产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗LAMP2抗体[H4B4]
目录 :
ab25631
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
H4B4
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 75
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 7j
  • 免疫组化; 人类; 图 5a
Seike T, Boontem P, Yanagi M, Li S, Kido H, Yamamiya D, et al. Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022;14:925-944 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12:1589 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫组化; 人类
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed 出版商
  • 免疫细胞化学; 人类; 图 4e
Merrill N, Schipper J, Karnes J, Kauffman A, Martin K, Mackeigan J. PI3K-C2? knockdown decreases autophagy and maturation of endocytic vesicles. PLoS ONE. 2017;12:e0184909 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s5c
Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed 出版商
  • 免疫印迹; 人类; 图 9b
Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch A, Muller S, et al. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. elife. 2017;6: pubmed 出版商
  • 免疫组化; 人类; 图 6a
White S, McDermott M, Sufit R, Kosmac K, Bugg A, Gonzalez Freire M, et al. Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. J Transl Med. 2016;14:284 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 5
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300; 图 6
Tillotson B, Goulatis L, Parenti I, Duxbury E, Shusta E. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation. PLoS ONE. 2015;10:e0145820 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Oliveira L, Falomir Lockhart L, Botelho M, Lin K, Wales P, Koch J, et al. Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells. Cell Death Dis. 2015;6:e1994 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Ye Z, Al Aidaroos A, Park J, Yuen H, Zhang S, Gupta A, et al. PRL-3 activates mTORC1 in Cancer Progression. Sci Rep. 2015;5:17046 pubmed 出版商
  • 免疫印迹; 人类; 1:100
Mancias J, Pontano Vaites L, Nissim S, Biancur D, Kim A, Wang X, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. elife. 2015;4: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:300
Tang Y, Ye M, Du Y, Qiu X, Lv X, Yang W, et al. EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus. Neuroscience. 2015;304:109-21 pubmed 出版商
  • 免疫细胞化学; 人类
Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed 出版商
  • 免疫细胞化学; 人类; 图 9.a,b.c
Huna A, Salmina K, Erenpreisa J, Vazquez Martin A, Krigerts J, Inashkina I, et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle. 2015;14:2969-84 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 2
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 2
Akizu N, Cantagrel V, Zaki M, Al Gazali L, Wang X, Rosti R, et al. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015;47:528-34 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Jansson P, Yamagishi T, Arvind A, Seebacher N, Gutierrez E, Stacy A, et al. Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp). J Biol Chem. 2015;290:9588-603 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s15a
Jewell J, Kim Y, Russell R, Yu F, Park H, Plouffe S, et al. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015;347:194-8 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1a
  • 免疫印迹; 人类; 图 5b
Zaganjor E, Weil L, Gonzales J, Minna J, Cobb M. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A. 2014;111:10568-73 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 8
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed 出版商
  • 免疫沉淀; 小鼠
Wolff N, Ghio A, Garrick L, Garrick M, Zhao L, Fenton R, et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J. 2014;28:2134-45 pubmed 出版商
  • 免疫印迹; 人类
Oshiro N, Rapley J, Avruch J. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem. 2014;289:2658-74 pubmed 出版商
  • 免疫细胞化学; 人类
Iordanova B, Hitchens T, Robison C, Ahrens E. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS ONE. 2013;8:e72720 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
