产品简要
公司名称 :
ACROBiosystems
产品类型 :
蛋白
产品名称 :
Biotinylated Human VEGF R2 / KDR Protein, Avitag™,His Tag
目录 :
激酶插入区受体-H82E5
规格 :
200微克, 25微克
价格 :
1380美元, 350美元
更多信息或购买 :
ACROBiosystems 产品网页
产品信息
公司名称 :
ACROBiosystems
产品类型 :
蛋白
目录 :
激酶插入区受体-H82E5
产品名称 :
Biotinylated Human VEGF R2 / KDR Protein, Avitag™,His Tag
规格 :
200微克, 25微克
价格 :
1380美元, 350美元
规格&价格 :
$350/25微克, $1380/200微克
靶标 :
血管内皮生长因子R2
宿主物种 :
人类
By Tag :
His Tag & Avi Tag
研究 :
For Research Use Only
来源 :
Biotinylated Human VEGF R2, Avitag,His Tag (KDR-H82E5) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 764 (Accession # AAI31823).
内毒素 :
Less than 1.0 EU per μg by the LAL method.
纯度 :
>95% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Biotinylated Human VEGF R2, Avitag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
配方 :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
重组 :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
储存 :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
背景 :
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
参考文献 :
(1) Holmes K,et al., 2007, Cell Signal. 19 (10): 2003–2012. (2) Stuttfeld E, et al., 2009, IUBMB Life 61 (9): 915–22. (3) Fujita, N, et al., 2008, Biochemical and biophysical research communications 372 (2): 367–372.
更多信息或购买 :
ACROBiosystems 产品网页
公司信息
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
order@acrobiosystems.com
http://www.acrobiosystems.com
1-800-810-0816
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics, vaccines and diagnostic kits.

Our team has worked tirelessly since the genomic sequence of SARS-CoV-2 was first published, developing a serial of critical reagents to fight COVID-19. Our team has successfully developed a new neutralizing antibody titer serologic assay kit for COVID-19 vaccine evaluation (Cat.No.TAS-K022) which really showed excellent performance.

As the emerging variants may have impacted on the development of the COVID-19 epidemic, our team is also going full steam ahead on developing a collection of spike mutants for the emerging variants of SARS-COV-2. The reagents can be used to evaluate the efficacy of the antibodies and vaccination.

We have also developed an extensive collection of recombinant proteins to support the development for bispecific antibodies, antibody drug conjugates and cell therapies.