产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗LAMP2A抗体
目录 :
ab18528
规格 :
100微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
文章摘录数: 32
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 2a, 2c, 2e
Lamprou I, Tsolou A, Kakouratos C, Mitrakas A, Xanthopoulou E, Kassela K, et al. Suppressed PLIN3 frequently occurs in prostate cancer, promoting docetaxel resistance via intensified autophagy, an event reversed by chloroquine. Med Oncol. 2021;38:116 pubmed 出版商
  • 免疫印迹; 人类; 图 2d, 5d, s3f
Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, et al. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model. Protein Cell. 2021;: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:5000; 图 s2a
Caballero B, Bourdenx M, Luengo E, Díaz A, Sohn P, Chen X, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021;12:2238 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5g
Bengoa Vergniory N, Faggiani E, Ramos Gonzalez P, Kirkiz E, Connor Robson N, Brown L, et al. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020;11:4885 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1a
Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2b
Ormeño F, Hormazabal J, Moreno J, Riquelme F, Rios J, Criollo A, et al. Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation. Front Mol Neurosci. 2020;13:19 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2a
  • 免疫印迹; 人类; 图 2c
Zhang J, He J, Johnson J, Rahman F, Gavathiotis E, Cuervo A, et al. Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Front Endocrinol (Lausanne). 2019;10:21 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 7B
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6d
Bartlett J, Trivedi P, Yeung P, Kienesberger P, Pulinilkunnil T. Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016;473:3769-3789 pubmed
  • 免疫组化-冰冻切片; 小鼠; 图 6
  • 免疫印迹; 小鼠; 图 5a
Ting W, Yang J, Kuo C, Xiao Z, Lu X, Yeh Y, et al. Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. Oncotarget. 2016;7:39017-39025 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 5
Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2
Li W, Zou J, Yue F, Song K, Chen Q, McKeehan W, et al. Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell. 2016;15:370-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s5
Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent M, Molkentin J. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet. 2016;25:1192-202 pubmed 出版商
Saini H, Sharma H, Mukherjee S, Chowdhury S, Chowdhury R. Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells. Cancer Cell Int. 2021;21:52 pubmed 出版商
Aivazidis S, Jain A, Rauniyar A, Anderson C, Marentette J, Orlicky D, et al. SNARE proteins rescue impaired autophagic flux in Down syndrome. PLoS ONE. 2019;14:e0223254 pubmed 出版商
Schott M, Weller S, Schulze R, Krueger E, Drizyte Miller K, Casey C, et al. Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol. 2019;218:3320-3335 pubmed 出版商
Wang C, Arrington J, Ratliff A, Chen J, Horton H, Nie Y, et al. Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice. J Biol Chem. 2019;294:13718-13728 pubmed 出版商
Sun L, Lian Y, Ding J, Meng Y, Li C, Chen L, et al. The role of chaperone-mediated autophagy in neurotoxicity induced by alpha-synuclein after methamphetamine exposure. Brain Behav. 2019;9:e01352 pubmed 出版商
Wu J, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath N, et al. Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. Transl Neurodegener. 2019;8:18 pubmed 出版商
Ho P, Leung C, Liu H, Pang S, Lam C, Xian J, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019;:1-24 pubmed 出版商
Wu Y, Zhang J, Fang L, Lee H, Zhao Y. A cytosolic chaperone complex controls folding and degradation of type III CD38. J Biol Chem. 2019;294:4247-4258 pubmed 出版商
Saito T, Nah J, Oka S, Mukai R, Monden Y, Maejima Y, et al. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019;129:802-819 pubmed 出版商
Wang C, Wang H, Zhang D, Luo W, Liu R, Xu D, et al. Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy. Nat Commun. 2018;9:3492 pubmed 出版商
Le Y, Zhang S, Ni J, You Y, Luo K, Yu Y, et al. Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer. Cell Death Dis. 2018;9:666 pubmed 出版商
Luan Y, Ren X, Zheng W, Zeng Z, Guo Y, Hou Z, et al. Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum. Front Neurosci. 2018;12:301 pubmed 出版商
Hallett P, Huebecker M, Brekk O, Moloney E, Rocha E, Priestman D, et al. Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiol Aging. 2018;67:189-200 pubmed 出版商
Matsui C, Deng L, Minami N, Abe T, Koike K, Shoji I. Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy. J Virol. 2018;92: pubmed 出版商
Zhang J, Johnson J, He J, Napolitano G, Ramadass M, Rocca C, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017;292:10328-10346 pubmed 出版商
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, et al. Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. Cancer Res. 2017;77:2938-2951 pubmed 出版商
Zhang S, Eitan E, Mattson M. Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal. J Neurochem. 2017;140:941-954 pubmed 出版商
产品信息
目录号 :
ab18528
ItemName :
抗LAMP2A抗体
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭标签 :
Not Conjugated
抗原修饰 :
No Modifications
规格 :
100微克
物种摘要 :
ChHm, Hu, Mk, Ms
用途 :
Flow Cyt, ICC/IF, IHC-P, WB
规格说明 :
Other sizes available: 100 µl,200 µl
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。