Oner S, Vural A, Lanier S. Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network. J Biol Chem. 2013;288:24091-103 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Stalder L, Heusermann W, Sokol L, Trojer D, Wirz J, Hean J, et al. The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J. 2013;32:1115-27 pubmed 出版商
  • 免疫细胞化学; 人类
Tattoli I, Philpott D, Girardin S. The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole. Biol Open. 2012;1:1215-25 pubmed 出版商
Napolitano F, Bruno G, Terracciano C, Franzese G, Palomba N, Scotto di Carlo F, et al. Rare Variants in Autophagy and Non-Autophagy Genes in Late-Onset Pompe Disease: Suggestions of Their Disease-Modifying Role in Two Italian Families. Int J Mol Sci. 2021;22: pubmed 出版商
Ponsford A, Ryan T, Raimondi A, Cocucci E, Wycislo S, Fröhlich F, et al. Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor. Autophagy. 2020;:1-19 pubmed 出版商
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, et al. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020;139:1001-1024 pubmed 出版商
Odle R, Walker S, Oxley D, Kidger A, Balmanno K, Gilley R, et al. An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis. Mol Cell. 2019;: pubmed 出版商
Selyunin A, Hutchens S, McHardy S, Mukhopadhyay S. Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis. Life Sci Alliance. 2019;2: pubmed 出版商
Marycz K, Weiss C, Smieszek A, Kornicka K. Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses. Stem Cells Int. 2018;2018:5340756 pubmed 出版商
Sørensen D, Holemans T, van Veen S, Martin S, Arslan T, Haagendahl I, et al. Parkinson disease related ATP13A2 evolved early in animal evolution. PLoS ONE. 2018;13:e0193228 pubmed 出版商
Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, et al. TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling. Cell Discov. 2018;4:1 pubmed 出版商
Tvingsholm S, Hansen M, Clemmensen K, Brix D, Rafn B, Frankel L, et al. Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1. Oncogenesis. 2018;7:14 pubmed 出版商
Al Akra L, Bae D, Sahni S, Huang M, Park K, Lane D, et al. Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones. J Biol Chem. 2018;293:3562-3587 pubmed 出版商
Corkery D, Clarke L, Gebremeskel S, Salsman J, Pinder J, Le Page C, et al. Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking. Oncogene. 2018;37:174-184 pubmed 出版商
Modica G, Skorobogata O, Sauvageau E, Vissa A, Yip C, Kim P, et al. Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking. J Cell Sci. 2017;130:2579-2590 pubmed 出版商
Lu S, Sung T, Lin N, Abraham R, Jessen B. Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS ONE. 2017;12:e0173771 pubmed 出版商
Hoxhaj G, Caddye E, Najafov A, Houde V, Johnson C, Dissanayake K, et al. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. elife. 2016;5: pubmed 出版商
Zhao G, Xu L, Pan H, Lin Q, Huang M, Cai J, et al. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget. 2015;6:38952-66 pubmed 出版商
Fan S, Snell C, Turley H, Li J, McCormick R, Perera S, et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 2016;35:3004-15 pubmed 出版商
Jubrail J, Morris P, Bewley M, Stoneham S, Johnston S, Foster S, et al. Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cell Microbiol. 2016;18:80-96 pubmed 出版商
Gutierrez E, Richardson D, Jansson P. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem. 2014;289:33568-89 pubmed 出版商
Cottam E, Whelband M, Wileman T. Coronavirus NSP6 restricts autophagosome expansion. Autophagy. 2014;10:1426-41 pubmed 出版商
Muñoz Montesino C, Roa F, Pena E, Gonzalez M, Sotomayor K, Inostroza E, et al. Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2. Free Radic Biol Med. 2014;70:241-54 pubmed 出版商
Matsuda Lennikov M, Suizu F, Hirata N, Hashimoto M, Kimura K, Nagamine T, et al. Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy. PLoS ONE. 2014;9:e79795 pubmed 出版商
Neutsch L, Eggenreich B, Herwig E, Marchetti Deschmann M, Allmaier G, Gabor F, et al. Biomimetic delivery strategies at the urothelium: targeted cytoinvasion in bladder cancer cells via lectin bioconjugates. Pharm Res. 2014;31:819-32 pubmed 出版商
