公司名称 :
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
产品名称 :
Anti-Amyloid Precursor Protein antibody [Y188]
目录 :
规格 :
10微升, 100微升
克隆性 :
宿主 :
domestic rabbit
共轭标签 :
克隆名称 :
反应物种 :
人类, 小鼠, 大鼠, pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
文章摘录数: 44
  • 免疫组化; 小鼠; 1:500
Lin L, Petralia R, Lake R, Wang Y, Hoffman D. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:150; 图 3b
  • 免疫印迹; 小鼠; 1:2000; 图 3f
Tang Y, Xu A, Shao S, Zhou Y, Xiong B, Li Z. Electroacupuncture Ameliorates Cognitive Impairment by Inhibiting the JNK Signaling Pathway in a Mouse Model of Alzheimer's Disease. Front Aging Neurosci. 2020;12:23 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 5a, 5d
Evonuk K, Doyle R, Moseley C, Thornell I, Adler K, Bingaman A, et al. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Sci Adv. 2020;6:eaax5936 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:15,000; 图 4
Newell E, Todd B, Luo Z, Evans L, Ferguson P, Bassuk A. A Mouse Model for Juvenile, Lateral Fluid Percussion Brain Injury Reveals Sex-Dependent Differences in Neuroinflammation and Functional Recovery. J Neurotrauma. 2020;37:635-646 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 2b
  • 免疫印迹; 人类; 图 2c
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 4c
  • 免疫细胞化学; 小鼠; 1:200; 图 1b
  • 免疫印迹; 小鼠; 图 1c
Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Tan J, Gleeson P. The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons. J Biol Chem. 2019;294:1618-1631 pubmed 出版商
  • 免疫组化; 小鼠; 图 5
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Ou Yang M, Kurz J, Nomura T, Popovic J, Rajapaksha T, Dong H, et al. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Sci Transl Med. 2018;10: pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 4b
Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7a
  • 免疫细胞化学; pigs ; 图 5d
Poulsen E, Iannuzzi F, Rasmussen H, Maier T, Enghild J, Jørgensen A, et al. An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. Front Mol Neurosci. 2017;10:59 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 1e
  • 免疫印迹基因敲除验证; 小鼠; 图 2
  • 免疫组化-自由浮动切片; 小鼠; 图 1d
  • 免疫印迹; 小鼠; 图 2
Del Turco D, Paul M, Schlaudraff J, Hick M, Endres K, Müller U, et al. Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci. 2016;9:134 pubmed
  • 免疫细胞化学; 人类; 1:200; 图 1a
Woodruff G, Reyna S, Dunlap M, van der Kant R, Callender J, Young J, et al. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016;17:759-773 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Galambos C, Minic A, Bush D, Nguyen D, Dodson B, Seedorf G, et al. Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension. PLoS ONE. 2016;11:e0159005 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:100; 图 4
  • 免疫印迹; 大鼠; 1:1000; 图 3
Zhao Y, Song J, Ma X, Zhang B, Li D, Pang H. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res. 2016;11:944-50 pubmed 出版商
  • 免疫印迹; 人类; 1:4000; 图 1
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn P, Kremmer E, et al. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 2016;8:458-65 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 3a
Das U, Wang L, Ganguly A, Saikia J, Wagner S, Koo E, et al. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016;19:55-64 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Lundgren J, Ahmed S, Schedin Weiss S, Gouras G, Winblad B, Tjernberg L, et al. ADAM10 and BACE1 are localized to synaptic vesicles. J Neurochem. 2015;135:606-15 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Alme M, Nystad A, Bø L, Myhr K, Vedeler C, Wergeland S, et al. Fingolimod does not enhance cerebellar remyelination in the cuprizone model. J Neuroimmunol. 2015;285:180-6 pubmed 出版商
  • 免疫组化; 小鼠; 图 3c
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Bhatt D, Puig K, Gorr M, Wold L, Combs C. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE. 2015;10:e0127102 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 表 4
