产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
丙H2A.X(磷酸化S139)抗体[3F2]
目录 :
ab22551
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
3F2
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪
文章摘录数: 70
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 图 s2c
  • 免疫印迹; 小鼠; 图 s2b
Aranda S, Alcaine Colet A, Blanco E, Borras E, Caillot C, Sabidó E, et al. Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation. Sci Adv. 2019;5:eaav2448 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 3
Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3c
Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, et al. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun. 2017;8:14182 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 2c
Hansen R, Mund A, Poulsen S, Sandoval M, Klement K, Tsouroula K, et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016;18:1357-1366 pubmed 出版商
  • 免疫组化; 小鼠; 图 7b
Czerwinska A, Nowacka J, Aszer M, Gawrzak S, Archacka K, Fogtman A, et al. Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7. Cell Cycle. 2016;15:2931-2942 pubmed
  • 免疫细胞化学; 人类; 1:200; 图 5
Ding X, Liu G, Xu B, Wu C, Hui N, Ni X, et al. Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates. Sci Rep. 2016;6:28218 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 2
Baleriola J, Álvarez Lindo N, de la Villa P, Bernad A, Blanco L, Suárez T, et al. Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina. Sci Rep. 2016;6:25928 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 s3
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet. 2016;12:e1005791 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Zhao M, Song Y, Niu H, Tian Y, Yang X, Xie K, et al. Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. Oncotarget. 2016;7:8956-67 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Ahn H, Kim K, Shin K, Lim K, Kim J, Lee J, et al. Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells. Oncotarget. 2015;6:44523-37 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3
Polettini J, Behnia F, Taylor B, Saade G, Taylor R, Menon R. Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?. PLoS ONE. 2015;10:e0137188 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, et al. Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PLoS ONE. 2015;10:e0125745 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000; 图 3b
Greve K, Lindgreen J, Terp M, Pedersen C, Schmidt S, Mollenhauer J, et al. Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. Mol Oncol. 2015;9:437-49 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7
Suchankova J, Legartova S, Sehnalová P, Kozubek S, Valente S, Labella D, et al. PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage. Eur J Histochem. 2014;58:2389 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Dai C, Sun F, Zhu C, Hu X. Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors. PLoS ONE. 2013;8:e63054 pubmed 出版商
  • 免疫细胞化学; 人类
Werwein E, Dzuganova M, Usadel C, Klempnauer K. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis. 2013;4:e511 pubmed 出版商
  • 免疫细胞化学; 人类
Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011;332:1443-6 pubmed 出版商
  • 免疫细胞化学; 小鼠
Song R, Ro S, Michaels J, Park C, McCarrey J, Yan W. Many X-linked microRNAs escape meiotic sex chromosome inactivation. Nat Genet. 2009;41:488-93 pubmed 出版商
Dutta P, Islam S, Choppara S, Sengupta P, Kumar A, Kumar A, et al. The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels. J Biol Chem. 2019;294:14879-14895 pubmed 出版商
Ge J, Li C, Li C, Huang Z, Zeng J, Han L, et al. SIRT6 participates in the quality control of aged oocytes via modulating telomere function. Aging (Albany NY). 2019;11:1965-1976 pubmed 出版商
Zhou Y, Chu L, Wang Q, Dai W, Zhang X, Chen J, et al. CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair. Cell Death Dis. 2018;9:887 pubmed 出版商
Evangelista F, Maglott Roth A, Stierlé M, Brino L, Soutoglou E, Tora L. Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair. J Cell Biol. 2018;217:3382-3397 pubmed 出版商
Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, et al. A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput Biol. 2017;13:e1005741 pubmed 出版商
Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X. Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. Cancer Res. 2017;77:3169-3180 pubmed 出版商
Matveevsky S, Bakloushinskaya I, Kolomiets O. Unique sex chromosome systems in Ellobius: How do male XX chromosomes recombine and undergo pachytene chromatin inactivation?. Sci Rep. 2016;6:29949 pubmed 出版商
Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, et al. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. Sci Rep. 2016;6:28217 pubmed 出版商
Menon R, Behnia F, Polettini J, Saade G, Campisi J, Velarde M. Placental membrane aging and HMGB1 signaling associated with human parturition. Aging (Albany NY). 2016;8:216-30 pubmed
Wang L, Xie L, Ramachandran S, Lee Y, Yan Z, Zhou L, et al. Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Chem Biol. 2015;22:849-61 pubmed 出版商
Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, et al. Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014;5:e1580 pubmed 出版商
Liu T, Sun Q, Li Q, Yang H, Zhang Y, Wang R, et al. Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma. Mol Cancer Ther. 2015;14:429-39 pubmed 出版商
Kim J, Kim J, Kim J, Kim S, Chung H, Park C. HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines. Genes Cancer. 2014;5:165-174 pubmed
Yoon S, Kim D, Kim K, Park K. Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells. Stem Cells Dev. 2014;23:2700-11 pubmed 出版商
Grassilli E, Ianzano L, Bonomo S, Missaglia C, Cerrito M, Giovannoni R, et al. GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. PLoS ONE. 2014;9:e100947 pubmed 出版商