Tattoli I, Sorbara M, Yang C, Tooze S, Philpott D, Girardin S. Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J. 2013;32:3066-78 pubmed 出版商
Yamagishi T, Sahni S, Sharp D, Arvind A, Jansson P, Richardson D. P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration. J Biol Chem. 2013;288:31761-71 pubmed 出版商
Zhang L, Fok J, Mirabella F, Aronson L, Fryer R, Workman P, et al. Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress. Cancer Lett. 2013;339:49-59 pubmed 出版商
Varjak M, Saul S, Arike L, Lulla A, Peil L, Merits A. Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. J Virol. 2013;87:10295-312 pubmed 出版商
Jerič B, Dolenc I, Mihelic M, Klarić M, Zavasnik Bergant T, Guncar G, et al. N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions. Biochim Biophys Acta. 2013;1833:2254-66 pubmed 出版商
Jiang L, Li X, Liu L, Zhang Q. Cellular uptake mechanism and intracellular fate of hydrophobically modified pullulan nanoparticles. Int J Nanomedicine. 2013;8:1825-34 pubmed 出版商
Bessadottir M, Egilsson M, Einarsdóttir E, Magnusdottir I, Ogmundsdóttir M, Omarsdottir S, et al. Proton-shuttling lichen compound usnic acid affects mitochondrial and lysosomal function in cancer cells. PLoS ONE. 2012;7:e51296 pubmed 出版商
Ke C, Chiang W, Liao Z, Chen H, Lai P, Sun J, et al. Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance. Biomaterials. 2013;34:1-10 pubmed 出版商
Lin L, Huang H, Juan H. Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays. PLoS ONE. 2012;7:e44615 pubmed 出版商
Lin L, Huang H, Ogihara S, Wang J, Wu M, McNeil P, et al. Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation. Int J Mol Sci. 2012;13:10176-92 pubmed 出版商
Ogmundsdóttir M, Heublein S, Kazi S, Reynolds B, Visvalingam S, Shaw M, et al. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS ONE. 2012;7:e36616 pubmed 出版商
Chaparro Riggers J, Liang H, DeVay R, Bai L, Sutton J, Chen W, et al. Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9. J Biol Chem. 2012;287:11090-7 pubmed 出版商
Chimote A, Kuras Z, Conforti L. Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes. J Biol Chem. 2012;287:2055-67 pubmed 出版商
Ho H, Kapadia R, Al Tahan S, Ahmad S, Ganesan A. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011;286:12509-23 pubmed 出版商
Bianco S, Vandepas L, Correa Medina M, Gereben B, Mukherjee A, Kuohung W, et al. KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology. 2011;152:1616-26 pubmed 出版商
Couve E, Schmachtenberg O. Autophagic activity and aging in human odontoblasts. J Dent Res. 2011;90:523-8 pubmed 出版商
Humphries W, Fay N, Payne C. Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy. Integr Biol (Camb). 2010;2:536-44 pubmed 出版商
Chiu Y, Ho Y, Chen Y, Peng S, Ke C, Chen K, et al. The characteristics, cellular uptake and intracellular trafficking of nanoparticles made of hydrophobically-modified chitosan. J Control Release. 2010;146:152-9 pubmed 出版商
Mukhopadhyay S, Bachert C, Smith D, Linstedt A. Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130. Mol Biol Cell. 2010;21:1282-92 pubmed 出版商
Vural A, Oner S, An N, Simon V, Ma D, Blumer J, et al. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. Mol Cell Biol. 2010;30:1528-40 pubmed 出版商
Lee P, Hsu S, Wang J, Tsai J, Lin K, Wey S, et al. The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials. 2010;31:1316-24 pubmed 出版商
Llarena M, Bailey D, Curtis H, O Hare P. Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6. Traffic. 2010;11:48-69 pubmed 出版商
Colle M, Piguet F, Bertrand L, Raoul S, Bieche I, Dubreil L, et al. Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate. Hum Mol Genet. 2010;19:147-58 pubmed 出版商
Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, et al. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet. 2008;82:992-1002 pubmed 出版商
产品信息
目录号 :
ab25631
ItemName :
抗LAMP2抗体[H4B4]
产品类型 :
一抗
宿主物种 :
小鼠
克隆性 :
单克隆
共轭标签 :
Not Conjugated
抗原修饰 :
No Modifications
克隆名称 :
H4B4
规格 :
100微克
物种摘要 :
AGMk, Hu, RMk
用途 :
Flow Cyt, ICC, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。