溃疡性结肠炎
基因
试剂
文献样例
产品评述样例
NOD2
nucleotide-binding oligomerization domain containing 2
总数:2
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. 2006 至该文献
ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
interleukin 23 receptor
总数:2
Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. 2009 至该文献
为了表明白介素23在由肠炎沙门菌亚型Typhimurium引发的肠炎反应中起着重要的作用，采用了R&D Systems公司的生物素标记的抗白介素23受体的多抗, 用来进行流式细胞分析。 更多
OCTN2
solute carrier family 22 (organic cation/carnitine transporter), member 5
总数:1
Organic cation/carnitine transporter, OCTN2, is differentially expressed in the adult rat epididymis. 2002 至该文献
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
DLG5
discs, large homolog 5 (Drosophila)
总数:1
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. 2009 至该文献
为了研究Sds22在调控表皮细胞的极性和形态中的作用，采用了Developmental Studies Hybridoma Bank公司的鼠抗Dlg抗体产品(1:100)，进行了免疫荧光实验。
NKX2-3
NK2 homeobox 3
CCNY
cyclin Y
HERC2
hect domain and RLD 2
BTNL2
butyrophilin-like 2 (MHC class II associated)
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
总数:3
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. 2010 至该文献
为了研究吐根信号对哺乳动物器官大小的调控作用，使用了Cell Signaling公司的Mst1抗体，进行了免疫印迹实验。 更多
ECM1
extracellular matrix protein 1
总数:1
The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. 2002 至该文献
ATP结合转运蛋白B超家族成员1 (ABCB1)
ATP-binding cassette, sub-family B (MDR/TAP), member 1
总数:13
Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. 2008 至该文献
为了研究MDR1运输能力的动态调节机制，在免疫印迹试验中使用了Calbiochem的鼠抗MDR1单抗。 更多
NOD1
nucleotide-binding oligomerization domain containing 1
MYO9B
myosin IXB
总数:1
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. 2005 至该文献
HLA-DR
major histocompatibility complex, class II, DR alpha
总数:18
Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. 2009 至该文献
为了证明维生素D调节了与多发性硬化症相关的主要组织相关性复合体II类基因HLA-DRB1*1501的表达,免疫细胞化学技术中使用了Sigma的异硫氰酸荧光素标记的单克隆抗体HLA-DR来标记细胞。 更多
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
总数:2
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. 2008 至该文献
IL 22
interleukin 22
总数:3
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. 2009 至该文献
为证实淋巴组织诱导物类似细胞可以产生白介素17和白介素22，使用了Antigenix America 公司的IL-22的ELISA试剂盒来进行ELISA分析。 更多
TNF-alpha
tumor necrosis factor
总数:151
TNF-alpha Regulates the Effects of Irradiation in the Mouse Bone Marrow Microenvironment. 2010 至该文献
为了研究TNF-a在射线诱导的骨髓细胞凋亡和骨髓功能障碍中的功能,使用了BD R&D Systems公司的抗鼠TNF-a抗体来阻断细胞的TNF-a通路的激活。 更多
MICB
MHC class I polypeptide-related sequence B
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
CTLA 4
cytotoxic T-lymphocyte-associated protein 4
总数:7
Follicular helper T cells are required for systemic autoimmunity. 2009 至该文献
为了研究滤泡辅助性T细胞的阳性筛选异常对系统性自身免疫的影响，使用了BD BioSciences公司的PE标记的抗CTLA-4抗体来进行流式细胞分析。 更多
IL 17F
interleukin 17F
PTPN2
protein tyrosine phosphatase, non-receptor type 2
总数:3
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 至该文献
为了研究MDA5 和PTPN2在调节胰岛beta细胞对病毒双链RNA副产物的反应中的作用，采用了Thermo Scientific公司的ON-TARGETplus rat PTPN2 SMARTpool产品，进行了RNA干扰实验。 更多
TPMT
thiopurine S-methyltransferase
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
总数:4
Indoleamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells. 2004 至该文献
