出版应用/物种/样本/稀释 | 参考文献 |
---|
| Li X, Zhu X, Wu H, Van Dyke T, Xu X, Morgan E, et al. Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis. Front Cell Dev Biol. 2021;9:703670 pubmed 出版商
|
| Cha S, Lee S, Wang J, Zhao Q, Bai D. Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration. Int J Mol Sci. 2021;22: pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:200; 图 3a
| Ling H, Zeng Q, Ge Q, Chen J, Yuan W, Xu R, et al. Osteoking Decelerates Cartilage Degeneration in DMM-Induced Osteoarthritic Mice Model Through TGF-β/smad-dependent Manner. Front Pharmacol. 2021;12:678810 pubmed 出版商
|
| Shao R, Zhang Z, Xu Z, Ouyang H, Wang L, Ouyang H, et al. H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Res. 2021;9:30 pubmed 出版商
|
- 免疫细胞化学; 人类; 图 1c
- 免疫印迹; 人类; 图 1e
| Hou M, Zhang Y, Zhou X, Liu T, Yang H, Chen X, et al. Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis. Cell Death Dis. 2021;12:483 pubmed 出版商
|
- 免疫组化-石蜡切片; 大鼠; 1:200; 图 5e
- 免疫印迹; 大鼠; 1:1000; 图 3b
| Cheng J, Duan X, Fu X, Jiang Y, Yang P, Cao C, et al. RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7. Front Cell Dev Biol. 2021;9:638382 pubmed 出版商
|
| Huang Y, Seitz D, Chevalier Y, Müller P, Jansson V, Klar R. Synergistic interaction of hTGF-β3 with hBMP-6 promotes articular cartilage formation in chitosan scaffolds with hADSCs: implications for regenerative medicine. BMC Biotechnol. 2020;20:48 pubmed 出版商
|
| Che H, Li J, Li Y, Ma C, Liu H, Qin J, et al. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. elife. 2020;9: pubmed 出版商
|
| Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679 pubmed 出版商
|
- 免疫组化-石蜡切片; 人类; 图 1c
- 免疫印迹; 人类; 图 2d
| Lu G, Li L, Wang B, Kuang L. LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes. Aging (Albany NY). 2020;12:3218-3237 pubmed 出版商
|
- 免疫组化-石蜡切片; 大鼠; 1:200; 图 11b
- 免疫印迹; 大鼠; 1:1000; 图 7a
| Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed 出版商
|
| Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. elife. 2019;8: pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:400; 图 4a
| Horigome Y, Ida Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M. Loss of autophagy in chondrocytes causes severe growth retardation. Autophagy. 2019;:1-11 pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:100; 图 2f, 3c
| Ji Q, Xu X, Kang L, Xu Y, Xiao J, Goodman S, et al. Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. Nat Commun. 2019;10:313 pubmed 出版商
|
| Li P, Zhang R, Wang L, Gan Y, Xu Y, Song L, et al. Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture. Biosci Rep. 2017;37: pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:2000; 图 1a
| Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S. Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner. J Cell Physiol. 2017;232:3317-3336 pubmed 出版商
|
| Niu N, Shao R, Yan G, Zou W. Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. J Biol Chem. 2016;291:26647-26657 pubmed 出版商
|
- 免疫组化; 人类; 图 1
- 免疫印迹; 人类; 图 1
| Yao Y, Deng Q, Song W, Zhang H, Li Y, Yang Y, et al. MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia. Stem Cell Reports. 2016;7:249-62 pubmed 出版商
|
| Wang Y, Yu H, Zhou Z, Guo Q, Wang L, Zhang H. Leptin Receptor Metabolism Disorder in Primary Chondrocytes from Adolescent Idiopathic Scoliosis Girls. Int J Mol Sci. 2016;17: pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:200; 图 3
| Bian Q, Jain A, Xu X, Kebaish K, Crane J, Zhang Z, et al. Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis. Sci Rep. 2016;6:27093 pubmed 出版商
|
- 免疫组化-石蜡切片; pigs ; 1:200; 图 7
- 免疫组化-石蜡切片; 大鼠; 1:200; 图 7
