产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗组蛋白H3(乙酰K27)抗体-ChIP级
目录 :
ab4729
规格 :
4毫克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, , 斑马鱼, fruit fly , 非洲爪蛙
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq, 其他
文章摘录数: 390
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:10,000; 图 3a
Cameron B, Lehrmann E, Chih T, Walters J, Buksch R, Snyder S, et al. Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway. Biol Open. 2021;10: pubmed 出版商
  • ChIP-Seq; 人类; 图 2c
Yue M, Liu T, Yan G, Luo X, Wang L. LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer. Cancer Cell Int. 2021;21:504 pubmed 出版商
  • 免疫印迹; 人类; 2 ug/ml; 图 4a
Lo Cascio C, McNamara J, Melendez E, Lewis E, Dufault M, Sanai N, et al. Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. JCI Insight. 2021;6: pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 4d
Keane L, Cheray M, Saidi D, Kirby C, Friess L, González Rodríguez P, et al. Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas. Neurooncol Adv. 2021;3:vdab096 pubmed 出版商
  • ChIP-Seq; 人类; 图 4a
  • 染色质免疫沉淀 ; 人类; 图 4d
Su C, Lu F, Soldan S, Lamontagne R, Tang H, Napoletani G, et al. EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes. PLoS Pathog. 2021;17:e1009834 pubmed 出版商
  • ChIP-Seq; 人类; 图 2e
Kaplun D, Starshin A, Sharko F, Gainova K, Filonova G, Zhigalova N, et al. Kaiso Regulates DNA Methylation Homeostasis. Int J Mol Sci. 2021;22: pubmed 出版商
  • ChIP-Seq; 人类; 图 7c
Qian X, Qu H, Zhang F, Peng S, Dou D, Yang Y, et al. Exosomal long noncoding RNA AGAP2-AS1 regulates trastuzumab resistance via inducing autophagy in breast cancer. Am J Cancer Res. 2021;11:1962-1981 pubmed
  • ChIP-Seq; 人类; 图 s1a
Yuan C, Chen H, Tu S, Huang H, Pan Y, Gui X, et al. A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks. Genome Biol. 2021;22:156 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:300; 图 s5
Gusyatiner O, Bady P, Pham M, Lei Y, Park J, Daniel R, et al. BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma. Neuro Oncol. 2021;23:1680-1692 pubmed 出版商
  • ChIP-Seq; 人类; 图 2a
Della Chiara G, Gervasoni F, Fakiola M, Godano C, D Oria C, Azzolin L, et al. Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ. Nat Commun. 2021;12:2340 pubmed 出版商
  • ChIP-Seq; 人类; 图 s12c
Gilan O, Rioja I, Knezevic K, Bell M, Yeung M, Harker N, et al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020;368:387-394 pubmed 出版商
  • ChIP-Seq; 人类; 图 1b
Cai W, Greer C, Chen J, Arnal Estapé A, Cao J, Yan Q, et al. Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. BMC Med Genomics. 2020;13:33 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 1:500; 图 6b
Cooper A, Butto T, Hammer N, Jagannath S, Fend Guella D, Akhtar J, et al. Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nat Commun. 2020;11:480 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2c, s3
Liu Q, Borcherding N, Shao P, Maina P, Zhang W, Qi H. Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance. EBioMedicine. 2020;51:102612 pubmed 出版商
  • ChIP-Seq; 鸡; 1 ug/ul; 图 3a
Tambalo M, Anwar M, Ahmed M, Streit A. Enhancer activation by FGF signalling during otic induction. Dev Biol. 2020;457:69-82 pubmed 出版商
  • ChIP-Seq; 人类; 图 4c
  • 染色质免疫沉淀 ; 人类; 图 5f, 4c, 6c
Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 e6a
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 s4a
Mews P, Egervári G, Nativio R, Sidoli S, Donahue G, Lombroso S, et al. Alcohol metabolism contributes to brain histone acetylation. Nature. 2019;574:717-721 pubmed 出版商
  • 免疫印迹; 人类; 图 2k
Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574:575-580 pubmed 出版商
  • ChIP-Seq; 小鼠; ; 图 1a
  • 染色质免疫沉淀 ; 小鼠; ; 图 s10
Kuang Z, Wang Y, Li Y, Ye C, Ruhn K, Behrendt C, et al. The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. Science. 2019;365:1428-1434 pubmed 出版商
  • ChIP-Seq; 人类; 图 3a
Wu S, Fatkhutdinov N, Rosin L, Luppino J, Iwasaki O, Tanizawa H, et al. ARID1A spatially partitions interphase chromosomes. Sci Adv. 2019;5:eaaw5294 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s5a
Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, et al. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. Nat Commun. 2019;10:2229 pubmed 出版商
  • ChIP-Seq; 人类; 图 9
Meyer M, Benkusky N, Kaufmann M, Lee S, Redfield R, Jones G, et al. Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse. J Biol Chem. 2019;294:9518-9535 pubmed 出版商
  • ChIP-Seq; 人类; 图 4a
Shi K, Yin X, Cai M, Yan Y, Jia C, Ma P, et al. PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors. elife. 2019;8: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 s3e
Benchetrit H, Jaber M, Zayat V, Sebban S, Pushett A, Makedonski K, et al. Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019;24:983-994.e7 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 6a
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Lavarone E, Barbieri C, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10:1679 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1m
Lytle N, Ferguson L, Rajbhandari N, Gilroy K, Fox R, Deshpande A, et al. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell. 2019;177:572-586.e22 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5b
Krimpenfort P, Snoek M, Lambooij J, Song J, van der Weide R, Bhaskaran R, et al. A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis. Nat Commun. 2019;10:1425 pubmed 出版商
  • ChIP-Seq; 人类; 图 s4e
Vodnala S, Eil R, Kishton R, Sukumar M, Yamamoto T, Ha N, et al. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science. 2019;363: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 2f
Kelly M, So J, Rogers A, Gregory G, Li J, Zethoven M, et al. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nat Commun. 2019;10:1347 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 2
Zhang S, Deng T, Tang W, He B, Furusawa T, Ambs S, et al. Epigenetic regulation of REX1 expression and chromatin binding specificity by HMGNs. Nucleic Acids Res. 2019;47:4449-4461 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 4h
Liu X, Wang Y, Lu H, Li J, Yan X, Xiao M, et al. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature. 2019;567:525-529 pubmed 出版商
  • ChIP-Seq; 人类; ; 图 3a, e4a
Sharifnia T, Wawer M, Chen T, Huang Q, Weir B, Sizemore A, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nat Med. 2019;25:292-300 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3e
Philips R, Lee J, Gaonkar K, Chanana P, Chung J, Romero Arocha S, et al. HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment. elife. 2019;8: pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3d
Collins P, Cella M, Porter S, Li S, Gurewitz G, Hong H, et al. Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells. Cell. 2019;176:348-360.e12 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1e
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 2e
  • 染色质免疫沉淀 ; 小鼠; 图 5c
Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1e
  • 免疫细胞化学; 小鼠; 图 s1b
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1a, 7b
Lee H, Willi M, Shin H, Liu C, Hennighausen L. Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation. Nucleic Acids Res. 2018;46:10796-10809 pubmed 出版商
  • 其他; 小鼠; 图 5d
Godfrey T, Wildman B, Beloti M, Kemper A, Ferraz E, Roy B, et al. The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. J Biol Chem. 2018;293:17646-17660 pubmed 出版商
  • ChIP-Seq; 人类; 图 5b
Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 8b
Piragyte I, Clapes T, Polyzou A, Klein Geltink R, Lefkopoulos S, Yin N, et al. A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nat Commun. 2018;9:3090 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 3b
Klein R, Tung P, Somanath P, Fehling H, Knoepfler P. Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018;31:83-94 pubmed 出版商
  • ChIP-Seq; 人类; 图 4a
Pulikkan J, Hegde M, Ahmad H, Belaghzal H, Illendula A, Yu J, et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018;174:172-186.e21 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5
