产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗毛细血管扩张性共济失调症突变蛋白抗体[2C1(1A1)]
目录 :
ab78
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2C1(1A1)
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
文章摘录数: 47
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:800; 图 3a
Mahata T, Sengar A, Basak M, Das K, Pramanick A, Verma S, et al. Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. Redox Biol. 2021;46:102105 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s4b
Waseem S, Kumar S, Lee K, Yoon B, Kim M, Kim H, et al. Protein Arginine Methyltransferase 1 Is Essential for the Meiosis of Male Germ Cells. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫印迹; 人类; 1:800; 图 s6a
  • 免疫印迹; 小鼠; 1:800; 图 6d
Pramanick A, Chakraborti S, Mahata T, Basak M, Das K, Verma S, et al. G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity. Redox Biol. 2021;43:101965 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5h
Collin G, Huna A, Warnier M, Flaman J, Bernard D. Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. Cell Death Dis. 2018;9:259 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s6a
Kang H, Park J, Choi K, Kim Y, Choi H, Jung C, et al. Chemical screening identifies ATM as a target for alleviating senescence. Nat Chem Biol. 2017;13:616-623 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 6b
Schmid Burgk J, Höning K, Ebert T, Hornung V. CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism. Nat Commun. 2016;7:12338 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
Lin L, Swerdel M, Lazaropoulos M, Hoffman G, Toro Ramos A, Wright J, et al. Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. Stem Cell Reports. 2015;5:1097-1108 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 s1
Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld F, et al. Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. Nat Commun. 2015;6:7677 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Yu H, Xie J, Li B, Sun Y, Gao Q, Ding Z, et al. TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. Sci Rep. 2015;5:9853 pubmed 出版商
  • 免疫印迹; 人类; 图 s11
Warren D, Tajsic T, Porter L, Minaisah R, Cobb A, Jacob A, et al. Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing. Cell Death Differ. 2015;22:1540-50 pubmed 出版商
  • 免疫印迹; 人类
Kawasumi M, Bradner J, Tolliday N, Thibodeau R, Sloan H, Brummond K, et al. Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 2014;74:7534-45 pubmed 出版商
  • 免疫印迹; 人类
Ferlazzo M, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, et al. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates. Mol Neurobiol. 2014;49:1200-11 pubmed 出版商
  • 免疫印迹; 人类
Gubanova E, Issaeva N, Gokturk C, Djureinovic T, Helleday T. SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways. Cell Cycle. 2013;12:3770-80 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 2
Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, et al. ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol. 2013;33:3113-24 pubmed 出版商
  • 免疫印迹; 人类
Sappino A, Buser R, Seguin Q, Fernet M, Lesne L, Gumy Pause F, et al. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis. 2012;1:e7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Rass E, Chandramouly G, Zha S, Alt F, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013;288:7086-95 pubmed 出版商
  • 免疫印迹; 小鼠
Singh K, Shukla P, Quan A, Desjardins J, Lovren F, Pan Y, et al. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012;287:6604-14 pubmed 出版商
Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, et al. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. elife. 2018;7: pubmed 出版商
Staples C, Barone G, Myers K, Ganesh A, Gibbs Seymour I, Patil A, et al. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. Cell Rep. 2016;16:2565-2575 pubmed 出版商
Ueno K, Takeuchi Y, Samura M, Tanaka Y, Nakamura T, Nishimoto A, et al. Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts. Sci Rep. 2016;6:28538 pubmed 出版商
Salzman D, Nakamura K, Nallur S, Dookwah M, Metheetrairut C, Slack F, et al. miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage. Nat Commun. 2016;7:10954 pubmed 出版商
