| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Albanese F, Mercatelli D, Finetti L, Lamonaca G, Pizzi S, Shimshek D, et al. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiol Dis. 2021;159:105487 pubmed 出版商 |
- 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 s7b
- 免疫印迹; 小鼠; 1:1000; 图 s7b
| Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed 出版商 |
- 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 s1a
- 免疫印迹; 小鼠; 1:2000; 图 s1a
| Kluss J, Conti M, Kaganovich A, Beilina A, Melrose H, Cookson M, et al. Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. NPJ Parkinsons Dis. 2018;4:13 pubmed 出版商 |
| Xiong Y, Neifert S, Karuppagounder S, Liu Q, Stankowski J, Lee B, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A. 2018;115:1635-1640 pubmed 出版商 |
| Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017;5:22 pubmed 出版商 |
- 免疫印迹基因敲除验证; 人类; 图 5b
- 免疫沉淀; 人类; 图 6e
| Yan R, Liu Z. LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. Protein Cell. 2017;8:55-66 pubmed 出版商 |
| Speidel A, Felk S, Reinhardt P, Sterneckert J, Gillardon F. Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells. PLoS ONE. 2016;11:e0165949 pubmed 出版商 |
| Smith G, Jansson J, Rocha E, Osborn T, Hallett P, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Mol Neurobiol. 2016;53:5161-77 pubmed 出版商 |
- 免疫沉淀; 人类; 图 2a
- 免疫印迹; 人类; 图 2b
| Ho D, Kim H, Kim J, Sim H, Ahn H, Kim J, et al. Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain. 2015;8:54 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:1000; 图 4
- 免疫印迹; 大鼠; 1:1000; 图 3
- 免疫印迹; 人类; 1:1000; 图 3
| Choi I, Kim B, Byun J, Baik S, Huh Y, Kim J, et al. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun. 2015;6:8255 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:3000; 图 1d
- 免疫印迹; 人类; 1:3000; 图 1c
| Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed 出版商 |
| Yun H, Kim H, Ga I, Oh H, Ho D, Kim J, et al. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J Biochem. 2015;157:485-95 pubmed 出版商 |
| Ho D, Yi S, Seo H, Son I, Seol W. Increased DJ-1 in urine exosome of Korean males with Parkinson's disease. Biomed Res Int. 2014;2014:704678 pubmed 出版商 |
- 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 7
| Law B, Spain V, Leinster V, Chia R, Beilina A, Cho H, et al. A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation. J Biol Chem. 2014;289:895-908 pubmed 出版商 |
- 免疫组化基因敲除验证; 小鼠; 图 4
- 免疫印迹基因敲除验证; 小鼠; 图 1, s2
- 免疫组化-自由浮动切片; 小鼠; 图 4
- 免疫组化基因敲除验证; 大鼠; 图 6
- 免疫组化-自由浮动切片; 大鼠; 图 6
- 免疫印迹; 人类; 图 1
| Davies P, Hinkle K, Sukar N, Sepulveda B, Mesias R, Serrano G, et al. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. Biochem J. 2013;453:101-13 pubmed 出版商 |
- 免疫组化基因敲除验证; 小鼠; 1:4000; 图 1
| Hinkle K, Yue M, Behrouz B, Dachsel J, Lincoln S, Bowles E, et al. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Mol Neurodegener. 2012;7:25 pubmed 出版商 |
| Lin C, Peng Y, Lin Y, Mersmann H, Ding S. LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells. Molecules. 2020;25: pubmed 出版商 |
| Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed 出版商 |
| Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, et al. LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy. 2019;:1-20 pubmed 出版商 |
| Bae Y, Joo H, Bae J, Hyeon S, Her S, Ko E, et al. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018;9:1125 pubmed 出版商 |
| Henderson M, Peng C, Trojanowski J, Lee V. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta Neuropathol Commun. 2018;6:45 pubmed 出版商 |
