多发性硬化症
基因
试剂
文献样例
产品评述样例
HLA-DRB1 (HLA-DRB1)
major histocompatibility complex, class II, DR beta 1
总数:7
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析,采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。 更多
IL7R
interleukin 7 receptor
总数:6
No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. 2011 至该文献
为了研究慢性疲劳症候群病人未感染鼠gamma逆转录病毒,采用Immunotech的抗CDw127抗体进行PCR实验。 更多
CD58
CD58 molecule
总数:6
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 至该文献
CD6
CD6 molecule
总数:1
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进,采用BD Biosciences的抗CD6抗体进行流式细胞分选实验。
CLEC16A
C-type lectin domain containing 16A
CD25
interleukin 2 receptor subunit alpha
总数:49
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 至该文献
为了研究树突细胞在调控自发性致死性自身免疫性疾病中的作用,采用了eBioscience公司的抗CD25抗体产品,进行了流失细胞分析实验。 更多
EVI5
ecotropic viral integration site 5
CYP27B1
cytochrome P450 family 27 subfamily B member 1
总数:1
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达,采用了Santa Cruz公司的抗CYP27B1(D-20,1:200)多克隆抗体进行免疫细胞化学实验。
DIPK1A
divergent protein kinase domain 1A
CBLB
Cbl proto-oncogene B
总数:3
LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. 2007 至该文献
髓磷脂碱蛋白 (MBP)
myelin basic protein
总数:35
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. 2010 至该文献
为了研究Nkx2.2和Nkx6.2在调节髓鞘形成中的作用,采用了Chemicon公司的鼠抗MBP抗体产品(1:5000),进行了免疫荧光实验。 更多
TNFR1
TNF receptor superfamily member 1A
总数:23
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. 2009 至该文献
为了研究TRAF2对应激诱导的细胞死亡的抑制机制,采用了Santa Cruz的抗TNFR1抗体进行免疫印迹实验 更多
HLA-DQB1 (HLA-DQB1)
major histocompatibility complex, class II, DQ beta 1
总数:1
Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. 2007 至该文献
为了研究CD80和CD86可能作为鼻咽癌预后的标记物,采用Novocastra Laboratories的抗HLA Class II (DR)抗体进行免疫组织化学实验。
IRF8
interferon regulatory factor 8
总数:4
IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. 2006 至该文献
HLA-DRB5 (HLA-DRB5)
major histocompatibility complex, class II, DR beta 5
总数:2
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. 2008 至该文献
Tyk2
tyrosine kinase 2
总数:13
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. 2008 至该文献
为研究新型酪氨酸激酶JAK-2抑制剂Z3可以抑制JAK-2介导的病理性细胞生长,采用了Santa Cruz 生物技术公司的抗Tyk2和抗磷酸化TyK2多克隆抗体分别进行免疫共沉淀实验和western免疫印迹实验。 。 更多
KLRB1
killer cell lectin like receptor B1
总数:6
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析,采用Biolegend的抗CD161抗体以5ug/ml浓度进行细胞多因子分选实验。 更多
IFNB1
interferon beta 1
总数:9
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 至该文献
HLA-A (HLA-A)
major histocompatibility complex, class I, A
总数:8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 至该文献
为了研究研究肿瘤和肿瘤基质细胞间的相互作用,采用了Santa Cruz Biotechnology HLA-A(A-18)抗体进行了免疫组化实验。 更多
VDR
vitamin D receptor
总数:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献
为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达,采用了Affinity BioReagents公司的抗VDR(MA1-710,1:400)单克隆抗体进行免疫细胞化学实验。 更多
CD1a
CD1a molecule
总数:15
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 至该文献
为了研究IRAK-1信号阻断对TLR2和TLR4诱导的人树突状细胞耐受有重要作用,采用BD Pharmingen的抗CD1a-FITC抗体进行流式细胞分选实验。 更多
DPB1
major histocompatibility complex, class II, DP beta 1
HLA-DR (HLA-DR)
major histocompatibility complex, class II, DR alpha
总数:22
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 至该文献
为了研究IRAK-1信号阻断对TLR2和TLR4诱导的人树突状细胞耐受有重要作用,采用Beckman-Coulter的抗HLA DR- PC5抗体进行流式细胞分选实验。 更多
HLA DQA1 (HLA DQA1)
major histocompatibility complex, class II, DQ alpha 1