Tamassia N, Arruda Silva F, Calzetti F, Lonardi S, Gasperini S, Gardiman E, et al. A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It. Front Immunol. 2018;9:795 pubmed 出版商
  • 免疫沉淀; 人类; 图 6b
Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A. Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA. Mol Cell Biol. 2018;38: pubmed 出版商
  • ChIP-Seq; 人类; 图 3a
Liu X, Wu H, Krzisch M, Wu X, Graef J, Muffat J, et al. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. 2018;172:979-992.e6 pubmed 出版商
  • ChIP-Seq; 斑马鱼; 图 s1a
Murphy P, Wu S, James C, Wike C, Cairns B. Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell. 2018;172:993-1006.e13 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4a
Shukla S, Cyrta J, Murphy D, Walczak E, Ran L, Agrawal P, et al. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell. 2017;32:792-806.e7 pubmed 出版商
  • ChIP-Seq; 人类; 图 3a
Kelso T, Porter D, Amaral M, Shokhirev M, Benner C, Hargreaves D. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. elife. 2017;6: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 s5a
Gao X, Lee H, Li W, Platt R, Barrasa M, Ma Q, et al. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proc Natl Acad Sci U S A. 2017;114:10107-10112 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Rong X, Wang B, Palladino E, de Aguiar Vallim T, Ford D, Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017;127:3640-3651 pubmed 出版商
  • ChIP-Seq; 人类; 图 4a
  • 免疫印迹; 人类; 图 3b
Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, et al. In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 2017;170:1028-1043.e19 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2f
Rubin A, Barajas B, Furlan Magaril M, Lopez Pajares V, Mumbach M, Howard I, et al. Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation. Nat Genet. 2017;49:1522-1528 pubmed 出版商
  • ChIP-Seq; 人类; 图 4e
van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49:1261-1266 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3e
  • 免疫印迹; 小鼠; 图 s6b
Mews P, Donahue G, Drake A, Luczak V, Abel T, Berger S. Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature. 2017;546:381-386 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Mildner A, Schönheit J, Giladi A, David E, Lara Astiaso D, Lorenzo Vivas E, et al. Genomic Characterization of Murine Monocytes Reveals C/EBP? Transcription Factor Dependence of Ly6C- Cells. Immunity. 2017;46:849-862.e7 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 4g
Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1
Lee H, Willi M, Wang C, Yang C, Smith H, Liu C, et al. Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice. Nucleic Acids Res. 2017;45:4606-4618 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 2d
Kazakevych J, Sayols S, Messner B, Krienke C, Soshnikova N. Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells. Nucleic Acids Res. 2017;45:5770-5784 pubmed 出版商
  • ChIP-Seq; 人类; 图 s6a
Wan L, Wen H, Li Y, Lyu J, Xi Y, Hoshii T, et al. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Nature. 2017;543:265-269 pubmed 出版商
  • ChIP-Seq; 人类; 图 4e
Canver M, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern E, et al. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017;49:625-634 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 6b
Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Wu N, Jia D, Bates B, Basom R, Eberhart C, MacPherson D. A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence. J Clin Invest. 2017;127:888-898 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6G
Barateau A, Vadrot N, Vicart P, Ferreiro A, Mayer M, Heron D, et al. A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus. PLoS ONE. 2017;12:e0169189 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5a
Maatouk D, Natarajan A, Shibata Y, Song L, Crawford G, Ohler U, et al. Genome-wide identification of regulatory elements in Sertoli cells. Development. 2017;144:720-730 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3b
Zeng X, Willi M, Shin H, Hennighausen L, Wang C. Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5. Cell Rep. 2016;17:3333-3346 pubmed 出版商
  • ChIP-Seq; 人类; 图 s4a
Ang Y, Rivas R, Ribeiro A, Srivas R, Rivera J, Stone N, et al. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell. 2016;167:1734-1749.e22 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 1b
Pan G, Ameur A, Enroth S, Bysani M, Nord H, Cavalli M, et al. PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c. Nucleic Acids Res. 2017;45:2408-2422 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4
Alfano L, Costa C, Caporaso A, Antonini D, Giordano A, Pentimalli F. HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget. 2016;7:78127-78139 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1a
Willi M, Yoo K, Wang C, Trajanoski Z, Hennighausen L. Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation. Nucleic Acids Res. 2016;44:10277-10291 pubmed
  • ChIP-Seq; 人类; 图 1d
Ghazavi F, de Moerloose B, Van Loocke W, Wallaert A, Helsmoortel H, Ferster A, et al. Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Oncotarget. 2016;7:73769-73780 pubmed 出版商
  • ChIP-Seq; fruit fly ; 1:1000; 图 3a
Loubiere V, Delest A, Thomas A, Bonev B, Schuettengruber B, Sati S, et al. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Nat Genet. 2016;48:1436-1442 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s4d
  • 免疫印迹; 人类; 图 2f
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed 出版商
  • ChIP-Seq; 非洲爪蛙; 图 6b
Walentek P, Quigley I, Sun D, Sajjan U, Kintner C, Harland R. Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis. elife. 2016;5: pubmed 出版商
  • ChIP-Seq; 人类; 图 1k
Platt J, Salama R, Smythies J, Choudhry H, Davies J, Hughes J, et al. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. EMBO Rep. 2016;17:1410-1421 pubmed
  • ChIP-Seq; 小鼠; 图 2a
Zhang X, Wu J, Wang J, Shen T, Li H, Lu J, et al. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol. 2016;17:162 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s5
Merry C, McMahon S, Forrest M, Bartels C, Saiakhova A, Bartel C, et al. Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer. Oncotarget. 2016;7:53230-53244 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 7a
  • 免疫印迹; 小鼠; 图 1c
Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, et al. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 2016;213:1459-77 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 S3
Yang W, Ng F, Chan K, Pu X, Poston R, Ren M, et al. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genet. 2016;12:e1006127 pubmed 出版商
  • ChIP-Seq; 人类; 图 5
Miller C, Pjanic M, Wang T, Nguyen T, Cohain A, Lee J, et al. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nat Commun. 2016;7:12092 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5a
Shin H, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, et al. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016;48:904-911 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2g
Gao X, Lin S, Ren F, Li J, Chen J, Yao C, et al. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016;7:11960 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1b
Klein Hessling S, Rudolf R, Muhammad K, Knobeloch K, Maqbool M, Cauchy P, et al. A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development. Nat Commun. 2016;7:11841 pubmed 出版商
  • ChIP-Seq; 人类; 图 1
Tasdemir N, Banito A, Roe J, Alonso Curbelo D, Camiolo M, Tschaharganeh D, et al. BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance. Cancer Discov. 2016;6:612-29 pubmed 出版商
  • ChIP-Seq; 人类; 图 8
Shearstone J, Golonzhka O, Chonkar A, Tamang D, Van Duzer J, Jones S, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS ONE. 2016;11:e0153767 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 1:300; 图 7b
Navarra A, Musto A, Gargiulo A, Petrosino G, Pierantoni G, Fusco A, et al. Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state. BMC Biol. 2016;14:24 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 3e
