产品简要
公司名称 :
Abbexa
产品类型 :
抗体
产品名称 :
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody
目录 :
abx010442
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
酶联免疫吸附测定, 免疫组化
更多信息或购买 :
产品信息
目录代码 :
abx010442
靶标 :
Serine/threonine-Protein Kinase B-Raf (BRAF)
产品名称 :
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody
简称 :
BRAF
Long Name :
Serine/threonine-Protein Kinase B-Raf
类别 :
一抗
宿主 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
抗体亚型 :
IgG1
规格1 :
100微升
产品描述 :
B-Raf is a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
UniProt Primary AC :
P15056
UniProt数据库进入名 :
BRAF_HUMAN
基因符号 :
BRAF
OMIM :
114500
HGNC :
1097
KEGG :
hsa:673
Ensembl :
ENSG00000157764
String :
9606.ENSP00000288602
纯化 :
Unpurified ascites.
缓冲液 :
腹水含0.03% 叠氮化钠
浓度 :
未确定
检测过的应用 :
酶联免疫吸附测定, 免疫组化
储存 :
分成小份儿保存在-20°C。 避免反复冻融
形式 :
液体
UNSPSC编码 :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
更多信息或购买 :
公司信息
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com44 (0)1223 75595
1 832 327 7413
1 832 327 7413
公司总部: 英国
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.