蛋白

人类丝氨酸蛋白酶抑制剂A8/AGT蛋白, 多聚组氨酸标签

SE8-H5227

50微克, 1毫克

310美元, 1800美元

蛋白

SE8-H5227

人类丝氨酸蛋白酶抑制剂A8/AGT蛋白, 多聚组氨酸标签

50微克, 1毫克

310美元, 1800美元

$310/50ug,$1800/1mg (250ug × 4)

丝氨酸蛋白酶抑制剂A8

人类

多组氨酸标签

For Research Use Only

Human Serpin A8, His Tag (SE8-H5227) is expressed from human 293 cells (HEK293). It contains AA Asp 34 - Ala 485 (Accession # NP_000020.1).

Less than 1.0 EU per μg by the LAL method.

>98% as determined by SDS-PAGE.

Human Serpin A8, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.

Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.

Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an α-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).

(1) Goodfriend T.L., et al., 1975, Circ. Res. 36:38-48. (2) Weir M.R., et al., 1999, Am. J. Hypertens. 12:205S-213S. (3) Jankowski V., 2007, Arterioscler. Thromb. Vasc. Biol. 27:297-302. (4) Fyhrquist F., 2008, J. Intern. Med. 264:224-236.