抗体

Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody

abx012006

100微升

单克隆

小鼠

未共轭

酶联免疫吸附测定, 免疫组化

Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)

Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody

v-erb-b2成红细胞白血病病毒致瘤基因2

Receptor Tyrosine-Protein Kinase ErbB-2

一抗

小鼠

单克隆

未共轭

IgG1, IgG2b

100微升

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

P04626

ERBB2_HUMAN

v-erb-b2成红细胞白血病病毒致瘤基因2

137800

3430

hsa:2064

ENSG00000141736

9606.ENSP00000269571

Unpurified ascites.

腹水含0.03% 叠氮化钠

未确定

酶联免疫吸附测定, 免疫组化

分成小份儿保存在-20°C。 避免反复冻融

液体

12352203

Shipped within 5-10 working days.

No