1型糖尿病

基因

试剂

文献样例

产品评述样例

HLA-DQB1 (HLA-DQB1)
major histocompatibility complex, class II, DQ beta 1

总数:1

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. 2007 至该文献

为了研究CD80和CD86可能作为鼻咽癌预后的标记物，采用Novocastra Laboratories的抗HLA Class II (DR)抗体进行免疫组织化学实验。

HLA DQA1 (HLA DQA1)
major histocompatibility complex, class II, DQ alpha 1

总数:4

Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 至该文献

为研究哺乳动物活细胞中非肌肉肌球蛋白II的装配，使用了Biomedical Technologies公司的抗MHC抗体来进行蛋白印迹分析。更多

PTPN22
protein tyrosine phosphatase non-receptor type 22

胰岛素 (insulin)

总数:25

Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. 2012 至该文献

为了研究氧化铁纳米颗粒对小鼠血糖的调控作用，Alpco的胰岛素酶联免疫吸附试剂盒被用于酶联免疫吸附实验。更多

HLA-DRB1 (HLA-DRB1)
major histocompatibility complex, class II, DR beta 1

总数:7

Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 至该文献

为了研究人造血系统细胞给以不同刺激的反应能通过单细胞多因子分选进行分析，采用Biolegend的抗HLADR抗体以2ug/ml浓度进行细胞多因子分选实验。更多

CTLA 4 (CTLA 4)
cytotoxic T-lymphocyte associated protein 4

总数:6

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. 2011 至该文献

为了揭示CTLA-4为何能够抑制CD28的激活，采用Santa Cruz的抗CTLA-4抗体进行免疫细胞化学试验。更多

IA 2 (IA 2)
protein tyrosine phosphatase receptor type N

ZnT 8
solute carrier family 30 member 8

GAD2
glutamate decarboxylase 2

总数:3

ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. 2010 至该文献

为了研究ADAM22在调控Kv1 K+通道合成物中的作用，使用了Developmental Studies Hybridoma Bank公司的抗GAD-65抗体，进行了免疫沉淀和免疫印迹实验。更多

CD25
interleukin 2 receptor subunit alpha

总数:49

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 至该文献

为了研究树突细胞在调控自发性致死性自身免疫性疾病中的作用，采用了eBioscience公司的抗CD25抗体产品，进行了流失细胞分析实验。更多

CLEC16A
C-type lectin domain containing 16A

IFIH1
interferon induced with helicase C domain 1

总数:2

Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 至该文献

为了研究呼由人变性肺病毒引起的吸道上皮细胞的细胞信号转导，采用了IMGENEX公司的抗MDA-5抗体进行免疫印迹实验。更多

PAX4
paired box 4

总数:1

PAX4 enhances beta-cell differentiation of human embryonic stem cells. 2008 至该文献

BACH2
BTB domain and CNC homolog 2

SUMO4
small ubiquitin like modifier 4

IL18RAP
interleukin 18 receptor accessory protein

HLA-DR (HLA-DR)
major histocompatibility complex, class II, DR alpha

总数:22

Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 至该文献

为了研究IRAK-1信号阻断对TLR2和TLR4诱导的人树突状细胞耐受有重要作用，采用Beckman-Coulter的抗HLA DR- PC5抗体进行流式细胞分选实验。更多

MICA
MHC class I polypeptide-related sequence A

总数:3

Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. 2008 至该文献

为了研究IFN-alpha和IFN-gamma在肿瘤细胞中的不同作用，采用了R&D Systems的MICA抗体进行了流式细胞实验。更多

AGER
advanced glycosylation end-product specific receptor

KIR2DL2
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

VDR
vitamin D receptor

总数:15

Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 至该文献

为了说明在膀胱中维生素D可以诱导一种人类抗菌肽cathelicidin的表达，采用了Affinity BioReagents公司的抗VDR（MA1-710，1：400）单克隆抗体进行免疫细胞化学实验。更多