Kanu N, Zhang T, Burrell R, Chakraborty A, Cronshaw J, DaCosta C, et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2016;35:4009-19 pubmed 出版商
Tengku Ahmad T, Jaafar F, Jubri Z, Abdul Rahim K, Rajab N, Makpol S. Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis. BMC Complement Altern Med. 2014;14:108 pubmed 出版商
Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed 出版商
Edwards T, Helmus M, Koeller K, Bashkin J, Fisher C. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways. J Virol. 2013;87:3979-89 pubmed 出版商
Sabatel H, Di Valentin E, Gloire G, Dequiedt F, Piette J, Habraken Y. Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-?B-dependent transcription of specific genes after genotoxic stress. PLoS ONE. 2012;7:e38246 pubmed 出版商
Shin J, Lee C, Lee K, Lee J, Lee K, Kim K, et al. Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor. Tumour Biol. 2012;33:1645-51 pubmed 出版商
Lee J, Sung C, Lee E, Do I, Kim H, Yoon S, et al. Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene. PLoS ONE. 2012;7:e34456 pubmed 出版商
Serra M, Marongiu F, Sini M, Laconi E. Hepatocyte senescence in vivo following preconditioning for liver repopulation. Hepatology. 2012;56:760-8 pubmed 出版商
Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont P, et al. CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res. 2012;40:4483-95 pubmed 出版商
Wysham W, Mhawech Fauceglia P, Li H, Hays L, Syriac S, Skrepnik T, et al. BRCAness profile of sporadic ovarian cancer predicts disease recurrence. PLoS ONE. 2012;7:e30042 pubmed 出版商
Min J, Choi E, Hwang K, Kim J, Sampath S, Venkitaraman A, et al. The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis. J Biol Chem. 2012;287:5091-101 pubmed 出版商
Demuth I, Dutrannoy V, Marques W, Neitzel H, Schindler D, Dimova P, et al. New mutations in the ATM gene and clinical data of 25 AT patients. Neurogenetics. 2011;12:273-82 pubmed 出版商
Zhang W, Peng G, Lin S, Zhang P. DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem. 2011;286:35899-905 pubmed 出版商
Castillo P, Bogliolo M, Surralles J. Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage. DNA Repair (Amst). 2011;10:518-25 pubmed 出版商
Urcuqui Inchima S, Patiño C, Zapata X, García M, Arteaga J, Chamot C, et al. Production of HIV particles is regulated by altering sub-cellular localization and dynamics of Rev induced by double-strand RNA binding protein. PLoS ONE. 2011;6:e16686 pubmed 出版商
Huang Y, Ratovitski E. Phospho-?Np63?/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY). 2010;2:959-68 pubmed
Mandriota S, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, et al. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. J Biol Chem. 2010;285:13092-106 pubmed 出版商
Vonlaufen N, Naguleswaran A, Coppens I, Sullivan W. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii. J Biol Chem. 2010;285:11154-61 pubmed 出版商
Mattiussi S, Lazzari C, Truffa S, Antonini A, Soddu S, Capogrossi M, et al. Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1). PLoS ONE. 2009;4:e6603 pubmed 出版商
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J, et al. Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol. 2008;10:812-24 pubmed 出版商
Gastaldo J, Viau M, Bencokova Z, Joubert A, Charvet A, Balosso J, et al. Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways. Toxicol Lett. 2007;173:201-14 pubmed
O Brien E, Barnes V, Zhao L, McKnight R, Yu X, Callaway C, et al. Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. Am J Physiol Regul Integr Comp Physiol. 2007;293:R314-22 pubmed
Kozlov S, Graham M, Peng C, Chen P, Robinson P, Lavin M. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006;25:3504-14 pubmed
Gumy Pause F, Wacker P, Maillet P, Betts D, Sappino A. ATM alterations in childhood non-Hodgkin lymphoma. Cancer Genet Cytogenet. 2006;166:101-11 pubmed
Coll Mulet L, Iglesias Serret D, Santidrian A, Cosialls A, de Frias M, Castaño E, et al. MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. Blood. 2006;107:4109-14 pubmed
产品信息
目录号 :
ab78
ItemName :
抗毛细血管扩张性共济失调症突变蛋白抗体[2C1(1A1)]
产品类型 :
抗体
宿主物种 :
小鼠
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
2C1(1A1)
规格 :
100微升
物种摘要 :
Hu, Mk, Ms, Rat
应用摘要 :
Flow Cyt, ICC/IF, IHC-P, IP, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。