产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗EIF2S1(磷酸化S51)抗体[E90]
目录 :
ab32157
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
E90
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, , pigs
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
文章摘录数: 64
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:500
López Doménech G, Howden J, Covill Cooke C, Morfill C, Patel J, Bürli R, et al. Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response. EMBO J. 2021;40:e100715 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a, 5a
  • 免疫印迹; 人类; 图 1a
Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed 出版商
  • 免疫印迹; 人类; 图 4k
Clementi E, Inglin L, Beebe E, Gsell C, Garajova Z, Markkanen E. Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction. BMC Biol. 2020;18:36 pubmed 出版商
  • 免疫印迹; 人类; 图 1a, 5c
Johnston B, Pringle E, McCormick C. KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. PLoS Pathog. 2019;15:e1008185 pubmed 出版商
  • 免疫印迹; 人类; 1:800; 图 1b
Soiberman U, Shehata A, Lu M, Young T, Daoud Y, Chakravarti S, et al. Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro. Invest Ophthalmol Vis Sci. 2019;60:3422-3431 pubmed 出版商
  • 免疫印迹; 人类; 图 s1i
Subramanian A, Capalbo A, Iyengar N, Rizzo R, Di Campli A, Di Martino R, et al. Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum. Cell. 2019;176:1461-1476.e23 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 ev5a
  • 免疫印迹; 大鼠; 1:500; 图 ev5a
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed 出版商
  • 免疫细胞化学; 人类; 图 6b
  • 免疫印迹; 人类; 图 ev4g
Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Muller M, et al. Queuosine-modified tRNAs confer nutritional control of protein translation. EMBO J. 2018;37: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2c
Grevet J, Lan X, Hamagami N, Edwards C, Sankaranarayanan L, Ji X, et al. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018;361:285-290 pubmed 出版商
  • 免疫印迹; 人类; 图 s4b
Ivanov I, Shin B, Loughran G, Tzani I, Young Baird S, Cao C, et al. Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing. Mol Cell. 2018;70:254-264.e6 pubmed 出版商
  • 流式细胞仪; 人类; 图 4a
Chung H, Calis J, Wu X, Sun T, Yu Y, Sarbanes S, et al. Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown. Cell. 2018;172:811-824.e14 pubmed 出版商
  • 免疫印迹; 仓鼠; 图 11a
Crespillo Casado A, Chambers J, Fischer P, Marciniak S, Ron D. PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 5a
Yan L, Deng Y, Gao J, Liu Y, Li F, Shi J, et al. Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production. Front Pharmacol. 2017;8:106 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 2c
Dimasi P, Quintiero A, Shelkovnikova T, Buchman V. Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose. Sci Rep. 2017;7:44088 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Mathieu A, Ohl Séguy E, Dubois M, Jean D, Jones C, Boudreau F, et al. Subcellular proteomics analysis of different stages of colorectal cancer cell lines. Proteomics. 2016;16:3009-3018 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 2
Golovko A, Kojukhov A, Guan B, Morpurgo B, Merrick W, Mazumder B, et al. The eIF2A knockout mouse. Cell Cycle. 2016;15:3115-3120 pubmed
  • 免疫组化-石蜡切片; 人类; 7 ug/ml; 图 2e
Ladoire S, Senovilla L, Enot D, Ghiringhelli F, Poirier Colame V, Chaba K, et al. Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate. Oncoimmunology. 2016;5:e1160193 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Averous J, Lambert Langlais S, Mesclon F, Carraro V, Parry L, Jousse C, et al. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Sci Rep. 2016;6:27698 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016;17:953-64 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Lee Y, Lee S, Lee C, Kim S, Song Y, Yoon M, et al. Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies. Sci Rep. 2016;6:24013 pubmed 出版商
  • 免疫印迹; 牛; 图 5c
Xia X, Che Y, Gao Y, Zhao S, Ao C, Yang H, et al. Arginine Supplementation Recovered the IFN-?-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2? Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Mol Cells. 2016;39:410-7 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Fusakio M, Willy J, Wang Y, Mirek E, Al Baghdadi R, Adams C, et al. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell. 2016;27:1536-51 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Sci Signal. 2016;9:ra18 pubmed 出版商
  • 流式细胞仪; 人类; 图 s10b
Lin H, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, et al. An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils. Mol Ther Methods Clin Dev. 2015;2:15046 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed 出版商
  • 免疫印迹; 人类
Krisenko M, Higgins R, Ghosh S, Zhou Q, Trybula J, Wang W, et al. Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. J Biol Chem. 2015;290:27803-15 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Panas M, Kedersha N, McInerney G. Methods for the characterization of stress granules in virus infected cells. Methods. 2015;90:57-64 pubmed 出版商
  • 免疫印迹; 小鼠
Roost M, van Iperen L, De Melo Bernardo A, Mummery C, Carlotti F, de Koning E, et al. Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell. 2014;6:22 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500
Way S, Podojil J, Clayton B, Zaremba A, Collins T, Kunjamma R, et al. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun. 2015;6:6532 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Tseng Y, Lin F, Cheng S, Tscharke D, Chulakasian S, Chou C, et al. Functional analysis of the short isoform of orf virus protein OV20.0. J Virol. 2015;89:4966-79 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 s1d