PTPN2
protein tyrosine phosphatase non-receptor type 2

总数:2

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 至该文献

为了研究MDA5 和PTPN2在调节胰岛beta细胞对病毒双链RNA副产物的反应中的作用，采用了R&D Systems公司的抗PTPN2抗体产品，进行了免疫印迹实验。更多

FOXP3
forkhead box P3

总数:17

The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 至该文献

为了研究酪氨酸激酶Tec在Th17细胞亚群CD44(high)CD62L(-)产生中的作用，采用了eBioscience公司Alexa 647标记的FoxP3抗体进行了细胞流式试验。更多

DPB1
major histocompatibility complex, class II, DP beta 1

人类白细胞抗原b (HLA B)
major histocompatibility complex, class I, B

总数:1

Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 至该文献

HLA-A (HLA-A)
major histocompatibility complex, class I, A

总数:8

Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 至该文献

为了研究研究肿瘤和肿瘤基质细胞间的相互作用，采用了Santa Cruz Biotechnology HLA-A（A-18)抗体进行了免疫组化实验。更多

SH2B3
SH2B adaptor protein 3

总数:1

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. 2010 至该文献

为了说明Lnk可以通过调节小鼠血小板中由外向内的整合蛋白αIIbβ3信号通路对体内血栓形成起到稳定作用，采用了Abcam公司的抗人Lnk抗体，进行免疫印迹试验。

KIR2DL5A
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A

KIR2DS3
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3

KIR2DL1
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

KIR2DS1
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1

KIR2DS2
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2

KIR2DS5
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5

KIR2DS4
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4

CD226
CD226 molecule

HLA-C (HLA-C)
major histocompatibility complex, class I, C

总数:7

Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 至该文献

为了研究主要组织相容性复合体作为一种附属因子在促进 HCoV-HKU1 感染过程中的作用，采用英杰的纯化的羊免疫球蛋白作为同型标准品。更多

KIR3DS1
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1

erbB3
erb-b2 receptor tyrosine kinase 3

总数:18

Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. 2009 至该文献

为了研究ErbB2和孕酮受体的信号交联及其对乳腺癌生长的影响，使用了Neomarkers公司的鼠源抗ErbB3单克隆抗体进行抗体抑制实验。更多

KIR3DL1
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1

KIR3DL3
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

CDKAL1
CDK5 regulatory subunit associated protein 1 like 1

PDX-1 (PDX-1)
pancreatic and duodenal homeobox 1

总数:8

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. 2008 至该文献

为了研究胰岛素抗性的糖尿病模型中，Gsk-3β是如何控制β细胞数量的，采用了Santa Cruz的Pdx1抗体，进行蛋白质印迹实验更多

脂联素 (adiponectin)
adiponectin, C1Q and collagen domain containing

总数:6

The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 至该文献

为了研究DLK在调控3T3-L1脂肪细胞分化中的作用，使用了Calbiochem公司的兔多克隆抗adiponectin抗体，进行了免疫印迹和沉淀实验。更多

葡萄糖激酶 (glucokinase)

总数:1

Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm. 2008 至该文献

为研究精子发生细胞特异性己糖激酶1(HK1S)在精子中的作用，采用了ABGENT公司的抗GCK(N-末端)多克隆抗体进行免疫印迹试验。

KIR3DL2
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

ICOS
inducible T cell costimulator

总数:3

Lack of disease specificity limits the usefulness of in vitro costimulation in HIV- and HCV-infected patients. 2008 至该文献

KIR2DL4
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

HNF1A
HNF1 homeobox A

总数:10

Inherent sexually dimorphic expression of hepatic CYP2C12 correlated with repressed activation of growth hormone-regulated signal transduction in male rats. 2008 至该文献

使用Santa Cruz生物公司的抗HNF-4α抗体进行免疫印迹实验来证明持续的GH通过GHR激活Erk1和Erk2引起CYP2C12表达增加。更多

CXCL10
C-X-C motif chemokine ligand 10

总数:12

Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. 2009 至该文献

为了说明VUE的胎盘转录组并鉴定了VUE是结合了产妇移植排斥反应和产妇抗新生儿移植物抗宿主疾病，使用了R&D Systems公司的抗CXCL10抗体来进行免疫细胞化学实验。更多

