肥胖症
基因
试剂
文献样例
产品评述样例
FTO
fat mass and obesity associated
melanocortin 4 receptor
肥胖荷尔蒙 (leptin)
总数:6
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗Ob抗体来进行免疫印迹分析。 更多
脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing
总数:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献
为了研究DLK在调控3T3-L1脂肪细胞分化中的作用，使用了Calbiochem公司的兔多克隆抗adiponectin抗体，进行了免疫印迹和沉淀实验。 更多
INSIG2
insulin induced gene 2
leptin receptor
总数:9
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 2007 至该文献
MTCH2
mitochondrial carrier 2
SH2B1
SH2B adaptor protein 1
总数:1
SLAM-associated protein as a potential negative regulator in Trk signaling. 2005 至该文献
ghrelin
ghrelin/obestatin prepropeptide
总数:6
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究格瑞林酰基转移酶抑制剂在小鼠中的作用，采用了Abcam抗ghrelin抗体进行了免疫印迹实验。 更多
TMEM18
transmembrane protein 18
KCTD15
potassium channel tetramerisation domain containing 15
GNPDA2
glucosamine-6-phosphate deaminase 2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
总数:1
UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. 2008 至该文献
NEGR1
neuronal growth regulator 1
RBP4
retinol binding protein 4, plasma
perilipin
perilipin 1
ADRB3
adrenergic, beta-3-, receptor
总数:1
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. 2003 至该文献
Santa Cruz Biotechnology的β3-肾上腺素受体抗体被用于蛋白质印迹实验，来证明在一个给定的外围组织中瘦蛋白直接作用的生理意义。
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:28
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析。 更多
FAAH
fatty acid amide hydrolase
UCP1
uncoupling protein 1 (mitochondrial, proton carrier)
总数:1
Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells. 2001 至该文献
visfatin
nicotinamide phosphoribosyltransferase
总数:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 至该文献
为了研究DBC1在调控SIRT1的活性和高脂饮食诱发的小鼠脂肪肝中的作用，采用了Bethyl Laboratories公司的NAMPT抗体产品，进行了免疫印迹实验
SEC16B
SEC16 homolog B (S. cerevisiae)
MC3R
melanocortin 3 receptor
LFG
Fas apoptotic inhibitory molecule 2
LYPLAL1
lysophospholipase-like 1
酪酪肽 (peptide YY)
总数:1
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. 2006 至该文献
PC 1
ectonucleotide pyrophosphatase/phosphodiesterase 1
总数:2
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. 2004 至该文献
PCSK1
proprotein convertase subtilisin/kexin type 1
总数:1
RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor. 2006 至该文献
NRXN3
neurexin 3
ERM
ets variant 5
总数:4
V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. 2009 至该文献
为了研究BRAF在调控RAF-MEK信号通路中的作用，采用了Abnova公司的抗ETV5抗体产品，进行了免疫印迹实验。 更多
FGF21
fibroblast growth factor 21
SIM1
single-minded homolog 1 (Drosophila)
resistin
总数:2
Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. 2004 至该文献
CIDE 3
cell death-inducing DFFA-like effector c
uncoupling protein 2
uncoupling protein 2 (mitochondrial, proton carrier)
总数:3
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 2005 至该文献
Santa Cruz Biotechnology的Ucp2抗体被用于蛋白质印迹实验，来研究通过破坏解偶联蛋白-2基因来增强对感染性微生物的抗性的分子机制。 更多
BCDIN3D
BCDIN3 domain containing
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
总数:1
Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. 2006 至该文献
激素敏感脂酶 (hormone sensitive lipase)
lipase, hormone-sensitive
ADRB2
adrenergic, beta-2-, receptor, surface
总数:7
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 至该文献