Toll样受体4 (TLR4)
toll-like receptor 4
总数:33
Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation. 2009 至该文献
为了研究乳酸诱导胰岛素耐受性的机制，采用了Santa Cruz Biotechnology的TLR4抗体进行免疫印迹分析。 更多
CD14
CD14 molecule
总数:70
PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans. 2010 至该文献
为了研究PPARgamm在调控dectin-1的表达和宿主抗真菌防御中的作用，采用了BD PharMingen公司的抗CD14抗体产品，进行了流式细胞分析实验。 更多
eotaxin
chemokine (C-C motif) ligand 11
总数:6
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. 2008 至该文献
使用R&D系统的重组鼠CCL11计算标准曲线来研究继发RSV感染时gamma干扰素的好处和坏处。 更多
白细胞介素10 (IL-10)
interleukin 10
总数:49
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. 2010 至该文献
为了研究鼠的cDCs在肝局部缺血/再灌注损伤中的作用，使用了BD Biosciences公司的抗IL-10抗体，进行了流式细胞分析实验。 更多
Mediterranean fever
IL 21
interleukin 21
总数:7
Follicular helper T cells are required for systemic autoimmunity. 2009 至该文献
为了研究滤泡辅助性T细胞的阳性筛选异常对系统性自身免疫的影响，使用了R&D Systems公司的羊抗小鼠IL-21抗体来进行酶联免疫吸附试验。 更多
白细胞介素2 (interleukin 2)
总数:36
Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses. 2009 至该文献
为确定二肽基肽酶IV在免疫系统的作用，用R&D Systems提供的IL2酶联免疫吸附测定试剂盒来检测IL2的含量。 更多
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
总数:16
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. 2009 至该文献
为研究γ干扰素诱导的TLR表达增加和功能增强在疟疾发热期天然免疫应答反应中发挥的角色，用R&D Systems提供的针对IL12p40的酶联免疫吸附试验试剂盒来检测IL12p40含量。 更多
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
总数:1
Disruption of the Nramp1 (also known as Slc11a1) gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver. 2002 至该文献
TIMP-1
TIMP metallopeptidase inhibitor 1
总数:17
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，在免疫印迹试验中使用了Santa Cruz Biotechnology的抗TIMP-1抗体作为第一抗体。 更多
ICAM-1
intercellular adhesion molecule 1
总数:45
Elevated serum macrophage migration inhibitory factor (MIF) concentrations in chronic kidney disease (CKD) are associated with markers of oxidative stress and endothelial activation. 2009 至该文献
为证实巨噬细胞游走抑制因子对慢性肾脏病细胞的氧化应激和内皮活化所起的重要作用，使用了伯乐公司的sICAM-1检验试剂盒来检测sICAM-1。 更多
T bet
T-box 21
总数:3
Follicular helper T cells are required for systemic autoimmunity. 2009 至该文献
为了研究滤泡辅助性T细胞的阳性筛选异常对系统性自身免疫的影响，使用了BD BioSciences公司的PerCP Cy5.5标记的抗Tbet抗体来进行流式细胞分析。 更多
MMP-1
matrix metallopeptidase 1 (interstitial collagenase)
总数:19
Matrix metalloproteinase-1 promotes muscle cell migration and differentiation. 2009 至该文献
为了研究MMP-1对肌细胞迁移和分化的促进作用，使用了Sigma的MMP-1来处理C2C12细胞。 更多
IFN-gamma
interferon, gamma
总数:118
A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection. 2009 至该文献
为了研究IL-17在调控李斯特菌感染中的作用，采用了 BD PharMingen 公司的抗IFNG 抗体产品，进行了流式细胞分析实验。 更多
白细胞介素1beta (IL-1beta)
interleukin 1, beta
总数:66
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. 2009 至该文献
为研究γ干扰素诱导的TLR表达增加和功能增强在疟疾发热期天然免疫应答反应中发挥的角色，用R&D Systems提供的针对IL-1β的酶联免疫吸附试验试剂盒来检测IL-1β含量。 更多
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Toll样受体2 (TLR2)
toll-like receptor 2
总数:18
PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans. 2010 至该文献
为了研究PPARgamm在调控dectin-1的表达和宿主抗真菌防御中的作用，采用了Serotec公司的抗TLR2抗体产品，进行了流式细胞分析实验。 更多
iNOS
nitric oxide synthase 2, inducible
总数:57
Nitric oxide synthase isoforms play distinct roles during acute peritonitis. 2010 至该文献