Lee H, Dai F, Zhuang L, Xiao Z, Kim J, Zhang Y, et al. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 2016;7:19134-46 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2
Hardy K, Wu F, Tu W, Zafar A, Boulding T, McCuaig R, et al. Identification of chromatin accessibility domains in human breast cancer stem cells. Nucleus. 2016;7:50-67 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:1000; 图 7
Akan I, Love D, Harwood K, Bond M, Hanover J. Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. J Biol Chem. 2016;291:9906-19 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 s8
Mo A, Luo C, Davis F, Mukamel E, Henry G, Nery J, et al. Epigenomic landscapes of retinal rods and cones. elife. 2016;5:e11613 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1
Goode D, Obier N, Vijayabaskar M, Lie A Ling M, Lilly A, Hannah R, et al. Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. Dev Cell. 2016;36:572-87 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s8
Weyemi U, Redon C, Choudhuri R, Aziz T, Maeda D, Boufraqech M, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Boulding T, Wu F, McCuaig R, Dunn J, Sutton C, Hardy K, et al. Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer. PLoS ONE. 2016;11:e0148065 pubmed 出版商
  • ChIP-Seq; 人类; 图 2
Liu X, Li H, Rajurkar M, Li Q, Cotton J, Ou J, et al. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016;14:1169-1180 pubmed 出版商
  • ChIP-Seq; 小鼠; 表  s3
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed 出版商
  • ChIP-Seq; 人类; 图 e3
Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016;529:413-417 pubmed 出版商
  • ChIP-Seq; 人类; 图 4
Conery A, Centore R, Neiss A, Keller P, Joshi S, Spillane K, et al. Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3g
Hagelkruys A, Mattes K, Moos V, Rennmayr M, Ringbauer M, Sawicka A, et al. Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development. Mol Cell Biol. 2016;36:462-74 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 3
Metser G, Shin H, Wang C, Yoo K, Oh S, Villarino A, et al. An autoregulatory enhancer controls mammary-specific STAT5 functions. Nucleic Acids Res. 2016;44:1052-63 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5
Park S, Shim J, Park H, Eum D, Park M, Mi Yi J, et al. MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. Oncogene. 2016;35:1292-301 pubmed 出版商
Wang W, Tang Y, Xiao Q, Lee W, Cheng B, Niu Z, et al. Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer. Nat Commun. 2021;12:4441 pubmed 出版商
Jian X, Felsenfeld G. Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Nat Commun. 2021;12:4338 pubmed 出版商
Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, et al. SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021;12:4090 pubmed 出版商
Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, et al. PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021;8:e2102060 pubmed 出版商
Gupte R, Nandu T, Kraus W. Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages. Nat Commun. 2021;12:3931 pubmed 出版商
Fang Y, Tang Y, Zhang Y, Pan Y, Jia J, Sun Z, et al. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression. Nucleic Acids Res. 2021;49:6281-6295 pubmed 出版商
Liu C, Toth R, Bakr A, Goyal A, Islam M, Breuer K, et al. Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response. Cancers (Basel). 2021;13: pubmed 出版商
Daly A, Dudley L, Peel M, Liebhaber S, Parker S, Camper S. Multi-omic profiling of pituitary thyrotropic cells and progenitors. BMC Biol. 2021;19:76 pubmed 出版商
Pinter S, Knodel F, Choudalakis M, Schnee P, Kroll C, Fuchs M, et al. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation. Nucleic Acids Res. 2021;49:4350-4370 pubmed 出版商
Zhao X, Wang M, Jiang H, Lwin T, Park P, Gao J, et al. Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma. Cell Rep. 2021;34:108870 pubmed 出版商
Haring N, van Bree E, Jordaan W, Roels J, Sotomayor G, Hey T, et al. ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters. Genome Res. 2021;31:551-563 pubmed 出版商
Duan A, Wang H, Zhu Y, Wang Q, Zhang J, Hou Q, et al. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. BMC Biol. 2021;19:38 pubmed 出版商
Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed 出版商
Jia Y, Zhou J, Tan T, Chung T, Wong R, Chooi J, et al. Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma. Blood Cancer J. 2021;11:32 pubmed 出版商
Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian X, et al. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging Cell. 2021;20:e13315 pubmed 出版商
Zhang W, Huang J, Cook D. Histone modification dynamics at H3K27 are associated with altered transcription of in planta induced genes in Magnaporthe oryzae. PLoS Genet. 2021;17:e1009376 pubmed 出版商
Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito J, et al. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. elife. 2021;10: pubmed 出版商
De Virgiliis F, Hutson T, Palmisano I, Amachree S, Miao J, Zhou L, et al. Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling. Nat Commun. 2020;11:6425 pubmed 出版商
Guerrero Martínez J, Ceballos Chávez M, Koehler F, Peiro S, Reyes J. TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains. Nat Commun. 2020;11:6196 pubmed 出版商
Zhao Y, Wang Z, Mao Y, Li B, Zhu Y, Zhang S, et al. NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice. Aging (Albany NY). 2020;12:23233-23250 pubmed 出版商
Maitituoheti M, Keung E, Tang M, Yan L, Alam H, Han G, et al. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Rep. 2020;33:108293 pubmed 出版商
Kent O, Saha M, Coyaud E, Burston H, Law N, Dadson K, et al. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nat Commun. 2020;11:4673 pubmed 出版商
Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, et al. Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Sci Adv. 2020;6:eaba3200 pubmed 出版商
Fitz James M, Tong P, Pidoux A, Özadam H, Yang L, White S, et al. Large domains of heterochromatin direct the formation of short mitotic chromosome loops. elife. 2020;9: pubmed 出版商
Shi H, Tao T, Abraham B, Durbin A, Zimmerman M, Kadoch C, et al. ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv. 2020;6:eaaz3440 pubmed 出版商
Wang A, Chen L, Wu R, Hao Y, McSwiggen D, Heckert A, et al. The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells. Mol Cell. 2020;79:221-233.e5 pubmed 出版商
Zhang Y, Chan H, Garcia Martinez L, Karl D, Weich N, Slingerland J, et al. Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer. Sci Adv. 2020;6:eaaz7249 pubmed 出版商
Braun T, Coblentz C, Smith B, Coleman D, Schonrock Z, Carratt S, et al. Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia. Proc Natl Acad Sci U S A. 2020;117:13670-13679 pubmed 出版商
Adam R, Yang H, Ge Y, Infarinato N, Gur Cohen S, Miao Y, et al. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nat Cell Biol. 2020;22:640-650 pubmed 出版商
Ray Jones H, Duffus K, McGovern A, Martin P, Shi C, Hankinson J, et al. Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31. BMC Biol. 2020;18:47 pubmed 出版商
Somerville T, Biffi G, Da ler Plenker J, Hur S, He X, Vance K, et al. Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. elife. 2020;9: pubmed 出版商
Amândio A, Lopez Delisle L, BOLT C, Mascrez B, Duboule D. A complex regulatory landscape involved in the development of mammalian external genitals. elife. 2020;9: pubmed 出版商
Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J, et al. A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020;11:1851 pubmed 出版商
Palomer X, Román Azcona M, Pizarro Delgado J, Planavila A, Villarroya F, Valenzuela Alcaraz B, et al. SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. Signal Transduct Target Ther. 2020;5:14 pubmed 出版商
Wang Y, Zhang X, Song Q, Hou Y, Liu J, Sun Y, et al. Characterization of the chromatin accessibility in an Alzheimer's disease (AD) mouse model. Alzheimers Res Ther. 2020;12:29 pubmed 出版商
Morales Torres C, Wu M, Hobor S, Wainwright E, Martin M, Patel H, et al. Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis. Nat Commun. 2020;11:1792 pubmed 出版商
Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, et al. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020;579:586-591 pubmed 出版商
Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, et al. Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Cancer Discov. 2020;10:724-745 pubmed 出版商
Yuan S, Natesan R, Sanchez Rivera F, Li J, Bhanu N, Yamazoe T, et al. Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Cancer Discov. 2020;10:854-871 pubmed 出版商
Ma H, Qian W, Bambousková M, Collins P, Porter S, Byrum A, et al. Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. MBio. 2020;11: pubmed 出版商
Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten G, et al. Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biol. 2020;21:59 pubmed 出版商
Li Y, Liao Z, Luo H, Benyoucef A, Kang Y, Lai Q, et al. Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Nucleic Acids Res. 2020;48:3119-3133 pubmed 出版商
Liu H, Duncan K, Helverson A, Kumari P, Mumm C, Xiao Y, et al. Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. elife. 2020;9: pubmed 出版商
Mao N, Gao D, Hu W, Gadal S, Hieronymus H, Wang S, et al. Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. Cancer Res. 2020;80:1428-1437 pubmed 出版商
Cárdenas H, Jiang G, Thomes Pepin J, Parker J, Condello S, Nephew K, et al. Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer. NPJ Precis Oncol. 2019;3:32 pubmed 出版商
Friman E, Deluz C, Meireles Filho A, Govindan S, Gardeux V, Deplancke B, et al. Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle. elife. 2019;8: pubmed 出版商
Sajwan S, Mannervik M. Gene activation by dCas9-CBP and the SAM system differ in target preference. Sci Rep. 2019;9:18104 pubmed 出版商
Braun T, Okhovat M, Coblentz C, Carratt S, Foley A, Schonrock Z, et al. Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia. Nat Commun. 2019;10:5455 pubmed 出版商
Kelly T, Brümmer A, Hooshdaran N, Tariveranmoshabad M, Zamudio J. Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities. Cell Rep. 2019;29:2702-2717.e7 pubmed 出版商
An Z, Liu P, Zheng J, Si C, Li T, Chen Y, et al. Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. Cell Rep. 2019;29:1986-2000.e8 pubmed 出版商
Williams R, Candido Ferreira I, Repapi E, Gavriouchkina D, Senanayake U, Ling I, et al. Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo. Dev Cell. 2019;51:255-276.e7 pubmed 出版商
Qadeer Z, Valle García D, Hasson D, Sun Z, Cook A, Nguyen C, et al. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. 2019;36:512-527.e9 pubmed 出版商
Inoue F, Kreimer A, Ashuach T, Ahituv N, Yosef N. Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction. Cell Stem Cell. 2019;25:713-727.e10 pubmed 出版商
Saga K, Park J, Nimura K, Kawamura N, Ishibashi A, Nonomura N, et al. NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis. J Exp Clin Cancer Res. 2019;38:416 pubmed 出版商
Cai D, Wang J, Gao B, Li J, Wu F, Zou J, et al. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019;10:4621 pubmed 出版商
Burr M, Sparbier C, Chan K, Chan Y, Kersbergen A, Lam E, et al. An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell. 2019;36:385-401.e8 pubmed 出版商
Lee J, Neumann M, Duro D, Schmid M. CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants. PLoS ONE. 2019;14:e0222778 pubmed 出版商
Wu R, Young I, Chen Y, Chuang S, Toubaji A, Wu M. Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. Nat Commun. 2019;10:4332 pubmed 出版商
Sato T, Yoo S, Kong R, Sinha A, Chandramani Shivalingappa P, Patel A, et al. Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Cancer Res. 2019;79:6084-6100 pubmed 出版商
Chao T, Zhang Q, Li Z, Tiwari S, Qin Y, Yau E, et al. The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. MBio. 2019;10: pubmed 出版商
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster B, et al. G-tract RNA removes Polycomb repressive complex 2 from genes. Nat Struct Mol Biol. 2019;26:899-909 pubmed 出版商
Gibson B, Doolittle L, Schneider M, Jensen L, Gamarra N, Henry L, et al. Organization of Chromatin by Intrinsic and Regulated Phase Separation. Cell. 2019;179:470-484.e21 pubmed 出版商
Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, et al. Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nat Commun. 2019;10:4297 pubmed 出版商
Inoue F, Eckalbar W, Wang Y, Murphy K, Matharu N, Vaisse C, et al. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2019;1:475-484 pubmed 出版商
Ding L, Su Y, Fassl A, Hinohara K, Qiu X, Harper N, et al. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. Nat Commun. 2019;10:4182 pubmed 出版商
Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, et al. MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Cancer Res. 2019;79:5711-5722 pubmed 出版商
Meyer S, Scuoppo C, Vlasevska S, Bal E, Holmes A, Holloman M, et al. Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma. Immunity. 2019;51:535-547.e9 pubmed 出版商
Sun Z, Xu X, He J, Murray A, Sun M, Wei X, et al. EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity. Nat Commun. 2019;10:3892 pubmed 出版商
Fons N, Sundaram R, Breuer G, Peng S, McLean R, Kalathil A, et al. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019;10:3790 pubmed 出版商
Meyer M, Lee S, Carlson A, Benkusky N, Kaufmann M, Jones G, et al. A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues. J Biol Chem. 2019;294:14467-14481 pubmed 出版商
Lindtner S, Catta Preta R, Tian H, Su Feher L, Price J, Dickel D, et al. Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Cell Rep. 2019;28:2048-2063.e8 pubmed 出版商
Carter B, Ku W, Kang J, Hu G, Perrie J, Tang Q, et al. Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq). Nat Commun. 2019;10:3747 pubmed 出版商
El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, van Blerkom P, et al. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019;178:1145-1158.e20 pubmed 出版商
Pacini V, Petit F, Querat B, Laverrière J, Cohen Tannoudji J, L hôte D. Identification of a pituitary ERα-activated enhancer triggering the expression of Nr5a1, the earliest gonadotrope lineage-specific transcription factor. Epigenetics Chromatin. 2019;12:48 pubmed 出版商
Madigan V, Yuziuk J, Chiarella A, Tyson T, Meganck R, Elmore Z, et al. Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. PLoS Pathog. 2019;15:e1007988 pubmed 出版商
Petermann F, Pekowska A, Johnson C, Jankovic D, Shih H, Jiang K, et al. The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1. Mol Cell. 2019;75:1229-1242.e5 pubmed 出版商
Zhou J, So K, Li Y, Li Y, Yuan J, Ding Y, et al. Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell. 2019;18:e12996 pubmed 出版商
Jakobsen J, Laursen L, Schuster M, Pundhir S, Schoof E, Ge Y, et al. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML. Sci Adv. 2019;5:eaaw4304 pubmed 出版商
Huang H, Zou X, Zhong L, Hou Y, Zhou J, Zhang Z, et al. CRISPR/dCas9-mediated activation of multiple endogenous target genes directly converts human foreskin fibroblasts into Leydig-like cells. J Cell Mol Med. 2019;: pubmed 出版商
Bell C, Fennell K, Chan Y, Rambow F, Yeung M, Vassiliadis D, et al. Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nat Commun. 2019;10:2723 pubmed 出版商
Rezazadeh S, Yang D, Tombline G, Simon M, Regan S, Seluanov A, et al. SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Res. 2019;: pubmed 出版商
Khan O, Giles J, McDonald S, Manne S, Ngiow S, Patel K, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature. 2019;: pubmed 出版商
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed 出版商
Maes M, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neurosci Lett. 2019;707:134310 pubmed 出版商
Bao J, Li M, Liang S, Yang Y, Wu J, Zou Q, et al. Integrated high-throughput analysis identifies super enhancers associated with chemoresistance in SCLC. BMC Med Genomics. 2019;12:67 pubmed 出版商
Zhao X, Ren Y, Lawlor M, Shah B, Park P, Lwin T, et al. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019;35:752-766.e9 pubmed 出版商
Duy C, Teater M, Garrett Bakelman F, Lee T, Meydan C, Glass J, et al. Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML. Cancer Discov. 2019;: pubmed 出版商
Pontis J, Planet E, Offner S, Turelli P, Duc J, Coudray A, et al. Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs. Cell Stem Cell. 2019;24:724-735.e5 pubmed 出版商
