产品简要
公司名称 :
艾博抗(上海)贸易有限公司
其他品牌 :
Epitomics, Ascent Scientific, MitoSciences
产品类型 :
抗体
产品名称 :
抗丙H2A.X(磷酸化S139)抗体[EP854(2)Y]-ChIP级
目录 :
ab81299
规格 :
10微升, 100微升
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
EP854(2)Y
反应物种 :
axolotl, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq, dot blot
文章摘录数: 34
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 4e
  • 免疫印迹; 人类; 图 2b
Yang W, Wu A, Hsu T, Liou J, Lo W, Chang K, et al. Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells. Cell Death Dis. 2021;12:884 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s3-2a
Bossaert M, Pipier A, Riou J, Noirot C, Nguyên L, Serre R, et al. Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands. elife. 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 6f
Plácido L, Romero Y, Maldonado M, Toscano Marquez F, Ramirez R, Calyeca J, et al. Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫印迹; 小鼠; 0.15 ug/ml; 图 6f
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed 出版商
  • 免疫沉淀; 人类; 图 s2c
House N, Parasuram R, Layer J, Price B. Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage. PLoS ONE. 2020;15:e0237759 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 图 s7a, s7b
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, et al. Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells. Cell Death Dis. 2020;11:519 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2g
Meng F, Qian M, Peng B, Peng L, Wang X, Zheng K, et al. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. elife. 2020;9: pubmed 出版商
  • 免疫组化-冰冻切片; axolotl; 1:250; 图 4e
Sousounis K, Bryant D, Martínez Fernández J, Eddy S, Tsai S, Gundberg G, et al. Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1d
Chen J, Li P, Song L, Bai L, Huen M, Liu Y, et al. 53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice. Cell Death Differ. 2020;: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 s3a
  • 免疫印迹; 小鼠; 1:5000; 图 s1a
  • 免疫印迹; 人类; 1:5000; 图 s1a
Wienert B, Wyman S, Richardson C, Yeh C, Akçakaya P, Porritt M, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science. 2019;364:286-289 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 5g
  • 免疫印迹; 小鼠; 图 4f
Ao Y, Zhang J, Liu Z, Qian M, Li Y, Wu Z, et al. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv. 2019;5:eaav5078 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1b
Mangeot P, Risson V, Fusil F, Marnef A, Laurent E, Blin J, et al. Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins. Nat Commun. 2019;10:45 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 2c
  • 免疫细胞化学; 小鼠; 1:500; 图 s1f
Schrank B, Aparicio T, Li Y, Chang W, Chait B, Gundersen G, et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018;559:61-66 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 st1
  • 免疫印迹; 人类; 1:6000; 图 st1
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O Neil N, et al. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours. Nat Commun. 2017;8:14432 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 s5
Penterling C, Drexler G, Böhland C, Stamp R, Wilke C, Braselmann H, et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS ONE. 2016;11:e0156599 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Heylmann D, Kaina B. The γH2AX DNA damage assay from a drop of blood. Sci Rep. 2016;6:22682 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, et al. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. PLoS ONE. 2015;10:e0130561 pubmed 出版商
Liu Q, Chen F, Yang T, Su J, Song S, Fu Z, et al. Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy. Aging Dis. 2021;12:1238-1251 pubmed 出版商
Miyazaki T, Shinkawa H, Takemura S, Tanaka S, Amano R, Kimura K, et al. Precancerous Lesions and Liver Atrophy as Risk Factors for Hepatolithiasis-Related Death after Liver Resection for Hepatolithiasis. Asian Pac J Cancer Prev. 2020;21:3647-3654 pubmed 出版商
Yu B, Ma J, Li J, Wang D, Wang Z, Wang S. Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. Nat Commun. 2020;11:2549 pubmed 出版商
Smith R, Lebeaupin T, Juhasz S, Chapuis C, D Augustin O, Dutertre S, et al. Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage. Nucleic Acids Res. 2019;47:11250-11267 pubmed 出版商
Elbialy A, Asakawa S, Watabe S, Kinoshita S. A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways. Biology (Basel). 2018;7: pubmed 出版商
Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, et al. Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018;72:250-262.e6 pubmed 出版商
McGuinness D, Mohammed S, Monaghan L, Wilson P, Kingsmore D, Shapter O, et al. A molecular signature for delayed graft function. Aging Cell. 2018;17:e12825 pubmed 出版商
Luczak M, Zhitkovich A. Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicol Appl Pharmacol. 2018;355:238-246 pubmed 出版商
Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, et al. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. elife. 2018;7: pubmed 出版商
Kwasna D, Abdul Rehman S, Natarajan J, Matthews S, Madden R, De Cesare V, et al. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell. 2018;70:150-164.e6 pubmed 出版商
Chang E, Novoa C, Aristizabal M, Coulombe Y, Segovia R, Chaturvedi R, et al. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. J Cell Biol. 2017;216:3991-4005 pubmed 出版商
Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed 出版商
Shkedy D, Singh N, Shemesh K, Amir A, Geiger T, Liefshitz B, et al. Regulation of Elg1 activity by phosphorylation. Cell Cycle. 2015;14:3689-97 pubmed 出版商
Sun J, Liu Q, Ahluwalia D, Li W, Meng F, Wang Y, et al. Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer. Cancer Biol Ther. 2015;16:438-49 pubmed 出版商
Dulev S, Tkach J, Lin S, Batada N. SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. EMBO Rep. 2014;15:1163-74 pubmed 出版商
Xie C, Xu L, Yang Z, Cao X, Li W, Lu N. Expression of ?H2AX in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett. 2014;7:159-163 pubmed
产品信息
目录号 :
ab81299
ItemName :
抗丙H2A.X(磷酸化S139)抗体[EP854(2)Y]-ChIP级
类别 :
抗体
宿主 :
克隆性 :
单克隆
共轭标签 :
未共轭
克隆名称 :
EP854(2)Y
规格 :
10微升, 100微升
物种摘要 :
Hu, Ms, Rat
应用摘要 :
ChIP, Dot, ICC/IF, IHC-P, IP, WB
公司信息
艾博抗(上海)贸易有限公司
上海市浦东新区伽利略路338号5幢4层5401室
cn.technical@abcam.com
http://www.abcam.cn
400-628-6880 86-21-5110 5938
公司总部: 英国
Abcam是全球知名的生命科学研究领域产品提供商,产品涵盖一抗、二抗、蛋白、多肽及ELISA kit。