产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗丙H2A.X(磷酸化S139)抗体
目录 :
ab11174
规格 :
50微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
Dictyostelium discoideum, axolotl, 人类, 小鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 51
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 3j
  • 免疫印迹; 小鼠; 图 6c, 6d
Carroll P, Freie B, Cheng P, Kasinathan S, Gu H, Hedrich T, et al. The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PLoS Biol. 2021;19:e3001085 pubmed 出版商
  • 免疫组化; 小鼠; 图 8g
Hendley A, Rao A, Leonhardt L, Ashe S, Smith J, Giacometti S, et al. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. elife. 2021;10: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3f
Lee J, Park I, Kwak M, Rhee W, Kim S, Shin J. HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells. Cell Death Discov. 2021;7:28 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 1c
House N, Parasuram R, Layer J, Price B. Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage. PLoS ONE. 2020;15:e0237759 pubmed 出版商
  • 免疫印迹; 人类
Wang C, Chen C, Lin M, Su H, Ho M, Yeh J, et al. TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. Biology (Basel). 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 s5h
Nielsen C, Zhang T, Barisic M, Kalitsis P, Hudson D. Topoisomerase IIα is essential for maintenance of mitotic chromosome structure. Proc Natl Acad Sci U S A. 2020;117:12131-12142 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 ev4
Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto Cerrato V, et al. Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors. EMBO Mol Med. 2020;12:e11217 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s8a
Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed 出版商
  • 免疫印迹; axolotl; 1:2000; 图 1f
Sousounis K, Bryant D, Martínez Fernández J, Eddy S, Tsai S, Gundberg G, et al. Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 4f
  • 免疫细胞化学; 人类; 1:100; 图 5c
Lambo S, Gröbner S, Rausch T, Waszak S, Schmidt C, Gorthi A, et al. The molecular landscape of ETMR at diagnosis and relapse. Nature. 2019;576:274-280 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2c
  • 免疫细胞化学; 小鼠; 图 2f
Varuzhanyan G, Rojansky R, Sweredoski M, Graham R, Hess S, Ladinsky M, et al. Mitochondrial fusion is required for spermatogonial differentiation and meiosis. elife. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 6b
Tacconi E, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, et al. Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med. 2019;11:e9982 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 5a
Ogawa S, Yamada M, Nakamura A, Sugawara T, Nakamura A, Miyajima S, et al. Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis. Stem Cell Reports. 2019;12:1366-1379 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Forte I, Indovina P, Iannuzzi C, Cirillo D, Di Marzo D, Barone D, et al. Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Int J Oncol. 2019;54:2189-2199 pubmed 出版商
  • 免疫印迹; 人类
Gao R, Chakraborty A, Geater C, Pradhan S, Gordon K, Snowden J, et al. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. elife. 2019;8: pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 3b
  • 免疫印迹; 人类; 1:1000; 图 3a
McKenzie L, LeClair J, Miller K, Strong A, Chan H, Oates E, et al. CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma. Sci Rep. 2019;9:4444 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 6b
Chen Q, Kassab M, Dantzer F, Yu X. PARP2 mediates branched poly ADP-ribosylation in response to DNA damage. Nat Commun. 2018;9:3233 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6b
  • 免疫细胞化学; 小鼠; 图 6a
Majumder K, Wang J, Boftsi M, Fuller M, Rede J, Joshi T, et al. Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. elife. 2018;7: pubmed 出版商
  • 免疫印迹; Dictyostelium discoideum; 图 1a
Rakhimova A, Ura S, Hsu D, Wang H, Pears C, Lakin N. Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep. 2017;7:43750 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Pal D, Pertot A, Shirole N, Yao Z, Anaparthy N, Garvin T, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. elife. 2017;6: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 2d
Hamdan M, Jones K, Cheong Y, Lane S. The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis. Sci Rep. 2016;6:36994 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Skrdlant L, Stark J, Lin R. Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C. BMC Mol Biol. 2016;17:18 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Dmitriev P, Bou Saada Y, Dib C, Ansseau E, Barat A, Hamade A, et al. DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients. Free Radic Biol Med. 2016;99:244-258 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 2