Zhang X, Wang Y, Chiang H, Hsieh Y, Lu C, Park B, et al. BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. Breast Cancer Res. 2019;21:51 pubmed 出版商
Chen L, Toke N, Luo S, Vasoya R, Fullem R, Parthasarathy A, et al. A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Nat Genet. 2019;51:777-785 pubmed 出版商
Hu X, Liu Z, Chen X, Schulz V, Kumar A, Hartman A, et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun. 2019;10:1695 pubmed 出版商
Wei F, Tang D, Li Z, Kashif M, Khan A, Lu H, et al. Molecular cloning and subcellular localization of six HDACs and their roles in response to salt and drought stress in kenaf (Hibiscus cannabinus L.). Biol Res. 2019;52:20 pubmed 出版商
Fukushima H, Takeda H, Nakamura R. Targeted in vivo epigenome editing of H3K27me3. Epigenetics Chromatin. 2019;12:17 pubmed 出版商
Pan J, McKenzie Z, D Avino A, Mashtalir N, Lareau C, St Pierre R, et al. The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. Nat Genet. 2019;51:618-626 pubmed 出版商
Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al. A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Nat Commun. 2019;10:1152 pubmed 出版商
Dey A, Yang W, Gegonne A, Nishiyama A, Pan R, Yagi R, et al. BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses. EMBO J. 2019;38: pubmed 出版商
Matthews S, Eshelman M, Berg A, Koltun W, Yochum G. The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells. PLoS ONE. 2019;14:e0212850 pubmed 出版商
Chung Y, Zhu Y, Wu M, Simonini S, Kuhn A, Armenta Medina A, et al. Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS. Nat Commun. 2019;10:886 pubmed 出版商
Zhou Q, Yu B, Anderson C, Huang Z, Hanus J, Zhang W, et al. LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus. elife. 2019;8: pubmed 出版商
Soffers J, Li X, Saraf A, Seidel C, Florens L, Washburn M, et al. Characterization of a metazoan ADA acetyltransferase complex. Nucleic Acids Res. 2019;47:3383-3394 pubmed 出版商
Chen L, Lin Y, Gallegos D, Hazlett M, Gómez Schiavon M, Yang M, et al. Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes. Cell Rep. 2019;26:1174-1188.e5 pubmed 出版商
Ueda S, Cordeiro I, Moriyama Y, Nishimori C, Kai K, Yu R, et al. Cux2 refines the forelimb field by controlling expression of Raldh2 and Hox genes. Biol Open. 2019;8: pubmed 出版商
Wang H, Long Q, Tang S, Xiao Q, Gao C, Zhao Q, et al. Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. Nucleic Acids Res. 2019;47:2349-2364 pubmed 出版商
Hemming M, Lawlor M, Andersen J, Hagan T, Chipashvili O, Scott T, et al. Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Cancer Res. 2019;79:994-1009 pubmed 出版商
García Carpizo V, Ruiz Llorente S, Sarmentero J, González Corpas A, Barrero M. CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines. Mol Cancer Res. 2019;17:720-730 pubmed 出版商
Ramón Vázquez A, de la Rosa J, Tabraue C, Lopez F, Díaz Chico B, Bosca L, et al. Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages. Mol Cell Biol. 2019;39: pubmed 出版商
Zuberbuehler M, Parker M, Wheaton J, Espinosa J, Salzler H, Park E, et al. The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. Nat Immunol. 2019;20:73-85 pubmed 出版商
Zhong S, Li L, Zhang Y, Zhang L, Lu J, Guo S, et al. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019;129:252-267 pubmed 出版商
Jang Y, Broun A, Wang C, Park Y, Zhuang L, Lee J, et al. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019;47:607-620 pubmed 出版商
Peeters J, Picavet L, Coenen S, Mauthe M, Vervoort S, Mocholí E, et al. Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy. Autophagy. 2019;15:98-112 pubmed 出版商
Yaacov R, Eshel R, Farhi E, Shemuluvich F, Kaplan T, Birnbaum R. Functional characterization of the ZEB2 regulatory landscape. Hum Mol Genet. 2018;: pubmed 出版商
Croft B, Ohnesorg T, Hewitt J, Bowles J, Quinn A, Tan J, et al. Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9. Nat Commun. 2018;9:5319 pubmed 出版商
Kalvisa A, Siersbæk M, Præstholm S, Christensen L, Nielsen R, Stöhr O, et al. Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver. PLoS Biol. 2018;16:e2006249 pubmed 出版商
Lukoseviciute M, Gavriouchkina D, Williams R, Hochgreb Hägele T, Senanayake U, Chong Morrison V, et al. From Pioneer to Repressor: Bimodal foxd3 Activity Dynamically Remodels Neural Crest Regulatory Landscape In Vivo. Dev Cell. 2018;47:608-628.e6 pubmed 出版商
Vervoort S, de Jong O, Roukens M, Frederiks C, Vermeulen J, Lourenço A, et al. Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis. elife. 2018;7: pubmed 出版商
Vanhauwaert S, Decaesteker B, De Brouwer S, Leonelli C, Durinck K, Mestdagh P, et al. In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors. Sci Rep. 2018;8:17468 pubmed 出版商
Ott C, Federation A, Schwartz L, Kasar S, Klitgaard J, Lenci R, et al. Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Cancer Cell. 2018;34:982-995.e7 pubmed 出版商
Marlétaz F, Firbas P, Maeso I, Tena J, Bogdanovic O, Perry M, et al. Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 2018;564:64-70 pubmed 出版商
Yuan W, Pepe Mooney B, Galli G, Dill M, Huang H, Hao M, et al. NUAK2 is a critical YAP target in liver cancer. Nat Commun. 2018;9:4834 pubmed 出版商
Brien G, Remillard D, Shi J, Hemming M, Chabon J, Wynne K, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. elife. 2018;7: pubmed 出版商
Mowery C, Reyes J, Cabal Hierro L, Higby K, Karlin K, Wang J, et al. Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Rep. 2018;25:1898-1911.e5 pubmed 出版商
Somerville T, Xu Y, Miyabayashi K, Tiriac H, Cleary C, Maia Silva D, et al. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep. 2018;25:1741-1755.e7 pubmed 出版商
Pattison J, Melo S, Piekos S, Torkelson J, Bashkirova E, Mumbach M, et al. Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nat Genet. 2018;50:1658-1665 pubmed 出版商
Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, et al. Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure. Nat Commun. 2018;9:4435 pubmed 出版商
Buxade M, Huerga Encabo H, Riera Borrull M, Quintana Gallardo L, López Cotarelo P, Tellechea M, et al. Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5. J Exp Med. 2018;215:2901-2918 pubmed 出版商
Paluvai H, Di Giorgio E, Brancolini C. Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53-dependent senescence and favors cell transformation. Mol Oncol. 2018;12:2165-2181 pubmed 出版商
Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Nucleic Acids Res. 2018;46:11743-11758 pubmed 出版商
Zhang E, He X, Zhang C, Su J, Lu X, Si X, et al. A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1. Genome Biol. 2018;19:154 pubmed 出版商
Vandenbon A, Kumagai Y, Lin M, Suzuki Y, Nakai K. Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation. Genome Biol. 2018;19:138 pubmed 出版商
Hou Q, Hu K, Liu X, Quan J, Liu Z. HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD. Biosci Rep. 2018;38: pubmed 出版商
Mandelbaum J, Shestopalov I, Henderson R, Chau N, Knoechel B, Wick M, et al. Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018;215:2673-2685 pubmed 出版商
Koohy H, Bolland D, Matheson L, Schoenfelder S, Stellato C, Dimond A, et al. Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells. Genome Biol. 2018;19:126 pubmed 出版商
Pane L, Fulcoli F, Cirino A, Altomonte A, Ferrentino R, Bilio M, et al. Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Dis Model Mech. 2018;11: pubmed 出版商
Zhang Y, Xue Y, Shi J, Ahn J, Mi W, Ali M, et al. The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3. Nat Struct Mol Biol. 2018;25:841-849 pubmed 出版商
Cajigas I, Chakraborty A, Swyter K, Luo H, Bastidas M, Nigro M, et al. The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain. Mol Cell. 2018;71:956-972.e9 pubmed 出版商
Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018;175:171-185.e25 pubmed 出版商
Strub T, Ghiraldini F, Carcamo S, Li M, Wroblewska A, Singh R, et al. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nat Commun. 2018;9:3440 pubmed 出版商
Li S, Xu C, Fu Y, Lei P, Yao Y, Yang W, et al. DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers. Nucleic Acids Res. 2018;46:11202-11213 pubmed 出版商