| Beck E, Barragan M, Tadros M, Gehrke S, Detamore M. Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel. Acta Biomater. 2016;38:94-105 pubmed 出版商
|
- 免疫组化-石蜡切片; 人类; 1:100; 图 7
| Sonomoto K, Yamaoka K, Kaneko H, Yamagata K, Sakata K, Zhang X, et al. Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold. PLoS ONE. 2016;11:e0153231 pubmed 出版商
|
- 免疫组化-冰冻切片; pigs ; 1:200; 图 8
| Beck E, Barragan M, Libeer T, Kieweg S, Converse G, Hopkins R, et al. Chondroinduction from Naturally Derived Cartilage Matrix: A Comparison Between Devitalized and Decellularized Cartilage Encapsulated in Hydrogel Pastes. Tissue Eng Part A. 2016;22:665-79 pubmed 出版商
|
- 免疫组化-冰冻切片; pigs ; 1:200; 图 9
- 免疫组化-冰冻切片; 大鼠; 1:200; 图 9
| Beck E, Barragan M, Tadros M, Kiyotake E, Acosta F, Kieweg S, et al. Chondroinductive Hydrogel Pastes Composed of Naturally Derived Devitalized Cartilage. Ann Biomed Eng. 2016;44:1863-80 pubmed 出版商
|
| Luo Z, Ma Y, Di T, Ma B, Li H, An J, et al. DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis. Aging (Albany NY). 2021;13:20258-20276 pubmed 出版商
|
| Cui H, Du X, Liu C, Chen S, Cui H, Liu H, et al. Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK/JNK/p38 signalling pathways. Adipocyte. 2021;10:201-215 pubmed 出版商
|
| Wang W, Zhu Y, Sun Z, Jin C, Wang X. Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling. Arthritis Res Ther. 2021;23:84 pubmed 出版商
|
| Huang H, Cheng T, Yang C, Chang C, Ho C, Chuang S, et al. Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis. Antioxidants (Basel). 2021;10: pubmed 出版商
|
| Chen J, Ma Y, Yang Z, Lan H, Liu G, Zhang Y, et al. TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy. Aging (Albany NY). 2020;12:24242-24254 pubmed 出版商
|
| Chen Z, Zhang W, Deng M, Li Y, Zhou Y. CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging (Albany NY). 2020;12:21971-21991 pubmed 出版商
|
| Sun J, Feng H, Xing W, Han Y, Suo J, Yallowitz A, et al. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv. 2020;6: pubmed 出版商
|
| Yang H, Chen C, Chen H, Duan X, Li J, Zhou Y, et al. Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis. Aging (Albany NY). 2020;12:12750-12770 pubmed 出版商
|
| Liu N, Fu D, Yang J, Liu P, Song X, Wang X, et al. Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway. Arthritis Res Ther. 2020;22:112 pubmed 出版商
|
| Bao J, Chen Z, Xu L, Wu L, Xiong Y. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. Aging (Albany NY). 2020;12:5152-5167 pubmed 出版商
|
| Zhang F, Huan L, Xu T, Li G, Zheng B, Zhao H, et al. Inflammatory macrophages facilitate mechanical stress-induced osteogenesis. Aging (Albany NY). 2020;12:3617-3625 pubmed 出版商
|
| Sirong S, Yang C, Taoran T, Songhang L, Shiyu L, Yuxin Z, et al. Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis. Bone Res. 2020;8:6 pubmed 出版商
|
| Chen H, Yang S, Shao R. Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture. Arthritis Res Ther. 2019;21:271 pubmed 出版商
|
| Arai H, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, et al. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019;29:603-616.e5 pubmed 出版商
|
| Hong K, Kim Y, Song S. Fine-Tunable and Injectable 3D Hydrogel for On-Demand Stem Cell Niche. Adv Sci (Weinh). 2019;6:1900597 pubmed 出版商
|
| Liu X, Liu L, Zhang H, Shao Y, Chen Z, Feng X, et al. MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin. Aging (Albany NY). 2019;11:6014-6028 pubmed 出版商
|
| Xie W, Zhao Y, Li F, Shu B, Lin S, Sun L, et al. Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice. BMC Complement Altern Med. 2019;19:191 pubmed 出版商
