Villanueva E, Tresse E, Liu Y, Duarte J, Jimenez Duran G, Ejlerskov P, et al. Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice. Ann Neurol. 2021;90:789-807 pubmed 出版商

Emmenegger M, De Cecco E, Hruska Plochan M, Eninger T, Schneider M, Barth M, et al. LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO Mol Med. 2021;13:e14745 pubmed 出版商

Liu D, Guo J, Su J, Svanbergsson A, Yuan L, Haikal C, et al. Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions. Transl Neurodegener. 2021;10:20 pubmed 出版商

Boutros S, Raber J, Unni V. Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex. J Parkinsons Dis. 2021;11:1091-1115 pubmed 出版商

Trinkaus V, Riera Tur I, Martinez Sanchez A, Bäuerlein F, Guo Q, Arzberger T, et al. In situ architecture of neuronal α-Synuclein inclusions. Nat Commun. 2021;12:2110 pubmed 出版商

Donadio V, Wang Z, Incensi A, Rizzo G, Fileccia E, Vacchiano V, et al. In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC. Neurology. 2021;96:e2513-e2524 pubmed 出版商

Chiu C, Weng Y, Huang Y, Chen R, Liu Y, Yeh T, et al. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death Dis. 2020;11:1018 pubmed 出版商

Niu H, Wang Q, Zhao W, Liu J, Wang D, Muhammad B, et al. IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum. Brain Pathol. 2020;30:1102-1118 pubmed 出版商

Wang X, Ma M, Zhou L, Jiang X, Hao M, Teng R, et al. Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy. Nat Commun. 2020;11:934 pubmed 出版商

Sampson T, Challis C, Jain N, Moiseyenko A, Ladinsky M, Shastri G, et al. A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice. elife. 2020;9: pubmed 出版商

Köppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, et al. Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro. Molecules. 2020;25: pubmed 出版商

Williams G, Marmion D, Schonhoff A, Jurkuvenaite A, Won W, Standaert D, et al. T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease. Acta Neuropathol. 2020;139:855-874 pubmed 出版商

Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed 出版商

Willard A, Isett B, Whalen T, Mastro K, Ki C, Mao X, et al. State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice. elife. 2019;8: pubmed 出版商

Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, et al. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Aging Cell. 2019;18:e12941 pubmed 出版商

Delic V, Chandra S, Abdelmotilib H, Maltbie T, Wang S, Kem D, et al. Sensitivity and specificity of phospho-Ser129 ?-synuclein monoclonal antibodies. J Comp Neurol. 2018;526:1978-1990 pubmed 出版商

Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017;5:22 pubmed 出版商

Kordower J, Goetz C, Chu Y, Halliday G, Nicholson D, Musial T, et al. Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. Ann Neurol. 2017;81:46-57 pubmed 出版商

Doucet Beaupré H, Gilbert C, Profes M, Chabrat A, Pacelli C, Giguère N, et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016;113:E4387-96 pubmed 出版商

Prusiner S, Woerman A, Mordes D, Watts J, Rampersaud R, Berry D, et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015;112:E5308-17 pubmed 出版商

Song L, Ma K, Yuan Y, Mu Z, Song X, Niu F, et al. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS ONE. 2015;10:e0131281 pubmed 出版商

Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed 出版商

Postupna N, Keene C, Latimer C, Sherfield E, Van Gelder R, Ojemann J, et al. Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Lab Invest. 2014;94:1161-72 pubmed 出版商

Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, et al. Time course and progression of wild type ?-synuclein accumulation in a transgenic mouse model. BMC Neurosci. 2013;14:6 pubmed 出版商

Thomzig A, Wagenführ K, Pinder P, Joncic M, Schulz Schaeffer W, Beekes M. Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease. Acta Neuropathol. 2021;141:861-879 pubmed 出版商

Mészáros L, Riemenschneider M, Gassner H, Marxreiter F, von Horsten S, Hoffmann A, et al. Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 2021;9:68 pubmed 出版商

Bengoa Vergniory N, Faggiani E, Ramos Gonzalez P, Kirkiz E, Connor Robson N, Brown L, et al. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020;11:4885 pubmed 出版商

Tanriöver G, Bacioglu M, Schweighauser M, Mahler J, Wegenast Braun B, Skodras A, et al. Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions. Acta Neuropathol Commun. 2020;8:133 pubmed 出版商

Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, et al. BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020;8:120 pubmed 出版商

Wang Y, Wang Q, Yu R, Zhang Q, Zhang Z, Li H, et al. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging (Albany NY). 2020;12:14232-14243 pubmed 出版商

