3-L1脂肪细胞分化中的作用，使用了Calbiochem公司的兔多克隆抗adiponectin抗体，进行了免疫印迹和沉淀实验。 更多
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
FABP4
fatty acid binding protein 4, adipocyte
总数:2
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗A-FABP抗体来进行免疫印迹分析。 更多
APOA5
apolipoprotein A-V
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多
RBP4
retinol binding protein 4, plasma
肥胖荷尔蒙 (leptin)
总数:6
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗Ob抗体来进行免疫印迹分析。 更多
载脂蛋白B (apoB)
apolipoprotein B (including Ag(x) antigen)
总数:14
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 至该文献
为了研究高效肝炎C病毒颗粒的形成条件，采用了Abcam公司的抗ApoB100抗体进行蛋白免疫印迹实验。 更多
apoA-I
apolipoprotein A-I
总数:13
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. 2008 至该文献
为了在一个转基因小鼠模型中研究载脂蛋白成员的不同作用，采用 Abcam公司的兔多克隆抗apoA-I抗体产品(1:10,000)，进行了免疫印迹实验。 更多
glutamyl transpeptidase
gamma-glutamyltransferase 1
TIARP
STEAP family member 4
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
总数:1
Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. 2007 至该文献
ADRB3
adrenergic, beta-3-, receptor
总数:1
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. 2003 至该文献
Santa Cruz Biotechnology的β3-肾上腺素受体抗体被用于蛋白质印迹实验，来证明在一个给定的外围组织中瘦蛋白直接作用的生理意义。
CETP
cholesteryl ester transfer protein, plasma
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
总数:1
Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. 2006 至该文献
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:28
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析。 更多
骨钙素 (osteocalcin)
bone gamma-carboxyglutamate (gla) protein
总数:2
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation. 2009 至该文献
为了测定在幼年皮肌炎病理性钙化中SIBLING蛋白和骨组分的存在，使用了R&D Systems公司的抗OC抗体来进行免疫组化实验。 更多
leptin receptor
总数:9
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 2007 至该文献
APOC3
apolipoprotein C-III
总数:3
Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. 2003 至该文献
ghrelin
ghrelin/obestatin prepropeptide
总数:6
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究格瑞林酰基转移酶抑制剂在小鼠中的作用，采用了Abcam抗ghrelin抗体进行了免疫印迹实验。 更多
microsomal triglyceride transfer protein
CLOCK
clock homolog (mouse)
总数:1
Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis. 2003 至该文献
性激素结合球蛋白 (sex hormone binding globulin)
sex hormone-binding globulin
总数:1
The inhibitory effect of androgen and sex-hormone-binding globulin on the intracellular cAMP level and tyrosinase activity of normal human melanocytes. 2003 至该文献
PC 1
ectonucleotide pyrophosphatase/phosphodiesterase 1
总数:2
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. 2004 至该文献
resistin
总数:2
Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. 2004 至该文献
LPIN1
lipin 1
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
glucokinase regulatory protein
glucokinase (hexokinase 4) regulator
visfatin
nicotinamide phosphoribosyltransferase
总数:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 至该文献
为了研究DBC1在调控SIRT1的活性和高脂饮食诱发的小鼠脂肪肝中的作用，采用了Bethyl Laboratories公司的NAMPT抗体产品，进行了免疫印迹实验
血管紧张素转化酶 (ACE)
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
总数:8
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 至该文献
为了研究通过定量蛋白质组学发现新的BACE1底物，采用Santa Cruz的ACE抗体以1:1,000稀释进行蛋白印迹实验。 更多
CD36
CD36 molecule (thrombospondin receptor)
总数:16
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 至该文献
为了说明在TRl信号通路的介导下间质干细胞能被极化成两种截然不同的表型，采用了eBiosciences公司的抗CD36抗体进行流式细胞术和免疫细胞化学实验。 更多
T cadherin
cadherin 13, H-cadherin (heart)
总数:5
Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A. 2008 至该文献
为了鉴定与丙肝病毒NS3/NS4A关联的目标分子，采用了Calbiochem的抗pan-钙黏蛋白抗体，进行蛋白质印迹实验 更多
FABP2
fatty acid binding protein 2, intestinal
PAI-1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
总数:15
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 至该文献
为了研究人纤溶酶原和钩端螺旋体内皮抑制素样蛋白A之间的相互作用，采用Novus Biologicals公司的山羊抗人纤溶酶原抗体进行酶联免疫吸附实验。 更多
脂蛋白脂肪酶 (lipoprotein lipase)
总数:2
Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. 2002 至该文献
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
总数:6
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. 2009 至该文献
为了研究Myc在介导肥厚型心肌病和心衰中的功能，使用了Santa Cruz Biotechnology公司的兔抗PGC-1α多克隆抗体来进行免疫组化实验。 更多
IGFBP1
insulin-like growth factor binding protein 1
总数:4
Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. 2003 至该文献
CNR1
cannabinoid receptor 1 (brain)
总数:3
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. 2008 至该文献
为了确认内源性大麻素信号途径的关键元件是否在骨关节炎和类风湿性关节炎患者的关节骨液中表达，采用了Calbiochem公司的抗大麻素受体1抗体进行了蛋白印迹实验。 更多
二肽基肽酶4 (DPP4)
dipeptidyl-peptidase 4
总数:6
Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation. 2009 至该文献
为了研究二肽肽酶IV对神经母细胞瘤的生长抑制机制，使用了Biomol公司的抗DPPIV抗体来进行免疫组化分析。 更多
LIPC
lipase, hepatic
IRS-1
insulin receptor substrate 1
总数:36
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. 2011 至该文献
为了通过磷酸化蛋白组学研究Grb10是胰岛素信号通路的负调控因子，采用Invitrogen的抗磷酸化IRS (Y612)进行蛋白印迹实验。 更多
cystatin C
总数:2
Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. 2004 至该文献
PEDF
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
总数:7
Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. 2010 至该文献
为了研究PEDF慢病毒属介导的基因在调控黑素瘤生长和肝微小转移中的作用，使用了Santa CruZ公司的抗PEDF抗体，进行了免疫印迹实验。 更多
eNOS
nitric oxide synthase 3 (endothelial cell)
总数:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 至该文献
为了研究purinergic在调控内皮细胞一氧化氮合成酶活性中的作用，采用了Upstate Laboratories公司的抗eNOS抗体产品，进行了免疫印迹实验。 更多
胰岛素 (insulin)
总数:22
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究在已经设计好的grelin o-酰基转移酶抑制剂的小鼠体内体重和葡萄糖的控制，采用了Linco抗insulin抗体进行了免疫印迹实验。 更多
HBA1
hemoglobin, alpha 1
总数:2
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. 2008 至该文献
为了鉴定在脑中的新寄主分子在CM.的显示病理学过程受影响，采用Novus Biologicals公司的抗血红蛋白α1抗体，进行蛋白质印迹实验。 更多
ApoE基因 (ApoE)
apolipoprotein E
总数:17
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 至该文献
为了研究高效肝炎C病毒颗粒的形成条件，采用了Calbiochem公司的抗ApoE抗体进行蛋白免疫印迹实验。 更多
AHSG
alpha-2-HS-glycoprotein
总数:1
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 至该文献
为了研究非定向基于活性的蛋白解谱对识别活细胞中专一表达酶所起的作用，使用了R&D systems公司的抗fetuin A抗体来进行蛋白印迹分析。
PON1
paraoxonase 1
总数:2
Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1). 2002 至该文献
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
总数:1
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，在免疫印迹试验中使用了Sigma的抗PreMMP-2抗体作为第一抗体。
CD40配体 (CD40 ligand)
总数:12
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响，采用了Santa Cruz公司的抗CD40L抗体(1:200)进行了免疫组织化学实验。 更多
白细胞介素18 (IL-18)
interleukin 18 (interferon-gamma-inducing factor)
总数:6
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.. 2005 至该文献
AGTR1
angiotensin II receptor, type 1
总数:9
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 至该文献
为了研究缺血性心脏病病人体内ETB和AT1受体表达量上调，采用Santa Cruz的兔抗AT1抗体进行免疫组织化学实验。 更多
ADRB2
adrenergic, beta-2-, receptor, surface
总数:7
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 至该文献
为了研究β2-肾上腺素受体激动剂fenoterol的立体化学在决定受体G蛋白选择性和下游信号通路中的功能，使用了Santa Cruz Biotechnology公司的抗ADRB2 C末端抗体来进行免疫印迹分析。 更多
FTO
fat mass and obesity associated
C3
complement component 3
总数:12
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield.. 2011 至该文献
为了研究HIV的糖基化外膜能够被PGT抗体识别从而中和HIV病毒，采用AbD serotec的山羊抗人C3抗体进行ELISA实验。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
osteoprotegerin
tumor necrosis factor receptor superfamily, member 11b
总数:2
Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin. 2007 至该文献
在夹心酶联免疫分析实验中使用了R&D Systems公司的小鼠抗人OPG和生物素标记的山羊抗人OPG用于检测人血管平滑肌细胞条件培养基中OPG的浓度。 更多
ICAM-1
intercellular adhesion molecule 1
总数:28
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy.. 2011 至该文献
为了研究在天然杀伤细胞免疫突触处皮质肌动蛋白的重塑，采用了R&D systems的抗ICAM-1抗体进行免疫细胞化学实验。 更多
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
总数:1
Regulation of human methylenetetrahydrofolate reductase by phosphorylation. 2005 至该文献
IGF-1
insulin-like growth factor 1 (somatomedin C)
总数:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 至该文献
为研究胰岛素生长因子在骨髓瘤细胞生长过程中所发挥的作用，及其受体表达与骨髓瘤患者预后的相关性，将Abcam公司提供的兔抗胰岛素样生长因子1抗体用于蛋白免疫印迹实验中。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用，采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多
BDNF
brain-derived neurotrophic factor
总数:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 至该文献
在免疫组化实验中使用Chemicon International抗BDNF抗体，来证明新生C57BL/6小鼠脑皮层神经营养因子的表达差异。 更多
Akt
v-akt murine thymoma viral oncogene homolog 1
总数:418
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H?-ATPase.. 2011 至该文献
为了研究泡状H+-ATPase参与到mTOR通路中mTORC1的转位和激活，采用Cell Signaling的抗Akt和抗S473磷酸化Akt抗体进行蛋白印迹实验。 更多
MCP-1
chemokine (C-C motif) ligand 2
总数:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响，采用了Santa Cruz公司的抗MCP-1抗体进行了免疫组织化学实验。 更多
雄激素受体 (androgen receptor)
总数:50
Estrogen receptor-{beta} activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNF{alpha} mediated. 2010 至该文献
为了研究雌激素受体beta激活的凋亡的调节机制和它的拮抗物在癌症治疗中的作用，使用了Santa Cruz Biotechnology公司的抗雄激素受体抗体来进行免疫组化试验。 更多
Toll样受体4 (TLR4)
toll-like receptor 4
总数:36
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. 2008 至该文献
为了研究回肠粘膜中TLR2、TLR4和及其转膜辅助受体CD14的表达情况，采用Santa Cruz Biotechnology公司的羊抗TLR4多克隆抗体（1：10）进行免疫组织化学实验。 更多