产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗PKR(磷酸化T446)抗体[E120]
目录 :
ab32036
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
E120
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片
文章摘录数: 32
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 大鼠; 1:100; 图 1g
  • 免疫印迹; 大鼠; 1:1000; 图 1e
Li Y, Li Y, Li L, Yin M, Wang J, Li X. PKR deficiency alleviates pulmonary hypertension via inducing inflammasome adaptor ASC inactivation. Pulm Circ. 2021;11:20458940211046156 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Colpitts C, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng C, et al. Hepatitis C virus exploits cyclophilin A to evade PKR. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 5h
Theivanthiran B, Evans K, Devito N, Plebanek M, Sturdivant M, Wachsmuth L, et al. A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. J Clin Invest. 2020;130:2570-2586 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 s4d
Zhu P, Khatiwada S, Cui Y, Reineke L, Dooling S, Kim J, et al. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019;366:843-849 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 7c
Sauer M, Juranek S, Marks J, De Magis A, Kazemier H, Hilbig D, et al. DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions. Nat Commun. 2019;10:2421 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Liu Y, Qu L, Liu Y, Roizman B, Zhou G. PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Proc Natl Acad Sci U S A. 2017;114:E6902-E6911 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7a
King B, Hershkowitz D, Eisenhauer P, Weir M, Ziegler C, Russo J, et al. A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol. 2017;91: pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Carpentier K, Esparo N, Child S, Geballe A. A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. PLoS Pathog. 2016;12:e1005966 pubmed 出版商
  • 免疫印迹; 人类; 图 8
Liu R, Moss B. Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. J Virol. 2016;90:7864-79 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 s1
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
  • 免疫印迹; 人类; 图 4
Yuen K, Xu B, Krantz I, Gerton J. NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep. 2016;14:93-102 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:400; 图 3
Li L, Ulrich R, Baumgärtner W, Gerhauser I. Interferon-stimulated genes-essential antiviral effectors implicated in resistance to Theiler's virus-induced demyelinating disease. J Neuroinflammation. 2015;12:242 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Burgess H, Mohr I. Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses. Cell Host Microbe. 2015;17:332-344 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Tseng Y, Lin F, Cheng S, Tscharke D, Chulakasian S, Chou C, et al. Functional analysis of the short isoform of orf virus protein OV20.0. J Virol. 2015;89:4966-79 pubmed 出版商
  • 免疫印迹; 人类
Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, et al. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS ONE. 2013;8:e54036 pubmed 出版商
Darweesh M, Kamel W, Gavrilin M, Akusjarvi G, Svensson C. Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation. Front Immunol. 2019;10:2791 pubmed 出版商
Gannon H, Zou T, Kiessling M, Gao G, Cai D, Choi P, et al. Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nat Commun. 2018;9:5450 pubmed 出版商
Nakamura K, Aizawa K, Aung K, Yamauchi J, Tanoue A. Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells. Sci Rep. 2017;7:41093 pubmed 出版商
Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, D Antonio M, et al. Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. ASN Neuro. 2016;8: pubmed 出版商
Nejepinska J, Malik R, Wagner S, Svoboda P. Reporters transiently transfected into mammalian cells are highly sensitive to translational repression induced by dsRNA expression. PLoS ONE. 2014;9:e87517 pubmed 出版商
Gantke T, Boussouf S, Janzen J, Morrice N, Howell S, Mühlberger E, et al. Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-?B1 p105 complex in co-transfected HEK-293 cells. Biochem J. 2013;452:359-65 pubmed 出版商
He Y, Correa A, Raso M, Hofstetter W, Fang B, Behrens C, et al. The role of PKR/eIF2? signaling pathway in prognosis of non-small cell lung cancer. PLoS ONE. 2011;6:e24855 pubmed 出版商
Treppendahl M, Qiu X, Søgaard A, Yang X, Nandrup Bus C, Hother C, et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 2012;119:206-16 pubmed 出版商
Sharma B, Altman J, Goussetis D, Verma A, Platanias L. Protein kinase R as mediator of the effects of interferon (IFN) gamma and tumor necrosis factor (TNF) alpha on normal and dysplastic hematopoiesis. J Biol Chem. 2011;286:27506-14 pubmed 出版商
Lee K, Kunkeaw N, Jeon S, Lee I, Johnson B, Kang G, et al. Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity. RNA. 2011;17:1076-89 pubmed 出版商
Kang J, Ahn B. HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2. Biochem Biophys Res Commun. 2011;407:248-53 pubmed 出版商
Russell S, Tisdale M. Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein. Endocrinology. 2010;151:4696-704 pubmed 出版商
Peidis P, Papadakis A, Muaddi H, Richard S, Koromilas A. Doxorubicin bypasses the cytoprotective effects of eIF2? phosphorylation and promotes PKR-mediated cell death. Cell Death Differ. 2011;18:145-54 pubmed 出版商
von Roretz C, Gallouzi I. Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem. 2010;285:16806-13 pubmed 出版商
Mounir Z, Krishnamoorthy J, Robertson G, Scheuner D, Kaufman R, Georgescu M, et al. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal. 2009;2:ra85 pubmed 出版商
Goggin K, Beaudoin S, Grenier C, Brown A, Roucou X. Prion protein aggresomes are poly(A)+ ribonucleoprotein complexes that induce a PKR-mediated deficient cell stress response. Biochim Biophys Acta. 2008;1783:479-91 pubmed
产品信息
目录号 :
ab32036
ItemName :
抗PKR(磷酸化T446)抗体[E120]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
E120
规格 :
10微升, 100微升
物种摘要 :
Hu
应用摘要 :
ChIP, 免疫组化-P, 免疫沉淀, 免疫印迹
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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