促红细胞生成素 (erythropoietin)

总数:7

Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 至该文献

为了确定在受体信号激活过程中促红细胞生成素受体的受体因素，使用了R&D Systems公司的抗Ras抗体来进行免疫沉淀实验和免疫印记分析。更多

胰岛素降解酶 (insulin degrading enzyme)

总数:3

Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts. 2008 至该文献

为了阐述Sca-1定位在肌质脂质微区，并且与催化胞内信使IDE有关，采用了Calbiochem公司的兔抗IDE抗体进行了蛋白印迹实验。更多

LTA
lymphotoxin alpha

STAT4
signal transducer and activator of transcription 4

总数:10

Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 至该文献

为了研究Stat4依赖的Th1相关基因的遗传程序，采用了Santa Cruz Biotechnology公司的抗Stat4抗体进行ChIP分析更多

AGTR1
angiotensin II receptor type 1

总数:9

Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 至该文献

为了研究缺血性心脏病病人体内ETB和AT1受体表达量上调，采用Santa Cruz的兔抗AT1抗体进行免疫组织化学实验。更多

ICAM-1 (ICAM-1)
intercellular adhesion molecule 1

总数:30

Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. 2011 至该文献

为了研究在天然杀伤细胞免疫突触处皮质肌动蛋白的重塑，采用了R&D systems的抗ICAM-1抗体进行免疫细胞化学实验。更多

CFB
complement factor B

白细胞介素2 (interleukin 2)

总数:17

CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 至该文献

为了研究肠道正常菌群如何调节免疫系统，采用了BD Pharmingen™ 抗IL-2 抗体进行了流式分析检测。更多

IL-12 (IL-12)
interleukin 12A

总数:9

Importance of stromal determinants in the generation of dendritic and natural killer cells in the human spleen. 2005 至该文献

肿瘤坏死因子甲 (TNF-alpha)
tumor necrosis factor

总数:68

UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 至该文献

为了研究UNC93B1介导的内涵体TLRs不同的运输机制，采用eBiosciences公司的抗TNFα-PE或-APC抗体进行流式细胞术试验。更多

结缔组织生长因子 (connective tissue growth factor)
cellular communication network factor 2

总数:11

c-Abl tyrosine kinase regulates cardiac growth and development. 2010 至该文献

为了研究c-Abl酪氨酸激酶在调控心脏的生长和发育中的作用，采用了Santa Cruz Biotechnologies公司的抗CTGF抗体(1:2,000)，进行了免疫印迹实验更多

eNOS
nitric oxide synthase 3

总数:36

Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 至该文献

为了研究purinergic在调控内皮细胞一氧化氮合成酶活性中的作用，采用了Upstate Laboratories公司的抗eNOS抗体产品，进行了免疫印迹实验。更多

PPARgamma
peroxisome proliferator activated receptor gamma

总数:28

De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 至该文献

为了通过基因组范围筛查的方式发现在脂肪生成过程中的PPAR Gamma和RXR的结合位点，使用了Santa Cruz Biotechnology公司的抗PPAR gamma抗体来进行免疫印迹分析和染色质免疫沉淀实验。更多

载脂蛋白A1 (apoA-I)
apolipoprotein A1

总数:13

Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. 2008 至该文献

为了在一个转基因小鼠模型中研究载脂蛋白成员的不同作用，采用 Abcam公司的兔多克隆抗apoA-I抗体产品(1:10,000)，进行了免疫印迹实验。更多

TCF7L2
transcription factor 7 like 2

总数:6

Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. 2008 至该文献

为了研究bis[2-(acylamino)phenyl] disulfide诱导的生长抑制的作用机制，采用了Upstate Biotechnology公司的TCF-4抗体进行免疫共沉淀实验及蛋白免疫印迹实验。更多