蛋白

v-erb-b2成红细胞白血病病毒致瘤基因2, 23-652aa, 人类, 多聚组氨酸标签, 杆状病毒

ATGP3586

50微克/10微克

960/240美元

v-erb-b2成红细胞白血病病毒致瘤基因2, 23-652aa, 人类, 多聚组氨酸标签, 杆状病毒

蛋白

960/240美元

ERBB2, also known as receptor tyrosine-protein kinase erbB-2 isoform, belongs to the epidermal growth factor (EGF) receptor family. It is an oncogene encoding a type 1 tyrosine kinase growth factor receptor. Its overexpression is associated with reduced disease free and overall survival. It is a predictor factor for poor response to chemotherapy and plays a key role in development, cell proliferation and differentiation. It is permanently coupled to phospholipase C gamma and involves tyrosine phosphorylation and activation of PLC gamma. It reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs. It results in cellular transformation and is associated with a variety of malignancy and breast, prostate, ovarian, lung cancers. Recombinant human ERBB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

人类

Receptor tyrosine-protein kinase erbB-2 isoform, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1

> 85% by SDS - PAGE

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.

50微克/10微克

0.25毫克/毫升(由布拉德福德Bradford检测确定)

可以储存在+4C短期(1-2周)。 为长期储存, 分成小份儿保存在-20C或-70C。 避免反复冻融

Hammam O., et al. (2014) J Egypt Soc Parasitol. 44:719-731.; Zavalishina LE., et al. (2014) Arkh Patol. 76:22-27.

NP_004439

< 1.0 EU per 1 microgram of protein (determined by LAL method)