产品简要
公司名称 :
ACROBiosystems
产品类型 :
蛋白
产品名称 :
人类Her2/v-erb-b2成红细胞白血病病毒致瘤基因2蛋白, Fc标签
目录 :
HE2-H5253
规格 :
100微克, 1毫克
价格 :
308美元, 1980美元
更多信息或购买 :
ACROBiosystems 产品网页
产品信息
公司名称 :
ACROBiosystems
产品类型 :
蛋白
目录 :
HE2-H5253
产品名称 :
人类Her2/v-erb-b2成红细胞白血病病毒致瘤基因2蛋白, Fc标签
规格 :
100微克, 1毫克
价格 :
308美元, 1980美元
规格&价格 :
$308/100ug,$1980/1mg (250ug × 4)
靶标 :
Her2
宿主物种 :
人类
By Tag :
Fc标签
研究 :
For Research Use Only
来源 :
Human Her2, Fc Tag (HE2-H5253) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # P04626-1).
内毒素 :
Less than 1.0 EU per μg by the LAL method.
纯度 :
>95% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human Her2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
配方 :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. The formulation may be subject to change. Please contact us if you need to confirm the exact formulation of the current lot
重组 :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
储存 :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
背景 :
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
参考文献 :
(1) Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067. (2) Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201. (3) Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37. (4) Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266. (5) Hellyer, N.J. et. al., 2001, J. Biol. Chem. 276:42153. (6) Daly, R.J., 1999, Growth Factors 16:255.
更多信息或购买 :
ACROBiosystems 产品网页
公司信息
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
order@acrobiosystems.com
http://www.acrobiosystems.com
1-800-810-0816
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics, vaccines and diagnostic kits.

Our team has worked tirelessly since the genomic sequence of SARS-CoV-2 was first published, developing a serial of critical reagents to fight COVID-19. Our team has successfully developed a new neutralizing antibody titer serologic assay kit for COVID-19 vaccine evaluation (Cat.No.TAS-K022) which really showed excellent performance.

As the emerging variants may have impacted on the development of the COVID-19 epidemic, our team is also going full steam ahead on developing a collection of spike mutants for the emerging variants of SARS-COV-2. The reagents can be used to evaluate the efficacy of the antibodies and vaccination.

We have also developed an extensive collection of recombinant proteins to support the development for bispecific antibodies, antibody drug conjugates and cell therapies.