系统性红斑狼疮
基因
试剂
文献样例
产品评述样例
IRF5
interferon regulatory factor 5
总数:1
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 至该文献
为了说明IRF5同HATs和HDACs一起调控促炎细胞因子的转录水平表达，使用了Abcam公司的山羊抗IRF5多克隆抗体进行免疫共沉淀实验。
STAT4
signal transducer and activator of transcription 4
总数:10
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 至该文献
为了研究Stat4依赖的Th1相关基因的遗传程序，采用了Santa Cruz Biotechnology公司的抗Stat4抗体进行ChIP分析 更多
BLK
B lymphoid tyrosine kinase
IFNA1
interferon, alpha 1
总数:11
The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide. 2010 至该文献
为了研究伊波拉病毒VP35蛋白在调节病毒和脂多糖诱导的树突细胞成熟中的作用，采用了PBL Laboratories公司的抗IFNalpha抗体产品，进行了流式细胞分析实验。 更多
C1QC
complement component 1, q subcomponent, C chain
CD247
CD247 molecule
总数:64
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence.. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进，采用eBioscience的抗CD3抗体以2.5ug/ml浓度进行细胞刺激实验。 更多
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
总数:6
Loss of CD103(+) intestinal dendritic cells during colonic inflammation. 2010 至该文献
为了了研究小鼠诱发大肠炎前后肠内树突状细胞可能的差异，采用了BD Pharmingen 公司的CD32抗体产品，进行了流式细胞分析实验。 更多
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
总数:3
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. 2008 至该文献
C1QA
complement component 1, q subcomponent, A chain
总数:1
Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis. 2005 至该文献
CD11b
integrin, alpha M (complement component 3 receptor 3 subunit)
总数:46
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation.. 2011 至该文献
为了研究p300调控的AML1-ETO融合蛋白乙酰化对白血病发生至关重要，采用Beckman-coulter的PE标记的抗CD11b抗体进行流式细胞分选实验。 更多
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
脱氧核糖核酸i (deoxyribonuclease I)
总数:2
Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. 2003 至该文献
Amersham-Pharmacia的抗Dnas1l3抗血清（1:4000）被用于蛋白质印迹实验，来研究脱氧核糖核酸酶1在人和小鼠全身性红斑狼疮(SLE)中的作用。 更多
FAM167A
family with sequence similarity 167, member A
C4A
complement component 4A (Rodgers blood group)
总数:2
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. 2009 至该文献
为了研究人体癌症细胞TLSDNA多聚酶eta和kappa在调控自然发生DNA结构中的作用，使用了Chemicon公司的C4单克隆抗体，进行了免疫印迹实验。 更多
MFGE8
milk fat globule-EGF factor 8 protein
总数:2
MFG-E8 in the retina and retinal pigment epithelium of rat and mouse. 2006 至该文献
OX40 ligand
tumor necrosis factor (ligand) superfamily, member 4
PDCD1
programmed cell death 1
总数:1
FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy. 2008 至该文献
A20
tumor necrosis factor, alpha-induced protein 3
总数:3
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.. 2011 至该文献
为了研究切割的NIK 导致非经典的NF- kB 活性 ，采用了Santa Cruz Biotechnology的抗A20抗体进行免疫印迹实验。 更多
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
总数:6
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. 2008 至该文献
为了研究人肿瘤石蜡切片中BAFF 和 APRI在乳腺癌中的表达，采用了Alexis公司的抗BAFF抗体(804-131-C100,Buffy-2克隆 )进行免疫组织化学分析 更多
BANK
B-cell scaffold protein with ankyrin repeats 1
IFNA2
interferon, alpha 2
总数:1
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. 2004 至该文献
为了研究p65/RelA通过蛋白酶降解，而且它的降解不仅仅调节量和稳定性同时也促使转录水平的终止，采用了Imgenex公司Iκ B alpha抗体，进行蛋白质印记实验。
TLR7
toll-like receptor 7
总数:2
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. 2006 至该文献
为了研究Toll样受体7抵抗丙型肝炎病毒的机制，使用Imgenex公司抗TLR7抗体进行流式细胞和免疫组化实验。 更多
CD16
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
总数:41
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy.. 2011 至该文献