总数:4
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 至该文献
为研究哺乳动物活细胞中非肌肉肌球蛋白II的装配,使用了Biomedical Technologies公司的抗MHC抗体来进行蛋白印迹分析。 更多
CIITA
class II major histocompatibility complex transactivator
总数:5
A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. 2009 至该文献
为了研究JAK-STAT1通道在调控HSV-1复制中的作用,使用了Biolegend公司的抗MHC class II-APC 抗体,来收集和染色受感染的细胞,进行了流式细胞计量实验。 更多
CB2
cannabinoid receptor 2
总数:6
Cannabinoid CB? receptor is downregulated in clear cell renal cell carcinoma. 2010 至该文献
为了研究大麻素受体CB1在肾透明细胞癌中的表达下调,采用Cayman Chemical公司抗CB2多克隆抗体进行了免疫印迹和免疫组织化学实验。 更多
维生素D结合蛋白 (vitamin D binding protein)
GC vitamin D binding protein
总数:3
An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene. 2007 至该文献
N-乙酰氨基葡糖转移酶类V (N acetylglucosaminyltransferase V)
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
总数:1
N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer. 2006 至该文献
水通道蛋白4 (aquaporin 4)
总数:10
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. 2008 至该文献
采用Santa Cruz生物技术公司的抗AQP4抗体(H-80),进行免疫组织化学实验来研究AQP4在阿尔茨海默病人的大脑皮层中的表达。 更多
HLA-C (HLA-C)
major histocompatibility complex, class I, C
总数:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 至该文献
为了研究主要组织相容性复合体作为一种附属因子在促进 HCoV-HKU1 感染过程中的作用,采用英杰的纯化的羊免疫球蛋白作为同型标准品。 更多
S1PR1
sphingosine-1-phosphate receptor 1
总数:3
Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. 2005 至该文献
ApoE基因 (ApoE)
apolipoprotein E
总数:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 至该文献
为了研究高效肝炎C病毒颗粒的形成条件,采用了Calbiochem公司的抗ApoE抗体进行蛋白免疫印迹实验。 更多
CTLA 4 (CTLA 4)
cytotoxic T-lymphocyte associated protein 4
总数:6
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. 2011 至该文献
为了揭示CTLA-4为何能够抑制CD28的激活,采用Santa Cruz的抗CTLA-4抗体进行免疫细胞化学试验。 更多
人类白细胞抗原b (HLA B)
major histocompatibility complex, class I, B
总数:1
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 至该文献
骨桥蛋白 (osteopontin)
secreted phosphoprotein 1
总数:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 至该文献
为了研究c-Src激酶是否会促使非典型小叶增生或小叶原位癌转变为浸润性小叶癌,使用了Calbiochem公司的抗osteopontin抗体(1:100)进行免疫荧光实验。 更多
IFIH1
interferon induced with helicase C domain 1
总数:2
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 至该文献
为了研究呼由人变性肺病毒引起的吸道上皮细胞的细胞信号转导,采用了IMGENEX公司的抗MDA-5抗体进行免疫印迹实验。 更多
IL-17 (IL-17)
interleukin 17A
总数:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了eBioscience公司的抗IL-17A抗体进行流式细胞计数和细胞刺激。 更多
IL-7 (IL-7)
interleukin 7
总数:3
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. 2009 至该文献
为了研究MOZ在调控造血祖细胞增殖中的作用,采用了BD Pharmingen 公司的抗IL7-R抗体产品,进行了流式分析实验。 更多
白细胞介素2 (interleukin 2)
总数:17
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 至该文献
为了研究肠道正常菌群如何调节免疫系统,采用了BD Pharmingen™ 抗IL-2 抗体进行了流式分析检测。 更多
CD40
CD40 molecule
总数:40
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 至该文献
为了研究在B细胞中TNIK在经典的NF-kB和JNK通路中扮演何种角色及如何发挥这种作用,采用了Santa Cruz Biotechnology的CD40 (C-20)抗体进行免疫印迹实验。 更多
IL-12 (IL-12)
interleukin 12A
总数:9
Importance of stromal determinants in the generation of dendritic and natural killer cells in the human spleen. 2005 至该文献
CXCL13
C-X-C motif chemokine ligand 13
总数:2
Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. 2009 至该文献
为了说明VUE的胎盘转录组并鉴定了VUE是结合了产妇移植排斥反应和产妇抗新生儿移植物抗宿主疾病,使用了Proteintech Group公司的抗CXCL13抗体来进行免疫细胞化学实验。 更多
EP4
prostaglandin E receptor 4
总数:9
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. 2008 至该文献
为了研究CD30信号在霍奇金细胞系和间变性大细胞淋巴瘤(ALCL)细胞系中的重要作用,采用了Abcam的鼠单克隆抗PTGER4抗体进行流式细胞分析。 更多
