RAS抗体 | ATGen ATGA0350 产品信息

产品简要

公司名称 :

ATGen

产品类型 :

抗体

产品名称 :

RAS抗体

ATGA0350

规格 :

100微升/50微升

价格 :

290/170美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

nonconjugated

克隆名称 :

AT2F8

反应物种 :

人类

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学

更多信息或购买 :

ATGen 产品网页

产品信息

目录代码 :

ATGA0350

产品名称 :

RAS抗体

产品类型 :

一抗

标价 :

290/170美元

克隆性 :

单克隆

宿主名称 :

小鼠

克隆 :

AT2F8

共轭标签 :

未共轭

抗体亚型 :

小鼠IgG2b, k

产品描述 :

All RAS protein family members belong to a class of protein called small GTPase, and are involved cellular signal transduction. RAS is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in RAS genes can lead to the production of permanently activated RAS proteins. This can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive RAS signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, NRas) are the most common oncogenes in human cancer; mutations that permanently activate RAS are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer. RAS inhibitors are being studied as a treatment for cancer, and other diseases with RAS overexpression.

交叉活性 :

人类

物种摘要 :

人类

背景 :

未共轭

免疫原 :

重组人类KRAS(1-186aa)纯化来自大肠杆菌

纯度 :

By protein-A affinity chromatography

包装 :

Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.

包装尺寸 :

100微升/50微升

浓度 :

1毫克/毫升

用途 :

The antibody has been tested by ELISA, Western blot analysis, ICC/IF and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

应用摘要 :

酶联免疫吸附测定, 免疫印迹, 免疫细胞化学/IF

储存 :

可以储存在+4C。为长期储存, 分成小份儿保存在-20C。避免反复冻融

一般参考 :

McGrath JP., et al. (1983) Nature. 304(5926): 501-506.; Schubbert S., et al. (2006) Nat Genet. 38(3): 331-336.

更多信息或购买 :

ATGen 产品网页

公司信息