为了研究β2-肾上腺素受体激动剂fenoterol的立体化学在决定受体G蛋白选择性和下游信号通路中的功能，使用了Santa Cruz Biotechnology公司的抗ADRB2 C末端抗体来进行免疫印迹分析。 更多
PNPLA3
patatin-like phospholipase domain containing 3
CNR1
cannabinoid receptor 1 (brain)
总数:3
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. 2008 至该文献
为了确认内源性大麻素信号途径的关键元件是否在骨关节炎和类风湿性关节炎患者的关节骨液中表达，采用了Calbiochem公司的抗大麻素受体1抗体进行了蛋白印迹实验。 更多
ADIPOR1
adiponectin receptor 1
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
FABP4
fatty acid binding protein 4, adipocyte
总数:2
De-Novo Identification of PPARgamma/RXR Binding Sites and Direct Targets during Adipogenesis. 2009 至该文献
为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗A-FABP抗体来进行免疫印迹分析。 更多
AGRP
agouti related protein homolog (mouse)
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多
AZGP1
alpha-2-glycoprotein 1, zinc-binding
总数:2
Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-{alpha} in adipocytes. 2010 至该文献
为了研究TNFalpha在调控锌α2糖蛋白在肥胖小鼠脂肪和肝脏组织表达中的作用，采用了 Santa Cruz Biotechnology公司的抗多克隆羊抗ZAG抗体产品(1:500)，进行了免疫印迹实验。 更多
脂蛋白脂肪酶 (lipoprotein lipase)
总数:2
Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. 2002 至该文献
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
总数:1
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，在免疫印迹试验中使用了Sigma的抗PreMMP-2抗体作为第一抗体。
TIARP
STEAP family member 4
胰岛素 (insulin)
总数:22
Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor.. 2010 至该文献
为了研究在已经设计好的grelin o-酰基转移酶抑制剂的小鼠体内体重和葡萄糖的控制，采用了Linco抗insulin抗体进行了免疫印迹实验。 更多
胰高血糖素 (glucagon)
总数:12
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. 2009 至该文献
为了研究线粒体黄素蛋白细胞凋亡诱导因子的效应，使用了西格玛公司的抗胰高血糖素抗体来进行免疫组化分析。 更多
MSRA
methionine sulfoxide reductase A
总数:1
TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of ?±-crystallin and cytochrome C in the eye lens. 2010 至该文献
为了说明TXNL6对氧压力下的晶状体MsrA修复及白内障的MsrA损伤修复有重要作用，使用了Abcam公司的MsrA抗体(1:1000)来进行免疫印记实验。
CES1
carboxylesterase 1
NEFA
nucleobindin 2
CD36
CD36 molecule (thrombospondin receptor)
总数:16
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 至该文献
为了说明在TRl信号通路的介导下间质干细胞能被极化成两种截然不同的表型，采用了eBiosciences公司的抗CD36抗体进行流式细胞术和免疫细胞化学实验。 更多
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
神经肽Y (neuropeptide Y)
总数:3
Regulation of neuropeptide Y in the rat amygdala following unilateral olfactory bulbectomy. 2002 至该文献
在免疫组化实验中使用了Sigma公司的兔多克隆兔抗大鼠NPY抗体（1：40000稀释）用于表明在嗅球切除术后（OBX）后神经递质NPY含量增加。 更多
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
总数:1
Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. 2009 至该文献
为了说明在双相障碍病人的额叶皮质中，G蛋白β和γ亚基以及GRK3的表达量是下降的，但GRK2得表达量并没有显著该变，采用了Millipore公司的抗GNB3（1：200）抗体进行免疫印迹实验。
BDNF
brain-derived neurotrophic factor
总数:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 至该文献
在免疫组化实验中使用Chemicon International抗BDNF抗体，来证明新生C57BL/6小鼠脑皮层神经营养因子的表达差异。 更多
载脂蛋白B (apoB)
apolipoprotein B (including Ag(x) antigen)
总数:14
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 至该文献
为了研究高效肝炎C病毒颗粒的形成条件，采用了Abcam公司的抗ApoB100抗体进行蛋白免疫印迹实验。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
CETP
cholesteryl ester transfer protein, plasma
脂肪酸合成酶 (fatty acid synthase)
总数:6
EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy. 2009 至该文献
为了研究表皮生长因子突变常常与肿瘤发生有关，研究了Akt介导的在表皮生长因子诱导下固醇调节结合蛋白1的切割以及移位机理，并发现了一种新的治疗由于表皮生长因子激活的胶质母细胞瘤，采用了Cell Signaling公司脂肪酸合成酶抗体，进行免疫化学荧光实验。 更多