肿瘤坏死因子甲 (TNF-alpha)
tumor necrosis factor
总数:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 至该文献
为了研究UNC93B1介导的内涵体TLRs不同的运输机制,采用eBiosciences公司的抗TNFα-PE或-APC抗体进行流式细胞术试验。 更多
KIR2DL2
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2
IFN丙 (IFN-gamma)
interferon gamma
总数:62
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进,采用R&D Systems的抗IFN-gamma抗体以5ug/ml浓度进行细胞刺激实验。 更多
KIR3DS1
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
BDNF
brain derived neurotrophic factor
总数:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 至该文献
在免疫组化实验中使用Chemicon International抗BDNF抗体,来证明新生C57BL/6小鼠脑皮层神经营养因子的表达差异。 更多
TNFSF13B
TNF superfamily member 13b
总数:6
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. 2008 至该文献
为了研究人肿瘤石蜡切片中BAFF 和 APRI在乳腺癌中的表达,采用了Alexis公司的抗BAFF抗体(804-131-C100,Buffy-2克隆 )进行免疫组织化学分析 更多
IL-10 (IL-10)
interleukin 10
总数:23
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 至该文献
为了研究肠道正常菌群如何调节免疫系统,采用了R&D Systems 抗IL-10 抗体进行了ELISA检测。 更多
Toll样受体3 (TLR3)
toll like receptor 3
总数:9
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 至该文献
为了在人体皮肤的冷冻切片上研究Toll样受体在疣和传染性软疣的表现,使用了Santa Cruz Biotechnology公司的羊多克隆的抗人体TLR3产品,进行了免疫组织化学实验。 更多
MIR155
microRNA 155
CD24
CD24 molecule
总数:10
Identification of potential therapeutic targets in human head & neck squamous cell carcinoma. 2009 至该文献
为了研究人头颈鳞状细胞癌的潜在治疗靶,使用了Chemicon公司的抗CD24抗体来进行免疫组化分析。 更多
高迁移率族蛋白B1 (HMGB1)
high mobility group box 1
总数:10
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 至该文献
为了研究DNA依赖的蛋白激酶在IRF-3依赖的先天性免疫反应中的作用,采用了Abcam 的抗HMGB1抗体进行了蛋白免疫印迹实验。 更多
IL1A
interleukin 1 alpha
总数:5
Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. 2006 至该文献
IL-1beta (IL-1beta)
interleukin 1 beta
总数:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 至该文献
为了研究IL-26诱导促炎因子的分泌和促进Th17细胞的产生,采用了R&D Systems公司的抗IL-1-beta抗体进行细胞刺激。 更多
CNR1
cannabinoid receptor 1
总数:4
Cannabinoid CB? receptor is downregulated in clear cell renal cell carcinoma. 2010 至该文献
为了研究大麻素受体CB1在肾透明细胞癌中的表达下调,采用ABR Affinity BioReagents公司抗CB1多克隆抗体进行了免疫印迹和免疫组织化学实验。 更多
FOXP3
forkhead box P3
总数:17
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 至该文献
为了研究酪氨酸激酶Tec在Th17细胞亚群CD44(high)CD62L(-)产生中的作用,采用了eBioscience公司Alexa 647标记的FoxP3抗体进行了细胞流式试验。 更多
基质金属蛋白酶-9 (MMP-9)
matrix metallopeptidase 9
总数:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 至该文献
为了研究蛋白激酶D1抑制乳腺肿瘤细胞侵袭的机制,采用了Epitomics公司的抗MMP-9抗体,进行了免疫组织化学实验。 更多
CHI3L1
chitinase 3 like 1
总数:2
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. 2008 至该文献
为了研究在基础成纤维细胞生长因子活性的调节中,YKL-40所起的作用,采用了R&D Systems的山羊抗人几丁质酶3-1多抗,进行蛋白质印迹和免疫组化实验实验 更多
HO-1 (HO-1)
heme oxygenase 1
总数:10
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 至该文献
使用Stressgen公司的抗HO-1(1:500) 抗体进行免疫印迹实验来研究心肌CPR和CPR依赖酶在阿霉素介导的急性心脏毒性中的作用。 更多
Toll样受体9 (TLR9)
toll like receptor 9
总数:6
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 至该文献
为了在人体皮肤的冷冻切片上研究Toll样受体在疣和传染性软疣的表现,使用了Santa Cruz Biotechnology公司的羊多克隆的抗人体TLR9产品,进行了免疫组织化学实验。 更多
小窝蛋白1 (caveolin-1)
caveolin 1
总数:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 至该文献
为了说明19号染色体的易位可能会引起Xp11.2易位相关的肾细胞癌,使用了Epitomics公司的抗calveolin-1抗体进行免疫组化实验。 更多
MCP-1 (MCP-1)
C-C motif chemokine ligand 2
总数:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响,采用了Santa Cruz公司的抗MCP-1抗体进行了免疫组织化学实验。 更多
IL1RN
interleukin 1 receptor antagonist
总数:1
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. 2006 至该文献