产品简要
公司名称 :
Abbexa
产品类型 :
抗体
产品名称 :
Cellular Tumor Antigen P53 (TP53) Antibody
目录 :
abx034998
规格 :
80微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
Abbexa 产品网页
产品信息
目录代码 :
abx034998
靶标 :
Cellular Tumor Antigen P53 (TP53)
产品名称 :
Cellular Tumor Antigen P53 (TP53) Antibody
简称 :
TP53
Long Name :
Cellular Tumor Antigen P53
类别 :
一抗
宿主 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
抗体亚型 :
IgG1 Kappa
规格1 :
80微升
规格2 :
400微升
产品描述 :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
UniProt Primary AC :
P04637
UniProt数据库进入名 :
P53_HUMAN
NCBI登录号 :
NP_000537.3, NP_001119584.1, NP_001119585.1, NP_001119586.1, NP_001119587.1, NP_001119588.1, NP_001119589.1, NP_001119590.1, NP_001263624.1, NP_001263625.1, NP_001263626.1, NP_001263627.1, NP_001263628.1, NP_00126
KEGG :
hsa:7157
String :
9606.ENSP00000269305
纯化 :
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
缓冲液 :
PBS含0.09% 叠氮化钠
检测过的应用 :
酶联免疫吸附测定, 免疫印迹
储存 :
分成小份儿保存在-20°C。 避免反复冻融
形式 :
液体
UNSPSC编码 :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
更多信息或购买 :
Abbexa 产品网页
公司信息
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
公司总部: 英国
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.