Francia S, Cabrini M, Matti V, Oldani A, d Adda di Fagagna F. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. J Cell Sci. 2016;129:1468-76 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 3
Flynn R, Do B, Rubin A, Calo E, Lee B, Kuchelmeister H, et al. 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016;23:231-8 pubmed 出版商
Tabor N, Ngwa C, Mitteaux J, Meyer M, Moruno Manchon J, Zhu L, et al. Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization. Aging (Albany NY). 2021;13:15917-15941 pubmed 出版商
Le Gal K, Wiel C, Ibrahim M, Henricsson M, Sayin V, Bergo M. Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice. Antioxidants (Basel). 2021;10: pubmed 出版商
Dong Q, Zhou C, Ren H, Zhang Z, Cheng F, Xiong Z, et al. Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells. Cell Commun Signal. 2020;18:167 pubmed 出版商
Xu S, Wang X, Wang T, Lin Z, Hu Y, Huang Z, et al. Flavonoids from Rosaroxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo. Aging (Albany NY). 2020;12:16368-16389 pubmed 出版商
Zhang F, Bieniasz P. HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. elife. 2020;9: pubmed 出版商
Hámori L, Kudlik G, Szebényi K, Kucsma N, Szeder B, Póti A, et al. Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line. Int J Mol Sci. 2020;21: pubmed 出版商
Wang H, Zhang S, Song L, Qu M, Zou Z. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene. 2020;39:2905-2920 pubmed 出版商
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed 出版商
Dias M, Fonseca C, Zeidler J, Albuquerque L, Da Silva M, Cararo Lopes E, et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Mol Oncol. 2019;13:290-306 pubmed 出版商
Tian M, Yang S, Yan X. Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities. Braz J Med Biol Res. 2018;51:e7151 pubmed 出版商
Hatano Y, Fukuda S, Makino H, Tomita H, Morishige K, Hara A. High-grade serous carcinoma with discordant p53 signature: report of a case with new insight regarding high-grade serous carcinogenesis. Diagn Pathol. 2018;13:24 pubmed 出版商
Li X, Zhang Z, Zhang Y, Cao Y, Wei H, Wu Z. Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation. J Exp Clin Cancer Res. 2018;37:39 pubmed 出版商
Calo E, Gu B, Bowen M, Aryan F, Zalc A, Liang J, et al. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018;554:112-117 pubmed 出版商
Yang Y, Lei T, Du S, Tong R, Wang H, Yang J, et al. Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. Int J Oncol. 2018;52:709-720 pubmed 出版商
Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed 出版商
Mack J, Mosqueiro T, Archer B, Jones W, Sunshine H, Faas G, et al. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017;8:1620 pubmed 出版商
Lane S, Morgan S, Wu T, Collins J, Merriman J, Elinati E, et al. DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes. Development. 2017;144:3475-3486 pubmed 出版商
Takahashi H, Inoue J, Sakaguchi K, Takagi M, Mizutani S, Inazawa J. Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells. Oncogene. 2017;36:4267-4276 pubmed 出版商
Jangi M, Fleet C, Cullen P, Gupta S, Mekhoubad S, Chiao E, et al. SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. Proc Natl Acad Sci U S A. 2017;114:E2347-E2356 pubmed 出版商
Xiong H, Nie X, Zou Y, Gong C, Li Y, Wu H, et al. Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization. J Cancer. 2017;8:345-353 pubmed 出版商
Kotzur T, Benavides Garcia R, Mecklenburg J, Sanchez J, Reilly M, Hermann B. Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol. 2017;15:7 pubmed 出版商
Benham Pyle B, Sim J, Hart K, PRUITT B, NELSON W. Increasing ?-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. elife. 2016;5: pubmed 出版商
Detappe A, Kunjachan S, Drané P, Kotb S, Myronakis M, Biancur D, et al. Key clinical beam parameters for nanoparticle-mediated radiation dose amplification. Sci Rep. 2016;6:34040 pubmed 出版商
Gunn A, Banos Pinero B, Paschke P, Sanchez Pulido L, Ariza A, Day J, et al. The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. J Cell Sci. 2016;129:3845-3858 pubmed
Karagounis I, Kalamida D, Mitrakas A, Pouliliou S, Liousia M, Giatromanolaki A, et al. Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. Br J Cancer. 2016;115:312-21 pubmed 出版商
Soo Lee N, Jin Chung H, Kim H, Yun Lee S, Ji J, Seo Y, et al. TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Nat Commun. 2016;7:10463 pubmed 出版商
产品信息
目录号 :
ab11174
ItemName :
抗丙H2A.X(磷酸化S139)抗体
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭标签 :
Not Conjugated
抗原修饰 :
磷酸化(139S)
规格 :
50微克
物种摘要 :
Chk, D dis, Hu, Ms
用途 :
Flow Cyt, ICC, ICC/IF, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。