产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗Notch1抗体[EP1238Y]
目录 :
ab52627
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
EP1238Y
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化基因敲除验证
文章摘录数: 31
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 8
Cheng F, Cheng Y, Zhao X, An L, Yang L, Li Z, et al. NEDD4 E3 ubiquitin protein ligase serves an important role in cutaneous melanoma occurrence and development. Exp Ther Med. 2021;22:1382 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b, 6b
Wang K, Liu S, Dou Z, Zhang S, Yang X. Loss of Krüppel-like factor 9 facilitates stemness in ovarian cancer ascites-derived multicellular spheroids via Notch1/slug signaling. Cancer Sci. 2021;112:4220-4233 pubmed 出版商
  • 免疫印迹; 人类; 图 9b
He W, Tang J, Li W, Li Y, Mei Y, He L, et al. Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial-mesenchymal transition. Cancer Cell Int. 2019;19:160 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5o
Chakrabarti R, Celià Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360: pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 3c
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 6b
  • 免疫细胞化学; 人类; 图 8a
Pamarthy S, Mao L, Katara G, Fleetwood S, Kulshreshta A, Gilman Sachs A, et al. The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling. Cell Death Dis. 2016;7:e2443 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Stoyanova T, Riedinger M, Lin S, Faltermeier C, Smith B, Zhang K, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016;113:E6457-E6466 pubmed
  • 免疫印迹; 人类; 图 4
  • 免疫印迹; 小鼠; 图 6
Singh N, Kotla S, Kumar R, Rao G. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine. 2015;2:1767-84 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 4
  • 免疫组化-石蜡切片; 小鼠; 图 4
Mandasari M, Sawangarun W, Katsube K, Kayamori K, Yamaguchi A, Sakamoto K. A facile one-step strategy for the generation of conditional knockout mice to explore the role of Notch1 in oroesophageal tumorigenesis. Biochem Biophys Res Commun. 2016;469:761-7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Chen X, Dong X, Gao H, Jiang Y, Jin Y, Chang Y, et al. Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep. 2016;13:689-96 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3a
Denicolaï E, Tabouret E, Colin C, Metellus P, Nanni I, Boucard C, et al. Molecular heterogeneity of glioblastomas: does location matter?. Oncotarget. 2016;7:902-13 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 3a
Shao H, Kong R, Ferrari M, Radtke F, Capobianco A, Liu Z. Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion. PLoS ONE. 2015;10:e0142815 pubmed 出版商
  • 免疫细胞化学; 人类; 5.0 ug/ml
Gomi K, Arbelaez V, Crystal R, Walters M. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS ONE. 2015;10:e0116507 pubmed 出版商
  • 免疫印迹; 人类; 1:5000
Nguyen D, Rubinstein L, Takebe N, Miele L, Tomaszewski J, Ivy P, et al. Notch1 phenotype and clinical stage progression in non-small cell lung cancer. J Hematol Oncol. 2015;8:9 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Xie F, Cai W, Liu Y, Li Y, Du B, Feng L, et al. Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling. Int J Mol Med. 2015;35:135-42 pubmed 出版商
  • 免疫印迹; 小鼠
Redmond E, Liu W, Hamm K, Hatch E, Cahill P, Morrow D. Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. PLoS ONE. 2014;9:e84122 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 3c
Gupta R, Sharma M, Suri V, Kakkar A, Singh M, Sarkar C. Study of chromosome 9q gain, Notch pathway regulators and Tenascin-C in ependymomas. J Neurooncol. 2014;116:267-74 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Murta D, Batista M, Silva E, Trindade A, Henrique D, Duarte A, et al. Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle. PLoS ONE. 2013;8:e72767 pubmed 出版商
Ni X, Zhang Y, Jia L, Lu W, Zhu Q, Ren J, et al. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging (Albany NY). 2021;13:5164-5184 pubmed 出版商
Zhu Q, Li J, Wu Q, Cheng Y, Zheng H, Zhan T, et al. Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment. Biol Res. 2020;53:5 pubmed 出版商
Cheng H, Zhu H, Cao M, Lu C, Bao S, Pan Y. HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression. Braz J Med Biol Res. 2018;52:e7718 pubmed 出版商
Kahn S, Wang X, Nitta R, Gholamin S, Theruvath J, Hutter G, et al. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018;9:4121 pubmed 出版商
Ernst A, Putscher A, Samatov T, Suling A, Galatenko V, Shkurnikov M, et al. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy. PLoS ONE. 2018;13:e0192525 pubmed 出版商
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed 出版商
Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann M, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628 pubmed 出版商
Young R, Fernando M, Hughes D, Brown N, Woll P. Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol. 2014;97:148-53 pubmed 出版商
Chen G, Sun L, Yu M, Meng D, Wang W, Yang Y, et al. The Jagged-1/Notch-1/Hes-1 pathway is involved in intestinal adaptation in a massive small bowel resection rat model. Dig Dis Sci. 2013;58:2478-86 pubmed 出版商
Giannelli M, Chellini F, Sassoli C, Francini F, Pini A, Squecco R, et al. Photoactivation of bone marrow mesenchymal stromal cells with diode laser: effects and mechanisms of action. J Cell Physiol. 2013;228:172-81 pubmed 出版商
Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012;92:688-702 pubmed 出版商
Lim S, Kim H, Quan X, Ahn S, Kim H, Hsieh D, et al. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol. 2011;9:83 pubmed 出版商
Firestein R, Bass A, Kim S, Dunn I, Silver S, Guney I, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008;455:547-51 pubmed 出版商
产品信息
目录号 :
ab52627
ItemName :
抗Notch1抗体[EP1238Y]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
EP1238Y
规格 :
10微升, 100微升
物种摘要 :
Cow, Hu, Ms
应用摘要 :
Flow Cyt, ICC/IF, IHC-P, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
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