Zhu Y, Li Y, Lou D, Gao Y, Yu J, Kong D, et al. Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells. Toxicol Appl Pharmacol. 2018;357:70-79 pubmed 出版商
Kong X, Martinez Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, et al. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018;19:973-985 pubmed 出版商
Watanabe T, Cui X, Yuan Z, Qi H, Lin H. MIWI2 targets RNAs transcribed from piRNA-dependent regions to drive DNA methylation in mouse prospermatogonia. EMBO J. 2018;37: pubmed 出版商
Sun Z, Chadwick B. Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Epigenetics Chromatin. 2018;11:45 pubmed 出版商
Bagchi R, Ferguson B, Stratton M, Hu T, Cavasin M, Sun L, et al. HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI Insight. 2018;3: pubmed 出版商
Ruzycki P, Zhang X, Chen S. CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin. 2018;11:42 pubmed 出版商
Nakagawa M, Shaffer A, Ceribelli M, Zhang M, Wright G, Huang D, et al. Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Cancer Cell. 2018;34:286-297.e10 pubmed 出版商
Chen X, Zhang M, Gan H, Wang H, Lee J, Fang D, et al. A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Nat Commun. 2018;9:2949 pubmed 出版商
Ye Y, He X, Lu F, Mao H, Zhu Z, Yao L, et al. A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation. Cell Death Dis. 2018;9:803 pubmed 出版商
Barakat T, Halbritter F, Zhang M, Rendeiro A, Perenthaler E, Bock C, et al. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Cell Stem Cell. 2018;23:276-288.e8 pubmed 出版商
Liu C, Angelozzi M, Haseeb A, Lefebvre V. SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Development. 2018;145: pubmed 出版商
He R, Kidder B. Culture of haploid blastocysts in FGF4 favors the derivation of epiblast stem cells with a primed epigenetic and transcriptional landscape. Sci Rep. 2018;8:10775 pubmed 出版商
Chen A, Liu A, Krishnakumar R, Freimer J, DeVeale B, Blelloch R. GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency. Cell Stem Cell. 2018;23:226-238.e4 pubmed 出版商
Rao A, LaBonne C. Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest. Development. 2018;145: pubmed 出版商
Xiao T, Li W, Wang X, Xu H, Yang J, WU Q, et al. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Proc Natl Acad Sci U S A. 2018;115:7869-7878 pubmed 出版商
Slaughter M, Shanle E, McFadden A, Hollis E, Suttle L, Strahl B, et al. PBRM1 bromodomains variably influence nucleosome interactions and cellular function. J Biol Chem. 2018;293:13592-13603 pubmed 出版商
Mansour M, He S, Li Z, Lobbardi R, Abraham B, Hug C, et al. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018;215:1929-1945 pubmed 出版商
Kaneko S, Li X. X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Sci Adv. 2018;4:eaar5598 pubmed 出版商
Zubritskiy A, Medvedeva Y. DNA sequence features in the establishing of H3K27ac. F1000Res. 2018;7:165 pubmed 出版商
Serandour A, Mohammed H, Miremadi A, Mulder K, Carroll J. TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers. Oncogene. 2018;37:5281-5291 pubmed 出版商
García Carpizo V, Ruiz Llorente S, Sarmentero J, Graña Castro O, Pisano D, Barrero M. CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation. Epigenetics Chromatin. 2018;11:30 pubmed 出版商
Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, et al. SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub. Nat Commun. 2018;9:2192 pubmed 出版商
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discov. 2018;8:850-865 pubmed 出版商
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed 出版商
Ma Z, Wang H, Cai Y, Wang H, Niu K, Wu X, et al. Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila. elife. 2018;7: pubmed 出版商
Bhattacharjee S, Bose P, Patel K, Roy S, Gain C, Gowda H, et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis. 2018;9:605 pubmed 出版商
Baizabal J, Mistry M, Garcia M, Gómez N, Olukoya O, Tran D, et al. The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position. Neuron. 2018;98:945-962.e8 pubmed 出版商
Collino A, Termanini A, Nicoli P, Diaferia G, Polletti S, Recordati C, et al. Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage. PLoS Genet. 2018;14:e1007380 pubmed 出版商
Grossi V, Forte G, Sanese P, Peserico A, Tezil T, Lepore Signorile M, et al. The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. Nucleic Acids Res. 2018;46:5587-5600 pubmed 出版商
Cho S, Xu J, Sun R, Mumbach M, Carter A, Chen Y, et al. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018;173:1398-1412.e22 pubmed 出版商
Jian X, Felsenfeld G. Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism. Proc Natl Acad Sci U S A. 2018;115:E4633-E4641 pubmed 出版商
Vian L, Pekowska A, Rao S, Kieffer Kwon K, Jung S, Baranello L, et al. The Energetics and Physiological Impact of Cohesin Extrusion. Cell. 2018;173:1165-1178.e20 pubmed 出版商
Bartels M, Govers A, Polak R, Vervoort S, van Boxtel R, Pals C, et al. Megakaryocyte lineage development is controlled by modulation of protein acetylation. PLoS ONE. 2018;13:e0196400 pubmed 出版商
Tyssowski K, DeStefino N, Cho J, Dunn C, Poston R, Carty C, et al. Different Neuronal Activity Patterns Induce Different Gene Expression Programs. Neuron. 2018;98:530-546.e11 pubmed 出版商
Lee J, Berry C, Kim K, Sen P, Kim T, Carrer A, et al. Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling. Genes Dev. 2018;32:497-511 pubmed 出版商
Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed 出版商
Lin D, Hiron T, O Callaghan C. Intragenic transcriptional interference regulates the human immune ligand MICA. EMBO J. 2018;37: pubmed 出版商
Jallow F, Brockman J, Helzer K, Rugowski D, Goffin V, Alarid E, et al. 17?-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc. 2018;2:293-309 pubmed 出版商
Zhang Y, Wang S, Kang W, Liu C, Dong Y, Ren F, et al. CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation. Oncogene. 2018;37:3485-3500 pubmed 出版商
Hall A, Battenhouse A, Shivram H, Morris A, Cowperthwaite M, Shpak M, et al. Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells. Cancer Res. 2018;78:2463-2474 pubmed 出版商
Sun C, Yin J, Fang Y, Chen J, Jeong K, Chen X, et al. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell. 2018;33:401-416.e8 pubmed 出版商
Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin S, et al. Dissecting super-enhancer hierarchy based on chromatin interactions. Nat Commun. 2018;9:943 pubmed 出版商
Kuuluvainen E, Domènech Moreno E, Niemelä E, Makela T. Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. Mol Cell Biol. 2018;38: pubmed 出版商
Gomez Lamarca M, Falo Sanjuan J, Stojnic R, Abdul Rehman S, Muresan L, Jones M, et al. Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics. Dev Cell. 2018;44:611-623.e7 pubmed 出版商
Xi Y, Shi J, Li W, Tanaka K, Allton K, Richardson D, et al. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018;19:150 pubmed 出版商
Fueyo R, Iacobucci S, PAPPA S, Estarás C, Lois S, Vicioso Mantis M, et al. Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation. Nucleic Acids Res. 2018;46:3351-3365 pubmed 出版商
Sallam T, Jones M, Thomas B, Wu X, Gilliland T, Qian K, et al. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018;24:304-312 pubmed 出版商
Zeid R, Lawlor M, Poon E, Reyes J, Fulciniti M, Lopez M, et al. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nat Genet. 2018;50:515-523 pubmed 出版商
Henriques T, Scruggs B, Inouye M, Muse G, Williams L, Burkholder A, et al. Widespread transcriptional pausing and elongation control at enhancers. Genes Dev. 2018;32:26-41 pubmed 出版商
Huang Y, Qi Y, Du J, Zhang D. Protosappanin A protects against atherosclerosis via anti- hyperlipidemia, anti-inflammation and NF-κB signaling pathway in hyperlipidemic rabbits. Iran J Basic Med Sci. 2018;21:33-38 pubmed 出版商
Qin Y, Roberts J, Grimm S, Lih F, Deterding L, Li R, et al. An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol. 2018;19:7 pubmed 出版商
Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed 出版商
Yan T, Ooi W, Qamra A, Cheung A, Ma D, Sundaram G, et al. HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. Nat Commun. 2018;9:100 pubmed 出版商
He Y, Lu J, Ye Z, Hao S, Wang L, Kohli M, et al. Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer. Nucleic Acids Res. 2018;46:1895-1911 pubmed 出版商