为了研究在天然杀伤细胞免疫突触处皮质肌动蛋白的重塑，采用了R&D systems的抗CD16抗体进行免疫细胞化学实验。 更多
白细胞介素18 (IL-18)
interleukin 18 (interferon-gamma-inducing factor)
总数:6
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.. 2005 至该文献
Toll样受体9 (TLR9)
toll-like receptor 9
总数:6
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 至该文献
为了在人体皮肤的冷冻切片上研究Toll样受体在疣和传染性软疣的表现，使用了Santa Cruz Biotechnology公司的羊多克隆的抗人体TLR9产品，进行了免疫组织化学实验。 更多
TRAF1
TNF receptor-associated factor 1
总数:3
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. 2010 至该文献
为了揭示HOIP在CD40信号通路中的泛素连接酶功能，使用了Santa Cruz Biotechnology公司的TRAF1抗体(N-19)来进行免疫印记实验。 更多
CD40配体 (CD40 ligand)
总数:12
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 至该文献
为了研究单核细胞趋化蛋白1和CD40配基化对血管内皮生长因子产量的影响，采用了Santa Cruz公司的抗CD40L抗体(1:200)进行了免疫组织化学实验。 更多
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
总数:6
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.. 2011 至该文献
为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析，采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。 更多
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
总数:2
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. 2008 至该文献
NKG2D
killer cell lectin-like receptor subfamily K, member 1
总数:5
Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. 2008 至该文献
为了研究IFN-alpha和IFN-gamma在肿瘤细胞中的不同作用，采用了R&D Systems的NKG2D抗体进行了阻断实验。 更多
过氧化氢酶 (catalase)
总数:8
Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma. 2009 至该文献
为了研究头颈部鳞癌中线粒体ND2突变引起的ROS增多和PDK2升高并最终导致HIF1alpha的聚集，采用了Calbiochem的兔多抗catalase抗体进行免疫印迹实验。 更多
白细胞介素17 (IL-17)
interleukin 17A
总数:16
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence.. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进，采用eBioscience的抗IL-17抗体进行流式细胞分选实验。 更多
IL 21
interleukin 21
总数:1
Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3. 2009 至该文献
为了证明在人的肝脏部位抗原3(LSA-3)上存在着多个不同的T细胞和B细胞表位，并研究其在诱导产生抗疟原虫的保护机制中的作用，采用了Unipath公司的小鼠抗IgG4抗体(1:3000)，进行了ELISA实验。
CD32
Fc fragment of IgG, low affinity IIa, receptor (CD32)
总数:7
Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain. 2009 至该文献
为探讨依替巴肽引起的血小板减少症和血栓形成的病因学，将BD Biosciences — Pharmingen提供的FITC标记的单克隆抗FcγRIIa抗体用于蛋白免疫印迹实验中。 更多
高迁移率族蛋白B1 (HMGB1)
high mobility group box 1
总数:9
Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. 2009 至该文献
为了研究在肾脏移植过程中供体Toll样受体4通过诱导局部出血和再灌注对肾脏损伤的影响，使用了Abnova公司的抗HMGB1抗体来进行免疫荧光试验。 更多
HLA G
major histocompatibility complex, class I, G
总数:1
HLA-G gene repression is reversed by demethylation. 2003 至该文献
KIR2DS1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
CD4
CD4 molecule
总数:109
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.. 2011 至该文献
为了研究能长期自我复制的人造血干细胞能够通过CD49f为标记物进行分离，采用Beckman coulter的抗CD4 PC5抗体进行流式细胞分选实验。 更多
KIR2DS2
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
CRP
C-reactive protein, pentraxin-related
总数:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 至该文献
为研究有活性的gp130在炎症性肝细胞肿瘤中所发挥的作用，将Abcam提供的单克隆抗C反应蛋白抗体应用于免疫组织化学实验中。 更多
CD25
interleukin 2 receptor, alpha
总数:44
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 至该文献
为了研究树突细胞在调控自发性致死性自身免疫性疾病中的作用，采用了eBioscience公司的抗CD25抗体产品，进行了流失细胞分析实验。 更多
TNF-alpha
tumor necrosis factor
总数:64
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 至该文献
为了研究NFAT5在高渗压力下对人类角膜缘上皮细胞的作用，采用了R&D Systems的TNF-alpha抗体进行了蛋白质印迹实验。 更多
KIR2DL2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
总数:2
Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. 2003 至该文献
