| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 免疫组化基因敲除验证; 小鼠; 1:1000; 图 4c
- 免疫印迹基因敲除验证; 小鼠; 1:500; 图 4a
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| Wang Z, Li Y, Zhan S, Zhang L, Zhang S, Tang Q, et al. SMAD4 Y353C promotes the progression of PDAC. BMC Cancer. 2019;19:1037 pubmed 出版商 |
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| Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed 出版商 |
| Rogers Z, McFarland C, Winters I, Naranjo S, Chuang C, Petrov D, et al. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nat Methods. 2017;14:737-742 pubmed 出版商 |
| Chatterjee A, Kosmacek E, Oberley Deegan R. MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway. Radiat Res. 2017;187:367-381 pubmed 出版商 |
| Yamaguchi J, Mino Kenudson M, Liss A, Chowdhury S, Wang T, Fernández Del Castillo C, et al. Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice. Gastroenterology. 2016;151:1232-1244.e10 pubmed 出版商 |
- 免疫组化基因敲除验证; 小鼠; 1:100; 图 2d
- 免疫组化-石蜡切片; 小鼠; 1:100; 图 2d
| Petit F, Deng C, Jamin S. Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice. Int J Biol Sci. 2016;12:667-76 pubmed 出版商 |
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| Wang Q, Li J, Wu W, Shen R, Jiang H, Qian Y, et al. Smad4-dependent suppressor pituitary homeobox 2 promotes PPP2R2A-mediated inhibition of Akt pathway in pancreatic cancer. Oncotarget. 2016;7:11208-22 pubmed 出版商 |
| Wang J, Liang W, Cui Y, He J, Liu H, Wang Y, et al. Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop. Neurochem Res. 2016;41:1073-84 pubmed 出版商 |
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| Chen R, Xu B, Chen S, Chen S, Zhang T, Ren J, et al. Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. World J Gastroenterol. 2014;20:14895-903 pubmed 出版商 |
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| Wang W, Zhu Y, Sun Z, Jin C, Wang X. Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling. Arthritis Res Ther. 2021;23:84 pubmed 出版商 |
| Long C, Cen S, Zhong Z, Zhou C, Zhong G. FOXO3 is targeted by miR-223-3p and promotes osteogenic differentiation of bone marrow mesenchymal stem cells by enhancing autophagy. Hum Cell. 2021;34:14-27 pubmed 出版商 |
| Chen J, Yi X, Gu P, Gao S. The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway. Braz J Med Biol Res. 2019;52:e8324 pubmed 出版商 |
| Yao L, Li J, Li L, Li X, Zhang R, Zhang Y, et al. Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways. BMC Complement Altern Med. 2019;19:14 pubmed 出版商 |
| Xue F, Yang J, Li Q, Zhou H. Down-regulation of microRNA-34a-5p promotes trophoblast cell migration and invasion via targetting Smad4. Biosci Rep. 2019;39: pubmed 出版商 |
| Wang Y, Chu J, Yi P, Dong W, Saultz J, Wang Y, et al. SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity. J Clin Invest. 2018;128:5123-5136 pubmed 出版商 |
| Lyu G, Guan Y, Zhang C, Zong L, Sun L, Huang X, et al. TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nat Commun. 2018;9:2560 pubmed 出版商 |
| Chen B, Ma J, Li C, Wang Y. Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial‑mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells. Mol Med Rep. 2018;18:16-24 pubmed 出版商 |
| Poduri A, Chang A, Raftrey B, Rhee S, Van M, Red Horse K. Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size. Development. 2017;144:3241-3252 pubmed 出版商 |
| Hao C, Yang S, Xu W, Shen J, Ye S, Liu X, et al. MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3. Sci Rep. 2016;6:22599 pubmed 出版商 |
| Xia X, Zhang K, Cen G, Jiang T, Cao J, Huang K, et al. MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4. Oncotarget. 2015;6:21046-63 pubmed |
| Cho S, Ha S, Huang S, Kim J, Kang M, Yoo H, et al. The prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell carcinoma. Med Oncol. 2014;31:236 pubmed 出版商 |
| Su D, Jing S, Guan L, Li Q, Zhang H, Gao X, et al. Role of Nodal-PITX2C signaling pathway in glucose-induced cardiomyocyte hypertrophy. Biochem Cell Biol. 2014;92:183-90 pubmed 出版商 |
| Ueno K, Hirata H, Shahryari V, Deng G, Tanaka Y, Tabatabai Z, et al. microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer. Br J Cancer. 2013;108:1659-67 pubmed 出版商 |
| Zhang Y, Fan K, Sun Q, Chen A, Shen W, Zhao Z, et al. Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-? signalling pathway. Nucleic Acids Res. 2012;40:9286-97 pubmed 出版商 |
| Yao L, Li F, Tang Z, Gao S, Wu Q. Smad4 expression in hepatocellular carcinoma differs by hepatitis status. Asian Pac J Cancer Prev. 2012;13:1297-303 pubmed |
| Shen Z, Braun R, Hu J, Xie Q, Chu H, Love R, et al. Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem. 2012;287:23294-305 pubmed 出版商 |
| Mollbrink A, Holmström P, Sjöström M, Hultcrantz R, Eriksson L, Stål P. Iron-regulatory gene expression during liver regeneration. Scand J Gastroenterol. 2012;47:591-600 pubmed 出版商 |
| Le Goff C, Mahaut C, Abhyankar A, Le Goff W, Serre V, Afenjar A, et al. Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome. Nat Genet. 2011;44:85-8 pubmed 出版商 |
| Wang W, Chen X, Li X, Wang L, Zhang H, He Y, et al. Interference RNA-based silencing of endogenous SMAD4 in porcine granulosa cells resulted in decreased FSH-mediated granulosa cells proliferation and steroidogenesis. Reproduction. 2011;141:643-51 pubmed 出版商 |
| Wu D, Zhu H, Zhao Q, Zhang Z, Wang S, Wang M, et al. Genetic variations in the SMAD4 gene and gastric cancer susceptibility. World J Gastroenterol. 2010;16:5635-41 pubmed |
| Wang W, Wang L, Li X, Chen X, Zhang H, He Y, et al. Effect of interrupted endogenous BMP/Smad signaling on growth and steroidogenesis of porcine granulosa cells. J Zhejiang Univ Sci B. 2010;11:719-27 pubmed 出版商 |
| Gabbi C, Kim H, Barros R, Korach Andre M, Warner M, Gustafsson J. Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice. Proc Natl Acad Sci U S A. 2010;107:14763-8 pubmed 出版商 |
| Gao Y, Yang G, Weng T, Du J, Wang X, Zhou J, et al. Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice. Mol Cell Biol. 2009;29:5941-51 pubmed 出版商 |
| Shim J, Greenblatt M, Xie M, Schneider M, Zou W, Zhai B, et al. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009;28:2028-41 pubmed 出版商 |
| Li M, Edamatsu H, Kitazawa R, Kitazawa S, Kataoka T. Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis. 2009;30:1424-32 pubmed 出版商 |
| Windish H, Lin P, Mattila J, Green A, Onuoha E, Kane L, et al. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. J Leukoc Biol. 2009;86:713-25 pubmed 出版商 |
| Doisne J, Bartholin L, Yan K, Garcia C, Duarte N, Le Luduec J, et al. iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med. 2009;206:1365-78 pubmed 出版商 |
| Büchmann Møller S, Miescher I, John N, Krishnan J, Deng C, Sommer L. Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol. 2009;330:329-38 pubmed 出版商 |