Filézac de L Etang A, Maharjan N, Cordeiro Braña M, Ruegsegger C, Rehmann R, Goswami A, et al. Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS. Nat Neurosci. 2015;18:227-38 pubmed 出版商
  • 免疫印迹; pigs ; 1:1000
Hsu W, Chen C, Huang S, Wu C, Chen I, Nadar M, et al. The untranslated regions of classic swine fever virus RNA trigger apoptosis. PLoS ONE. 2014;9:e88863 pubmed 出版商
  • 免疫印迹; pigs
Banduseela V, Chen Y, Kultima H, Norman H, Aare S, Radell P, et al. Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle. Physiol Genomics. 2013;45:477-86 pubmed 出版商
Humeau J, Leduc M, Cerrato G, Loos F, Kepp O, Kroemer G. Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy. Cell Death Dis. 2020;11:433 pubmed 出版商
Humeau J, Sauvat A, Cerrato G, Xie W, Loos F, Iannantuoni F, et al. Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress. EMBO Mol Med. 2020;12:e11622 pubmed 出版商
Bastola P, Bilkis R, De Souza C, Minn K, Chien J. Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors. Sci Rep. 2019;9:11002 pubmed 出版商
Hodgson R, Varanda B, Ashe M, Allen K, Campbell S. Cellular eIF2B subunit localization: implications for the integrated stress response and its control by small molecule drugs. Mol Biol Cell. 2019;30:942-958 pubmed 出版商
Rabouw H, Langereis M, Anand A, Visser L, de Groot R, Walter P, et al. Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proc Natl Acad Sci U S A. 2019;116:2097-2102 pubmed 出版商
Agnew T, Goldsworthy M, Aguilar C, Morgan A, Simon M, Hilton H, et al. A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways. Cell Rep. 2018;25:3315-3328.e6 pubmed 出版商
Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, et al. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018;30:261-272 pubmed 出版商
Pareek G, Thomas R, Pallanck L. Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration. Cell Death Dis. 2018;9:304 pubmed 出版商
Cormerais Y, Massard P, Vucetic M, Giuliano S, Tambutte E, Durivault J, et al. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018;293:2877-2887 pubmed 出版商
Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, et al. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy. 2018;14:336-346 pubmed 出版商
Clayton B, Huang A, Kunjamma R, Solanki A, Popko B. The integrated stress response in hypoxia-induced diffuse white matter injury. J Neurosci. 2017;: pubmed 出版商
Yadav V, Gao X, Willard B, Hatzoglou M, Banerjee R, Kabil O. Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway. J Biol Chem. 2017;292:13143-13153 pubmed 出版商
Barber C, Netherton C, Goatley L, Moon A, Goodbourn S, Dixon L. Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP. Virology. 2017;504:107-113 pubmed 出版商
Park I, Heo S, Song I, Kim Y, Park H, Bang W, et al. Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer. Oncotarget. 2016;7:59957-59964 pubmed 出版商
Qi Y, Liu H, Daniels M, Zhang G, Xu H. Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Cell Death Differ. 2016;23:291-302 pubmed 出版商
Portovedo M, Ignacio Souza L, Bombassaro B, Coope A, Reginato A, Razolli D, et al. Saturated fatty acids modulate autophagy's proteins in the hypothalamus. PLoS ONE. 2015;10:e0119850 pubmed 出版商
Kosakowska Cholody T, Lin J, Srideshikan S, Scheffer L, Tarasova N, Acharya J. HKH40A downregulates GRP78/BiP expression in cancer cells. Cell Death Dis. 2014;5:e1240 pubmed 出版商
Ill Raga G, Köhler C, Radiske A, Lima R, Rosen M, Muñoz F, et al. Consolidation of object recognition memory requires HRI kinase-dependent phosphorylation of eIF2? in the hippocampus. Hippocampus. 2013;23:431-6 pubmed 出版商
Ye J, Cardona M, Llovera M, Comella J, Sanchis D. Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway. J Mol Cell Cardiol. 2012;53:578-87 pubmed 出版商
Vanderperre B, Staskevicius A, Tremblay G, McCoy M, O Neill M, Cashman N, et al. An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein. FASEB J. 2011;25:2373-86 pubmed 出版商
Zhang F, Moon A, Childs K, Goodbourn S, Dixon L. The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection. J Virol. 2010;84:10681-9 pubmed 出版商
Gorbatyuk M, Knox T, Lavail M, Gorbatyuk O, Noorwez S, Hauswirth W, et al. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci U S A. 2010;107:5961-6 pubmed 出版商
Konsavage W, Zhang L, VARY T, Shenberger J. Hyperoxia inhibits protein synthesis and increases eIF2? phosphorylation in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2010;298:L678-86 pubmed 出版商
Cantero Recasens G, Fandos C, Rubio Moscardo F, Valverde M, Vicente R. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet. 2010;19:111-21 pubmed 出版商
Kren B, Wong P, Shiota A, Zhang X, Zeng Y, Steer C. Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2009;297:G1181-92 pubmed 出版商
Parlati F, Lee S, Aujay M, Suzuki E, Levitsky K, Lorens J, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009;114:3439-47 pubmed 出版商
Farny N, Kedersha N, Silver P. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA. 2009;15:1814-21 pubmed 出版商
Duffy C, Mbong E, Baines J. VP22 of herpes simplex virus 1 promotes protein synthesis at late times in infection and accumulation of a subset of viral mRNAs at early times in infection. J Virol. 2009;83:1009-17 pubmed 出版商
Wu D, Yang H, Zhao Y, Sharan C, Goodwin J, Zhou L, et al. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. J Pharmacol Exp Ther. 2008;326:395-405 pubmed 出版商
产品信息
目录号 :
ab32157
ItemName :
抗EIF2S1(磷酸化S51)抗体[E90]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
E90
规格 :
10微升, 100微升
物种摘要 :
AGMk, Dm, Hu, Ms, N cra, Plnts, Rat
应用摘要 :
Dot, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。