Leadem B, Kagiampakis I, Wilson C, Cheung T, Arnott D, Trojer P, et al. A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine. Cancer Res. 2018;78:1127-1139 pubmed 出版商
Rodríguez Carballo E, Lopez Delisle L, Zhan Y, Fabre P, Beccari L, El Idrissi I, et al. The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes. Genes Dev. 2017;31:2264-2281 pubmed 出版商
Mack S, Pajtler K, Chavez L, Okonechnikov K, Bertrand K, Wang X, et al. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature. 2018;553:101-105 pubmed 出版商
Sanchez G, Richmond P, Bunker E, Karman S, Azofeifa J, Garnett A, et al. Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Nucleic Acids Res. 2017;: pubmed 出版商
Halstead A, Kapadia C, Bolzenius J, Chu C, Schriefer A, Wartman L, et al. Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. elife. 2017;6: pubmed 出版商
He H, Li W, Liyanarachchi S, Wang Y, Yu L, Genutis L, et al. The role of NRG1 in the predisposition to papillary thyroid carcinoma. J Clin Endocrinol Metab. 2017;: pubmed 出版商
Song S, Jeon M, Nam J, Kang J, Lee Y, Kang J, et al. Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene. 2018;37:993-1004 pubmed 出版商
Schwarzer W, Abdennur N, Goloborodko A, Pekowska A, Fudenberg G, Loe Mie Y, et al. Two independent modes of chromatin organization revealed by cohesin removal. Nature. 2017;551:51-56 pubmed 出版商
Dimitrov V, Bouttier M, Boukhaled G, Salehi Tabar R, Avramescu R, Memari B, et al. Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice. J Biol Chem. 2017;292:20657-20668 pubmed 出版商
Stroud H, Su S, Hrvatin S, Greben A, Renthal W, Boxer L, et al. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017;171:1151-1164.e16 pubmed 出版商
Pan X, Fang Y, Yang X, Zheng D, Chen L, Wang L, et al. Chromatin states responsible for the regulation of differentially expressed genes under 60Co~γ ray radiation in rice. BMC Genomics. 2017;18:778 pubmed 出版商
Hamed M, Khilji S, Dixon K, Blais A, Ioshikhes I, Chen J, et al. Insights into interplay between rexinoid signaling and myogenic regulatory factor-associated chromatin state in myogenic differentiation. Nucleic Acids Res. 2017;45:11236-11248 pubmed 出版商
Isobe K, Jung H, Yang C, Claxton J, Sandoval P, Burg M, et al. Systems-level identification of PKA-dependent signaling in epithelial cells. Proc Natl Acad Sci U S A. 2017;114:E8875-E8884 pubmed 出版商
Zhang X, Choi P, FRANCIS J, Gao G, Campbell J, Ramachandran A, et al. Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. Cancer Discov. 2018;8:108-125 pubmed 出版商
Mumbach M, Satpathy A, Boyle E, Dai C, Gowen B, Cho S, et al. Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nat Genet. 2017;49:1602-1612 pubmed 出版商
Liang Y, Wu Y, Chen X, Zhang S, Wang K, Guan X, et al. A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma. Biosci Rep. 2017;37: pubmed 出版商
Doi T, Ogata T, Yamauchi J, Sawada Y, Tanaka S, Nagao M. Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury. J Neurosci. 2017;37:10290-10309 pubmed 出版商
Van Bortle K, Phanstiel D, Snyder M. Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation. Genome Biol. 2017;18:180 pubmed 出版商
Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed 出版商
Shah N, Wang P, Wongvipat J, Karthaus W, Abida W, Armenia J, et al. Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer. elife. 2017;6: pubmed 出版商
Britton E, Rogerson C, Mehta S, Li Y, Li X, Fitzgerald R, et al. Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. PLoS Genet. 2017;13:e1006879 pubmed 出版商
Simeonov D, Gowen B, Boontanrart M, Roth T, Gagnon J, Mumbach M, et al. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017;549:111-115 pubmed 出版商
Mellén M, Ayata P, Heintz N. 5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes. Proc Natl Acad Sci U S A. 2017;114:E7812-E7821 pubmed 出版商
Ke L, Zhou H, Wang C, Xiong G, Xiang Y, Ling Y, et al. Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis. Proc Natl Acad Sci U S A. 2017;114:9683-9688 pubmed 出版商
Hashwah H, Schmid C, Kasser S, Bertram K, Stelling A, Manz M, et al. Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth. Proc Natl Acad Sci U S A. 2017;114:9701-9706 pubmed 出版商
Horton S, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford Rogers R, et al. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nat Cell Biol. 2017;19:1093-1104 pubmed 出版商
Choi A, Illendula A, Pulikkan J, Roderick J, Tesell J, Yu J, et al. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. Blood. 2017;130:1722-1733 pubmed 出版商
Boeva V, Louis Brennetot C, Peltier A, Durand S, Pierre Eugène C, Raynal V, et al. Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Nat Genet. 2017;49:1408-1413 pubmed 出版商
Oka R, Zicola J, Weber B, Anderson S, Hodgman C, Gent J, et al. Genome-wide mapping of transcriptional enhancer candidates using DNA and chromatin features in maize. Genome Biol. 2017;18:137 pubmed 出版商
Wang S, Tang Z, Chen C, Shimada M, Koche R, Wang L, et al. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell. 2017;67:308-321.e6 pubmed 出版商
Zhao J, Osipovich O, Koues O, Majumder K, Oltz E. Activation of Mouse Tcrb: Uncoupling RUNX1 Function from Its Cooperative Binding with ETS1. J Immunol. 2017;199:1131-1141 pubmed 出版商
Gulchina Y, Xu S, Snyder M, Elefant F, Gao W. Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. J Neurochem. 2017;143:320-333 pubmed 出版商
Soto Feliciano Y, Bartlebaugh J, Liu Y, Sanchez Rivera F, Bhutkar A, Weintraub A, et al. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes Dev. 2017;31:973-989 pubmed 出版商
Keck K, Moquin S, He A, Fernandez S, Somberg J, Liu S, et al. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps. J Biol Chem. 2017;292:13284-13295 pubmed 出版商
Gabriele M, Vulto van Silfhout A, Germain P, Vitriolo A, Kumar R, Douglas E, et al. YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. Am J Hum Genet. 2017;100:907-925 pubmed 出版商
Peng X, So K, He L, Zhao Y, Zhou J, Li Y, et al. MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Res. 2017;45:8785-8805 pubmed 出版商
Stolzenburg L, Yang R, Kerschner J, FOSSUM S, Xu M, Hoffmann A, et al. Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity. Nucleic Acids Res. 2017;45:8773-8784 pubmed 出版商
Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed 出版商
Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, et al. Epigenetic modifications of the VH region after DJH recombination in Pro-B cells. Immunology. 2017;152:218-231 pubmed 出版商
Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, et al. The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis. Neuron. 2017;94:550-568.e10 pubmed 出版商
Saleheen D, Zhao W, Young R, Nelson C, Ho W, Ferguson J, et al. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. Circulation. 2017;135:2336-2353 pubmed 出版商
Fossum S, Mutolo M, Tugores A, Ghosh S, Randell S, Jones L, et al. Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease. J Biol Chem. 2017;292:10938-10949 pubmed 出版商
Shapira S, Lim H, Rajakumari S, Sakers A, Ishibashi J, Harms M, et al. EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes Dev. 2017;31:660-673 pubmed 出版商
Perreault A, Benton M, Koury M, Brandt S, Venters B. Epo reprograms the epigenome of erythroid cells. Exp Hematol. 2017;51:47-62 pubmed 出版商
Kissig M, Ishibashi J, Harms M, Lim H, Stine R, Won K, et al. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing. EMBO J. 2017;36:1528-1542 pubmed 出版商
Lai B, Lee J, Jang Y, Wang L, Peng W, Ge K. MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res. 2017;45:6388-6403 pubmed 出版商
Timblin G, Xie L, Tjian R, Schlissel M. Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation. Mol Cell Biol. 2017;37: pubmed 出版商
Klann T, Black J, Chellappan M, Safi A, Song L, Hilton I, et al. CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome. Nat Biotechnol. 2017;35:561-568 pubmed 出版商
Zaghloul E, Gissberg O, Moreno P, Siggens L, Hällbrink M, Jørgensen A, et al. CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression. Nucleic Acids Res. 2017;45:5153-5169 pubmed 出版商