|
| Dubey N, Wei H, Yu S, Williams D, Wang J, Deng Y, et al. Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade. Aging Dis. 2019;10:483-496 pubmed 出版商
|
| Peng L, Zhou Y, Lu W, Zhu W, Li Y, Chen K, et al. Characterization of a novel polyvinyl alcohol/chitosan porous hydrogel combined with bone marrow mesenchymal stem cells and its application in articular cartilage repair. BMC Musculoskelet Disord. 2019;20:257 pubmed 出版商
|
| Sahu N, Viljoen H, Subramanian A. Continuous low-intensity ultrasound attenuates IL-6 and TNFα-induced catabolic effects and repairs chondral fissures in bovine osteochondral explants. BMC Musculoskelet Disord. 2019;20:193 pubmed 出版商
|
| He J, Zhang A, Song Z, Guo S, Chen Y, Liu Z, et al. The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep. 2019;39: pubmed 出版商
|
| Xia C, Wang P, Fang L, Ge Q, Zou Z, Dong R, et al. Activation of β-catenin in Col2-expressing chondrocytes leads to osteoarthritis-like defects in hip joint. J Cell Physiol. 2019;234:18535-18543 pubmed 出版商
|
| Foyt D, Taheem D, Ferreira S, Norman M, Petzold J, Jell G, et al. Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation. Acta Biomater. 2019;89:73-83 pubmed 出版商
|
| Yang Y, Wang Y, Kong Y, Zhang X, Zhang H, Gang Y, et al. Mechanical stress protects against osteoarthritis via regulation of the AMPK/NF-κB signaling pathway. J Cell Physiol. 2019;234:9156-9167 pubmed 出版商
|
| Xu S, Wu X. miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6. Biosci Rep. 2019;39: pubmed 出版商
|
| Ji M, Jiang H, Zhang X, Shi P, Li C, Wu H, et al. Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nat Commun. 2018;9:5051 pubmed 出版商
|
| Chan C, Gulati G, Sinha R, Tompkins J, Lopez M, Carter A, et al. Identification of the Human Skeletal Stem Cell. Cell. 2018;175:43-56.e21 pubmed 出版商
|
| Xiao Z, He J, Su G, Chen M, Hou Y, Chen S, et al. Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice. Arthritis Res Ther. 2018;20:207 pubmed 出版商
|
| Chen Y, Zhang D, Ho K, Lin S, Suen W, Zhang H, et al. GPR120 is an important inflammatory regulator in the development of osteoarthritis. Arthritis Res Ther. 2018;20:163 pubmed 出版商
|
| Lach M, Kulcenty K, Jankowska K, Trzeciak T, Richter M, Suchorska W. Effect of cellular mass on chondrogenic differentiation during embryoid body formation. Mol Med Rep. 2018;18:2705-2714 pubmed 出版商
|
| Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, et al. Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis. Stem Cell Reports. 2018;11:228-241 pubmed 出版商
|
| Dikina A, Alt D, Herberg S, McMillan A, Strobel H, Zheng Z, et al. A Modular Strategy to Engineer Complex Tissues and Organs. Adv Sci (Weinh). 2018;5:1700402 pubmed 出版商
|
| Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, et al. Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells. PLoS ONE. 2018;13:e0198079 pubmed 出版商
|
| Fang H, Li X, Shen H, Sun B, Teng H, Li P. Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high-magnitude compression though inhibiting the p38 MAPK pathway. Biosci Rep. 2018;: pubmed 出版商
|
| Stelcer E, Kulcenty K, Rucinski M, Jopek K, Trzeciak T, Richter M, et al. Expression of Pluripotency Genes in Chondrocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2018;19: pubmed 出版商
|
| Shi J, Pang L, Jiao S. The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture. Biosci Rep. 2018;38: pubmed 出版商
|
| Zhang Q, Yin Z, Zhang F, Cao K, Sun H. CTHRC1 mediates IL?1??induced apoptosis in chondrocytes via JNK1/2 signaling. Int J Mol Med. 2018;41:2270-2278 pubmed 出版商
|
