产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗YAP1抗体[EP1674Y]
目录 :
ab52771
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
EP1674Y
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫细胞化学基因敲除验证
文章摘录数: 49
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1j
Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics. 2021;11:5650-5674 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 1i
Liu J, You Y, Tian Z, Xiao M, Zheng J, Wang Y, et al. Increased nuclear translation of YAP might act as a potential therapeutic target for NF1-related plexiform neurofibroma. Int J Med Sci. 2021;18:2008-2016 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1a
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed 出版商
  • 免疫细胞化学基因敲除验证; 人类; 图 1b
Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu F, et al. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biol. 2019;17:e3000201 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3i
Rausch V, Bostrom J, Park J, Bravo I, Feng Y, Hay D, et al. The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Curr Biol. 2019;29:242-255.e6 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5c
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Zhou Y, Huang T, Zhang J, Wong C, Zhang B, Dong Y, et al. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene. 2017;36:6518-6530 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 1h
Dieffenbach P, Haeger C, Coronata A, Choi K, Varelas X, Tschumperlin D, et al. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017;313:L628-L647 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1h
  • 免疫印迹; 人类; 图 1g
Zhu G, Chen Y, Zhang X, Wu Q, Zhao Y, Chen Y, et al. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT. Sci Rep. 2017;7:44940 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7d
  • 免疫印迹; 人类; 图 3d
Chorzalska A, Kim J, Roder K, Tepper A, Ahsan N, Rao R, et al. Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia. Stem Cells Dev. 2017;26:656-677 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 4
Ye L, Qiu L, Zhang H, Chen H, Jiang C, Hong H, et al. Cardiomyocytes in Young Infants With Congenital Heart Disease: a Three-Month Window of Proliferation. Sci Rep. 2016;6:23188 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 5
  • 免疫印迹; 人类; 图 4
Qin L, Dong Z, Zhang J. 14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016;7:17726-36 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Yang S, Zhang L, Purohit V, Shukla S, Chen X, Yu F, et al. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Oncotarget. 2015;6:36019-31 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1
Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3e
  • 免疫印迹; 人类; 图 5b
Stein C, Bardet A, Roma G, Bergling S, Clay I, Ruchti A, et al. YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. PLoS Genet. 2015;11:e1005465 pubmed 出版商
  • 免疫沉淀; 人类; 图 4a
Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, et al. Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 2015;34:1349-70 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Zhang L, Yang S, Chen X, Stauffer S, Yu F, Lele S, et al. The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells. Mol Cell Biol. 2015;35:1350-62 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Yang S, Zhang L, Chen X, Chen Y, Dong J. Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1. J Biol Chem. 2015;290:6191-202 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4c
  • 免疫组化; 人类; 图 7b
  • 免疫印迹; 人类; 图 1a
Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, et al. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene. 2015;34:73-83 pubmed 出版商
Li L, Ugalde A, Scheele C, Dieter S, Nagel R, Ma J, et al. A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis. Genome Biol. 2021;22:54 pubmed 出版商
Ni X, Xie Q, Zhao J, Xu Y, Ji M, Hu W, et al. The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial-mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP1. Aging (Albany NY). 2021;13:4357-4369 pubmed 出版商
Seo H, Kim H, Yoon J, Kweon T, Park Y, Kang J, et al. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Cell Death Dis. 2020;11:815 pubmed 出版商
Feldker N, Ferrazzi F, Schuhwerk H, Widholz S, Guenther K, Frisch I, et al. Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer. EMBO J. 2020;:e103209 pubmed 出版商
Wei F, Wang A, Wang Q, Han W, Rong R, Wang L, et al. Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. Aging (Albany NY). 2020;12:12002-12018 pubmed 出版商
Hoxha S, Shepard A, Troutman S, Diao H, Doherty J, Janiszewska M, et al. YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators. Cancer Res. 2020;80:2512-2522 pubmed 出版商
Zhou Y, Zhang J, Li H, Huang T, Wong C, Wu F, et al. AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis. Oncogene. 2020;39:4375-4389 pubmed 出版商
Kimura M, Horie T, Baba O, Ide Y, Tsuji S, Ruiz Rodriguez R, et al. Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity. EMBO Rep. 2020;21:e48389 pubmed 出版商
Liu J, Zhao X, Wang K, Zhang X, Yu Y, Lv Y, et al. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Cell Death Dis. 2019;10:452 pubmed 出版商
Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, et al. CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. Cancer Sci. 2019;110:2284-2295 pubmed 出版商
Yoshida M, Horiguchi H, Kikuchi S, Iyama S, Ikeda H, Goto A, et al. miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. PLoS ONE. 2019;14:e0213220 pubmed 出版商
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, et al. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature. 2018;563:265-269 pubmed 出版商
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen Y, et al. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. Cell Death Dis. 2018;9:1091 pubmed 出版商
Ooki A, Vandenbussche C, Kates M, Hahn N, Matoso A, McConkey D, et al. CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer. Br J Cancer. 2018;119:961-970 pubmed 出版商
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, et al. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med. 2018;24:1599-1610 pubmed 出版商
Gao F, Yu X, Meng R, Wang J, Jia L. STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells. Onco Targets Ther. 2018;11:5371-5381 pubmed 出版商
Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed 出版商
Molina L, Bell D, Tao J, Preziosi M, Pradhan Sundd T, Singh S, et al. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018;188:1895-1909 pubmed 出版商
Liu M, Jin L, Sun S, Liu P, Feng X, Cheng Z, et al. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018;37:1637-1653 pubmed 出版商
Foster C, Gualdrini F, Treisman R. Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics. Genes Dev. 2017;31:2361-2375 pubmed 出版商
Crook Z, Sevilla G, Friend D, Brusniak M, Bandaranayake A, Clarke M, et al. Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets. Nat Commun. 2017;8:2244 pubmed 出版商
Lin C, Xu X. YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis. Biomed Pharmacother. 2017;95:789-794 pubmed 出版商
Ma X, Wang H, Ji J, Xu W, Sun Y, Li W, et al. Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A. 2017;114:1934-1939 pubmed 出版商
Ye L, Yin M, Xia Y, Jiang C, Hong H, Liu J. Decreased Yes-Associated Protein-1 (YAP1) Expression in Pediatric Hearts with Ventricular Septal Defects. PLoS ONE. 2015;10:e0139712 pubmed 出版商
Kang W, Tong J, Lung R, Dong Y, Zhao J, Liang Q, et al. Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma. Mol Cancer. 2015;14:52 pubmed 出版商
Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015;17:95-103 pubmed 出版商
Sheen Chen S, Huang C, Tsai C, Liu Y, Wu S, Huang C, et al. Yes-associated protein is not an independent prognostic marker in breast cancer. Anticancer Res. 2012;32:3321-5 pubmed
Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, et al. TGF-? synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 2012;209:479-94 pubmed 出版商
Kang W, Tong J, Chan A, Lee T, Lung R, Leung P, et al. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res. 2011;17:2130-9 pubmed 出版商
Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, et al. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011;71:873-83 pubmed 出版商
产品信息
目录号 :
ab52771
ItemName :
抗YAP1抗体[EP1674Y]
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
EP1674Y
规格 :
10微升, 100微升
物种摘要 :
Hu
应用摘要 :
Flow Cyt, ICC/IF, IHC-P, IP, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。