Curina A, Termanini A, Barozzi I, Prosperini E, Simonatto M, Polletti S, et al. High constitutive activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins. Genes Dev. 2017;31:399-412 pubmed 出版商
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed 出版商
Hogg S, Vervoort S, Deswal S, Ott C, Li J, Cluse L, et al. BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1. Cell Rep. 2017;18:2162-2174 pubmed 出版商
Soccio R, Li Z, Chen E, Foong Y, Benson K, DiSpirito J, et al. Targeting PPAR? in the epigenome rescues genetic metabolic defects in mice. J Clin Invest. 2017;127:1451-1462 pubmed 出版商
Vető B, Bojcsuk D, Bacquet C, Kiss J, Sipeki S, Martin L, et al. The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2. PLoS ONE. 2017;12:e0172020 pubmed 出版商
Schjerven H, Ayongaba E, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, et al. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017;214:793-814 pubmed 出版商
Abraham B, Hnisz D, Weintraub A, Kwiatkowski N, Li C, Li Z, et al. Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017;8:14385 pubmed 出版商
Schuetze K, Stratton M, Blakeslee W, Wempe M, Wagner F, Holson E, et al. Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017;361:140-150 pubmed 出版商
Droog M, Nevedomskaya E, Dackus G, Fles R, Kim Y, Hollema H, et al. Estrogen receptor ? wields treatment-specific enhancers between morphologically similar endometrial tumors. Proc Natl Acad Sci U S A. 2017;114:E1316-E1325 pubmed 出版商
Chen S, Lu W, Yueh M, Rettenmeier E, Liu M, Paszek M, et al. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017;114:E1432-E1440 pubmed 出版商
Vander Lugt B, Riddell J, Khan A, Hackney J, Lesch J, DeVoss J, et al. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation. J Cell Biol. 2017;216:779-792 pubmed 出版商
Chronis C, Fiziev P, Papp B, Butz S, Bonora G, Sabri S, et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming. Cell. 2017;168:442-459.e20 pubmed 出版商
Quigley I, Kintner C. Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression. PLoS Genet. 2017;13:e1006538 pubmed 出版商
Liu X, Gao Y, Ye H, Gerrin S, Ma F, Wu Y, et al. Positive feedback loop mediated by protein phosphatase 1α mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer. Nucleic Acids Res. 2017;45:3738-3751 pubmed 出版商
Ashoor H, Louis Brennetot C, Janoueix Lerosey I, Bajic V, Boeva V. HMCan-diff: a method to detect changes in histone modifications in cells with different genetic characteristics. Nucleic Acids Res. 2017;45:e58 pubmed 出版商
van Rooij F, Qayyum R, Smith A, Zhou Y, Trompet S, Tanaka T, et al. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017;100:51-63 pubmed 出版商
Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed 出版商
Ye Y, Li M, Gu L, Chen X, Shi J, Zhang X, et al. Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. Cell Death Differ. 2017;24:409-420 pubmed 出版商
Yamamoto K, Tateishi K, Kudo Y, Hoshikawa M, Tanaka M, Nakatsuka T, et al. Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer. Oncotarget. 2016;7:61469-61484 pubmed 出版商
von Schimmelmann M, Feinberg P, Sullivan J, Ku S, Badimon A, Duff M, et al. Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nat Neurosci. 2016;19:1321-30 pubmed 出版商
Guerreiro I, Gitto S, Novoa A, Codourey J, Nguyen Huynh T, Gonzalez F, et al. Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. elife. 2016;5: pubmed 出版商
Loponte S, Segré C, Senese S, Miccolo C, Santaguida S, Deflorian G, et al. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Sci Rep. 2016;6:30213 pubmed 出版商
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed 出版商
Rensch T, Villar D, Horvath J, Odom D, Flicek P. Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data. Genome Biol. 2016;17:139 pubmed 出版商
Mendoza Parra M, Saravaki V, Cholley P, Blum M, Billoré B, Gronemeyer H. Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification. F1000Res. 2016;5:54 pubmed 出版商
Khateb M, Fourier N, Barnea Yizhar O, Ram S, Kovalev E, Azriel A, et al. The Third Intron of the Interferon Regulatory Factor-8 Is an Initiator of Repressed Chromatin Restricting Its Expression in Non-Immune Cells. PLoS ONE. 2016;11:e0156812 pubmed 出版商
Riso V, Cammisa M, Kukreja H, Anvar Z, Verde G, Sparago A, et al. ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells. Nucleic Acids Res. 2016;44:8165-78 pubmed 出版商
Hu T, Wei G, Xi M, Yan J, Wu X, Wang Y, et al. Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway. Int J Mol Med. 2016;38:83-94 pubmed 出版商
Liu Y, Giannopoulou E, Wen D, Falciatori I, Elemento O, Allis C, et al. Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells. Nat Commun. 2016;7:11275 pubmed 出版商
Prokesch A, Pelzmann H, Pessentheiner A, Huber K, Madreiter Sokolowski C, Drougard A, et al. N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes. Sci Rep. 2016;6:23723 pubmed 出版商
Sérandour A, Avner S, Mahé E, Madigou T, Guibert S, Weber M, et al. Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets. Genome Biol. 2016;17:56 pubmed 出版商
Krijger P, Di Stefano B, de Wit E, Limone F, van Oevelen C, de Laat W, et al. Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming. Cell Stem Cell. 2016;18:597-610 pubmed 出版商
Choi S, Gearhart M, Cui Z, Bosnakovski D, Kim M, Schennum N, et al. DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes. Nucleic Acids Res. 2016;44:5161-73 pubmed 出版商
Duren R, Boudreaux S, Conneely O. Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells. PLoS ONE. 2016;11:e0150450 pubmed 出版商
Gang X, Yang Y, Zhong J, Jiang K, Pan Y, Karnes R, et al. P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth. Oncotarget. 2016;7:15135-49 pubmed 出版商
Planello A, Singhania R, Kron K, Bailey S, Roulois D, Lupien M, et al. Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation. Oncotarget. 2016;7:15772-86 pubmed 出版商
Saintamand A, Vincent Fabert C, Garot A, Rouaud P, Oruc Z, Magnone V, et al. Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730 pubmed 出版商
Yang Y, Su Z, Song X, Liang B, Zeng F, Chang X, et al. Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster. Sci Rep. 2016;6:20961 pubmed 出版商
Drier Y, Cotton M, Williamson K, Gillespie S, Ryan R, Kluk M, et al. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet. 2016;48:265-72 pubmed 出版商
Zimmermann M, Arruda Silva F, Bianchetto Aguilera F, Finotti G, Calzetti F, Scapini P, et al. IFNα enhances the production of IL-6 by human neutrophils activated via TLR8. Sci Rep. 2016;6:19674 pubmed 出版商
Sunkel B, Wu D, Chen Z, Wang C, Liu X, Ye Z, et al. Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic Acids Res. 2016;44:4105-22 pubmed 出版商
Luo Z, Lin C, Woodfin A, Bartom E, Gao X, Smith E, et al. Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity. Genes Dev. 2016;30:92-101 pubmed 出版商
Enuka Y, Lauriola M, Feldman M, Sas Chen A, Ulitsky I, Yarden Y. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res. 2016;44:1370-83 pubmed 出版商
Zhang X, Choi P, FRANCIS J, Imielinski M, Watanabe H, Cherniack A, et al. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat Genet. 2016;48:176-82 pubmed 出版商
Kramer H, Lai C, Patel H, Periyasamy M, Lin M, Feller S, et al. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Res. 2016;44:582-94 pubmed 出版商
Singh A, Sun Y, Li L, Zhang W, Wu T, Zhao S, et al. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports. 2015;5:323-36 pubmed 出版商
Sive J, Basilico S, Hannah R, Kinston S, Calero Nieto F, Göttgens B. Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia. Leukemia. 2016;30:14-23 pubmed 出版商
Wang Q, Li Y, Dong J, Li B, Kaberlein J, Zhang L, et al. Regulation of MEIS1 by distal enhancer elements in acute leukemia. Leukemia. 2014;28:138-46 pubmed 出版商
产品信息
目录号 :
ab4729
ItemName :
抗组蛋白H3(乙酰K27)抗体-ChIP级
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭标签 :
Not Conjugated
抗原修饰 :
乙酰化(27K)
规格 :
4毫克
物种摘要 :
At, Chk, Chyzon, Cow, Dm, Hu, Mk, Ms, P fal, Rat, Rice, Zfsh
用途 :
ChIP, ChIP/Chip, CHIPseq, ICC/IF, IHC-Fr, IHC-P, PepArr, WB
规格说明 :
Other sizes available: 25 µg,25 µl,100 µg,100 µl,200 µl,1000 µg
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。