Hériché J, Lees J, Morilla I, Walter T, Petrova B, Roberti M, et al. Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation. Mol Biol Cell. 2014;25:2522-36 pubmed 出版商
Li W, Zhang L, Li H, Zheng S, Zhao L. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS ONE. 2014;9:e94751 pubmed 出版商
Wang M, Kern A, Hülskötter M, Greninger P, Singh A, Pan Y, et al. EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res. 2014;74:2825-34 pubmed 出版商
Sokolenko A, Bulanova D, Iyevleva A, Aleksakhina S, Preobrazhenskaya E, Ivantsov A, et al. High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients. Int J Cancer. 2014;134:2352-8 pubmed 出版商
Azad A, Bukczynska P, Jackson S, Haupt Y, Haput Y, Cullinane C, et al. Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells. Int J Radiat Oncol Biol Phys. 2014;88:385-94 pubmed 出版商
Guo P, Lan J, Ge J, Nie Q, Guo L, Qiu Y, et al. MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated. Exp Cell Res. 2014;320:200-8 pubmed 出版商
Viñas Castells R, Frias A, Robles Lanuza E, Zhang K, Longmore G, Garcia de Herreros A, et al. Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. Nucleic Acids Res. 2014;42:1079-94 pubmed 出版商
Slatter T, Park L, Anderson K, Lailai Tasmania V, Herbison P, Clow W, et al. Smoking during pregnancy causes double-strand DNA break damage to the placenta. Hum Pathol. 2014;45:17-26 pubmed 出版商
Budovsky A, Shteinberg A, Maor H, Duman O, Yanai H, Wolfson M, et al. Uncovering the geroprotective potential of medicinal plants from the Judea region of Israel. Rejuvenation Res. 2014;17:134-9 pubmed 出版商
Li J, Bonifati S, Hristov G, Marttila T, Valmary Degano S, Stanzel S, et al. Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas. EMBO Mol Med. 2013;5:1537-55 pubmed 出版商
Pfäffle H, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, et al. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013;73:6254-63 pubmed 出版商
Huang S, Murai J, Dalla Rosa I, Dexheimer T, Naumova A, Gmeiner W, et al. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Res. 2013;41:7793-803 pubmed 出版商
Dai X, Ding J, Zhang R, Ren J, Ma C, Wu G. Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway. Int J Radiat Biol. 2013;89:724-31 pubmed 出版商
Tang S, Bai C, Yang P, Chen X. 14-3-3? boosts bleomycin-induced DNA damage response by inhibiting the drug-resistant activity of MVP. J Proteome Res. 2013;12:2511-24 pubmed 出版商
Tang S, Bao H, Zhang Y, Yao J, Yang P, Chen X. 14-3-3? mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage. PLoS ONE. 2013;8:e55268 pubmed 出版商
Beggs A, Domingo E, McGregor M, Presz M, Johnstone E, Midgley R, et al. Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. Oncotarget. 2012;3:1348-55 pubmed
Reinson T, Toots M, Kadaja M, Pipitch R, Allik M, Ustav E, et al. Engagement of the ATR-dependent DNA damage response at the human papillomavirus 18 replication centers during the initial amplification. J Virol. 2013;87:951-64 pubmed 出版商
Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, et al. Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents. Transl Res. 2013;161:156-64 pubmed 出版商
Greenlee A, Shiao M, Snyder E, Buaas F, Gu T, Stearns T, et al. Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1. PLoS ONE. 2012;7:e46359 pubmed 出版商
Wolyniec K, Levav Cohen Y, Jiang Y, Haupt S, Haupt Y. The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress. Oncogene. 2013;32:3510-9 pubmed 出版商
Lee Y, Yu Y, Gunawardena H, Xie L, Chen X. BCLAF1 is a radiation-induced H2AX-interacting partner involved in ?H2AX-mediated regulation of apoptosis and DNA repair. Cell Death Dis. 2012;3:e359 pubmed 出版商
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A. 2012;109:11800-5 pubmed 出版商
Whelan G, Kreidl E, Peters J, Eichele G. The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions. Nucleus. 2012;3:330-4 pubmed
Yin D, Wang Q, Chen L, Liu M, Han C, Yan Q, et al. Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin. PLoS ONE. 2011;6:e27154 pubmed 出版商
Azad A, Jackson S, Cullinane C, Natoli A, Neilsen P, Callen D, et al. Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res. 2011;9:1696-707 pubmed 出版商
Lukas C, Savic V, Bekker Jensen S, Doil C, Neumann B, Pedersen R, et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol. 2011;13:243-53 pubmed 出版商
Strub T, Giuliano S, Ye T, Bonet C, Keime C, Kobi D, et al. Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30:2319-32 pubmed 出版商
Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle. 2011;10:457-68 pubmed
Roig A, Hight S, Minna J, Shay J, Rusek A, Story M. DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle. Int J Radiat Biol. 2010;86:194-204 pubmed 出版商
Petermann E, Orta M, Issaeva N, Schultz N, Helleday T. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell. 2010;37:492-502 pubmed 出版商
Wu M, Kang M, Schoene N, Cheng W. Selenium compounds activate early barriers of tumorigenesis. J Biol Chem. 2010;285:12055-62 pubmed 出版商
Yang X, Zou P, Yao J, Yun D, Bao H, Du R, et al. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. J Proteome Res. 2010;9:1402-15 pubmed 出版商
Brower J, Lim C, Jorgensen M, Oh S, Terada N. Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells. Reproduction. 2009;138:463-70 pubmed 出版商
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Roig A, Hight S, Shay J. Two- and three-dimensional models for risk assessment of radiation-enhanced colorectal tumorigenesis. Radiat Res. 2009;171:33-40 pubmed 出版商
Sasaki T, Marcon E, McQuire T, Arai Y, Moens P, Okada H. Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis. J Cell Biol. 2008;182:449-58 pubmed 出版商
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产品信息
目录代码 :
ab22551
产品名称 :
丙H2A.X(磷酸化S139)抗体[3F2]
宿主物种 :
小鼠
克隆性 :
单克隆
抗原修饰 :
磷酸化
产品类型 :
一抗
规格 :
100微克
SwissProt号 :
P16104
抗体亚型 :
IgG1
交叉活性 :
Reacts with: Human, Mouse.
应用摘要 :
ELISA, Flow Cyt, ICC/IF, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。