产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗CDKN2A/p16INK4a抗体[EPR1473]-C末端
目录 :
ab108349
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
EPR1473
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
文章摘录数: 32
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1a
Leon K, Buj R, Lesko E, Dahl E, Chen C, Tangudu N, et al. DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. J Cell Biol. 2021;220: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1e
Buj R, Leon K, Anguelov M, Aird K. Suppression of p16 alleviates the senescence-associated secretory phenotype. Aging (Albany NY). 2021;13:3290-3312 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1b
Karnan S, Ota A, Murakami H, Rahman M, Hasan M, Wahiduzzaman M, et al. Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma. Cell Death Discov. 2020;6:127 pubmed 出版商
  • 免疫印迹; 人类; 图 5d
Varela Eirin M, Carpintero Fernández P, Sánchez Temprano A, Varela Vazquez A, Paíno C, Casado Diaz A, et al. Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis. Aging (Albany NY). 2020;12:15882-15905 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Shao Q, Esseltine J, Huang T, Novielli Kuntz N, Ching J, SAMPSON J, et al. Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. Biomolecules. 2019;9: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1d
  • 免疫印迹; 人类; 1:1000; 图 1g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed 出版商
  • 免疫印迹; 人类; 图 e8o
Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, et al. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019;569:509-513 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s5c
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 6b
Liang C, Ma Y, Yong L, Yang C, Wang P, Liu X, et al. Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. Cancer Sci. 2019;110:166-179 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2f
Zhang Y, Wang J, Huang W, Cai J, Ba J, Wang Y, et al. Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nat Commun. 2018;9:3613 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2d
Laporte A, Barrott J, Yao R, Poulin N, Brodin B, Jones K, et al. HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma. PLoS ONE. 2017;12:e0169407 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1f
Lee J, Yu K, Kim H, Kang I, Kim J, Lee B, et al. BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1. Aging (Albany NY). 2016;8:1670-89 pubmed 出版商
Fafián Labora J, O Loghlen A. NF-κB/IKK activation by small extracellular vesicles within the SASP. Aging Cell. 2021;20:e13426 pubmed 出版商
Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian X, et al. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging Cell. 2021;20:e13315 pubmed 出版商
Wu J, Cheng I, Saovieng S, Jean W, Kao C, Liu Y, et al. Aerobic exercise induces tumor suppressor p16INK4a expression of endothelial progenitor cells in human skeletal muscle. Aging (Albany NY). 2020;12:20226-20234 pubmed 出版商
Coryell P, Goraya S, Griffin K, Redick M, Sisk S, Purvis J. Autophagy regulates the localization and degradation of p16INK4a. Aging Cell. 2020;19:e13171 pubmed 出版商
Wei F, Wang A, Wang Q, Han W, Rong R, Wang L, et al. Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. Aging (Albany NY). 2020;12:12002-12018 pubmed 出版商
Xie J, Lin J, Wei M, Teng Y, He Q, Yang G, et al. Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice. Bone Res. 2019;7:23 pubmed 出版商
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed 出版商
Borghesan M, Fafián Labora J, Eleftheriadou O, Carpintero Fernández P, Pàez Ribes M, Vizcay Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019;27:3956-3971.e6 pubmed 出版商
Gong C, Pan W, Hu W, Chen L. Bone morphogenetic protein-7 retards cell subculture-induced senescence of human nucleus pulposus cells through activating the PI3K/Akt pathway. Biosci Rep. 2019;39: pubmed 出版商
Varela Eirin M, Varela Vazquez A, Guitián Caamaño A, Paíno C, Mato V, Largo R, et al. Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis. 2018;9:1166 pubmed 出版商
Li Z, Liu T, Ma J, Guo Q, Ma L, Lv Q, et al. TGF-β induces corneal endothelial senescence via increase of mitochondrial reactive oxygen species in chronic corneal allograft failure. Aging (Albany NY). 2018;10:3474-3485 pubmed 出版商
Gao X, Lu A, Tang Y, Schneppendahl J, Liebowitz A, Scibetta A, et al. Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration. Stem Cell Res Ther. 2018;9:316 pubmed 出版商
Kumar B, Prasad M, Bhat Nakshatri P, Anjanappa M, Kalra M, Marino N, et al. Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade. Cancer Res. 2018;78:5107-5123 pubmed 出版商
Yang C, Jiao Y, Wei B, Yang Z, Wu J, Jensen J, et al. Aged cells in human skeletal muscle after resistance exercise. Aging (Albany NY). 2018;10:1356-1365 pubmed 出版商
Rahman T, Ullah K, Guo M, Pan H, Liu J, Ren J, et al. Androgen-induced alterations in endometrial proteins crucial in recurrent miscarriages. Oncotarget. 2018;9:24627-24641 pubmed 出版商
Lee J, Yu K, Lee B, Kang I, Kim J, Jung E, et al. GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging. Exp Mol Med. 2018;50:63 pubmed 出版商
Li X, Zhang Z, Zhang Y, Cao Y, Wei H, Wu Z. Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation. J Exp Clin Cancer Res. 2018;37:39 pubmed 出版商
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed 出版商
Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, et al. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. EMBO J. 2017;36:2280-2295 pubmed 出版商
Bellio M, Rodrigues C, Landin A, Hatzistergos K, Kuznetsov J, Florea V, et al. Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration. Am J Physiol Heart Circ Physiol. 2016;311:H1509-H1519 pubmed 出版商
产品信息
目录号 :
ab108349
ItemName :
抗CDKN2A/p16INK4a抗体[EPR1473]-C末端
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
EPR1473
规格 :
10微升, 100微升
物种摘要 :
Hu
应用摘要 :
Flow Cyt, ICC/IF, IHC-P, IP, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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