产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗胰高血糖素抗体[K79bB10]
目录 :
ab10988
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
K79bB10
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫组化, 免疫细胞化学, 流式细胞仪, 放射免疫分析法, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
文章摘录数: 62
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 s1e
Zheng H, Xu P, Jiang Q, Xu Q, Zheng Y, Yan J, et al. Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice. Microbiome. 2021;9:145 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 s2c
Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 4f
Kamm D, Pyles K, Sharpe M, Healy L, Colca J, McCommis K. Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. 2021;296:100807 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 2e
Blanchet E, Pessemesse L, Feillet Coudray C, Coudray C, Cabello C, Bertrand Gaday C, et al. p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 6f
  • 免疫组化; 小鼠; 图 6a
Zhang X, Wang X, Yuan Z, Radford S, Liu C, Libutti S, et al. Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34:108830 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 6b
Pittala S, Levy I, De S, Kumar Pandey S, Melnikov N, Hyman T, et al. The VDAC1-based R-Tf-D-LP4 Peptide as a Potential Treatment for Diabetes Mellitus. Cells. 2020;9: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 7a
Xu H, Du X, Xu J, Zhang Y, Tian Y, Liu G, et al. Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function. PLoS Biol. 2020;18:e3000603 pubmed 出版商
  • 免疫组化; 小鼠; 1:400; 图 2k, s12a
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 2c
Jang I, Pottekat A, Poothong J, Yong J, Lagunas Acosta J, Charbono A, et al. PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity. elife. 2019;8: pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 1d
Al Amily I, Dunér P, Groop L, Salehi A. The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflugers Arch. 2019;471:633-645 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1ii
Chandravanshi B, Bhonde R. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. J Cell Biochem. 2017;118:2672-2683 pubmed 出版商
  • 免疫组化; 人类; 图 2D
Muraro M, Dharmadhikari G, Grün D, Groen N, Dielen T, Jansen E, et al. A Single-Cell Transcriptome Atlas of the Human Pancreas. Cell Syst. 2016;3:385-394.e3 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 7b
Grün D, Muraro M, Boisset J, Wiebrands K, Lyubimova A, Dharmadhikari G, et al. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. 2016;19:266-277 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4c
Roth Flach R, Danai L, DiStefano M, Kelly M, Menendez L, Jurczyk A, et al. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem. 2016;291:16221-30 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:500; 图 4e
Mohan H, Gasner M, Ramesh N, Unniappan S. Ghrelin, ghrelin-O-acyl transferase, nucleobindin-2/nesfatin-1 and prohormone convertases in the pancreatic islets of Sprague Dawley rats during development. J Mol Histol. 2016;47:325-36 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5c
Shirakawa J, Okuyama T, Kyohara M, Yoshida E, Togashi Y, Tajima K, et al. DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid. Diabetol Metab Syndr. 2016;8:16 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1s
Patel A, Yamashita N, Ascano M, Bodmer D, Boehm E, Bodkin Clarke C, et al. RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome. Nat Commun. 2015;6:10119 pubmed 出版商
  • 免疫组化; 犬
Shields E, Lam C, Cox A, Rankin M, Van Winkle T, Hess R, et al. Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes. PLoS ONE. 2015;10:e0129809 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:250; 图 3
Wang L, Liang J, Leung P. The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. PLoS ONE. 2015;10:e0128216 pubmed 出版商
  • 流式细胞仪; 人类; 1:200; 图 4
Sharivkin R, Walker M, Soen Y. Functional proteomics screen enables enrichment of distinct cell types from human pancreatic islets. PLoS ONE. 2015;10:e0115100 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
  • 免疫组化-石蜡切片; 小鼠; 1:300
Novikova L, Smirnova I, Rawal S, Dotson A, Benedict S, Stehno Bittel L. Variations in rodent models of type 1 diabetes: islet morphology. J Diabetes Res. 2013;2013:965832 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200
Pérez R, Benoit Y, Gudas L. Deletion of retinoic acid receptor ? (RAR?) impairs pancreatic endocrine differentiation. Exp Cell Res. 2013;319:2196-204 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Farmer K, Williams S, Novikova L, Ramachandran K, Rawal S, Blagg B, et al. KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Exp Diabetes Res. 2012;2012:671673 pubmed 出版商
Sobel J, Guay C, Elhanani O, Rodríguez Trejo A, Stoll L, Menoud V, et al. Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation. Sci Rep. 2021;11:8800 pubmed 出版商
Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed 出版商
Han M, Perry R, Camporez J, Scherer P, Shulman G, Gao G, et al. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes Dev. 2021;35:133-146 pubmed 出版商
Zhao Q, Zhou J, Pan Y, Ju H, Zhu L, Liu Y, et al. The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body 18F-FDG PET/CT study. Acta Diabetol. 2020;57:1383-1393 pubmed 出版商
Zhu L, Zhong Q, Yang T, Xiao X. Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p. Aging (Albany NY). 2019;11:12236-12245 pubmed 出版商
Guay C, Kruit J, Rome S, Menoud V, Mulder N, Jurdzinski A, et al. Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development. Cell Metab. 2019;29:348-361.e6 pubmed 出版商
Wei S, Han R, Zhao J, Wang S, Huang M, Wang Y, et al. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutr Metab (Lond). 2018;15:80 pubmed 出版商
Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, et al. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Sci Rep. 2018;8:15374 pubmed 出版商
Ceasrine A, Lin E, Lumelsky D, Iyer R, Kuruvilla R. Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. elife. 2018;7: pubmed 出版商
Stuhlmann T, Planells Cases R, Jentsch T. LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion. Nat Commun. 2018;9:1974 pubmed 出版商
Grote C, Wilson N, Katz N, Guilford B, Ryals J, Novikova L, et al. Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels. Exp Neurol. 2018;305:97-107 pubmed 出版商
Riopel M, Seo J, Bandyopadhyay G, Li P, Wollam J, Chung H, et al. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018;128:1458-1470 pubmed 出版商
Sheets T, Park K, Park C, Swift S, Powell A, Donovan D, et al. Targeted Mutation of NGN3 Gene Disrupts Pancreatic Endocrine Cell Development in Pigs. Sci Rep. 2018;8:3582 pubmed 出版商
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, et al. Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. J Clin Invest. 2018;128:1178-1189 pubmed 出版商
Siniscalco D, Trotta M, Brigida A, Maisto R, Luongo M, Ferraraccio F, et al. Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin. Biology (Basel). 2018;7: pubmed 出版商
Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, et al. Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest. 2017;127:3835-3844 pubmed 出版商
Harrington S, Williams S, Otte V, Barchman S, Jones C, Ramachandran K, et al. Improved yield of canine islet isolation from deceased donors. BMC Vet Res. 2017;13:264 pubmed 出版商
Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed 出版商
Rodríguez Calvo T, Zapardiel Gonzalo J, Amirian N, Castillo E, Lajevardi Y, Krogvold L, et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes. 2017;66:1334-1345 pubmed 出版商
McCommis K, Hodges W, Bricker D, Wisidagama D, Compan V, Remedi M, et al. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Mol Metab. 2016;5:602-614 pubmed 出版商
Lau J, Grapengiesser E, Hellman B. Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells. J Diabetes Res. 2016;2016:4930741 pubmed 出版商
Kuroda Y, Maruyama K, Fujii H, Sugawara I, Ko S, Yasuda H, et al. Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion. PLoS ONE. 2016;11:e0146544 pubmed 出版商
Coelho P, Bury L, Shahbazi M, Liakath Ali K, Tate P, Wormald S, et al. Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biol. 2015;5:150209 pubmed 出版商
Jacovetti C, Matkovich S, Rodríguez Trejo A, Guay C, Regazzi R. Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning. Nat Commun. 2015;6:8084 pubmed 出版商
Jafarian A, Taghikani M, Abroun S, Allahverdi A, Lamei M, Lakpour N, et al. The Generation of Insulin Producing Cells from Human Mesenchymal Stem Cells by MiR-375 and Anti-MiR-9. PLoS ONE. 2015;10:e0128650 pubmed 出版商
Lelliott C, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, et al. Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. PLoS ONE. 2014;9:e112109 pubmed 出版商
Schwasinger Schmidt T, Robbins D, Williams S, Novikova L, Stehno Bittel L. Long-term liraglutide treatment is associated with increased insulin content and secretion in ?-cells, and a loss of ?-cells in ZDF rats. Pharmacol Res. 2013;76:58-66 pubmed 出版商
Farhat B, Almelkar A, Ramachandran K, Williams S, Huang H, Zamierowksi D, et al. Small human islets comprised of more β-cells with higher insulin content than large islets. Islets. 2013;5:87-94 pubmed 出版商
Muller I, Rössler O, Wittig C, Menger M, Thiel G. Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size. Endocrinology. 2012;153:3040-53 pubmed 出版商
Huang H, Farmer K, Windscheffel J, Yost K, Power M, Wright D, et al. Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice. Exp Diabetes Res. 2011;2011:481427 pubmed 出版商
Mohanasundaram D, DROGEMULLER C, Brealey J, Jessup C, Milner C, Murgia C, et al. Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in New world primate (Callithrix jacchus) and human pancreatic islets. Gen Comp Endocrinol. 2011;174:71-9 pubmed 出版商
Huang H, Novikova L, Williams S, Smirnova I, Stehno Bittel L. Low insulin content of large islet population is present in situ and in isolated islets. Islets. 2011;3:6-13 pubmed 出版商
Thatava T, Nelson T, Edukulla R, Sakuma T, Ohmine S, Tonne J, et al. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011;18:283-93 pubmed 出版商
Kakabadze Z, Gupta S, Brandhorst D, Korsgren O, Berishvili E. Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine. Transpl Int. 2011;24:175-83 pubmed 出版商
Lu J, Herrera P, Carreira C, Bonnavion R, Seigne C, Calender A, et al. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010;138:1954-65 pubmed 出版商
Shu L, Matveyenko A, Kerr Conte J, Cho J, McIntosh C, Maedler K. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet. 2009;18:2388-99 pubmed 出版商
Gonzalez R, Tiwari A, Unniappan S. Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun. 2009;381:643-8 pubmed 出版商
Peterson R, Krull D, Butler L. Applications of laser scanning cytometry in immunohistochemistry and routine histopathology. Toxicol Pathol. 2008;36:117-32 pubmed 出版商
Hanley S, Rosenberg L. Transforming growth factor beta is a critical regulator of adult human islet plasticity. Mol Endocrinol. 2007;21:1467-77 pubmed
产品信息
目录号 :
ab10988
ItemName :
抗胰高血糖素抗体[K79bB10]
产品类型 :
抗体
宿主物种 :
小鼠
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
K79bB10
规格 :
100微升
物种摘要 :
Dog, Hu, Mmst, Ms, Pig, Rat
纯度 :
Proprietary Purification
应用摘要 :
Dot, ICC/IF, IHC-Fr, IHC-P, RIA
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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