产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗哺乳动物雷帕霉素靶蛋白(磷酸化S2448)抗体[EPR426(2)]
目录 :
Ab109268
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
EPR426(2)
反应物种 :
人类, 小鼠, 大鼠, , domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
文章摘录数: 53
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 1a
Liao M, Hu F, Qiu Z, Li J, Huang C, Xu Y, et al. Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis. Aging (Albany NY). 2021;13:22412-22431 pubmed 出版商
  • 免疫印迹; 人类; 图 6k
Shijie L, Zhen P, Kang Q, Hua G, Qingcheng Y, Dongdong C. Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways. Clin Transl Med. 2021;11:e377 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 7a
Xiao J, Tu B, Zhou X, Jiang X, Xu G, Zhang J, et al. Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2021;19:162 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4f, 6d
Li X, Huang K, Liu X, Ruan H, Ma L, Liang J, et al. Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway. Front Pharmacol. 2021;12:639574 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 9c
  • 免疫印迹; 小鼠; 1:1000; 图 9a
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, et al. Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development. Front Pharmacol. 2021;12:659597 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Delp J, Cediel Ulloa A, Suciu I, Kranaster P, van Vugt Lussenburg B, Munic Kos V, et al. Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021;95:591-615 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Li H, Xu W, Xia Z, Liu W, Pan G, Ding J, et al. Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling. Aging (Albany NY). 2021;13:4522-4551 pubmed 出版商
  • 免疫印迹; domestic rabbit; 1:10,000; 图 8c, 8d
Wang Y, Gao G, Wu Y, Wang Y, Wu X, Zhou Q. S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway. Invest Ophthalmol Vis Sci. 2020;61:19 pubmed 出版商
  • 免疫印迹; 人类; 1:20,000; 图 4a
Cui P, Jing P, Liu X, Xu W. Prognostic Significance of PD-L1 Expression and Its Tumor-Intrinsic Functions in Hypopharyngeal Squamous Cell Carcinoma. Cancer Manag Res. 2020;12:5893-5902 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Liu W, Yang L, Liu Y, Yuan D, Zhao Z, Wang Q, et al. Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice. Biosci Rep. 2020;40: pubmed 出版商
  • 免疫印迹; 人类; 图 4d, 5a
Yin Y, Wang X, Li T, Ren Q, Li L, Sun X, et al. MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling. Cancer Med. 2020;9:1544-1552 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2g
Liu C, Wang X, Zhang Y. The Roles of HK2 on Tumorigenesis of Cervical Cancer. Technol Cancer Res Treat. 2019;18:1533033819871306 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 4a
  • 免疫印迹; 小鼠; 1:100; 图 4c
Wang X, Han Y, Liu J, Zhang Y, Cheng K, Guo J, et al. Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway. Mediators Inflamm. 2019;2019:4312016 pubmed 出版商
  • 免疫印迹; 牛; 图 2c
Guo Z, Zhao K, Feng X, Yan D, Yao R, Chen Y, et al. mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. Biomed Res Int. 2019;2019:5196028 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Tang K, Tang H, Du Y, Tian T, Xiong S. PAR-2 promotes cell proliferation, migration and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma. Biosci Rep. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1f
Zhong H, Wu H, Bai H, Wang M, Wen J, Gong J, et al. Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. BMC Complement Altern Med. 2019;19:122 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Cai Y, Xue F, Qin H, Chen X, Liu N, Fleming C, et al. Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell Rep. 2019;27:3034-3048.e5 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 4a
  • 免疫印迹; 人类; 1:1000; 图 5a
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Fei J, Sun Y, Duan Y, Xia J, Yu S, Ouyang P, et al. Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway. Biosci Rep. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Zhao J, Sun H, Zhang J, Wang M, Du X, Zhang J. Long non-coding RNA ANRIL down-regulates microRNA-7 to protect human trabecular meshwork cells in an experimental model for glaucoma. Eur Rev Med Pharmacol Sci. 2019;23:3173-3182 pubmed 出版商
  • 免疫印迹; 人类; 1:30,000; 图 6d
Liu X, Zhao P, Wang X, Wang L, Zhu Y, Song Y, et al. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. J Exp Clin Cancer Res. 2019;38:184 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5e
Guo Y, Pei X. Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling. Evid Based Complement Alternat Med. 2019;2019:7517431 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5a
Fu S, Xu H, Gu M, Liu C, Wang Q, Wan X, et al. Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity. Sci Rep. 2017;7:43771 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Zhang H, Wang W, Ren L, Zhao X, Wang Z, Zhuang D, et al. The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis. Cell Physiol Biochem. 2016;40:1079-1093 pubmed
  • 免疫印迹; 大鼠; 图 4e