| Yang G, Li S, Li B, Cheng L, Jiang P, Tian Z, et al. Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1β-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-κB Pathway. Biomed Res Int. 2017;2017:8686207 pubmed 出版商
|
| Zhou H, Shi J, Zhang C, Li P. Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture. Biosci Rep. 2018;38: pubmed 出版商
|
| Zhang H, VOYTIK HARBIN S, Brookes S, Zhang L, Wallace J, Parker N, et al. Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage. Laryngoscope. 2017;: pubmed 出版商
|
| Han X, Leng X, Zhao M, Wu M, Chen A, Hong G, et al. Resveratrol increases nucleus pulposus matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture. Biosci Rep. 2017;37: pubmed 出版商
|
| Li P, Hou G, Zhang R, Gan Y, Xu Y, Song L, et al. High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway. Arthritis Res Ther. 2017;19:209 pubmed 出版商
|
| Brunt L, Begg K, Kague E, Cross S, Hammond C. Wnt signalling controls the response to mechanical loading during zebrafish joint development. Development. 2017;144:2798-2809 pubmed 出版商
|
| Cochis A, Grad S, Stoddart M, Farè S, Altomare L, Azzimonti B, et al. Bioreactor mechanically guided 3D mesenchymal stem cell chondrogenesis using a biocompatible novel thermo-reversible methylcellulose-based hydrogel. Sci Rep. 2017;7:45018 pubmed 出版商
|
| Li P, Gan Y, Xu Y, Wang L, Ouyang B, Zhang C, et al. 17beta-estradiol Attenuates TNF-?-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-?B Pathway. Int J Biol Sci. 2017;13:145-156 pubmed 出版商
|
| Hatakeyama A, Uchida S, Utsunomiya H, Tsukamoto M, Nakashima H, Nakamura E, et al. Isolation and Characterization of Synovial Mesenchymal Stem Cell Derived from Hip Joints: A Comparative Analysis with a Matched Control Knee Group. Stem Cells Int. 2017;2017:9312329 pubmed 出版商
|
| Suchorska W, Augustyniak E, Richter M, Trzeciak T. Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs). Stem Cell Rev. 2017;13:299-308 pubmed 出版商
|
| Yasuda H, Oh C, Chen D, de Crombrugghe B, Kim J. A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6. J Biol Chem. 2017;292:528-538 pubmed 出版商
|
| Gan Y, Li S, Li P, Xu Y, Wang L, Zhao C, et al. A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-?3-Loaded Nanoparticles for Nucleus Pulposus Regeneration. Stem Cells Int. 2016;2016:9042019 pubmed
|
| Qin C, Zhang B, Zhang L, Zhang Z, Wang L, Tang L, et al. MyD88-dependent Toll-like receptor 4 signal pathway in intervertebral disc degeneration. Exp Ther Med. 2016;12:611-618 pubmed
|
| Zhong L, Huang X, Karperien M, Post J. Correlation between Gene Expression and Osteoarthritis Progression in Human. Int J Mol Sci. 2016;17: pubmed 出版商
|
| Hwang P, Jing L, Chen J, Lim F, Tang R, Choi H, et al. N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Sci Rep. 2016;6:28038 pubmed 出版商
|
| Miyatake K, Muneta T, Ojima M, Yamada J, Matsukura Y, Abula K, et al. Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration. BMC Musculoskelet Disord. 2016;17:238 pubmed 出版商
|
| Li P, Shi R, Chen D, Gan Y, Xu Y, Song L, et al. Surgical removal and controlled trypsinization of the outer annulus fibrosus improves the bioactivity of the nucleus pulposus in a disc bioreactor culture. BMC Musculoskelet Disord. 2016;17:133 pubmed 出版商
|
| Dang P, Dwivedi N, Phillips L, Yu X, Herberg S, Bowerman C, et al. Controlled Dual Growth Factor Delivery From Microparticles Incorporated Within Human Bone Marrow-Derived Mesenchymal Stem Cell Aggregates for Enhanced Bone Tissue Engineering via Endochondral Ossification. Stem Cells Transl Med. 2016;5:206-17 pubmed 出版商
|