Takaichi Y, Chambers J, Inoue H, Ano Y, Takashima A, Nakayama H, et al. Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:86 pubmed 出版商

Chung E, Choi Y, Park J, Nah W, Park J, Jung Y, et al. Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein. Sci Adv. 2020;6:eaba1193 pubmed 出版商

Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, et al. The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol. 2020;139:977-1000 pubmed 出版商

Choi I, Zhang Y, Seegobin S, Pruvost M, Wang Q, Purtell K, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020;11:1386 pubmed 出版商

Ardah M, Ghanem S, Abdulla S, Lv G, Emara M, Paleologou K, et al. Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. BMC Complement Med Ther. 2020;20:73 pubmed 出版商

Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed 出版商

Klingstedt T, Ghetti B, Holton J, Ling H, Nilsson K, Goedert M. Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy. Acta Neuropathol Commun. 2019;7:193 pubmed 出版商

Earls R, Menees K, Chung J, Barber J, Gutekunst C, Hazim M, et al. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. J Neuroinflammation. 2019;16:250 pubmed 出版商

Lavenir I, Passarella D, Masuda Suzukake M, Curry A, Holton J, Ghetti B, et al. Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice. Acta Neuropathol Commun. 2019;7:148 pubmed 出版商

Sorrentino Z, Goodwin M, Riffe C, Dhillon J, Xia Y, Gorion K, et al. Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression. Acta Neuropathol Commun. 2019;7:142 pubmed 出版商

Van Den Berge N, Ferreira N, Gram H, Mikkelsen T, Alstrup A, Casadei N, et al. Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats. Acta Neuropathol. 2019;: pubmed 出版商

Lohmann S, Bernis M, Tachu B, Ziemski A, Grigoletto J, TAMGUNEY G. Oral and intravenous transmission of α-synuclein fibrils to mice. Acta Neuropathol. 2019;: pubmed 出版商

Chen S, Cai F, Wang J, Yang Z, Gu C, Wang G, et al. Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling. Mol Med Rep. 2019;20:529-538 pubmed 出版商

Froula J, Castellana Cruz M, Anabtawi N, Camino J, Chen S, Thrasher D, et al. Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice. J Biol Chem. 2019;294:10392-10406 pubmed 出版商

Dhillon J, Trejo Lopez J, Riffe C, Levites Y, Sacino A, Borchelt D, et al. Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils. Acta Neuropathol Commun. 2019;7:80 pubmed 出版商

Chen X, Kordich J, Williams E, Levine N, Cole Strauss A, Marshall L, et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2019;116:5765-5774 pubmed 出版商

Henderson M, Sengupta M, McGeary I, Zhang B, Olufemi M, Brown H, et al. LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice. Acta Neuropathol Commun. 2019;7:28 pubmed 出版商

Croft C, Cruz P, Ryu D, Ceballos Diaz C, Strang K, Woody B, et al. rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies. J Exp Med. 2019;216:539-555 pubmed 出版商

Yamasaki T, Holmes B, Furman J, Dhavale D, Su B, Song E, et al. Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics. J Biol Chem. 2019;294:1045-1058 pubmed 出版商

Williams G, Schonhoff A, Jurkuvenaite A, Thome A, Standaert D, Harms A. Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease. J Neuroinflammation. 2018;15:244 pubmed 出版商

Wang B, Underwood R, Kamath A, Britain C, McFerrin M, McLean P, et al. 14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein. J Neurosci. 2018;38:8211-8232 pubmed 出版商

Terada M, Suzuki G, Nonaka T, Kametani F, Tamaoka A, Hasegawa M. The effect of truncation on prion-like properties of α-synuclein. J Biol Chem. 2018;293:13910-13920 pubmed 出版商

Chen Q, Haikal C, Li W, Li M, Wang Z, Li J. Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease. Transl Neurodegener. 2018;7:13 pubmed 出版商

Froula J, Henderson B, González J, Vaden J, McLean J, Wu Y, et al. α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta Neuropathol Commun. 2018;6:35 pubmed 出版商

Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of ?-synuclein and neuroinflammation. Cell Death Dis. 2018;9:440 pubmed 出版商

Tarutani A, Arai T, Murayama S, Hisanaga S, Hasegawa M. Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods. Acta Neuropathol Commun. 2018;6:29 pubmed 出版商

Svarcbahs R, Julku U, Norrbacka S, Myöhänen T. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Sci Rep. 2018;8:1552 pubmed 出版商