为了研究一氧化氮合成酶亚型在调节急性腹膜炎作用，采用了Transduction laboratories公司的单克隆抗iNOS抗体产品，进行了免疫印迹实验。 更多
白细胞介素18 (IL-18)
interleukin 18 (interferon-gamma-inducing factor)
总数:10
Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice. 2009 至该文献
为了证实PEDF有抗炎效应，使用了Millipore公司的抗IL-18抗体来进行蛋白印迹分析。 更多
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
总数:126
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 至该文献
为了研究mTOR通路对Notch信号通路和细胞分化的调节作用，使用了Cell Signaling Technology公司的抗STAT3和磷酸化STAT3抗体来进行免疫印迹分析。 更多
HO-1
heme oxygenase (decycling) 1
总数:20
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. 2008 至该文献
Stressgen公司的抗HO-1抗体(SPA-896)进行免疫印迹实验来研究HO-1在Treg介导的抑制中的作用。 更多
MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
总数:21
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. 2003 至该文献
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
总数:106
Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways. 2009 至该文献
为了研究痘苗病毒双链RNA结合蛋白E3抑制细胞因子表达的机制，使用了Epitomics公司的抗NF-kB p50抗体来进行免疫印记分析。 更多
白细胞介素8 (IL-8)
interleukin 8
总数:56
Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. 2009 至该文献
为了研究已故捐献者DD)和活人捐献者(LD)肝脏移植在分子水平上的显著差异，采用了Epitomics公司的IL-8抗体，进行了免疫组织化学实验。 更多
PPARgamma
peroxisome proliferator-activated receptor gamma
总数:41
Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer. 2008 至该文献
为了研究对自诱导铜绿假单胞菌表达为炎症反应的细胞中的氧化物酶体增殖物激活受体的作用，在免疫印迹试验中使用了Cell Signaling的抗PPARγ抗体。 更多
TGF-beta1
transforming growth factor, beta 1
总数:58
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. 2009 至该文献
在T细胞发育调节过程中，为了阐明全反式维甲酸对TGF-β-诱导调节的Foxp3和Il10基因的截然相反的作用，采用了R&D Systems的人重组TGF-β1 进行流式细胞试验。 更多
TNFR1
tumor necrosis factor receptor superfamily, member 1A
总数:26
Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression. 2005 至该文献
MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
总数:10
Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer. 2009 至该文献
使用R&D系统重组人MIF进行免疫印迹实验来研究非小细胞肺癌人体标本中是否CD74的表达与血管活性和CXC趋化因子的表达水平有相关性。 更多
Janus激酶2 (Jak2)
Janus kinase 2
总数:37
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. 2010 至该文献
为了说明TC-PTP作为一种炎性细胞因子信号的调控因子能够在肠炎中涉及到，使用了Cell Signaling Technology公司的Jak2和磷酸化Jak2多克隆抗体进行蛋白印迹实验。 更多
白细胞介素17 (IL-17)
interleukin 17A
总数:30
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. 2009 至该文献
为了研究CD161+的功能，它能够被IL-23激活，介导破坏性组织的炎症反应，采用了R&D Systems的抗白介素17A进行中和实验。 更多
p16
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
总数:64
Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. 2010 至该文献
为了研究胰脏β细胞中Sei1的作用及其与核心细胞分裂周期调节因子之间的关系，使用了Santa Cruz公司 p19Arf 抗体，进行了免疫印迹和免疫沉淀实验。 更多
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
白细胞介素6 (IL-6)
interleukin 6 (interferon, beta 2)
总数:101
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. 2010 至该文献
为了研究鼠的cDCs在肝局部缺血/再灌注损伤中的作用，使用了BD Biosciences公司的抗IL-6抗体，进行了流式细胞计量实验。 更多
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
总数:58
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2010 至该文献
为了研究mPGES-1在调控肿瘤生长、侵润和转移中的作用，采用了Santa Cruz Biotechnology公司的抗COX-2抗体产品，进行了免疫印迹实验。 更多
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
总数:1
Regulation of human methylenetetrahydrofolate reductase by phosphorylation. 2005 至该文献