  • 免疫印迹; 人类; 表 4
  • 免疫印迹; 小鼠; 表 3
Plagg B, Marksteiner J, Kniewallner K, Humpel C. Platelet dysfunction in hypercholesterolemia mice, two Alzheimer's disease mouse models and in human patients with Alzheimer's disease. Biogerontology. 2015;16:543-58 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
La Rosa L, Perrone L, Nielsen M, Calissano P, Andersen O, Matrone C. Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction. Front Cell Neurosci. 2015;9:109 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Hohsfield L, Humpel C. Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model. PLoS ONE. 2015;10:e0121930 pubmed 出版商
  • 免疫细胞化学; 人类
Maloney J, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990-1000 pubmed 出版商
  • 免疫印迹; 小鼠
Durk M, Han K, Chow E, Ahrens R, Henderson J, Fraser P, et al. 1?,25-Dihydroxyvitamin D3 reduces cerebral amyloid-? accumulation and improves cognition in mouse models of Alzheimer's disease. J Neurosci. 2014;34:7091-101 pubmed 出版商
Qu Y, Wang W, Chen T, Yang Y, Zhang Y, Wang D. The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling. Aging (Albany NY). 2021;13:11150-11169 pubmed 出版商
Liu B, Kou J, Li F, Huo D, Xu J, Zhou X, et al. Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase. Aging (Albany NY). 2020;12:8622-8639 pubmed 出版商
Qureshi Y, Patel V, Berman D, Kothiya M, Neufeld J, Vardarajan B, et al. An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect. Mol Cell Biol. 2018;38: pubmed 出版商
György B, Lööv C, Zaborowski M, Takeda S, Kleinstiver B, Commins C, et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018;11:429-440 pubmed 出版商
Stern A, Ghura S, Gannon P, Akay Espinoza C, Phan J, Yee A, et al. BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. J Neurosci. 2018;38:4288-4300 pubmed 出版商
Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed 出版商
Zhang J, Huang P, Wang Z, Dong H. Application of FTIR spectroscopy for traumatic axonal injury: a possible tool for estimating injury interval. Biosci Rep. 2017;37: pubmed 出版商
Triaca V, Sposato V, Bolasco G, Ciotti M, Pelicci P, Bruni A, et al. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell. 2016;15:661-72 pubmed 出版商
Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed 出版商
Poulsen E, Larsen A, Zollo A, Jørgensen A, Sanggaard K, Enghild J, et al. New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. Int J Mol Sci. 2015;16:29446-53 pubmed 出版商
Sajadi K, Lin D, Steward J, Balog B, Dissaranan C, Zaszczurynski P, et al. Pudendal nerve stretch reduces external urethral sphincter activity in rats. J Urol. 2012;188:1389-95 pubmed 出版商
Rama N, Goldschneider D, Corset V, Lambert J, Pays L, Mehlen P. Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. J Biol Chem. 2012;287:30014-23 pubmed 出版商
Matrone C, Barbagallo A, La Rosa L, Florenzano F, Ciotti M, Mercanti D, et al. APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci. 2011;31:11756-61 pubmed 出版商
Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed 出版商
Mastrangelo M, Sudol K, Narrow W, Bowers W. Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. Am J Pathol. 2009;175:2076-88 pubmed 出版商
JANELSINS M, Mastrangelo M, PARK K, Sudol K, Narrow W, Oddo S, et al. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008;173:1768-82 pubmed 出版商
Mastrangelo M, Bowers W. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci. 2008;9:81 pubmed 出版商
Frazer M, Hughes J, Mastrangelo M, Tibbens J, Federoff H, Bowers W. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther. 2008;16:845-53 pubmed 出版商
目录号 :
ItemName :
Anti-Amyloid Precursor Protein antibody [Y188]
类别 :
宿主 :
克隆性 :
共轭标签 :
克隆名称 :
规格 :
10微升, 100微升
物种摘要 :
Hu, Ms, Rat
应用摘要 :
Flow Cyt, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP, WB
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。