Sun H, Zhang M, Cheng K, Li P, Han S, Li R, et al. Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy. Oncotarget. 2016;7:76238-76249 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 3a
Wu C, Luo J. Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway. Med Sci Monit. 2016;22:3860-3867 pubmed
  • 免疫组化-冰冻切片; 小鼠; 图 7a
  • 免疫印迹; 小鼠; 图 7b
Zhang L, Justus S, Xu Y, Pluchenik T, Hsu C, Yang J, et al. Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa. Hum Mol Genet. 2016;25:4244-4255 pubmed 出版商
  • 免疫印迹; 人类; 图 s6c
Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6
Puchert M, Adams V, Linke A, Engele J. Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise. Cell Signal. 2016;28:1205-15 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 4
Gao B, Han Y, Wang L, Lin Y, Sun Z, Lu W, et al. Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells. Cell Death Dis. 2016;7:e2235 pubmed 出版商
  • 免疫印迹; 人类; 图 5H
Wiersma V, de Bruyn M, Wei Y, van Ginkel R, Hirashima M, Niki T, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11:1373-88 pubmed 出版商
  • 免疫组化; 大鼠
Nistala R, Habibi J, Aroor A, Sowers J, Hayden M, Meuth A, et al. DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat. Obesity (Silver Spring). 2014;22:2172-9 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, et al. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS ONE. 2014;9:e101526 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Peng Y, Shi Y, Ding Z, Ke A, Gu C, Hui B, et al. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells. Autophagy. 2013;9:2056-68 pubmed 出版商
Sun D, Wang Y, Wang L, Guo X. MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2. Anal Cell Pathol (Amst). 2021;2021:1328682 pubmed 出版商
Zhang J, Han L, Yu J, Li H, Li Q. miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis. Aging (Albany NY). 2021;13:10431-10449 pubmed 出版商
Rao Z, Li J, Shi B, Zeng Y, Liu Y, Sun Z, et al. Dietary Tryptophan Levels Impact Growth Performance and Intestinal Microbial Ecology in Weaned Piglets via Tryptophan Metabolites and Intestinal Antimicrobial Peptides. Animals (Basel). 2021;11: pubmed 出版商
Meng W, Meng J, Jiang H, Feng X, Wei D, Ding Q. FKBP4 Accelerates Malignant Progression of Non-Small-Cell Lung Cancer by Activating the Akt/mTOR Signaling Pathway. Anal Cell Pathol (Amst). 2020;2020:6021602 pubmed 出版商
Wei F, Wang A, Wang Q, Han W, Rong R, Wang L, et al. Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. Aging (Albany NY). 2020;12:12002-12018 pubmed 出版商
Liang Y, Zhu D, Hou L, Wang Y, Huang X, Zhou C, et al. MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. Br J Cancer. 2020;: pubmed 出版商
Liu W, Zhao Z, Liu Y, Pan H, Lin L. Weipiling ameliorates gastric precancerous lesions in Atp4a-/- mice. BMC Complement Altern Med. 2019;19:318 pubmed 出版商
Pan C, Chen C, Shih C, Wang M, Wang J, Wu C. Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta. Aging (Albany NY). 2019;11:8085-8102 pubmed 出版商
Jin J, Qiu S, Wang P, Liang X, Huang F, Wu H, et al. Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming. J Exp Clin Cancer Res. 2019;38:377 pubmed 出版商
Saucedo S, Gonzalez A, Gomez M, Contreras R, Laporte D, Sáez C, et al. Oligo-carrageenan kappa increases glucose, trehalose and TOR-P and subsequently stimulates the expression of genes involved in photosynthesis, and basal and secondary metabolisms in Eucalyptus globulus. BMC Plant Biol. 2019;19:258 pubmed 出版商
Dong S, Zhang X, Liu D. Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. Biol Open. 2019;: pubmed 出版商
Chen S, Cai F, Wang J, Yang Z, Gu C, Wang G, et al. Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling. Mol Med Rep. 2019;20:529-538 pubmed 出版商
Sun L, Jin X, Xie L, Xu G, Cui Y, Chen Z. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019;19:247 pubmed 出版商
Cioni J, Lin J, Holtermann A, Koppers M, Jakobs M, Azizi A, et al. Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons. Cell. 2019;176:56-72.e15 pubmed 出版商
Lin X, Han L, Weng J, Wang K, Chen T. Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells. Biosci Rep. 2018;38: pubmed 出版商
Wang S, Zheng Y, He Z, Zhou W, Cheng Y, Zhang C. SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade. Cancer Cell Int. 2018;18:132 pubmed 出版商
Nie X, Zheng J, Ricupero C, He L, Jiao K, Mao J. mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018;14:e1007491 pubmed 出版商
Yao C, Chow J, Lin P, Hu T, Kuo H, Huang J, et al. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evid Based Complement Alternat Med. 2016;2016:5989681 pubmed 出版商
Zhu H, Zhang Y, Chen J, Qiu J, Huang K, Wu M, et al. IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced. PLoS ONE. 2017;12:e0169038 pubmed 出版商
Fan G, Yu J, Asare P, Wang L, Zhang H, Zhang B, et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J Cell Mol Med. 2016;20:1908-19 pubmed 出版商
产品信息
目录号 :
ab109268
ItemName :
抗哺乳动物雷帕霉素靶蛋白(磷酸化S2448)抗体[EPR426(2)]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
EPR426(2)
规格 :
10微升, 100微升
物种摘要 :
Hu, Ms, Pig
应用摘要 :
Dot, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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