产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗毛细血管扩张性共济失调症突变蛋白抗体[Y170]
目录 :
ab32420
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
Y170
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, reverse phase protein lysate microarray, 免疫印迹基因敲除验证
文章摘录数: 32
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 1f
Lei X, Cao K, Chen Y, Shen H, Liu Z, Qin H, et al. Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells. J Exp Clin Cancer Res. 2021;40:224 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Ali R, Alabdullah M, Miligy I, Normatova M, Babaei Jadidi R, Nateri A, et al. ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1b
  • 免疫印迹; 人类; 图 1a
Savva C, De Souza K, Ali R, Rakha E, Green A, Madhusudan S. Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers. Breast Cancer Res Treat. 2019;175:105-115 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Wang L, Wang Q, Liu Y, Dong Q, Hu H, Miao Z, et al. ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells. J Gastric Cancer. 2017;17:295-305 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2a
  • 免疫印迹; 人类; 图 2a
Royba E, Miyamoto T, Natsuko Akutsu S, Hosoba K, Tauchi H, Kudo Y, et al. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells. Sci Rep. 2017;7:5996 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • 免疫组化; 人类; 图 6c
Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, et al. Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling. Cell Rep. 2017;18:1970-1981 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 人类; 图 s2d
Golia B, Moeller G, Jankevicius G, Schmidt A, Hegele A, Preißer J, et al. ATM induces MacroD2 nuclear export upon DNA damage. Nucleic Acids Res. 2017;45:244-254 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5a
Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS ONE. 2016;11:e0167454 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Zhang Y, Zhang Y, Zhong C, Xiao F. Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes. Sci Rep. 2016;6:34578 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Wang W, Long L, Wang L, Tan C, Fei X, Chen L, et al. Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro. Cancer Lett. 2016;371:274-84 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
Ye P, Zhang M, Fan S, Zhang T, Fu H, Su X, et al. Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis. PLoS ONE. 2015;10:e0143207 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 7
Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal Khoshbeen M, et al. Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget. 2015;6:18558-76 pubmed
  • 免疫印迹; 人类
Shamanna R, Singh D, Lu H, Mirey G, Keijzers G, Salles B, et al. RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex. Carcinogenesis. 2014;35:2415-24 pubmed 出版商
  • 免疫印迹; 人类
Lu H, Fang E, Sykora P, Kulikowicz T, Zhang Y, Becker K, et al. Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. Cell Death Dis. 2014;5:e1226 pubmed 出版商
Ditano J, Donahue K, Tafe L, McCleery C, Eastman A. Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Sci Rep. 2021;11:7077 pubmed 出版商
Lung R, Tong J, Ip L, Lam K, Chan A, Chak W, et al. EBV-encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1. J Cell Mol Med. 2020;: pubmed 出版商
Chakraborty A, Jenjaroenpun P, Li J, El Hilali S, McCulley A, Haarer B, et al. Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome. Cell Rep. 2020;32:108179 pubmed 出版商
Yenerall P, Das A, Wang S, Kollipara R, Li L, Villalobos P, et al. RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol. 2019;: pubmed 出版商
Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, et al. PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin. Cell Death Dis. 2018;9:931 pubmed 出版商
Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018;9:1418 pubmed 出版商
Lung R, Hau P, Yu K, Yip K, Tong J, Chak W, et al. EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. J Pathol. 2018;244:394-407 pubmed 出版商
Avgousti D, Della Fera A, Otter C, Herrmann C, Pancholi N, Weitzman M. Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome. J Virol. 2017;91: pubmed 出版商
Kugler J, Postnikov Y, Furusawa T, Kimura S, Bustin M. Elevated HMGN4 expression potentiates thyroid tumorigenesis. Carcinogenesis. 2017;38:391-401 pubmed 出版商
Feng X, Li H, Kornaga E, Dean M, Lees Miller S, Riabowol K, et al. Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer. Oncotarget. 2016;7:85798-85812 pubmed 出版商
Ávila Arroyo S, Nuñez G, García Fernández L, Galmarini C. Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines. J Breast Cancer. 2015;18:329-38 pubmed 出版商
Lin L, Swerdel M, Lazaropoulos M, Hoffman G, Toro Ramos A, Wright J, et al. Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. Stem Cell Reports. 2015;5:1097-1108 pubmed 出版商
Beggs A, Domingo E, McGregor M, Presz M, Johnstone E, Midgley R, et al. Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. Oncotarget. 2012;3:1348-55 pubmed
Freund A, Laberge R, Demaria M, Campisi J. Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell. 2012;23:2066-75 pubmed 出版商
Sánchez Molina S, Mortusewicz O, Bieber B, Auer S, Eckey M, Leonhardt H, et al. Role for hACF1 in the G2/M damage checkpoint. Nucleic Acids Res. 2011;39:8445-56 pubmed 出版商
Rodier F, Coppe J, Patil C, Hoeijmakers W, Muñoz D, Raza S, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009;11:973-9 pubmed 出版商
产品信息
目录号 :
ab32420
ItemName :
抗毛细血管扩张性共济失调症突变蛋白抗体[Y170]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
Y170
规格 :
10微升, 100微升
物种摘要 :
Hu
应用摘要 :
Flow Cyt, ICC/IF, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。