Refolo V, Bez F, Polissidis A, Kuzdas Wood D, Sturm E, Kamaratou M, et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun. 2018;6:2 pubmed 出版商

Rey N, George S, Steiner J, Madaj Z, Luk K, Trojanowski J, et al. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathol. 2018;135:65-83 pubmed 出版商

Zapiec B, Dieriks B, Tan S, Faull R, Mombaerts P, Curtis M. A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction. Brain. 2017;140:2722-2736 pubmed 出版商

Arawaka S, Sato H, Sasaki A, Koyama S, Kato T. Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates. Acta Neuropathol Commun. 2017;5:48 pubmed 出版商

Mandel R, Marmion D, Kirik D, Chu Y, Heindel C, McCown T, et al. Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. Acta Neuropathol Commun. 2017;5:47 pubmed 出版商

Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, et al. Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2017;5:46 pubmed 出版商

de Oliveira R, Vicente Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017;15:e2000374 pubmed 出版商

Huang J, Yang J, Shen Y, Jiang H, Han C, Zhang G, et al. HMGB1 Mediates Autophagy Dysfunction via Perturbing Beclin1-Vps34 Complex in Dopaminergic Cell Model. Front Mol Neurosci. 2017;10:13 pubmed 出版商

Shimozawa A, Ono M, Takahara D, Tarutani A, Imura S, Masuda Suzukake M, et al. Propagation of pathological ?-synuclein in marmoset brain. Acta Neuropathol Commun. 2017;5:12 pubmed 出版商

Rabl R, Breitschaedel C, Flunkert S, Duller S, Amschl D, Neddens J, et al. Early start of progressive motor deficits in Line 61 ?-synuclein transgenic mice. BMC Neurosci. 2017;18:22 pubmed 出版商

Scheffold A, Holtman I, Dieni S, Brouwer N, Katz S, Jebaraj B, et al. Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta Neuropathol Commun. 2016;4:87 pubmed 出版商

Bourdenx M, Dovero S, Engeln M, Bido S, Bastide M, Dutheil N, et al. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathol Commun. 2015;3:46 pubmed 出版商

Spinelli K, Osterberg V, Meshul C, Soumyanath A, Unni V. Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice. PLoS ONE. 2015;10:e0128510 pubmed 出版商

Gispert S, Brehm N, Weil J, Seidel K, Rüb U, Kern B, et al. Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet. 2015;24:1061-76 pubmed 出版商

Beekes M, Thomzig A, Schulz Schaeffer W, Burger R. Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?. Acta Neuropathol. 2014;128:463-76 pubmed 出版商

Pérez Revuelta B, Hettich M, Ciociaro A, Rotermund C, Kahle P, Krauss S, et al. Metformin lowers Ser-129 phosphorylated ?-synuclein levels via mTOR-dependent protein phosphatase 2A activation. Cell Death Dis. 2014;5:e1209 pubmed 出版商

Betemps D, Verchère J, Brot S, Morignat E, Bousset L, Gaillard D, et al. Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological ?-synuclein by enhanced ELISA. Acta Neuropathol Commun. 2014;2:29 pubmed 出版商

Kurowska Z, Englund E, Widner H, Lindvall O, Li J, Brundin P. Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. J Parkinsons Dis. 2011;1:83-92 pubmed 出版商

Wang S, Xu B, Liou L, Ren Q, Huang S, Luo Y, et al. ?-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proc Natl Acad Sci U S A. 2012;109:16119-24 pubmed 出版商

Chu Y, Morfini G, Langhamer L, He Y, Brady S, Kordower J. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain. 2012;135:2058-73 pubmed 出版商

Foulds P, Mitchell J, Parker A, Turner R, Green G, Diggle P, et al. Phosphorylated ?-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J. 2011;25:4127-37 pubmed 出版商

Mougenot A, Nicot S, Bencsik A, Morignat E, Verchère J, Lakhdar L, et al. Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging. 2012;33:2225-8 pubmed 出版商

Mbefo M, Paleologou K, Boucharaba A, Oueslati A, Schell H, Fournier M, et al. Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem. 2010;285:2807-22 pubmed 出版商

Liu P, Wang X, Gao N, Zhu H, Dai X, Xu Y, et al. G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression. Brain Res. 2010;1307:134-41 pubmed 出版商

Fournier M, Vitte J, Garrigue J, Langui D, Dullin J, Saurini F, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PLoS ONE. 2009;4:e6629 pubmed 出版商

Schell H, Hasegawa T, Neumann M, Kahle P. Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice. Neuroscience. 2009;160:796-804 pubmed 出版商