蛋白

ActiveMax® Human TGF-Beta 1 / TGFB1 Protein, Tag Free

TG1-H4212

50微克, 1毫克

599美元, 3090美元

蛋白

TG1-H4212

ActiveMax® Human TGF-Beta 1 / TGFB1 Protein, Tag Free

50微克, 1毫克

599美元, 3090美元

$599/50ug,$3090/1mg (500ug × 2)

TGF乙1

人类

Tag Free

For Research Use Only

ActiveMax® Human TGFB1, Tag Free (TG1-H4212) is expressed from human 293 cells (HEK293). It contains AA Ala 279 - Ser 390 (Accession # P01137-1).

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

ActiveMax® Human TGFB1, Tag Free on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Lyophilized from 0.22 μm filtered solution in 0.085% TFA in 30% ACN. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. This product does not contains polyhis tag, but there exists extremely low level of polyhis tag which might interfere with your assay when using together with anti-his tag secondary antibody.

Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 12 months under sterile conditions after reconstitution.

Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

(1) Ghadami M, et al., 2000, Am. J. Hum. Genet. 66 (1): 143–7. (2) Assoian R, et al., 1983, J Biol Chem , 258 (11): 7155–60. (3) Derynck R, et al., 1985, Nature 316 (6030): 701–5. (4) Letterio J, Roberts A, 1998, Annu Rev Immunol 16: 137–61.