产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗Janus激酶2(磷酸化Y1007+Y1008)抗体[E132]
目录 :
ab32101
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
E132
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
文章摘录数: 27
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 5c, 6a, 8d
Liu W, Long Q, Zhang W, Zeng D, Hu B, Liu S, et al. miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis. Aging (Albany NY). 2021;13:19760-19775 pubmed 出版商
  • 免疫组化; 人类; 图 6a
  • 免疫印迹; 人类; 图 1i, 2a
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Hu D, Chen H, Lou L, Zhang H, Yang G. SKA3 promotes lung adenocarcinoma metastasis through the EGFR-PI3K-Akt axis. Biosci Rep. 2020;40: pubmed 出版商
  • 免疫组化; 大鼠; 图 5a
  • 免疫印迹; 大鼠; 图 4ba
Wang T, Sun X, Cui H, Liu K, Zhao J. The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway. Mol Med Rep. 2020;21:1097-1106 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 8a
Zhong B, Shi D, Wu F, Wang S, Hu H, Cheng C, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death Dis. 2019;10:687 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Mohan K, Ueda G, Kim A, Jude K, Fallas J, Guo Y, et al. Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science. 2019;364: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
You Y, Qin Z, Zhang H, Yuan Z, Yu X. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Biosci Rep. 2019;: pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 6a
Luo L, Xie D, Zhang X, Jiang R. Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation. Exp Ther Med. 2016;12:2009-2014 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Jhaveri K, Teplinsky E, Silvera D, Valeta Magara A, Arju R, Giashuddin S, et al. Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy. Clin Breast Cancer. 2016;16:113-22.e1 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Andreasen S, Therkildsen M, Grauslund M, Friis Hansen L, Wessel I, Homøe P. Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland. APMIS. 2015;123:706-15 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 5d
Wei Z, Xia G, Wu Y, Chen W, Xiang Z, Schwarz R, et al. CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. Cancer Lett. 2015;359:335-43 pubmed 出版商
  • 免疫印迹; 人类
Sedek M, van der Velden L, Strous G. Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem. 2014;289:65-73 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫组化-石蜡切片; 小鼠
Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, et al. Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ER?(+) tumorigenesis. Cell Death Differ. 2014;21:234-46 pubmed 出版商
Wang W, Tang Y, Xiao Q, Lee W, Cheng B, Niu Z, et al. Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer. Nat Commun. 2021;12:4441 pubmed 出版商
Zhuang M, Ding X, Song W, Chen H, Guan H, Yu Y, et al. Correlation of IL-6 and JAK2/STAT3 signaling pathway with prognosis of nasopharyngeal carcinoma patients. Aging (Albany NY). 2021;13:16667-16683 pubmed 出版商
Cheng Y, Li S, Chuang W, Li C, Chen G, Chang C, et al. Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. Int J Mol Sci. 2019;20: pubmed 出版商
Xu J, Wang H, Wang H, Chen Q, Zhang L, Song C, et al. The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1. Hereditas. 2019;156:11 pubmed 出版商
Schulz Heddergott R, Stark N, Edmunds S, Li J, Conradi L, Bohnenberger H, et al. Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. Cancer Cell. 2018;34:298-314.e7 pubmed 出版商
Chen K, Sun Y, Diao Y, Zhang T, Dong W. Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett. 2018;16:167-178 pubmed 出版商
Zhang K, Che S, Pan C, Su Z, Zheng S, Yang S, et al. The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. J Cell Mol Med. 2018;22:3679-3690 pubmed 出版商
Byrne R, Rath E, Hladik A, Niederreiter B, Bonelli M, Frantal S, et al. A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model. PLoS ONE. 2012;7:e35194 pubmed 出版商
Kirabo A, Park S, Majumder A, Gali M, Reinhard M, Wamsley H, et al. The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow. Neoplasia. 2011;13:1058-68 pubmed
Fiskus W, Verstovsek S, Manshouri T, Rao R, Balusu R, Venkannagari S, et al. Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells. Clin Cancer Res. 2011;17:7347-58 pubmed 出版商
Kirabo A, Oh S, Kasahara H, Wagner K, Sayeski P. Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice. J Mol Cell Cardiol. 2011;50:1026-34 pubmed 出版商
Lin M, Chang K, Lin S, Miner J. Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol. 2010;344:707-19 pubmed 出版商
Dawson M, Bannister A, Göttgens B, Foster S, Bartke T, Green A, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature. 2009;461:819-22 pubmed 出版商
Devi Y, Shehu A, Stocco C, Halperin J, Le J, Seibold A, et al. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology. 2009;150:3327-35 pubmed 出版商
产品信息
目录号 :
ab32101
ItemName :
抗Janus激酶2(磷酸化Y1007+Y1008)抗体[E132]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
E132
规格 :
10微升, 100微升
物种摘要 :
Hu, Ms, Rat
应用摘要 :
Dot, ELISA, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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