抗体

Sonic Hedgehog Protein (SHH) Antibody

abx015984

100微升

单克隆

小鼠

未共轭

人类, 小鼠, 猕猴

免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪

Sonic Hedgehog Protein (SHH)

Sonic Hedgehog Protein (SHH) Antibody

SHH

Sonic Hedgehog Protein

一抗

小鼠

单克隆

未共轭

IgG1

100微升

This gene encodes a protein that is instrumental in patterning the early embryo.It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites.Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar.The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing.More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres.HPE is manifested by facial deformities.It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Purified from ascites by Protein G chromatography.

PBS, 含0.05% 叠氮化钠

1毫克/毫升

酶联免疫吸附测定, 免疫印迹, 免疫组化, FCM

分成小份儿保存在-20°C。 避免反复冻融

液体

12352203

Shipped within 5-10 working days.

No