出版应用/物种/样本/稀释 | 参考文献 |
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- 免疫印迹; 大鼠; 1:2000; 图 6a, 6e, 6i
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| Nguyen A, Tsika E, Kelly K, Levine N, Chen X, West A, et al. Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. Proc Natl Acad Sci U S A. 2020;117:17296-17307 pubmed 出版商
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| Kluss J, Conti M, Kaganovich A, Beilina A, Melrose H, Cookson M, et al. Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. NPJ Parkinsons Dis. 2018;4:13 pubmed 出版商
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| Xiong Y, Neifert S, Karuppagounder S, Liu Q, Stankowski J, Lee B, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A. 2018;115:1635-1640 pubmed 出版商
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| Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017;5:22 pubmed 出版商
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| Speidel A, Felk S, Reinhardt P, Sterneckert J, Gillardon F. Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells. PLoS ONE. 2016;11:e0165949 pubmed 出版商
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| Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, et al. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016;473:2671-85 pubmed 出版商
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| Gomez R, Wawro P, Lis P, Alessi D, Pfeffer S. Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. J Cell Biol. 2019;218:4157-4170 pubmed 出版商
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| Ho D, Lee H, Son I, Seol W. G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses. Anim Cells Syst (Seoul). 2019;23:106-111 pubmed 出版商
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| Mir R, Tonelli F, Lis P, MacArtney T, Polinski N, Martinez T, et al. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J. 2018;475:1861-1883 pubmed 出版商
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| Liu Z, Bryant N, Kumaran R, Beilina A, Abeliovich A, Cookson M, et al. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. Hum Mol Genet. 2017;: pubmed 出版商
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