FOXP3
forkhead box P3
总数:15
Identification of IL-17-producing FOXP3+ regulatory T cells in humans. 2009 至该文献
为了确定IL-17+，FOXP3+调节性T细胞产生于外周血中，使用了eBioscience公司的标记有藻红蛋白或别藻蓝蛋白的抗FOXP3抗体（克隆PCH101）进行免疫荧光实验。 更多
CD274
CD274 molecule
总数:5
A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. 2009 至该文献
为了研究JAK-STAT1通道在调控HSV-1复制中的作用，使用了Biolegend公司的抗B7-H1抗体，来收集和染色受感染的细胞，进行了流式细胞计量实验。 更多
信号传导子及转录激活子1 (STAT1)
signal transducer and activator of transcription 1, 91kDa
总数:82
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. 2010 至该文献
为研究MUC1-C和STAT1通路在人类不良预后乳癌中的相互作用，采用了Santa Cruz Biotechnology公司的抗STAT1抗体进行免疫沉淀试验。 更多
肿瘤坏死因子受体超家族成员6 (Fas)
Fas (TNF receptor superfamily, member 6)
总数:52
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 至该文献
为了说明YB-1、GST、ABCB5和ERK3能够成为乳腺癌细胞耐药性治疗的潜在靶点，使用了Santa Cruz Biotechnology公司的FAS抗体(1:500)来进行免疫印记实验。 更多
KIR3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
E-selectin
selectin E
总数:5
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. 2008 至该文献
使用R & D 单克隆抗E选择蛋白抗体(BBIG-E4)进行免疫组织化学实验来研究是否类风湿关节炎肿瘤坏死因子(TNF)α封闭疗法产生的异质临床反应，可以用治疗开始之前滑膜(TNF)α的表达水平预测。 更多
TNFR2
tumor necrosis factor receptor superfamily, member 1B
总数:14
Control of chemokine gradients by the retinal pigment epithelium. 2008 至该文献
IFN-gamma
interferon, gamma
总数:59
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence.. 2011 至该文献
为了研究血脑屏障的完整性和中枢神经免疫沉默能够被Shh信号通路促进，采用R&D Systems的抗IFN-gamma抗体以5ug/ml浓度进行细胞刺激实验。 更多
MBL2
mannose-binding lectin (protein C) 2, soluble
总数:4
Protein kinase CK2 phosphorylation regulates the interaction of Kaposi's sarcoma-associated herpesvirus regulatory protein ORF57 with its multifunctional partner hnRNP K. 2004 至该文献
MECP2
methyl CpG binding protein 2 (Rett syndrome)
总数:5
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. 2004 至该文献
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
总数:1
Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. 2007 至该文献
为了研究CD80和CD86可能作为鼻咽癌预后的标记物，采用Novocastra Laboratories的抗HLA Class II (DR)抗体进行免疫组织化学实验。
CTLA 4
cytotoxic T-lymphocyte-associated protein 4
总数:5
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell Extrinsic Function of CTLA-4.. 2011 至该文献
为了揭示CTLA-4为何能够抑制CD28的激活，采用Santa Cruz的抗CTLA-4抗体进行免疫细胞化学试验。 更多
白细胞介素10 (IL-10)
interleukin 10
总数:20
Identification of IL-17-producing FOXP3+ regulatory T cells in humans. 2009 至该文献
为了确定IL-17+，FOXP3+调节性T细胞产生于外周血中，使用了R&D Systems公司的白介素10酶联免疫吸附试剂盒进行酶联免疫吸附实验。 更多
FasL
Fas ligand (TNF superfamily, member 6)
总数:12
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. 2006 至该文献
ER
estrogen receptor 1
总数:108
The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas. 2010 至该文献
为了研究c-erbB-2的表达量对子宫内膜癌的影响，使用了Spring Bioscience公司的ER兔单抗(M3011, 1:100稀释)来进行免疫组化实验。 更多
eNOS
nitric oxide synthase 3 (endothelial cell)
总数:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 至该文献
为了研究purinergic在调控内皮细胞一氧化氮合成酶活性中的作用，采用了Upstate Laboratories公司的抗eNOS抗体产品，进行了免疫印迹实验。 更多
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:41
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes.. 2011 至该文献
为了研究具有分解代谢功能的细胞器和具有合成代谢功能的细胞器二者在空间上的结合在促进分泌蛋白合成中的作用，采用R&D systems的抗IL6抗体进行免疫细胞化学试验。 更多
TGF-beta1
transforming growth factor, beta 1
总数:33
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 至该文献
为研究CD147促使成肌纤维细胞分化在组织变构中的作用，采用了R&D Systems公司的抗pan-TGFβ抗体进行抑制试验。 更多